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11. 发明授权

US08861527B1 Network-assisted routing for topology-aware overlay networks 有权
标题翻译：用于拓扑感知覆盖网络的网络辅助路由
公开(公告)号：US08861527B1
公开(公告)日：2014-10-14
申请号：US13407980
申请日：2012-02-29
申请人： Qi Bao , Feng Zhang , Qin Xin
发明人： Qi Bao , Feng Zhang , Qin Xin
IPC分类号： H04L12/46 , H04L12/18 , H04W8/08 , H04L12/715
CPC分类号： H04L12/1836 , H04L12/4633 , H04L45/64 , H04W8/085
摘要： An overlay network has a hierarchical cluster tree (HCT) structure on an underlying physical network, the HCT structure having clusters of local area networks (LANs) associated with respective sub-spaces of a hash key space. A cluster proxy node (CP) maintains a routing table and channels to both a parent cluster and member LANs, with routing information associating each LAN with a physical-network address (PA) of a corresponding LAN representative node (LR). Nodes sending routing request messages each containing a key value to the CP node, which returns routing response messages each including PA information from the routing table and/or the parent cluster. The PA information in the response for a given request includes a PA of an LR of a request-specific LAN whose sub-space contains the key value in the request message. A node uses the PA information to send a message to the LR node using the physical network.
摘要翻译：覆盖网络在底层物理网络上具有层次聚类树（HCT）结构，HCT结构具有与散列密钥空间的相应子空间相关联的局域网（LAN）簇。集群代理节点（CP）将路由表和通道维护到父集群和成员LAN，路由信息将每个LAN与对应的LAN代表节点（LR）的物理网络地址（PA）相关联。节点向CP节点发送每个包含密钥值的路由请求消息，其返回路由响应消息，每个路由响应消息包括来自路由表和/或父集群的PA信息。针对给定请求的响应中的PA信息包括其请求消息中的子空间包含密钥值的请求特定LAN的LR的PA。节点使用PA信息使用物理网络向LR节点发送消息。

12. 发明授权

US08815956B2 Sweet flavor modifier 有权
标题翻译：甜味调味剂
公开(公告)号：US08815956B2
公开(公告)日：2014-08-26
申请号：US13572237
申请日：2012-08-10
申请人： Catherine Tachdjian , Xiao-Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy James Davis , Vincent Darmohusodo , Melissa Sue Wong , Victor Selchau
发明人： Catherine Tachdjian , Xiao-Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy James Davis , Vincent Darmohusodo , Melissa Sue Wong , Victor Selchau
IPC分类号： A23L1/236
CPC分类号： C07D405/12 , A23L2/60 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/42 , C07D215/54 , C07D401/12 , C07D451/06
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.
摘要翻译：本发明包括具有结构式（I）的化合物或其盐或溶剂化物。这些化合物可用作甜味调味剂。本发明还包括包含本发明化合物的组合物和增强组合物甜味的方法。

13. 发明申请

US20140186958A1 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS 有权
公开(公告)号：US20140186958A1
公开(公告)日：2014-07-03
申请号：US14105017
申请日：2013-12-12
申请人： Feng Zhang , Le Cong , Randall Jeffrey Platt , Neville Espi Sanjana , Fei Ran
发明人： Feng Zhang , Le Cong , Randall Jeffrey Platt , Neville Espi Sanjana , Fei Ran
IPC分类号： C12N15/85
CPC分类号： C12N15/63 , C12N7/00 , C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/85 , C12N15/86 , C12N2320/30 , C12N2740/15043
摘要： The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.

14. 发明申请

US20140054581A1 ARRAY SUBSTRATE, MANUFACTURING METHOD THEREOF, AND DISPLAY DEVICE 审中-公开
标题翻译：阵列基板，其制造方法和显示装置
公开(公告)号：US20140054581A1
公开(公告)日：2014-02-27
申请号：US13878475
申请日：2012-12-23
申请人： Youngsuk Song , Guanbao Hui , Seongyeol Yoo , Seungjin Choi , Feng Zhang
发明人： Youngsuk Song , Guanbao Hui , Seongyeol Yoo , Seungjin Choi , Feng Zhang
IPC分类号： H01L27/12
CPC分类号： H01L27/124 , G02F1/1343 , G02F1/1362 , G02F1/136209 , G02F2001/134318 , G02F2001/134372 , G02F2001/136222 , G02F2203/01 , G02F2203/02 , H01L27/1259
摘要： Embodiments of the invention relate to an array substrate, a manufacturing method thereof and a display device comprising the array substrate. The array substrate comprises a gate line and a data line which define a pixel region, the pixel region comprises a thin film transistor region and an electrode pattern region, a gate electrode, a gate insulation layer, an active layer, a source electrode, a drain electrode and a passivation layer are formed in the thin film transistor region, the gate insulation layer, a pixel electrode, the passivation layer and a common electrode are formed in the electrode pattern region, and the common electrode and the pixel electrode form a multi-dimensional electric field. A color resin layer is formed between the gate insulation layer and the pixel electrode.
摘要翻译：本发明的实施例涉及阵列基板，其制造方法和包括阵列基板的显示装置。阵列基板包括栅极线和限定像素区域的数据线，像素区域包括薄膜晶体管区域和电极图案区域，栅极电极，栅极绝缘层，有源层，源极电极，漏电极和钝化层形成在薄膜晶体管区域中，栅极绝缘层，像素电极，钝化层和公共电极形成在电极图案区域中，并且公共电极和像素电极形成多个维电场。在栅极绝缘层和像素电极之间形成着色树脂层。

15. 发明授权

US08603790B2 Systems, methods and compositions for optical stimulation of target cells 有权
标题翻译：用于光学刺激靶细胞的系统，方法和组合物
公开(公告)号：US08603790B2
公开(公告)日：2013-12-10
申请号：US12988567
申请日：2009-04-08
申请人： Karl Deisseroth , Feng Zhang , Viviana Gradinaru
发明人： Karl Deisseroth , Feng Zhang , Viviana Gradinaru
IPC分类号： C12N13/00 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12Q1/02 , A61F5/00
CPC分类号： A61N5/062 , A61K31/713 , A61K41/0057 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N2005/063 , A61N2005/0651 , A61N2005/0662 , A61N2005/067 , C07K14/405 , C07K14/47 , C12N7/00 , C12N15/79 , C12N15/85 , C12N15/86 , C12N2740/10043 , C12N2740/15043 , C12N2740/15045 , C12N2750/14143
摘要： Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.
摘要翻译：结合光响应离子通道分子实现方法，系统和装置。使用响应于光刺激的光激活离子通道分子来实现一种这样的方法。该方法包括在细胞中工程化光活化离子通道分子; 以及响应于提供给所述离子通道分子的具有不激活ChR2离子通道的性质的光刺激，激活离子通道分子，以允许离子通过光活化的离子通道分子。

16. 发明申请

US20130224264A1 HIGH-LOADING, CONTROLLED-RELEASE MAGNESIUM ORAL DOSAGE FORMS AND METHODS FOR MAKING AND USING SAME 有权
公开(公告)号：US20130224264A1
公开(公告)日：2013-08-29
申请号：US13859098
申请日：2013-04-09
申请人： Stephen F. Brandon , Feng Zhang , Stuart Schoenherr
发明人： Stephen F. Brandon , Feng Zhang , Stuart Schoenherr
IPC分类号： A61K33/06
CPC分类号： A61K31/194 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/2886 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： Disclosed are high loading, controlled-release dosage forms for oral administration of magnesium salts. For example, an oral dosage form can comprise from about 80% to about 95% magnesium lactate and one or more components. As another example, an oral dosage form can comprise at least about 50% magnesium salt and exhibit a controlled release dissolution profile. Also disclosed are methods for making controlled release dosage forms for oral administration of a therapeutically effective amount of magnesium salt to a mammal. Also disclosed are methods for treating a disorder characterized by magnesium deficiency and methods for preventing or alleviating low magnesium levels.

17. 发明申请

US20130149463A1 METHOD OF MANUFACTURING PATTERNED GRAPHENE FILM 审中-公开
标题翻译：制作图形图形薄膜的方法
公开(公告)号：US20130149463A1
公开(公告)日：2013-06-13
申请号：US13805407
申请日：2012-08-09
申请人： Feng Zhang , Tianming Dai , Qi Yao
发明人： Feng Zhang , Tianming Dai , Qi Yao
IPC分类号： B05D5/00
CPC分类号： B05D5/00 , B82Y30/00 , B82Y40/00 , C01B32/184 , C23C18/06 , C23C18/1208 , C23C18/1279 , C23C18/1295 , G03F7/40 , G03F7/422
摘要： Embodiments of the invention provide a method of manufacturing a patterned graphene film. The method comprises the following steps: Step 1: a photoresist layer/electron-beam resist layer is coated on a substrate and patterned, the photoresist layer/electron-beam resist layer in a region for forming the patterned graphene film is removed; Step 2: a solution of oxidized graphene is coated on the substrate formed with the photoresist layer/electro-beam resist layer patterned in Step 1, so that a film of oxidized graphene is formed; Step 3: the substrate obtained in Step 2 is placed in a hydrazine steam, so that the film of oxidized graphene formed in Step 2 is reduced and a graphene film is obtained; and Step 4: the photoresist layer/electron-beam resist layer and the graphene film on the photoresist layer/electrone-beam resist layer are removed, so that the patterned graphene film is obtained.
摘要翻译：本发明的实施例提供一种制造图案化石墨烯薄膜的方法。该方法包括以下步骤：步骤1：将光致抗蚀剂层/电子束抗蚀剂层涂覆在基板上并图案化，去除用于形成图案化石墨烯膜的区域中的光致抗蚀剂层/电子束抗蚀剂层; 步骤2：将氧化石墨烯的溶液涂布在由步骤1中图案化的光致抗蚀剂层/电子束抗蚀剂层形成的基板上，形成氧化石墨烯的膜; 步骤3：将步骤2中获得的基材置于肼蒸汽中，使步骤2中形成的氧化石墨烯的膜减少，得到石墨烯膜; 和步骤4：除去光刻胶层/电子束抗蚀剂层上的光致抗蚀剂层/电子束抗蚀剂层和石墨烯膜，从而获得图案化的石墨烯膜。

18. 发明申请

US20130137173A1 NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS 审中-公开
标题翻译：设计师TAL效应的核素特异性识别序列
公开(公告)号：US20130137173A1
公开(公告)日：2013-05-30
申请号：US13554922
申请日：2012-07-20
申请人： Feng Zhang , Le Cong
发明人： Feng Zhang , Le Cong
IPC分类号： C12N5/071
CPC分类号： C12N15/63
摘要： The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus.
摘要翻译：本发明涉及改变感兴趣的基因座的表达或特异性靶向动物细胞中的目的基因组的表达的方法，其可能涉及使基因组座位与包含脱氧核糖核酸（DNA）的非天然存在或工程化组合物接触）结合多肽，DNA结合结构域包含至少五个或更多个转录激活子样效应子（TALE）单体和至少一种或多种特异性命令靶向感兴趣的基因组座位的半单体，以及 C端封端区，其中所述多肽包括至少一个或多个效应域，并且其中所述多肽由密码子优化的核酸分子编码和翻译，使得所述多肽优先结合所述基因组座位的DNA。

19. 发明授权

US08450107B1 Nucleotide-specific recognition sequences for designer TAL effectors 有权
标题翻译：设计师TAL效应器的核苷酸特异性识别序列
公开(公告)号：US08450107B1
公开(公告)日：2013-05-28
申请号：US13604945
申请日：2012-09-06
申请人： Feng Zhang , Le Cong
发明人： Feng Zhang , Le Cong
IPC分类号： C12N15/85 , C12N15/00
CPC分类号： C12N5/06 , C07K14/03 , C07K14/195 , C07K14/4703 , C07K2319/80 , C12N5/0686 , C12N9/1241 , C12N9/22 , C12N15/635 , C12Q1/6816 , C12Q2522/10
摘要： The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus.
摘要翻译：本发明涉及改变感兴趣的基因座的表达或特异性靶向动物细胞中的目的基因组的表达的方法，其可能涉及使基因组座位与包含脱氧核糖核酸（DNA）的非天然存在或工程化组合物接触）结合多肽，DNA结合结构域包含至少五个或更多个转录激活子样效应子（TALE）单体和至少一种或多种特异性命令靶向感兴趣的基因组座位的半单体，以及 C端封端区，其中所述多肽包括至少一个或多个效应域，并且其中所述多肽由密码子优化的核酸分子编码和翻译，使得所述多肽优先结合所述基因组座位的DNA。

20. 发明申请

US20120270273A1 TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS 有权
标题翻译：转录激活剂类效应物
公开(公告)号：US20120270273A1
公开(公告)日：2012-10-25
申请号：US13353662
申请日：2012-01-19
申请人： Feng Zhang , Le Cong , Sriram Kosuri , George M. Church
发明人： Feng Zhang , Le Cong , Sriram Kosuri , George M. Church
IPC分类号： C12N15/62 , C12P19/34 , C12N15/63
CPC分类号： C07K14/195 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/60 , C07K2319/80 , C12P19/34
摘要： Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.
摘要翻译：本文提供了可用于构建设计者转录激活子样效应子（dTALE）多肽的组合物，试剂盒和方法。

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