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11. 发明授权

US09031701B2 Characterization of blood hemostasis and oxygen transport parameters 有权
标题翻译：血液止血和氧气输送参数的表征
公开(公告)号：US09031701B2
公开(公告)日：2015-05-12
申请号：US13397481
申请日：2012-02-15
申请人： Francesco Viola , William F. Walker
发明人： Francesco Viola , William F. Walker
IPC分类号： C12Q1/68 , G01N15/06 , G01N21/00 , G01N33/00 , G01N31/12 , C12Q1/56 , G05B21/00 , G01N33/48 , G01N33/49 , G01N29/024 , G01N29/028
CPC分类号： G01N29/028 , G01N29/024 , G01N29/032 , G01N29/44 , G01N33/49 , G01N33/4905 , G01N33/492 , G01N2291/018 , G01N2291/022 , G01N2291/02466 , G01N2291/02818 , G01N2291/044
摘要： An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.
摘要翻译：公开了一种用于确定血液样品如血液的止血和氧气输送参数的综合系统。该系统包括诸如超声波传感器的测量系统，其被配置为确定表征血液样本的数据。例如，数据可以是血液样本响应于超声脉冲的位移。该系统的集成方面可以是常见的传感器，采样部分或数据，用于快速和有效地确定两个参数。参数也可用于校正或改进测量参数。例如，可以使用HCT测量将生理调节应用于止血参数。此外，可以应用物理调整，例如通过使用通过血样或通过血液样本的声音脉冲的速度或衰减进行校准。这些参数可以显示在GUI上以指导治疗。

12. 发明授权

US08761477B2 Systems and method for adaptive beamforming for image reconstruction and/or target/source localization 有权
标题翻译：用于图像重建和/或目标/源定位的自适应波束成形的系统和方法
公开(公告)号：US08761477B2
公开(公告)日：2014-06-24
申请号：US11992368
申请日：2006-09-19
申请人： William F. Walker , Francesco Viola
发明人： William F. Walker , Francesco Viola
IPC分类号： G06K9/00 , H04W8/02
CPC分类号： G01S7/52046 , G01S7/52026 , G01S7/5205 , G01S7/52052 , G01S15/8977
摘要： Methods, systems and computer readable media for reconstruction of target locations and amplitudes from signals received from one or more real targets in a space are provided, wherein the signals are at least one of signals received from the near-field and broadband signals. The space is modeled as a region of interest, and an array manifold matrix is calculated from signals received from hypothetical targets in the region of interest. One or more signal vectors received from the one or more real targets are reshaped into a data vector. A hypothetical target configuration is identified that, when applied to a signal model comprising the array manifold matrix, matches the data vector, a reconstruction vector is calculated. The reconstruction vector is reshaped into a reconstructed representation of the real targets in the space, and at least one of outputting the reconstructed representation for viewing by a user, and storing the reconstructed representation for later use are performed.
摘要翻译：提供了用于从从空间中的一个或多个实际目标接收的信号重构目标位置和幅度的方法，系统和计算机可读介质，其中所述信号是从近场和宽带信号接收的信号中的至少一个。该空间被建模为感兴趣的区域，并且根据从感兴趣区域中的假想目标接收到的信号计算阵列歧管矩阵。从一个或多个实际目标接收到的一个或多个信号向量重新形成数据向量。识别出假设的目标配置，当应用于包括阵列歧管矩阵的信号模型时，与数据矢量匹配，计算重构矢量。将重构矢量重新形成为空间中的真实目标的重建表示，并且执行输出用于观看的重建表示中的至少一个，并且存储用于稍后使用的重构表示。

13. 发明授权

US07892188B2 Method and apparatus for characterization of clot formation 有权
标题翻译：用于表征血块形成的方法和装置
公开(公告)号：US07892188B2
公开(公告)日：2011-02-22
申请号：US10971178
申请日：2004-10-22
申请人： William F. Walker , Michael Lawrence , Francesco Viola , Margaret D. Kramer
发明人： William F. Walker , Michael Lawrence , Francesco Viola , Margaret D. Kramer
IPC分类号： A61B5/103 , A61B5/117 , A61B5/00 , A61B8/00
CPC分类号： A61B5/02028 , A61B5/0048 , A61B8/08 , A61B8/485 , G01N29/11 , G01N29/343 , G01N2291/02466 , G01N2291/02475 , G01N2291/02827 , G01N2291/044
摘要： Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood. Acoustic pulses and/or optical waves reflected from the blood, or a flexible member in contact with the blood that moves with the blood, are received and measured to estimate at least one characteristic of the physical displacement induced thereby.
摘要翻译：用于表征软组织的至少一种物理性质的变化的方法，装置和系统。产生一系列声脉冲并引导到软组织中，使得至少一个脉冲具有足够高的强度以引起组织的物理位移。从组织反射的波或与组织一起移动的柔性构件被接收和测量以估计由此引起的物理位移的至少一个特征。生成，接收和估计步骤的重复提供了至少一种物理特性随时间的表征。用于表征血液的至少一种物理性质的方法，装置和系统，通过产生一系列声脉冲并将一系列脉冲引导到血液中，使得脉冲中的至少一个具有足够高的强度以引起血液的物理位移血液。接收和测量从血液反射的声波脉冲和/或光波，或与血液一起移动的血液接触的柔性部件，以估计由此引起的物理位移的至少一个特性。

14. 发明授权

US10962508B2 Ultrasound-based method and related system to evaluate hemostatic function of whole blood 有权
公开(公告)号：US10962508B2
公开(公告)日：2021-03-30
申请号：US13496349
申请日：2010-09-17
申请人： William F. Walker , Francesco Viola , F. William Mauldin, II
发明人： William F. Walker , Francesco Viola , F. William Mauldin, II
IPC分类号： G01N29/02 , G01N29/34 , G01N29/032 , G01N29/44 , G01N33/49 , G01N29/024 , C12M1/42
摘要： Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material.

15. 发明授权

US08740818B2 Method and apparatus for characterization of clot formation 有权
标题翻译：用于表征血块形成的方法和装置
公开(公告)号：US08740818B2
公开(公告)日：2014-06-03
申请号：US12909600
申请日：2010-10-21
申请人： William F. Walker , Michael B. Lawrence , Francesco Viola , Margaret Kramer Sande
发明人： William F. Walker , Michael B. Lawrence , Francesco Viola , Margaret Kramer Sande
IPC分类号： A61B5/103 , A61B5/117 , A61B8/00 , A61B5/00 , A61B19/00
CPC分类号： A61B5/02028 , A61B5/0048 , A61B8/08 , A61B8/485 , G01N29/11 , G01N29/343 , G01N2291/02466 , G01N2291/02475 , G01N2291/02827 , G01N2291/044
摘要： Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood. Acoustic pulses and/or optical waves reflected from the blood, or a flexible member in contact with the blood that moves with the blood, are received and measured to estimate at least one characteristic of the physical displacement induced thereby.
摘要翻译：用于表征软组织的至少一种物理性质的变化的方法，装置和系统。产生一系列声脉冲并引导到软组织中，使得至少一个脉冲具有足够高的强度以引起组织的物理位移。从组织反射的波或与组织一起移动的柔性构件被接收和测量以估计由此引起的物理位移的至少一个特征。生成，接收和估计步骤的重复提供了至少一种物理特性随时间的表征。用于表征血液的至少一种物理性质的方法，装置和系统，通过产生一系列声脉冲并将一系列脉冲引导到血液中，使得脉冲中的至少一个具有足够高的强度以引起血液的物理位移血液。接收和测量从血液反射的声波脉冲和/或光波，或与血液一起移动的血液接触的柔性部件，以估计由此引起的物理位移的至少一个特性。

16. 发明申请

US20120294767A1 PORTABLE HEMOSTASIS ANALYZER 审中-公开
标题翻译：便携式HEMOSTASIS分析仪
公开(公告)号：US20120294767A1
公开(公告)日：2012-11-22
申请号：US13475347
申请日：2012-05-18
申请人： Francesco Viola , William F. Walker
发明人： Francesco Viola , William F. Walker
IPC分类号： G01N33/50
CPC分类号： G01N29/024 , G01N29/222 , G01N33/86 , G01N2291/02466 , G01N2291/02818 , G01N2291/02827 , G01N2291/044 , G01N2291/101
摘要： Provided are devices, systems and methods for the use of a portable unit for the evaluation of hemostasis. For example, a portable system for determining a plurality of hemostatic parameters may be included. The system includes a blood sample receptacle, an analyzer and a housing. The blood sample receptacle is configured to hold at least one blood sample. The analyzer is configured to determine at least two hemostatic parameters of the at least one blood sample. The housing is configured to operably couple the blood sample receptacle and the analyzer. The housing is portable and may, for example, have a thickness of 17.5 cm or smaller.
摘要翻译：提供了用于使用便携式单元来评估止血的装置，系统和方法。例如，可以包括用于确定多个止血参数的便携式系统。该系统包括血液样本容器，分析器和壳体。血液样本容器配置成容纳至少一个血液样本。分析器被配置为确定至少一个血液样品的至少两个止血参数。壳体被配置为可操作地连接血液样本容器和分析器。外壳是便携式的，例如可以具有17.5cm或更小的厚度。

17. 发明申请

US20120232803A1 CHARACTERIZATION OF BLOOD HEMOSTASIS AND OXYGEN TRANSPORT PARAMETERS 有权
标题翻译：血液透析和氧运输参数的表征
公开(公告)号：US20120232803A1
公开(公告)日：2012-09-13
申请号：US13397481
申请日：2012-02-15
申请人： Francesco Viola , William F. Walker
发明人： Francesco Viola , William F. Walker
IPC分类号： G06F19/00
CPC分类号： G01N29/028 , G01N29/024 , G01N29/032 , G01N29/44 , G01N33/49 , G01N33/4905 , G01N33/492 , G01N2291/018 , G01N2291/022 , G01N2291/02466 , G01N2291/02818 , G01N2291/044
摘要： An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.
摘要翻译：公开了一种用于确定血液样品如血液的止血和氧气输送参数的综合系统。该系统包括诸如超声波传感器的测量系统，其被配置为确定表征血液样本的数据。例如，数据可以是血液样本响应于超声脉冲的位移。该系统的集成方面可以是常见的传感器，采样部分或数据，用于快速和有效地确定两个参数。参数也可用于校正或改进测量参数。例如，可以使用HCT测量将生理调节应用于止血参数。此外，可以应用物理调整，例如通过使用通过血样或通过血液样本的声音脉冲的速度或衰减进行校准。这些参数可以显示在GUI上以指导治疗。

18. 发明申请

US20110137588A1 METHODS, APPARATUS, OR SYSTEMS FOR CHARACTERIZING PHYSICAL PROPERTY IN NON-BIOMATERIAL OR BIO-MATERIAL 有权
标题翻译：用于表征非生物材料或生物材料中物理性质的方法，装置或系统
公开(公告)号：US20110137588A1
公开(公告)日：2011-06-09
申请号：US12940838
申请日：2010-11-05
申请人： William F. Walker , Francesco Viola , F. William Mauldin
发明人： William F. Walker , Francesco Viola , F. William Mauldin
IPC分类号： G01N29/22 , G06F19/00
CPC分类号： G01N29/07 , G01N2291/02466 , G01N2291/02827 , G01N2291/044 , G01N2291/102
摘要： Techniques (e.g., system, apparatus, method, machine-readable medium) can be configured for characterizing a rheological or other structural physical property of a sample of a substance. In an example, this can include acoustically bidirectionally deforming the portion of the sample over a deformation range about a neutral-deformation locus within the deformation range, measuring a deformation response of at least a portion of the sample to the insonification, and characterizing the physical property of the sample using the measured response of at least a portion of the sample to the insonification, even in the presence of a flowing substance.
摘要翻译：技术（例如，系统，装置，方法，机器可读介质）可以被配置为表征物质样品的流变学或其它结构物理性质。在一个示例中，这可以包括在变形范围内围绕中性 - 变形轨迹的变形范围使样本的部分声学双向变形，测量样品的至少一部分对于失真的变形响应，以及表征物理即使在存在流动物质的情况下，样品的至少一部分的测量响应也与样品的性质相关。

19. 发明申请

US20120244564A1 ULTRASOUND-BASED METHOD AND RELATED SYSTEM TO EVALUATE HEMOSTATIC FUNCTION OF WHOLE BLOOD 审中-公开
标题翻译：基于超声波的方法和相关系统评估全血细胞的HEMOSTATIC功能
公开(公告)号：US20120244564A1
公开(公告)日：2012-09-27
申请号：US13496349
申请日：2010-09-17
申请人： William F. Walker , Francesco Viola , F. William Mauldin, II
发明人： William F. Walker , Francesco Viola , F. William Mauldin, II
IPC分类号： G01N29/02 , C12M1/42
CPC分类号： G01N29/343 , G01N29/024 , G01N29/032 , G01N29/34 , G01N29/4472 , G01N33/4905 , G01N2291/02466 , G01N2291/025 , G01N2291/02827 , G01N2291/044
摘要： Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material
摘要翻译：用于通过对材料施加力来评估材料的机械性能的方法和系统，所述材料足以物理地移动材料的一部分，测量材料的位移，当所测量的位移不在预定的位移范围内时自适应地调节力值，其中所述力分别根据所测量的位移是否低于或高于所述预定范围而增加或减小，并且计算由所述材料的位移产生的机械性能值

20. 发明申请

US20110034805A1 METHOD AND APPARATUS FOR CHARACTERIZATION OF CLOT FORMATION 有权
标题翻译：用于表征衣物形成的方法和装置
公开(公告)号：US20110034805A1
公开(公告)日：2011-02-10
申请号：US12909600
申请日：2010-10-21
申请人： William F. Walker , Michael B. Lawrence , Francesco Viola , Margaret Kramer Sande
发明人： William F. Walker , Michael B. Lawrence , Francesco Viola , Margaret Kramer Sande
IPC分类号： A61B8/06 , A61B8/08 , A61M37/00
CPC分类号： A61B5/02028 , A61B5/0048 , A61B8/08 , A61B8/485 , G01N29/11 , G01N29/343 , G01N2291/02466 , G01N2291/02475 , G01N2291/02827 , G01N2291/044
摘要： Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood. Acoustic pulses and/or optical waves reflected from the blood, or a flexible member in contact with the blood that moves with the blood, are received and measured to estimate at least one characteristic of the physical displacement induced thereby.
摘要翻译：用于表征软组织的至少一种物理性质的变化的方法，装置和系统。产生一系列声脉冲并引导到软组织中，使得至少一个脉冲具有足够高的强度以引起组织的物理位移。从组织反射的波或与组织一起移动的柔性构件被接收和测量以估计由此引起的物理位移的至少一个特征。生成，接收和估计步骤的重复提供了至少一种物理特性随时间的表征。用于表征血液的至少一种物理性质的方法，装置和系统，通过产生一系列声脉冲并将一系列脉冲引导到血液中，使得脉冲中的至少一个具有足够高的强度以引起血液的物理位移血液。接收和测量从血液反射的声波脉冲和/或光波，或与血液一起移动的血液接触的柔性部件，以估计由此引起的物理位移的至少一个特性。

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