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11. 发明授权

US06277851B1 Bicyclic amino-pyrazinone compounds 失效
标题翻译：双环氨基 - 吡嗪酮化合物
公开(公告)号：US06277851B1
公开(公告)日：2001-08-21
申请号：US09594852
申请日：2000-06-15
申请人： Guillaume De Nanteuil , Philippe Gloanec , Tony Verbeuren , Alain Rupin , Marie-Odile Vallez
发明人： Guillaume De Nanteuil , Philippe Gloanec , Tony Verbeuren , Alain Rupin , Marie-Odile Vallez
IPC分类号： A61K3150
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04 , Y02P20/55
摘要： A compound selected from those of formula (I): wherein: R1 represents hydrogen, optionally substituted alkyl, cycloalkyl or heterocycloalkyl or a group of formula (G): wherein A1 represents single, —CH2—, —CH2—CH2— or —N(CH3)— or oxygen or sulphur, and X1 and X2, which may be identical or different, each represent carbon or nitrogen, R represents hydrogen or linear or branched (C1-C6)alkyl, represents a saturated ring having from 4 to 7 ring members, n represents integer wherein 1≦n≦6, Ar represents aryl or heteroaryl, its isomers, N-oxydes and pharmaceutically-acceptable acid or base addition salts thereof.
摘要翻译：选自式（I）的化合物：其中：R 1表示氢，任选取代的烷基，环烷基或杂环烷基或式（G）的基团：其中A1表示单，-CH 2 - ， - CH 2 -CH 2 - 或-N （CH 3） - 或氧或硫，以及可以相同或不同的X 1和X 2各自表示碳或氮，R表示氢或直链或支链（C 1 -C 6）烷基，表示具有4至7个环成员，n表示其中1≤n≤6的整数，Ar表示芳基或杂芳基，其异构体，N-氧化物及其药学上可接受的酸或碱加成盐。

12. 发明授权

US06302837B1 Benzothiophene, benzofuran and indole compounds 失效
标题翻译：苯并噻吩，苯并呋喃和吲哚化合物
公开(公告)号：US06302837B1
公开(公告)日：2001-10-16
申请号：US09687308
申请日：2000-10-13
申请人： Guillaume De Nanteuil , Christine Lila , Tony Verbeuren , Alain Rupin
发明人： Guillaume De Nanteuil , Christine Lila , Tony Verbeuren , Alain Rupin
IPC分类号： A61K314436
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D333/58 , C07D333/60 , C07D401/06 , C07D409/06 , C07D409/14
摘要： A compound selected from those of formula (I): wherein: X represents oxygen, sulphur, or NR3 wherein R3 is as defined in the description, Y represents oxygen, sulphur, NR3, or may represent single bond in certain cases, T represents nitrogen, carbon, or CH, A represents single bond, alkylene, arylene, cycloalkylene, heterocycloalkylene, heteroarylene, or —SO2—R4— wherein R4 is as defined in the description, W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycloalkyloxy or heteroaryloxy, or hydroxyamino, U1 represents hetero, or alkylene wherein one or more of carbon may optionally be replaced by one or more hetero atoms, V1 represents arylene, heteroarylene,or heterocycloalkylene, U2 represents single bond, hetero or alkylene wherein one or more carbon may optionally be replaced by one or more hetero atoms, V2 represents aryl, heteroaryl, or heterocycloalkyl, Ra, Rb, Rc, which may be identical or different, each independently of the others represents a group as defined in the description, R1 represents aryl substituted by from one to five substituents, 1,3-dihydro-2H-indol-2-one, 3,4-dihydro-2(1H)-quinolinone, 1-hydroxy-2(1H)-pyridinone group, or heteroaryl, R2 represents halogen, alkyl, aryl, arylalkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful as inhibitors of PAI-1 in the treatment of thrombosis, pathologies for which the origin is thrombosis, or pathologies causing an increase in risk of thrombosis.
摘要翻译：选自式（I）的化合物：其中：X表示氧，硫或NR 3，其中R3如说明书中所定义，Y表示氧，硫，NR 3，或在某些情况下可表示单键，T表示氮，碳或CH，A表示单键，亚烷基，亚芳基，亚环烷基，亚杂环亚烷基，亚杂芳基或-SO 2 -R 4 - ，其中R 4如说明书中所定义，W表示羟基，烷氧基，芳氧基，芳基烷氧基，环烷氧基，杂芳基氧基或羟基氨基，U1表示杂或亚烷基，其中一个或多个碳可以任选被一个或多个杂原子替代，V 1表示亚芳基，亚杂芳基或杂环亚烷基，U 2表示单键，杂或亚烷基，其中一个或多个碳可任选地被一个或多个杂原子替代，V 2表示芳基，杂芳基或杂环烷基，R a，R b，R c可以相同或不同，各自独立地表示t定义的基团他描述，R1代表被1至5个取代基取代的芳基，1,3-二氢-2H-吲哚-2-酮，3,4-二氢-2（1H） - 喹啉酮，1-羟基-2（1H） - 吡啶酮基或杂芳基，R 2表示卤素，烷基，芳基，芳基烷基，环烷基，杂环烷基，杂环烷基烷基，杂芳基或杂芳基烷基，其异构体及其药学上可接受的酸或碱加成盐，以及含有它们的药物作为治疗血栓形成的PAI-1的抑制剂，来自血栓形成的病理学，或导致血栓形成风险增加的病理学。

13. 发明授权

US07442692B2 Indanyl-piperazine compounds 失效
标题翻译：茚基 - 哌嗪化合物
公开(公告)号：US07442692B2
公开(公告)日：2008-10-28
申请号：US11391916
申请日：2006-03-29
申请人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
发明人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
IPC分类号： A61K31/551 , A61K31/495 , A61K31/496 , C07D295/084 , C07D295/125 , C07D295/145
CPC分类号： C07D213/40 , C07D295/096 , C07D295/135 , C07D295/155 , C07D333/20
摘要： A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, or R1 represents a hydrogen atom, and R2 and R3 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, —X— represents a group selected from —(CH2)m—O-Ak-, —(CH2)m—NR4-Ak-, —(CO)—NR4-Ak- and —(CH2)m—NR4-(CO)—, m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R4 represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
摘要翻译：选自式（I）的化合物的化合物：其中：R 3表示氢原子，R 1和R 2与带有它们的碳原子形成苯，萘或喹啉环结构，每个环结构任选被取代，或R 1表示氢原子，R 2和R 2 3个与携带它们的碳原子一起形成苯，萘或喹啉环结构，每个环结构可以被取代，n表示1或2，-X-表示选自 - （ CH 2 - （CH 2）n -O - ， - （CH 2 CH 2）m -NR 2 -Ak-， - （CO）-NR 4 - 和 - （CH 2）2 -N （CO） - ，m表示1和6之间的整数，包括1和6，Ak表示任选取代的亚烷基链，并且R 4表示氢原子或烷基，Ar 表示芳基或杂芳基，其对映异构体，diastero 异构体及其与药学上可接受的酸的加成盐。含有该药物的医药产品可用于治疗需要5-羟色胺再摄取抑制剂和/或NK1拮抗剂的病症。

14. 发明申请

US20060223830A1 Indanyl-piperazine compounds 失效
标题翻译：茚基 - 哌嗪化合物
公开(公告)号：US20060223830A1
公开(公告)日：2006-10-05
申请号：US11391916
申请日：2006-03-29
申请人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
发明人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D213/40 , C07D295/096 , C07D295/135 , C07D295/155 , C07D333/20
摘要： A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, or R1 represents a hydrogen atom, and R2 and R3 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, —X— represents a group selected from —(CH2)m—O-Ak-, —(CH2)m—NR4-Ak-, —(CO)—NR4-Ak- and —(CH2)m—NR4-(CO)—, m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R4 represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
摘要翻译：选自式（I）的化合物的化合物：其中：R 3表示氢原子，R 1和R 2与带有它们的碳原子形成苯，萘或喹啉环结构，每个环结构任选被取代，或R 1表示氢原子，R 2和R 2 3个与携带它们的碳原子一起形成苯，萘或喹啉环结构，每个环结构可以被取代，n表示1或2，-X-表示选自 - （ CH 2 - （CH 2）n -O - ， - （CH 2 CH 2）m -NR 2 -Ak-， - （CO）-NR 4 - 和 - （CH 2）2 -N （CO） - ，m表示1和6之间的整数，包括1和6，Ak表示任选取代的亚烷基链，并且R 4表示氢原子或烷基，Ar 表示芳基或杂芳基，其对映异构体，diastero 异构体及其与药学上可接受的酸的加成盐。含有该药物的医药产品可用于治疗需要5-羟色胺再摄取抑制剂和/或NK1拮抗剂的病症。

15. 发明授权

US06706742B2 Alpha-amino-acid compounds 失效
标题翻译： α-氨基酸化合物
公开(公告)号：US06706742B2
公开(公告)日：2004-03-16
申请号：US10146272
申请日：2002-05-15
申请人： Guillaume De Nanteuil , Bernard Portevin , Alain Benoist , Nigel Levens , Olivier Nosjean , Bernadette Husson-Robert , Michelle Boulanger
发明人： Guillaume De Nanteuil , Bernard Portevin , Alain Benoist , Nigel Levens , Olivier Nosjean , Bernadette Husson-Robert , Michelle Boulanger
IPC分类号： C07D27704
CPC分类号： C07D295/185 , C07D207/16 , C07D277/04 , C07D277/06 , Y02P20/55
摘要： Compound selected from those of formula (I): wherein: represents an optionally substituted 5-membered nitrogen-containing heterocycle, Ak represents an alkylene chain, X represents a single bond or phenylene, R1 and R2, which may be identical or different, each represent hydrogen or alkyl, R3 represents alkyl, nitro or cyano, Y represents NR4 or CHNO2, R4 represents hydrogen or alkyl, its tautomers when they exist, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid, with the exclusion of compounds wherein, simultaneously, represents an unsubstituted 5-membered nitrogen-containing heterocycle, Ak represents —(CH2)3—, X represents a single bond, Y represents NH and R3 represents nitro. Medicinal products containing the same which are useful as dipeptidyl peptidase IV inhibitors.
摘要翻译：选自式（I）的化合物的化合物：其中：表示任选取代的5元含氮杂环，Ak表示亚烷基链，X表示单键或亚苯基，R 1和R 2可以相同或不同，各自相同或不同代表氢或烷基，R3代表烷基，硝基或氰基，Y代表NR4或CHNO2，R4代表氢或烷基，其互变异构体存在时，其光学异构体及其与药学上可接受的酸的加成盐，排除化合物其中，同时代表未取代的5元含氮杂环，Ak表示 - （CH2）3-，X表示单键，Y表示NH，R3表示硝基。含有该二价基团的肽酶IV 抑制剂。

16. 发明授权

US06716843B2 Alpha-amino acid sulphonyl compounds 失效
标题翻译： α-氨基酸磺酰基化合物
公开(公告)号：US06716843B2
公开(公告)日：2004-04-06
申请号：US10109407
申请日：2002-03-28
申请人： Guillaume De Nanteuil , Bernard Portevin , Alain Benoist , Nigel Levens , Olivier Nosjean , Bernadette Husson-Robert
发明人： Guillaume De Nanteuil , Bernard Portevin , Alain Benoist , Nigel Levens , Olivier Nosjean , Bernadette Husson-Robert
IPC分类号： A61K3140
CPC分类号： C07D277/04 , C07D207/16 , C07D231/04 , C07D233/06 , C07D277/06 , C07D277/10 , Y02P20/55
摘要： Compound of formula (I): wherein: represents an optionally substituted, 5-membered, nitrogen-containing heterocycle, R1 represents hydrogen, alkyl, acyl, prolyl, alanyl, histidylprolyl or phenylalanylprolyl, Ak represents an alkylene or heteroalkylene chain, X represents a single bond or optionally substituted phenylene, R2 represents optionally substituted alkyl, (C3-C10)cycloalkyl, or —NR2aR2b wherein R2a and R2b, which may be the same or different, each represent hydrogen or alkyl or, together with the nitrogen atom carrying them, form a nitrogen-containing heterocycle, Y represents R3 represents hydrogen or a group selected from alkyl, (C3-C7) cycloalkyl and aryl, R4, R5 and R6, which may be the same or different, each represent hydrogen or alkyl, or R4 and R6, or R5 and R6, together with the atoms carrying them, form an imidazolidine or dihydrobenzimidazole ring, its optical isomers and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful as inhibitors of dipeptidyl-peptidase IV.
摘要翻译：式（I）化合物：其中：表示任选取代的5元含氮杂环，R 1表示氢，烷基，酰基，脯氨酰基，丙氨酰，组氨酰脯氨酰基或苯丙氨酰脯氨酰基，Ak表示亚烷基或杂亚烷基链，X表示单键或任选取代的亚苯基，R 2表示任选取代的烷基，（C 3 -C 10）环烷基或-NR 2 a R 2b，其中可以相同或不同的R 2a和R 2b各自代表氢或烷基，或与携带它们的氮原子一起，形成含氮杂环，Y表示R 3表示氢或选自烷基，（C 3 -C 7）环烷基和芳基的基团，R 4，R 5和R 6可以相同或不同，各自表示氢或烷基，或R 4 和R6或R5和R6与携带它们的原子一起形成咪唑烷或二氢苯并咪唑环，其光学异构体及其与药学上可接受的酸的加成盐。含有相同的喔 ch可用作二肽基肽酶IV的抑制剂。

17. 发明授权

US06114360A Pyrrole compounds 失效
标题翻译：吡咯化合物
公开(公告)号：US06114360A
公开(公告)日：2000-09-05
申请号：US390416
申请日：1999-09-03
申请人： Guillaume De Nanteuil , Bernard Portevin , Jacqueline Bonnet , Charles Tordjman
发明人： Guillaume De Nanteuil , Bernard Portevin , Jacqueline Bonnet , Charles Tordjman
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/407 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61P19/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D209/44 , C07D209/52 , C07D209/72 , C07D401/04 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D487/04 , C07D491/16
CPC分类号： C07D401/14 , C07D209/44 , C07D209/52 , C07D209/72 , C07D405/14 , C07D409/04 , C07D409/14 , C07D487/04
摘要： Compounds of formula (I): ##STR1## wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C.sub.1 -C.sub.6)-acyl,R.sub.1 and R.sub.2, which may be identical or different, each represents independently of the other aryl, heteroaryl, or (C.sub.5 -C.sub.7)-cycloalkyl, or one of those groups optionally substituted,A, together with the atoms in common with the pyrrole, represents saturated or unsaturated, monocyclic or bicyclic (C.sub.3 -C.sub.12)-cycloalkyl, or a saturated heterocycle having 5 to 7 ring members and containing one or two nitrogen, or 7-oxabicyclo[2.2.1] heptane, or one of those groups optionally substituted, their isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, pharmaceutical compositions thereof, and use thereof as medicaments.
摘要翻译：式（I）的化合物：其中：R表示氢，烷基，任选取代的氨基或直链或支链（C 1 -C 6） - 酰基，可以相同或不同的R 1和R 2各自独立地表示其它芳基，杂芳基或（C5-C7） - 环烷基，或任选取代的那些基团之一，A与与吡咯共同的原子一起代表饱和或不饱和的单环或双环（C 3 -C 12） - 环烷基或饱和杂环，其具有5至7个环成员并含有一个或两个氮或7-氧杂双环[2.2.1]庚烷，或任选取代的那些基团之一，其异构体，以及其与药学上可接受的酸或碱的加成盐，其药物组合物及其作为药物的用途。

18. 发明授权

US6063804A Pyrrole compounds 失效
标题翻译：吡咯化合物
公开(公告)号：US6063804A
公开(公告)日：2000-05-16
申请号：US199640
申请日：1998-11-25
申请人： Guillaume De Nanteuil , Bernard Portevin , Jacqueline Bonnet , Charles Tordjman
发明人： Guillaume De Nanteuil , Bernard Portevin , Jacqueline Bonnet , Charles Tordjman
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/407 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61P19/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D209/44 , C07D209/52 , C07D209/72 , C07D401/04 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D487/04 , C07D491/16 , C07D209/02
CPC分类号： C07D401/14 , C07D209/44 , C07D209/52 , C07D209/72 , C07D405/14 , C07D409/04 , C07D409/14 , C07D487/04
摘要： Compounds of formula (I): ##STR1## wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C.sub.1 -C.sub.6)-acyl,R.sub.1 and R.sub.2, which may be identical or different, each represents independently of the other aryl, heteroaryl, or (C.sub.5 -C.sub.7)-cycloalkyl, or one of those groups optionally substituted,A, together with the atoms in common with the pyrrole, represents saturated or unsaturated, monocyclic or bicyclic (C.sub.3 -C.sub.12)-cycloalkyl, or a saturated heterocycle having 5 to 7 ring members and containing one or two nitrogen, or 7-oxabicyclo[2.2.1]heptane, or one of those groups optionally substituted,their isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, pharmaceutical compositions thereof, and use thereof as medicaments.
摘要翻译：式（I）的化合物：其中：R表示氢，烷基，任选取代的氨基或直链或支链（C 1 -C 6） - 酰基，可以相同或不同的R 1和R 2各自独立地表示其它芳基，杂芳基或（C5-C7） - 环烷基，或任选取代的那些基团之一，A与与吡咯共同的原子一起代表饱和或不饱和的单环或双环（C 3 -C 12） - 环烷基或饱和杂环，其具有5至7个环成员并含有一个或两个氮或7-氧杂双环[2.2.1]庚烷，或任选取代的那些基团之一，其异构体，以及其与药学上可接受的酸或碱的加成盐，其药物组合物及其作为药物的用途。

19. 发明授权

US6040327A Benzimidazole, benzoxazole and benzothiazole compounds 失效
标题翻译：苯并咪唑，苯并恶唑和苯并噻唑化合物
公开(公告)号：US6040327A
公开(公告)日：2000-03-21
申请号：US120487
申请日：1998-07-22
申请人： Guillaume De Nanteuil , Bernard Portevin , Jacqueline Bonnet , Armel Fradin
发明人： Guillaume De Nanteuil , Bernard Portevin , Jacqueline Bonnet , Armel Fradin
IPC分类号： C07D235/06 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4427 , A61P29/00 , A61P43/00 , C07D235/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D235/12 , C07D249/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： A compound of formula (I): ##STR1## wherein: R.sub.1 represents halogen or a different group as defined in the description,Ra and Rb, which mnay be identical or different, represent hydrogen, alkyl, or hydroxy,X represents oxygen or sulphur or NR, R being H or alkyl,R.sub.2 represents optionally-substituted aryl,R'.sub.2 represents hydrogen or optionally-substituted aryl,its isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same, are useful as inhibitors of interleukin 1.beta..
摘要翻译：式（I）的化合物：其中：R1表示卤素或描述中定义的不同基团，Ra和Rb可以相同或不同，表示氢，烷基或羟基，X表示氧或硫或NR， R为H或烷基，R 2表示任选取代的芳基，R'2表示氢或任选取代的芳基，其异构体及其药学上可接受的酸或碱的加成盐，以及含有该芳基的药物可用作抑制剂的白细胞介素1β。

20. 发明授权

US07439263B2 Pyrrolidine and thiazolidine compounds 失效
标题翻译：吡咯烷和噻唑烷化合物
公开(公告)号：US07439263B2
公开(公告)日：2008-10-21
申请号：US11131510
申请日：2005-05-18
申请人： Guillaume De Nanteuil , Alain Benoist , Murielle Combettes , Elizabeth Harley
发明人： Guillaume De Nanteuil , Alain Benoist , Murielle Combettes , Elizabeth Harley
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D405/12 , C07D207/10 , C07D207/16 , C07D277/12 , C07D295/185 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I): wherein: X1 represents an atom or group selected from CR4aR4b, O, S(O)q1 and NR5, wherein R4a, R4b, q1 and R5 are as defined in the description, m1 represents zero or an integer from 1 to 4 inclusive, m2 represents an integer from 1 to 4 inclusive, n1 and n2, which may be identical or different, each represent an integer from 1 to 3 inclusive, R1 represents hydrogen or a group selected from carboxy, alkoxycarbonyl, optionally substituted carbamoyl and optionally substituted alkyl, R2 represents hydrogen or alkyl, Ak represents an optionally substituted alkylene chain, p represents zero, 1 or 2, R3 represents hydrogen or cyano, X2 and X3, which may be identical or different, each represent either S(O)q2, or CR6aR6b, wherein q2, R6a and R6b are as defined in the description, its optical isomers, where they exist, and its addition salts with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful as DPP-IV inhibitors.
摘要翻译：式（I）的化合物：其中：X 1表示选自CR 4a R 4a，O，S（O） q1和NR5，其中R 4a 4a，R 4b，q 1和...， R 5如描述中所定义，m 1表示0或1至4的整数，其中m 2表示1的整数，至4个，其中可以相同或不同的n 1和n 2各自表示1至3的整数，包括1和3的整数，R 1，表示氢或选自羧基，烷氧基羰基，任选取代的氨基甲酰基和任选取代的烷基的基团，R 2表示氢或烷基，Ak表示任选取代的亚烷基链，p表示0,1或2，R 3或3表示氢或氰基，X 2和X 3可以相同或不同，各自表示S（O） q2，或CR 6a R 6b，其中q2

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