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    • 17. 发明申请
    • IMAGE-GUIDED INTENSITY-MODULATED X-RAY BRACHYTHERAPY SYSTEM
    • 图像强度调制的X射线穿透系统
    • WO2005120201A2
    • 2005-12-22
    • PCT/US2005019984
    • 2005-06-07
    • FORD HENRY HEALTH SYSTEMYIN FANG-FANGKIM JAE HO
    • YIN FANG-FANGKIM JAE HO
    • A61N5/10
    • A61N5/1027A61N5/1007A61N5/1031A61N5/1048A61N5/1067A61N2005/1061
    • In some embodiments, without limitation, the invention comprises a modulated image-guided x-ray brachytherapy system including a source providing low-energy photons, the source configured for placement at least partially within a patient, a control system configured to modulate the source, and an imaging systems for locating the source relative to a treatment location in the patient. The system may further comprises a target at least partially within the patient, a generator located outside the patient for providing low-energy photons, the generator configured to direct low-energy photons to the target, and a conduit between the generator and the target providing a path for the low-energy photons to travel inside the patient. The system may further comprise an in situ x-ray generator for insertion within the patient. The system may further comprise a radioactive pellet.
    • 在一些实施例中,但不限于,本发明包括调制图像引导的x射线近距离放射治疗系统,其包括提供低能量光子的源,所述源被配置为至少部分地放置在患者体内,被配置为调制源, 以及用于将源相对于患者中的治疗位置定位的成像系统。 所述系统还可以包括至少部分地在患者体内的目标,位于患者外部的用于提供低能量光子的发生器,所述发生器被配置为将低能量光子引导到靶,以及发电机和靶之间的管道, 低能量光子在患者体内行进的途径。 系统还可以包括用于插入患者体内的原位X射线发生器。 该系统还可以包括放射性丸粒。
    • 18. 发明申请
    • IMAGING AND TARGETING TUMORS USING SICKLE CELLS
    • 使用SICKLE细胞成像和靶向肿瘤
    • WO0197678A3
    • 2002-04-04
    • PCT/US0119846
    • 2001-06-22
    • FORD HENRY HEALTH SYSTEMKIM JAE HOBROWN STEPHEN LAWRENCESWERDLOW PAUL S
    • KIM JAE HOBROWN STEPHEN LAWRENCESWERDLOW PAUL S
    • A61K47/48A61K49/00A61K49/18A61K51/12A01N63/00A01N35/00C12N15/63
    • A61K49/0002A61K47/6901A61K49/1896A61K51/1203
    • According to the present invention, there is provided a delivery vehicle including sickle red blood cells carrying a moiety. The moiety can be any type of diagnostic or therapeutic agent. The present invention further provides for a method of diagnosing systemic hypoxia, acidosis, or hypertonicity by administering sickle red blood cells to a patient and detecting the location of the sickle red blood cells. Additionally, the present invention provides for a method of therapeutic treatment of systemic hypoxia, acidosis, or hypertonicity by administering sickle red blood cells to a patient. Further, the present invention provides for a delivery vehicle that specifically localizes or concentrates at systemic hypoxia, acidosis, or hypertonicity areas. The delivery vehicle is used in diagnosing and therapeutically treating these areas of hypoxia, acidosis, or hypertonicity also. The present invention further provides for a method of making the delivery vehicle described herein.
    • 根据本发明,提供一种包含携带部分的镰状红细胞的输送载体。 该部分可以是任何类型的诊断或治疗剂。 本发明还提供了通过向患者施用镰状红细胞并检测镰状红细胞的位置来诊断全身缺氧,酸中毒或高渗性的方法。 此外,本发明提供了通过向患者施用镰状红细胞来治疗全身缺氧,酸中毒或高渗性的方法。 此外,本发明提供了特异性定位或集中在全身缺氧,酸中毒或高渗性区域的输送载体。 运送车辆也用于诊断和治疗这些缺氧,酸中毒或高渗性的区域。 本发明还提供了制造本文所述的输送车辆的方法。
    • 19. 发明申请
    • OLIGOPEPTIDE FOR ENHANCING OSTEOINTEGRATION AND OSTEOGENESIS
    • 用于增强骨质疏松和骨质疏松症的寡肽
    • WO2009151288A3
    • 2010-03-25
    • PCT/KR2009003141
    • 2009-06-11
    • OSSTEM IMPLANT CO LTDKANG EUN JUNGEOM TAE GWANKIM JAE HOLEE JEONG KEUN
    • KANG EUN JUNGEOM TAE GWANKIM JAE HOLEE JEONG KEUN
    • A61K38/02
    • A61K38/02
    • The present invention relates to an oligopeptide for enhancing osteointegration and osteogenesis. More specifically, it relates to bioactive oligopeptide compounds having the general structural formula (C or K)-(I, K or P)-(I, P or K)-(K or P)-(K, P or S)-(P or S)-(A or S)-(A, P or S)-(A, P or T)-(E, P or T)-(E, L or T)-(E, L or S)-(A, L or S)-(A, I or S)-(A, I or S)-(I, M or S)-(L, M or S)-(C, L or M). The oligopeptide of the present invention is effective in bone filler replacement, vertical treatment and horizontal treatment. By using this invention, the continuous action of the oligopeptide on the surface of an implant treated with a thin film of the same can reduce the time of initial osteointegration. Additionally, an increase in the success rate of surgical operations on osteopenia patients can be achieved by inducing an increase in osteoblasts and function. It is also possible to achieve bone formation when bone mass is insufficient, without bone replacement, leading to a reduction in surgical operation costs.
    • 本发明涉及用于增强骨整合和成骨的寡肽。 更具体地说,本发明涉及具有通式(C或K) - (I,K或P) - (I,P或K) - (K或P) - (K,P或S) - (A,P或S) - (A,P或T) - (E,P或T) - (E,L或T) - (E,L或S) ) - (A,L或S) - (A,I或S) - (A,I或S) - (I,M或S) - (L,M或S) - (C,L或M)。 本发明的寡肽在骨填充剂置换,垂直处理和水平处理中是有效的。 通过使用本发明,寡聚肽在用其薄膜处理的植入物的表面上的连续作用可以减少初始骨整合的时间。 此外,通过诱导成骨细胞和功能的增加可以实现对骨质减少患者的手术操作的成功率的增加。 当骨质量不足而没有骨置换时,也可以实现骨形成,导致外科手术成本的降低。