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11. 发明专利

JPH02193917A SUPPRESSING AGENT OF ENZYME FORMATION 失效
公开(公告)号：JPH02193917A
公开(公告)日：1990-07-31
申请号：JP1222289
申请日：1989-01-21
申请人： HAYASHIBARA BIOCHEM LAB , SANSHO SEIYAKU KK , MISHIMA YUTAKA
发明人： MISHIMA YUTAKA , OYAMA YASUAKI , KURIMOTO MASASHI
IPC分类号： A61K31/19 , A61K8/00 , A61K8/30 , A61K8/36 , A61K8/365 , A61P17/00 , A61P43/00 , A61Q19/02
摘要： PURPOSE:To obtain a suppressing agent of enzyme formation containing specific organic acids and unsaturated fatty acids as active ingredients and capable of suppressing formation of tyrosinase, exhibiting melanin formation suppressing effect and attaining fair-skinning effect. CONSTITUTION:The suppressing agent of enzyme formation containing (A) organic acids selected from acetic acids, lactic acids and pyruvic acids and (B) unsaturated fatty acids, preferably 12-22C unsaturated fatty acids (e.g. lauroleic acid, oleic acid, linoleic acid, arachidonic acid or eicosatetraenoic acid) as active ingredients and free from substantially inhibiting activity of an enzyme while having excellent tyrosinase formation suppressing action in a living cell. The components A and B are metabolism related substances and extremely high in safety and further have high stability to heat and pH and are also capable of readily carrying out heat sterilization and long-term storage and can be advantageously utilized for treatment and prevention of local pigmentation disorder such as stain, ephelis or sun-burn and systemic pigmentation disorder such as Addison's disease.

12. 发明专利

JPH02152998A HUMAN GAMMA-INTERFERON, ITS PRODUCTION AND USE 失效
公开(公告)号：JPH02152998A
公开(公告)日：1990-06-12
申请号：JP18406988
申请日：1988-07-23
申请人： HAYASHIBARA BIOCHEM LAB
发明人： KURIMOTO MASASHI , MIHASHI MASAKAZU
IPC分类号： C12P21/02 , A61K38/00 , A61K38/21 , A61P7/06 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/08 , A61P43/00 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/57 , C07K16/24 , C12N5/08 , C12R1/91
摘要： NEW MATERIAL:A human gamma-interferon containing a sugar chain of formula II (NeuAc is N-acetylneuraminic acid; GlcNAc is N-acetyl-D-glucosamine; Gal is D-galactose; Man is D-mannose; Fuc is L-fucose) bonded to one or both of asparagine units existing at the 25th and the 97th from the N-terminal of a polypeptide chain of formula I, etc. USE:A remedy and preventive for viral diseases, cancers and immunological diseases. PREPARATION:The objective compound of formula I can be prepared e.g. by injecting an antiserum prepared from a rabbit into neonatal hamster to weaken the immune reaction of the hamster, subcutaneously transplanting a human- originated KG-1 cell to the hamster, extracting the cell after 3 weeks, culturing in the presence of an inducing agent (e.g. lipopolysaccharide) and separating the product from the culture liquid by a column chromatography using an anti- human gamma-interferon antibody column.

13. 发明专利

JPS61115026A Production of novel lymphokine ii 失效
标题翻译：生产新型LYMPHOKINE II
公开(公告)号：JPS61115026A
公开(公告)日：1986-06-02
申请号：JP2839685
申请日：1985-02-18
申请人： Hayashibara Biochem Lab Inc
发明人： MIHASHI MASAKAZU , KURIMOTO MASASHI
IPC分类号： C07K14/195 , A61K35/12 , A61K38/00 , A61K38/16 , A61P35/00 , C07K14/005 , C07K14/52 , C07K14/525 , C07K14/555 , C12P21/00 , C12R1/91
摘要： NEW MATERIAL:A lymphokine II (molecular weight, 20,000±2,000; isoelectric point, pI=6.2±0.3; mobility, Rf=0.29±0.02 by Disc-PAGE; solubility, soluble in water, saline water and phosphate buffer solution, hardly soluble or insoluble in ethyl ether, etc.; color reactions, positive to protein by Lawry reaction and micro-biuret reaction, positive to glucide by phenol sulfuric acid method; stability, stable at 60°C for 30min at 7.2pH, stable at 4.0W11.0pH at 4°C for 16hr, and stable for ≥1 month in frozen state at -10°C).
USE: Agent for suppressing the proliferation of various malignant tumor cells.
PREPARATION: The novel lymphokine II is produced by the cell prepared by transplanting a human-originated cell capable of producing the novel lymphokine II (e.g. leukocyte, lymphocyte, etc.) to a warm-blooded animal other than human, or by the cell proliferated under the supply of the body fluid of said warm- blooded animal. The lymphokine is essentially harmless to the normal human cell.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：新材料：淋巴细胞毒素II（分子量，20,000+或-2,000;等电点，pI = 6.2±或-0.3;迁移率，Rf = 0.29±或-0.02通过Disc-PAGE;溶解度，可溶于水，盐水和磷酸盐缓冲溶液，难溶于乙醚等不溶物;通过Lawry反应和微缩二脲反应对蛋白质呈阳性反应，通过苯酚硫酸法对葡萄糖呈阳性;稳定性在60℃稳定30分钟 7.2pH，在4℃下4.0-11.0pH稳定16小时，在-10℃下在冷冻状态下稳定> = 1个月）。用途：抑制各种恶性肿瘤细胞增殖的药剂。制备：新型淋巴因子II由通过将能够产生新淋巴因子II（例如白细胞，淋巴细胞等）的人源性细胞移植到除人之外的温血动物或通过细胞增殖而制备的细胞在所述温血动物的体液供应下。淋巴因子基本上对正常人细胞无害。

14. 发明公开

EP1438964A4 PROCESS FOR PRODUCING COLLAGEN PRODUCTION ENHANCERS AND USE THEREOF 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON KOLLAGEN-PRODUKTIONSVERSTÄRKERNUND VERWENDUNG
公开(公告)号：EP1438964A4
公开(公告)日：2004-12-29
申请号：EP02762761
申请日：2002-08-08
申请人： HAYASHIBARA BIOCHEM LAB
发明人： MIYATA SATOMI , USHIO SHINPEI , KURIMOTO MASASHI
IPC分类号： A23K1/18 , A23G9/32 , A23G9/36 , A23K1/16 , A23L1/076 , A23L1/30 , A23L1/302 , A23L2/38 , A61K8/06 , A61K8/34 , A61K8/67 , A61K8/96 , A61K8/98 , A61K31/341 , A61K31/375 , A61K35/64 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/08 , A61K7/00 , A61K7/48
CPC分类号： A23G9/366 , A23K20/10 , A23K20/174 , A23L2/38 , A23L21/20 , A23L33/15 , A23V2002/00 , A61K8/676 , A61K8/988 , A61K31/375 , A61K35/644 , A61Q19/00 , A61Q19/08 , A61K2300/00 , A23V2250/708 , A23V2250/636 , A23V2250/204 , A23V2250/2117 , A23V2250/6416
摘要： Concerning foods, drinks, cosmetics, drugs, feeds and so on, it is intended to prevent the skin from aging and maintaining and improving health. More specifically speaking, the technical feature resides in preparing a TGF-β production/collagen production enhancer containing as the active ingredients royal jelly and L-ascorbic acid or a TGF-β production enhancer containing as the active ingredient royal jelly alone, orally or percutaneously administering the former to fibroblasts or the latter to keratinocytes, thus enhancing the production of TGF-β in fibroblasts/keratinocytes of the subject animal to thereby enhance the production of collagen in fibroblasts or promote the proliferation of keratinocytes. Thus, the production of collagen, which is a major constituent of derm, tissues and organs, can be enhanced or fibroblasts occurring in derm constituting the skin or keratinocytes occurring in epiderm can be activated.
摘要翻译：关于食品，饮料，化妆品，药品，饲料等，其目的是防止皮肤老化，维持和改善健康。更具体地说，其技术特征在于制备含有作为活性成分的蜂王浆和L-抗坏血酸或TGF-β产生促进剂的TGF-β产生/胶原产生增强剂，其中含有蜂王浆作为活性成分单独，口服或经皮给予前者成纤维细胞或后者给予角质形成细胞，从而增强受试动物的成纤维细胞/角质形成细胞中TGF-β的产生，从而增强成纤维细胞中胶原的产生或促进角质形成细胞的增殖。因此，可以增强作为皮肤，组织和器官的主要成分的胶原蛋白的产生，或者可以激活在构成表皮中发生的皮肤或角质形成细胞中发生的成纤维细胞。

15. 发明公开

EP1514540A4 CALCIUM-CONTAINING TISSUE STRENGTHENING AGENTS AND USE THEREOF 有权
标题翻译：中含钙织物斯塔克剂及其使用
公开(公告)号：EP1514540A4
公开(公告)日：2006-03-08
申请号：EP02807341
申请日：2002-05-02
申请人： HAYASHIBARA BIOCHEM LAB
发明人： MIYAKE MASAKI , USHIO SHIMPEI , IWAKI KANSO , KURIMOTO MASASHI
IPC分类号： A23L1/30 , A23L1/302 , A23L1/304 , A61K8/49 , A61K31/12 , A61K31/343 , A61K31/352 , A61P19/08 , A61P19/10 , A61P43/00 , A61Q11/00 , C07C49/796 , C07C49/83 , C07C49/835 , C07D307/83 , C07D311/30 , C07D311/32 , C07D311/62
CPC分类号： C07D311/30 , A23L33/105 , A23L33/11 , A23L33/15 , A23L33/16 , A61K8/4973 , A61K8/498 , A61K31/12 , A61K31/343 , A61K31/352 , A61Q11/00 , C07C49/796 , C07C49/83 , C07C49/835 , C07D307/83 , C07D311/32 , C07D311/62
摘要： It is intended to provide agents having an effect of strengthening calcium-containing tissues and being safely usable. Namely, calcium-containing tissue strengthening agents characterized by containing at least one member selected from among flavons, flavonols, flavanones, flavanonols, anthocyanidines, flavanols, chalcons and aurones.

16. 发明专利

JP2007056036A Peptide and use thereof 有权
标题翻译：肽及其用途
公开(公告)号：JP2007056036A
公开(公告)日：2007-03-08
申请号：JP2006287127
申请日：2006-10-23
申请人： Hayashibara Biochem Lab Inc , Sankyo Co Ltd , 三共株式会社 , 株式会社林原生物化学研究所
发明人： SAITO SABURO , KAWAGUCHI JUNKO , HIRAHARA KAZUKI , SHIRAISHI AKIO , SERIZAWA NOBUKI , KURIMOTO MASASHI , HINO KATSUHIKO
IPC分类号： C07K7/04 , A61K31/7004 , A61K31/7016 , A61K38/00 , A61P37/08
摘要： PROBLEM TO BE SOLVED: To provide a peptide composed of essentially only T cell epitope of cedar pollen allergen and provide an anti-cedar-pollinosis agent containing the peptide as an active component.
SOLUTION: The invention provides 4 kinds of peptides having a specific amino acid sequence and composed of 13-16 amino acids, and an anti-cedar-pollinosis agent containing the peptide as an active component. The agent is usable as a desensitization agent having low risk of side actions such as anaphylaxis.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供由雪松花粉变应原的基本上只有T细胞表位组成的肽，并提供含有该肽作为活性成分的抗雪松 - 花粉刺剂。解决方案：本发明提供了具有特定氨基酸序列并由13-16个氨基酸组成的4种肽，以及含有肽作为活性成分的抗雪松 - 花粉症剂。该试剂可用作具有低反应风险的脱敏剂，例如过敏反应。版权所有（C）2007，JPO＆INPIT

17. 发明专利

JP2004189660A External preparation for skin and application thereof 有权
公开(公告)号：JP2004189660A
公开(公告)日：2004-07-08
申请号：JP2002358669
申请日：2002-12-10
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： YAMAUCHI HIROSHI , TANIGUCHI MUTSUKO , SHIBUYA TAKASHI , KURIMOTO MASASHI
IPC分类号： A61K8/00 , A61K8/42 , A61K8/73 , A61K8/97 , A61K31/16 , A61K36/28 , A61P17/00 , A61P17/02 , A61P21/00 , A61Q9/04 , A61K35/78 , A61K7/155
摘要： PROBLEM TO BE SOLVED: To provide a new external preparation for the skin for relieving pain in the skin; to provide a method of depilation or epilation by using the same; to provide a method for stabilizing a component for topically relieving the pain; and to provide a composition containing the stabilized component for topically relieving the pain. SOLUTION: The external preparation for the skin contains the component for topically relieving the pain, derived from Spilanthes acmella L. var. oleracea Clarke and/or Spilanthes oleracea L. The method of depilation or epilation comprises bringing the external preparation for the skin into contact with the skin by coating or sticking the preparation on or to the skin site to be depilated or epilated of a mammal including a human being, optionally applying iontophoresis therapy after the contact to topically benumb the skin site by introducing the topical pain-relieving component in the external preparation for the skin, and carrying out the depilation or epilation. The method for stabilizing the topical pain-relieving component involves adding saccharides such as α,α-trehalose to N-isobutyldeca-trans-2-cis-6-trans-8-trieneamide as the topical pain-relieving component derived from the Spilanthes acmella L. var. oleracea Clarke and/or the Spilanthes oleracea L. COPYRIGHT: (C)2004,JPO&NCIPI

18. 发明专利

JP2004154014A Thermostable kojibiose phosphorylase 有权
公开(公告)号：JP2004154014A
公开(公告)日：2004-06-03
申请号：JP2002320576
申请日：2002-11-01
申请人： Bio Oriented Technol Res Advancement Inst , Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所 , 生物系特定産業技術研究推進機構
发明人： YAMAMOTO TAKUO , MUKAI KAZUHISA , NAKADA TETSUYA , KUBOTA MICHIO , FUKUDA SHIGEHARU , KURIMOTO MASASHI , TSUJISAKA YOSHIO
IPC分类号： C12N15/09 , C12N9/12
摘要： PROBLEM TO BE SOLVED: To provide a thermostable kojibiose phosphorylase, and to provide a method for producing the enzyme. SOLUTION: A solution is achieved by the following. The novel enzyme has significantly raised reaction optimum temperature and thermostability as compared with those of a wild type kojibiose phosphorylase. The method for producing the enzyme comprises culturing a DNA encoding the enzyme and a microorganism producing the enzyme in a nutrient culture medium and collecting the produced enzyme from the resultant cultured product. COPYRIGHT: (C)2004,JPO

19. 发明专利

JP2004154013A High-polymerization oligosaccharide-forming kojibiose phosphorylase 有权
公开(公告)号：JP2004154013A
公开(公告)日：2004-06-03
申请号：JP2002320569
申请日：2002-11-01
申请人： Bio Oriented Technol Res Advancement Inst , Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所 , 生物系特定産業技術研究推進機構
发明人： YAMAMOTO TAKUO , MUKAI KAZUHISA , NAKADA TETSUYA , KUBOTA MICHIO , FUKUDA SHIGEHARU , KURIMOTO MASASHI , TSUJISAKA YOSHIO
IPC分类号： C12N15/09 , C12N9/12
摘要： PROBLEM TO BE SOLVED: To provide a high-polymerization oligosaccharide-forming kojibiose phosphorylase, and to provide a method for producing the same. SOLUTION: The problem is solved as follows: the novel enzyme has the ability to produce a koji oligosaccharide having higher polymerization than that of a wild type kojibiose phosphorylase; the method for producing the enzyme comprises culturing a DNA encoding the enzyme and a microorganism producing the enzyme in a nutrient culture medium and collecting the produced enzyme from the resultant cultured product. COPYRIGHT: (C)2004,JPO

20. 发明专利

JP2003327542A POLYPEPTIDE INDUCING PRODUCTION OF INTERFERON-γ 有权
标题翻译：多糖诱导干扰素-γ的产生
公开(公告)号：JP2003327542A
公开(公告)日：2003-11-19
申请号：JP2003157234
申请日：2003-06-02
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： USHIO SHINPEI , TORIGOE KAKUJI , TANIMOTO TADAO , OKAMURA HARUKI , KURIMOTO MASASHI
IPC分类号： A61K38/00 , A61K38/16 , A61K38/19 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/04 , A61P43/00 , C07H21/04 , C07K1/20 , C07K1/22 , C07K7/06 , C07K7/08 , C07K14/52 , C07K14/54 , C07K14/555 , C07K14/57 , C07K16/24 , C12N1/21 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C07K16/244 , A61K38/00 , C07K14/52 , C07K14/54 , C07K16/24
摘要： PROBLEM TO BE SOLVED: To provide a polypeptide inducing production of interferon-γ on immunocompetent cell, a DNA encoding the peptide, a recombinant DNA including the DNA and a transformant, and a method of production for a polypeptide using the transformant.
SOLUTION: The invention includes the polypeptide having a specific amino acid sequence, the DNA encoding the polypeptide, a replicatable recombinant DNA comprising an autonomous replicatable vector and the DNA, the transformant comprising the recombinant DNA properly transformed into a host, and method for producing the polypeptide comprises culturing the transformant in a culture medium and collecting produced polypeptides from the cultured product.
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供在免疫活性细胞上产生干扰素-γ的多肽，编码该肽的DNA，包含该DNA和转化体的重组DNA，以及使用该转化体的多肽生产方法。解决方案：本发明包括具有特定氨基酸序列的多肽，编码多肽的DNA，包含自主可复制载体的可重复重组DNA和DNA，包含正确转化宿主的重组DNA的转化体，以及方法用于产生多肽的方法包括在培养基中培养转化体并从培养产物中收集产生的多肽。版权所有（C）2004，JPO

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