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11. 发明授权

US06388258B1 Solid state gamma camera 失效
标题翻译：固态伽马相机
公开(公告)号：US06388258B1
公开(公告)日：2002-05-14
申请号：US09420904
申请日：1999-10-20
申请人： Gideon Berlad , Yaron Hefetz
发明人： Gideon Berlad , Yaron Hefetz
IPC分类号： G01T116
CPC分类号： G01T1/1642 , A61B6/4258 , G01T1/247 , G01T1/2928
摘要： A gamma camera for imaging radiation emitted from or transmitted by an object including a gamma camera head having a front input surface which produces signals, when a photon associated with the radiation is detected by the head, indicative of the position of the position of the detection on the input surface and at a given resolution in the absence of dithering of the head; and a dithering system which differentially translates the detector head or the object in at least one direction parallel to the input surface so that the dithering system translates the detector head or the object by an amount at least equal to the given resolution but less than 50 times the given resolution during acquisition of the signals.
摘要翻译：一种伽马照相机，用于成像由包括伽马相机头的物体发射或发射的辐射的伽马照相机，所述伽马相机头具有产生信号的前输入表面，当与头部相关联的光线被检测时，指示检测位置的位置在没有头部抖动的情况下在输入表面上以给定的分辨率; 以及抖动系统，其在与输入表面平行的至少一个方向上差异地转换检测器头或物体，使得抖动系统将检测器头部或物体平移至少等于给定分辨率但小于50倍的量在采集信号期间给定的分辨率。

12. 发明申请

US20050161606A1 Gamma camera and CT system 审中-公开
标题翻译：伽玛相机和CT系统
公开(公告)号：US20050161606A1
公开(公告)日：2005-07-28
申请号：US11044758
申请日：2005-01-26
申请人： Adi Balan , Yigal Shrem , Albert Lonn , Benny Hajaj , Naor Wainer , Yaron Hefetz , Gideon Berlad , Leonid Yakubovsky
发明人： Adi Balan , Yigal Shrem , Albert Lonn , Benny Hajaj , Naor Wainer , Yaron Hefetz , Gideon Berlad , Leonid Yakubovsky
IPC分类号： G01T1/161 , G01T1/164 , G21K1/12
CPC分类号： G01T1/1615 , A61B6/037 , A61B6/4429 , A61B6/5235 , A61B6/541 , A61B6/584
摘要： A method of producing a nuclear medicine image of a subject, comprising: acquiring nuclear imaging data suitable to produce a nuclear tomographic image, said nuclear image data being acquired by a gamma camera head rotating about the subject; acquiring X-ray imaging data suitable to produce an X-ray tomographic image for attenuation correction of the gamma camera image, said X-ray imaging data being acquired by detectors irradiated by an X-ray source rotating around the subject; reducing the sensitivity of gamma camera head while the X-rays are produced; and reconstructing an attenuation corrected nuclear medicine image utilizing the nuclear imaging data and X-ray imaging data.
摘要翻译：一种产生受试者的核医学图像的方法，包括：获取适于产生核断层图像的核成像数据，所述核图像数据由围绕被摄体旋转的伽马相机头获取; 获取适于产生用于伽马相机图像的衰减校正的X射线断层图像的X射线成像数据，所述X射线成像数据由被围绕被摄体旋转的X射线源照射的检测器获取; 在产生X射线时降低伽马相机头的灵敏度; 以及利用核成像数据和X射线成像数据重建衰减校正的核医学图像。

13. 发明申请

US20050006586A1 Gamma camera and CT system 失效
标题翻译：伽玛相机和CT系统
公开(公告)号：US20050006586A1
公开(公告)日：2005-01-13
申请号：US10900936
申请日：2004-07-28
申请人： Adi Balan , Yigal Shrem , Albert Lonn , Benny Hajaj , Naor Wainer , Yaron Hefetz , Gideon Berlad , Leonid Yakubovsky
发明人： Adi Balan , Yigal Shrem , Albert Lonn , Benny Hajaj , Naor Wainer , Yaron Hefetz , Gideon Berlad , Leonid Yakubovsky
IPC分类号： G01T1/161 , G01T1/164 , G21K1/12
CPC分类号： G01T1/1615 , A61B6/037 , A61B6/4429 , A61B6/5235 , A61B6/541 , A61B6/584
摘要： Apparatus for producing attenuation corrected nuclear medicine images of patients, comprising: at least one gamma camera head that acquires nuclear image data suitable to produce a nuclear tomographic image at a first controllable rotation rate about an axis; at least one X-ray CT imager that acquires X-ray data suitable to produce an attenuation image for correction of the nuclear tomographic image at a second controllable rotation rate about the axis; and a controller that controls the data acquisition and first and second rotation rates to selectively provide at least one of the following modes of operation: (i) a movement gated NM imaging mode in which the second rotation rate is substantially higher than the first rotation rate and the data from each view of the X-ray acquisition is associated with one of a plurality of respiration gated time periods; (ii) a cardiac gated NM imaging mode in which the second rotation rate is substantially higher than the first rotation rate and the data from each view of the X-ray acquisition for different rotations is averaged, wherein the X-ray data is not correlated with the cardiac cycle; and (iii) a cardiac gated NM imaging mode in which the second rotation rate is higher than the first rotation rate and the X-ray data is binned in accordance with a same binning as the NM data.
摘要翻译：用于产生患者的衰减校正核医学图像的装置，包括：至少一个伽马相机头，其获取适于以围绕轴线的第一可控旋转速率产生核断层图像的核图像数据; 至少一个X射线CT成像器，其获取适于产生用于以围绕所述轴线的第二可控旋转速率校正所述核断层图像的衰减图像的X射线数据; 以及控制器，其控制数据采集和第一和第二旋转速率以选择性地提供以下操作模式中的至少一种：（i）运动选通NM成像模式，其中第二旋转速率基本上高于第一旋转速率并且来自X射线获取的每个视图的数据与多个呼吸选通时间段中的一个相关联; （ii）心脏门控NM成像模式，其中第二旋转速率基本上高于第一旋转速率，并且来自用于不同旋转的X射线获取的每个视图的数据被平均，其中X射线数据不相关与心动周期; 和（iii）心脏门控NM成像模式，其中第二旋转速率高于第一旋转速率，并且X射线数据根据与NM数据相同的组合进行分样。

14. 发明授权

US06841782B1 Gamma camera and CT system 有权
标题翻译：伽玛相机和CT系统
公开(公告)号：US06841782B1
公开(公告)日：2005-01-11
申请号：US10009375
申请日：1999-06-06
申请人： Adi Balan , Yigal Shrem , Albert Lonn , Benny Hajaj , Naor Wainer , Yaron Hefetz , Gideon Berlad , Leonid Yakubovsky
发明人： Adi Balan , Yigal Shrem , Albert Lonn , Benny Hajaj , Naor Wainer , Yaron Hefetz , Gideon Berlad , Leonid Yakubovsky
IPC分类号： G01T1/161 , A61B6/00 , A61B6/03 , A61B6/08 , G01T1/164 , G01T1/169
CPC分类号： G01T1/169 , A61B6/032 , A61B6/037 , A61B6/08 , A61B6/488 , A61B6/5205 , A61B6/5235 , A61B6/541 , A61B6/584 , G01T1/1611 , G01T1/1648
摘要： A method of producing a nuclear medicine image of a subject comprising the steps of acquiring nuclear image data suitable to produce a nuclear tomographic image, the data being acquired by at least one gamma camera head (12, 14) rotating about the subject at an average first rate, acquiring x-ray imaging data suitable to produce an x-ray tomographic image for attenuation correction of the gamma camera image, the data being acquired by an array of detectors (20) irradiated by an x-ray source (18) rotating around the subject at an average second rate which is within a factor of 10 of the first rate, and reconstructing an attenuation corrected nuclear medicine image utilizing the nuclear imaging data and x-ray imaging data.
摘要翻译：一种产生受试者的核医学图像的方法，包括以下步骤：获取适于产生核断层图像的核图像数据，所述数据由至少一个伽马照相机头（12,14）获取，所述伽马照相机头（12,14）平均围绕被摄体旋转获取适于产生用于伽马相机图像的衰减校正的X射线断层图像的X射线成像数据，所述X射线成像数据是由旋转的X射线源（18）照射的检测器阵列（20）获取的，以所述第一速率的10倍的平均第二速率围绕所述受试者，并且利用所述核成像数据和x射线成像数据重构衰减校正的核医学图像。

15. 发明授权

US5689115A Advanced nuclear medicine system 失效
标题翻译：先进核医学系统
公开(公告)号：US5689115A
公开(公告)日：1997-11-18
申请号：US562375
申请日：1995-11-24
申请人： Adi Balan , Gideon Berlad , Alex Fishler , Doy Maor , Alex Silberklang
发明人： Adi Balan , Gideon Berlad , Alex Fishler , Doy Maor , Alex Silberklang
IPC分类号： G01T1/161 , G01T1/164 , G01T1/166
CPC分类号： G01T1/1642 , A61B6/4258 , A61B6/037
摘要： A method of acquiring an analog electrical pulse signal caused by a radiation event impinging on a detector crystal and viewed by a plurality of detector units. An image is formed based on a plurality of the events, each of which is captured by some of the detector units. The method of acquiring includes. (a) adding a linearity enhancement signal to the analog signal; and (b) converting the analog signal to a digital signal, where the linearity enhancement signal is slowly varying relative to the length of an analog signal pulse. Alternatively or additionally, a resolution enhancement signal is added to the analog signal before (b) converting the analog signal to a digital signal. The resolution enhancement signal varying relatively quickly compared to the length of an analog signal pulse.
摘要翻译：一种获取模拟电脉冲信号的方法，该模拟电脉冲信号由照射在检测器晶体上并由多个检测器单元观察的辐射事件引起。基于多个事件形成图像，每个事件由一些检测器单元捕获。收购方法包括。（a）向模拟信号添加线性增强信号; 和（b）将模拟信号转换成数字信号，其中线性增强信号相对于模拟信号脉冲的长度缓慢变化。或者或另外，在（b）将模拟信号转换为数字信号之前，将分辨率增强信号添加到模拟信号。与模拟信号脉冲的长度相比，分辨率增强信号变化相对较快。

16. 发明授权

US06937750B2 Registration of nuclear medicine images 有权
标题翻译：注册核医学图像
公开(公告)号：US06937750B2
公开(公告)日：2005-08-30
申请号：US10294168
申请日：2002-11-14
申请人： Alex Natanzon , Gideon Berlad
发明人： Alex Natanzon , Gideon Berlad
IPC分类号： G01T1/164 , G06T3/00 , G06T7/00 , G06K9/00
CPC分类号： G06K9/32 , G01T1/1615 , G01T1/1648 , G06K2209/05 , G06T3/0068 , G06T7/30 , G06T2207/30004
摘要： A method of registering a plurality of functional images includes providing a plurality of functional images, providing a plurality of structural images, each one of which having a known positional relationship to at least one of said plurality of functional images, and finding a first mapping transformation between pairs of functional images based on the first mapping transformation and the positional transformation.
摘要翻译：一种登记多个功能图像的方法包括提供多个功能图像，提供多个结构图像，每个结构图像中的每一个与所述多个功能图像中的至少一个具有已知的位置关系，并且找到第一映射变换在基于第一映射变换和位置变换的功能图像对之间。

17. 发明申请

US20060182325A1 Registration of nuclear medicine images 失效
公开(公告)号：US20060182325A1
公开(公告)日：2006-08-17
申请号：US11339534
申请日：2006-01-26
申请人： Alex Natanzon , Gideon Berlad
发明人： Alex Natanzon , Gideon Berlad
IPC分类号： G06K9/00
CPC分类号： G06K9/32 , G01T1/1615 , G01T1/1648 , G06K2209/05 , G06T3/0068 , G06T7/30 , G06T2207/30004
摘要： A method of registering a plurality of functional images includes providing a plurality of functional images, providing a plurality of structural images, each one of which having a known positional relationship to at least one of said plurality of functional images, and finding a first mapping transformation between pairs of functional images based on the first mapping transformation and the positional transformation.

18. 发明授权

US5438202A Stabilized scatter free gamma camera images 失效
标题翻译：稳定的无散射伽马相机图像
公开(公告)号：US5438202A
公开(公告)日：1995-08-01
申请号：US254571
申请日：1994-06-06
申请人： Alex Matanzon , Gideon Berlad , Dov Maop , Yigal Shrem , Adrian Sott
发明人： Alex Matanzon , Gideon Berlad , Dov Maop , Yigal Shrem , Adrian Sott
IPC分类号： G01T1/164 , G06F17/00 , G01T1/161
CPC分类号： G01T1/1647 , G01T1/1642 , G01T1/1648
摘要： A system for recording fewer of the events that are caused by unwanted photons with greater stability. The system locally determines the energy spectrum and fits for each pixel of the image the determined energy spectrum with a modified trial function composed of: a photopeak component of known energy shape, Compton scatter components having theoretically derived energy shapes and, when applicable, also measured or calculated energy spectra of other unwanted photons. The modified trial function also takes into consideration unknown local deviations in the outputs of electronic components. The amplitude of the photopeak distribution resulting from the fit is used to obtain the local content of wanted interactions in the image. This enables removal of Compton contamination and also the contamination caused by interaction of the gamma photons with lead components.
摘要翻译：用于记录较少稳定性的由不需要的光子引起的事件的系统。该系统局部地确定能量谱并且利用经修改的试验函数对图像的每个像素进行拟合，该修改的试验函数由以下组成：具有已知能量形状的光峰分量，具有理论上衍生的能量形状的康普顿散射分量，并且在适用时也被测量或计算其他不需要的光子的能谱。修改的试验功能还考虑了电子部件输出中的未知局部偏差。由拟合得到的光峰分布的幅度用于获得图像中所需相互作用的局部内容。这样可以消除康普顿污染物以及伽马光子与铅成分的相互作用引起的污染。

19. 发明授权

US06559450B1 Gamma camera with two sequential correction maps 有权
标题翻译：伽玛相机具有两个顺序校正图
公开(公告)号：US06559450B1
公开(公告)日：2003-05-06
申请号：US09297239
申请日：1999-04-26
申请人： Gideon Berlad , Naor Wainer
发明人： Gideon Berlad , Naor Wainer
IPC分类号： G01T1164
CPC分类号： G01T1/1647 , G01T1/1642
摘要： A method of correcting errors in imaging data in a Gamma Camera including determining a first correction map based on one or both of (1) calculated corrections and (2) a first data acquisition, determining a second correction map based on a second data acquisition and correcting the imaging data based on the first and second correction maps. In a preferred embodiment of the invention, error correction is implemented using a neural network. Alternatively, a neural network can be used to perform the entire calculation of event position and/or energy.
摘要翻译：一种校正伽马相机中成像数据中的误差的方法，包括基于（1）计算校正中的一个或两个确定第一校正图，以及（2）第一数据采集，基于第二数据采集确定第二校正图，以及基于第一和第二校正图来校正成像数据。在本发明的优选实施例中，使用神经网络来实现纠错。或者，可以使用神经网络来执行事件位置和/或能量的整个计算。

20. 发明授权

US6140650A Calibration of PET cameras 失效
标题翻译： PET相机校准
公开(公告)号：US6140650A
公开(公告)日：2000-10-31
申请号：US13044
申请日：1998-01-26
申请人： Gideon Berlad
发明人： Gideon Berlad
IPC分类号： G01T1/29 , G01T1/166
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method of calibrating a PET (Positron Emission Tomograph) scanner includes:acquisition of data from a plurality of coincidence radiation events, using at least one detector; anddetermination of values for a set with at least one calibration factor, which factor affects an analytically defined calibration criterion. Preferably, the detector has at least one rotating planar detector and the acquisition of data includes acquiring data from a plurality of rotational positions of the detector.
摘要翻译：校准PET（正电子发射断层扫描仪）扫描仪的方法包括：使用至少一个检测器从多个重合辐射事件获取数据; 并确定具有至少一个校准因子的集合的值，该因素影响分析定义的校准标准。优选地，检测器具有至少一个旋转平面检测器，并且数据采集包括从检测器的多个旋转位置获取数据。

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