专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20060106112A1 Treating neurological disorders using selective antagonists of persistent sodium current 有权
标题翻译：使用持续钠电流的选择性拮抗剂治疗神经障碍
公开(公告)号：US20060106112A1
公开(公告)日：2006-05-18
申请号：US11326036
申请日：2006-01-05
申请人： George Ehring , Joseph Adorante , Larry Wheeler , Thomas Malone , Scott Whitcup
发明人： George Ehring , Joseph Adorante , Larry Wheeler , Thomas Malone , Scott Whitcup
IPC分类号： A61K31/13
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译：本发明提供了通过向哺乳动物施用有效量的相对于瞬时钠电流具有至少20倍的持续钠电流选择性的选择性持续性钠通道拮抗剂来治疗哺乳动物神经系统疾病的方法。

12. 发明申请

US20050244475A1 Biodegradable intravitreal tyrosine kinase implants 有权
标题翻译：可生物降解的玻璃体内酪氨酸激酶植入物
公开(公告)号：US20050244475A1
公开(公告)日：2005-11-03
申请号：US11119001
申请日：2005-04-29
申请人： Jeffrey Edelman , Patrick Hughes , Thomas Malone , Gerald DeVries , Joan-En Chang-Lin , Jane Shiah , Thierry Nivaggioli , Lon Spada , Wendy Blanda
发明人： Jeffrey Edelman , Patrick Hughes , Thomas Malone , Gerald DeVries , Joan-En Chang-Lin , Jane Shiah , Thierry Nivaggioli , Lon Spada , Wendy Blanda
IPC分类号： A61F2/00 , A61K9/00 , A61K9/20 , A61K31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/204 , A61K31/404 , A61K31/454 , A61K31/5377 , A61K47/34
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.
摘要翻译：生物相容性眼内植入物包括酪氨酸激酶抑制剂和可生物降解的聚合物，其有效促进酪氨酸激酶抑制剂延长一段时间的眼睛玻璃体。植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症如眼后病症的发生。

13. 发明授权

US08517709B2 Methods and pressure vessels for solid-state microcellular processing of thermoplastic rolls or sheets 有权
标题翻译：用于固态微孔加工热塑性辊或片材的方法和压力容器
公开(公告)号：US08517709B2
公开(公告)日：2013-08-27
申请号：US13300445
申请日：2011-11-18
申请人： Krishna V Nadella , Steven Powers , Thomas Malone
发明人： Krishna V Nadella , Steven Powers , Thomas Malone
IPC分类号： B29C44/34
CPC分类号： C08J9/00 , B29C44/3446 , B29C44/3453 , C08J9/122 , C08J2201/032 , C08J2203/06
摘要： Disclosed herein are methods and pressure vessels for solid-state microcellular processing of thermoplastic rolls and sheets. In one embodiment, the present invention is directed to a method for making a gas impregnated interleaved roll, which method comprises: providing a pressure vessel having an internal pressure chamber and a rotatable shaft horizontally positioned within the pressure chamber; placing an interleaved roll about the rotatable shaft and within the pressure chamber, wherein the interleaved roll is made from a thermoplastic material sheet interleaved together with a gas-channeling material sheet; pressurizing the pressure chamber to a selected pressure; rotating the rotatable shaft having the interleaved roll thereabouts (thereby rotating the interleaved roll) while under pressure for a selected period of time; and depressurizing the internal chamber to yield the gas impregnated interleaved roll. In other embodiments, the invention is directed to multi-chambered pressure vessels for gas impregnation of thermoplastic rolls, sheets, and films.
摘要翻译：本文公开了用于热塑性辊和片材的固态微孔加工的方法和压力容器。在一个实施例中，本发明涉及一种用于制造气体浸渍的交错辊的方法，该方法包括：提供压力容器，该压力容器具有水平地定位在压力室内的内部压力室和可旋转轴; 在所述压力室内围绕所述可旋转轴放置交错辊，其中所述交错辊由与气体通道材料片交错在一起的热塑性材料板制成; 将压力室加压至选定的压力; 在压力下旋转具有交错辊的旋转轴（从而使交错的辊旋转）一段选定的时间; 并对内部室进行减压以产生气体浸渍的交错辊。在其他实施例中，本发明涉及用于气体浸渍热塑性辊，片材和薄膜的多室压力容器。

14. 发明授权

US07531665B2 Kinase inhibitors for the treatment of disease 有权
标题翻译：用于治疗疾病的激酶抑制剂
公开(公告)号：US07531665B2
公开(公告)日：2009-05-12
申请号：US10829139
申请日：2004-04-20
申请人： Steven W. Andrews , Michael E. Garst , Xialing Guo , Jonathan J. Hebert , Thomas Malone , Julie A. Wurster , Clarence Eugene Hull, III
发明人： Steven W. Andrews , Michael E. Garst , Xialing Guo , Jonathan J. Hebert , Thomas Malone , Julie A. Wurster , Clarence Eugene Hull, III
IPC分类号： C07D401/14
CPC分类号： C07D403/06 , C07D209/34 , C07D405/04
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译：本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

15. 发明申请

US20060287399A1 TREATING PAIN USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT 有权
公开(公告)号：US20060287399A1
公开(公告)日：2006-12-21
申请号：US11461517
申请日：2006-08-01
申请人： George Ehring , Joseph Adorante , John Donello , Larry Wheeler , Thomas Malone
发明人： George Ehring , Joseph Adorante , John Donello , Larry Wheeler , Thomas Malone
IPC分类号： A61K31/13
CPC分类号： A61K31/235 , A61K31/13 , A61K31/136 , A61K31/381 , A61K31/433 , A61K31/4439
摘要： The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.

16. 发明申请

US20050257222A1 Method of virtualizing I/O resources in a computer system 有权
公开(公告)号：US20050257222A1
公开(公告)日：2005-11-17
申请号：US11187679
申请日：2005-07-22
申请人： Brad Davis , Thomas Malone
发明人： Brad Davis , Thomas Malone
IPC分类号： G06F3/00 , G06F9/50 , G06F12/02 , G06F12/10
CPC分类号： G06F12/1081 , G06F12/0284 , G06F12/1072
摘要： A method of virtualizing hardware resources in a multiprocessor computing environment is provided. Each resource is provided a resource address. A hardware resource map is provided to store virtual resource addresses and physical resource addresses. Remapping hardware is utilized to redirect virtual addresses to physical addresses. The method of virtualizing hardware resources may be applied to any resource mapped across the bus, including memory address space, and I/O address space. Accordingly, the method of virtualizing hardware resources through platform firmware enables dynamic routing of resource accesses during run-time.

17. 发明申请

US20050054695A1 Treating neurological disorders using selective antagonists of persistent sodium current 有权
标题翻译：使用持续钠电流的选择性拮抗剂治疗神经障碍
公开(公告)号：US20050054695A1
公开(公告)日：2005-03-10
申请号：US10928949
申请日：2004-08-27
申请人： George Ehring , Joseph Adorante , Larry Wheeler , Thomas Malone , Scott Whitcup
发明人： George Ehring , Joseph Adorante , Larry Wheeler , Thomas Malone , Scott Whitcup
IPC分类号： A61K31/00 , A61K31/136 , A61K31/235 , A61K31/381 , A61K31/4439 , A61K31/433 , A61K31/13
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译：本发明提供了通过向哺乳动物施用有效量的相对于瞬时钠电流具有至少20倍的持续钠电流选择性的选择性持续性钠通道拮抗剂来治疗哺乳动物神经系统疾病的方法。

18. 发明申请

US20050038076A1 Process for preparing isomerically pure prodrugs of proton pump inhibitors 失效
标题翻译：制备质子泵抑制剂的异构纯的前体药物的方法
公开(公告)号：US20050038076A1
公开(公告)日：2005-02-17
申请号：US10891317
申请日：2004-07-13
申请人： Michael Garst , Lloyd Dolby , Shervin Esfandiari , Vivian MacKenzie , Alfred Avey , David Muchmore , Geoffrey Cooper , Thomas Malone
发明人： Michael Garst , Lloyd Dolby , Shervin Esfandiari , Vivian MacKenzie , Alfred Avey , David Muchmore , Geoffrey Cooper , Thomas Malone
IPC分类号： C07D401/12 , C07D43/02 , A61K31/4439
CPC分类号： C07D401/12 , C04B35/632
摘要： Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.
摘要翻译：通过合成方案和实验描述显示了用于制备包含取代的苯并咪唑核的质子泵抑制剂异构纯的N-芳基磺酰基衍生物的合成方法。

19. 发明申请

US20050020320A1 Vehicle display device having a wireless transmitter 有权
标题翻译：具有无线发射机的车辆显示装置
公开(公告)号：US20050020320A1
公开(公告)日：2005-01-27
申请号：US10912008
申请日：2004-08-05
申请人： Patrick Lavelle , Thomas Malone , James Tranchina
发明人： Patrick Lavelle , Thomas Malone , James Tranchina
IPC分类号： G09G5/00 , H04B1/06 , H04B1/20 , H04M3/42 , H05K11/02
CPC分类号： H04B1/205
摘要： There is provided a display device for a vehicle having a seat. The display device includes an assembly housing adapted to mount at a rear portion of the seat. A receiver is adapted to receive at least one of video and audio signals from at least one external input device. At least one wireless transmitter operatively coupled to the receiver, is adapted to wirelessly transmit the audio signals to at least one wireless headphone set. The display device is adapted to reproduce the video signals. In some embodiments of the invention, the at least one wireless transmitter is adapted to transmit the audio signals based on Code-Division Multiple Access (CDMA) technology.
摘要翻译：提供了一种具有座椅的车辆的显示装置。显示装置包括适于安装在座椅后部的组件壳体。接收器适于从至少一个外部输入设备接收视频和音频信号中的至少一个。可操作地耦合到接收器的至少一个无线发射器适于将音频信号无线地传输到至少一个无线耳机组。显示装置适于再现视频信号。在本发明的一些实施例中，所述至少一个无线发射器适于基于码分多址（CDMA）技术发送音频信号。

20. 发明授权

US06765012B2 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors 失效
标题翻译： 3-（芳基氨基）亚甲基-1,3-二氢-2H-吲哚-2-酮作为激酶抑制剂
公开(公告)号：US06765012B2
公开(公告)日：2004-07-20
申请号：US10256879
申请日：2002-09-27
申请人： Steven W. Andrews , Julie A. Wurster , Edward H. Wang , Thomas Malone
发明人： Steven W. Andrews , Julie A. Wurster , Edward H. Wang , Thomas Malone
IPC分类号： A61K31435
CPC分类号： C07D295/088 , A61K31/404 , C07D209/34 , C07D295/135 , C07D401/10 , C07D403/12
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译：本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式