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11. 发明申请

WO2013022280A3 N1-CYCLIC AMINE-N2-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N1循环胺-N 2取代的双胍衍生物，其制备方法和包含其的药物组合物
公开(公告)号：WO2013022280A3
公开(公告)日：2013-04-25
申请号：PCT/KR2012006328
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO LTD , KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
发明人： KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P35/00 , C07C277/02
CPC分类号： C07D307/52 , C07D295/215 , C07D333/20
摘要： An N1-cyclic amine-N2-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
摘要翻译：提供式1的N 1 - 环胺-N 2取代双胍衍生物或其药学上可接受的盐，其制备方法和包含双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。双胍衍生物具有抑制癌细胞增殖的作用，并且还表现出抗肿瘤活性，包括抑制癌症转移和癌症复发，因为即使以小剂量施用也能有效地激活与能量代谢控制有关的AMPK 与常规药物相比。此外，双胍衍生物通过AMPK活化降低血糖和脂质浓度高度有效，因此可有效用于治疗糖尿病，肥胖，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢综合征。

12. 发明公开

EP2522653A4 BIGUANIDE DERIVATIVE, A PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE BIGUANIDE DERIVATIVE AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：双胍类，工艺用于生产和药物组合物BY双胍类为活动
公开(公告)号：EP2522653A4
公开(公告)日：2013-06-12
申请号：EP11731936
申请日：2011-01-06
申请人： HANALL BIOPHARMA CO LTD
发明人： KIM SUNG WUK , JUN SUNG SOO , MIN CHANG HEE , KIM YOUNG WOONG , KANG MIN SEOK , OH BYUNG KYU , PARK SE HWAN , KIM YONG EUN , KIM DUCK , LEE JI SUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P3/10 , A61P35/00 , C07C277/02
CPC分类号： A61K31/155 , A61K31/341 , A61K31/4406 , A61K31/472 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07C279/26 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20
摘要： A biguanide derivative compound with N4-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK and inhibition of cancer cell proliferation in a low dose, compared with conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

13. 发明公开

EP2742019A4 N1-CYCLIC AMINE-N5-SUBSTITUTED PHENYL BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权转让
标题翻译： N1-环胺N5-取代双胍类，生产和药物组合物，以便方法
公开(公告)号：EP2742019A4
公开(公告)日：2015-01-07
申请号：EP12821403
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO LTD
发明人： KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P35/00 , C07C277/02
CPC分类号： C07D211/14 , C07D205/04 , C07D207/04 , C07D207/06 , C07D211/06 , C07D223/04 , C07D257/04 , C07D295/14 , C07D295/215
摘要： An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

14. 发明公开

EP2742020A4 N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权转让
标题翻译： N1-N5环胺取代双胍类，PROCESS FOR THEIR和药物成分，以便
公开(公告)号：EP2742020A4
公开(公告)日：2015-03-11
申请号：EP12822708
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO LTD
发明人： KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P35/00 , C07C277/02
CPC分类号： C07D295/215 , C07D205/04 , C07D213/40 , C07D307/52 , C07D333/20

15. 发明公开

KR20180056834A 손목결합 선글라스 有权
公开(公告)号：KR20180056834A
公开(公告)日：2018-05-30
申请号：KR20160154655
申请日：2016-11-21
申请人： KIM YONG EUN
发明人： KIM YONG EUN
IPC分类号： G02C7/10 , G02C5/08 , G02C5/16
CPC分类号： G02C7/10 , G02C5/08 , G02C5/16
摘要： 본발명은손목결합선글라스에관한것으로서, 렌즈가결합된한 쌍의안경테와; 상기한 쌍의안경테의외측단부에결합되며, 외력의인가여부에따라직선형태로펼쳐져서사용자의귀에거치되거나, 원형으로말려져서사용자의손목에감겨지는한 쌍의손목결합다리와;상기한 쌍의안경테의중심영역에결합되어상기한 쌍의안경테의손목결합다리가서로모여지는방향으로상기한 쌍의안경테가접혀지도록지지하는접힘브릿지부를포함하는것을특징으로한다.

16. 发明授权

KR101212305B1 One body type radiation panel for far infrared ray heater 有权
标题翻译：一个身体类型的辐射面板，用于红外辐射加热器
公开(公告)号：KR101212305B1
公开(公告)日：2012-12-14
申请号：KR20120088547
申请日：2012-08-13
申请人： KIM YONG EUN , KIM KI HAN
发明人： KIM KI HAN , KIM YONG EUN
IPC分类号： F24C7/04 , H05B3/10 , H05B3/20
摘要： PURPOSE: A radiant panel for an infrared heater with an integral structure is provided with a simple structure as the integral structure has the strength against thermal stress. CONSTITUTION: A radiant panel(20) for an infrared heater with an integral structure comprises an upper plate(22), side plates(24), and lower plate(26), integrally. The inward and outward corrugations(41,42) are formed on the upper plate of the radiant panel. A coating layer(40) is formed on the inward and outward corrugations. A receiving hole(32) with a ring-shaped closed section is integrally formed on the radiant panel. Joining pieces(36) are integrally formed on the outer surface of the lower plate. The coating layer is made of 52~62wt.% of silicon dioxide, 15~25wt.% of alumina, 4~6wt.% of sodium oxide, 4~6wt.% of magnesium oxide, 4~6wt.% of potassium oxide, and 4~6wt.% of iron oxide.
摘要翻译：目的：一体化结构的红外线加热器的辐射面板具有简单的结构，因为整体结构具有抗热应力的强度。一种用于具有一体结构的红外线加热器的辐射面板（20）包括上板（22），侧板（24）和下板（26）。向内和向外的波纹（41,42）形成在辐射板的上板上。在内向和外向的波纹上形成涂层（40）。在辐射板上一体地形成有环形封闭部分的接收孔（32）。连接片（36）一体地形成在下板的外表面上。涂层由二氧化硅52〜62重量％，氧化铝15〜25重量％，氧化钠4〜6重量％，氧化镁4〜6重量％，氧化钾4〜6重量％和4〜6重量％的氧化铁。

17. 发明授权

KR102174071B1 휴대용 단말기 거치장치 有权
公开(公告)号：KR102174071B1
公开(公告)日：2020-11-04
申请号：KR20190085794
申请日：2019-07-16
申请人： KIM YONG EUN , KIM EUN JOONG
发明人： KIM YONG EUN , KIM EUN JOONG
IPC分类号： H04M1/04
摘要： 보다간단한구조로제조가용이하고, 사용이보다편안하고간편하도록, 지면에지지되는본체, 상기본체앞쪽에형성되어거치대상의하단을받쳐지지하는거치부, 및상기거치부뒤쪽에마련되며거치부에지지된거치대상의후면을받쳐세운상태로지지하는수직지지부를포함하고, 상기수직지지부는상기본체에분리되어상기본체에착탈가능하게결합되고, 상기본체와상기수직지지부사이를결합하기위한결합부를더 포함하고, 상기결합부는상기본체상부에간격을두고형성되는적어도하나이상의홀, 상기홀과대응되는위치에서상기수직지지부하부에형성되어상기홀에끼워지는적어도하나이상의돌기를포함하는휴대용단말기거치장치를제공한다.

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