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11. 发明授权

US09192362B2 Device and method for closure of vessel access site 有权
标题翻译：关闭船只进入现场的装置和方法
公开(公告)号：US09192362B2
公开(公告)日：2015-11-24
申请号：US13059157
申请日：2009-08-17
申请人： Ram H. Paul, Jr. , Brian L. Bates , Bradley L. Trembacki
发明人： Ram H. Paul, Jr. , Brian L. Bates , Bradley L. Trembacki
IPC分类号： A61B17/00 , A61B18/14 , A61B17/30 , A61B17/29
CPC分类号： A61B17/0057 , A61B18/1442 , A61B18/1445 , A61B18/1447 , A61B2017/00986 , A61B2017/2905 , A61B2017/2926 , A61B2017/2927 , A61B2017/301 , A61B2017/303 , A61B2017/305
摘要： A device for closure of an opening formed in a body vessel includes a grasping member and a sheath movable thereover. The grasping member comprises a tubular body having a plurality of grasping fingers extending from a distal end of the tubular body. The fingers radially extend from the tubular body at a first angle, and are collapsible therefrom to a second angle. The fingers have a distal tip configured for grasping an outer wall of the body vessel surrounding the vessel opening when the fingers are at the first angle. The sheath is slidable over the tubular body and at least a portion of the grasping fingers for collapsing the fingers from the first angle to the second angle, thereby causing the collapsed fingers to at least substantially close the opening.
摘要翻译：用于封闭形成在身体容器中的开口的装置包括抓握构件和可在其上移动的护套。抓持构件包括具有从管状体的远端延伸的多个抓取指状物的管状体。指状物从管状体以第一角度径向延伸，并且可从其收缩至第二角度。手指具有构造成当手指处于第一角度时抓住围绕容器开口的身体容器的外壁的远侧末端。护套可以在管状体上滑动并且至少一部分把持指状物用于将手指从第一角度折叠到第二角度，从而使折叠的手指至少基本上关闭开口。

12. 发明授权

US08679175B2 Artificial valve prosthesis with a free leaflet portion 有权
标题翻译：具有自由叶片部分的人造瓣膜假体
公开(公告)号：US08679175B2
公开(公告)日：2014-03-25
申请号：US13346149
申请日：2012-01-09
申请人： Ram H. Paul, Jr. , Gary B. Shirley
发明人： Ram H. Paul, Jr. , Gary B. Shirley
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2220/005 , A61F2220/0058 , A61F2250/0036
摘要： One embodiment of the present invention provides an implantable valve prosthesis. The valve prosthesis includes a frame defining a lumen extending between a proximal frame end and a distal frame end along a longitudinal axis, and a first valve leaflet positioned within the lumen and having a distal edge attached to the frame and a proximal edge free of the frame. The first valve leaflet comprises a first and a second slit extend distally from the proximal edge and defining a free portion of the first valve leaflet between the first and second slits. The first valve leaflet is movable between a first position that allows fluid flow in a first, antegrade, direction and a second position that restricts flow in a second, retrograde direction.
摘要翻译：本发明的一个实施例提供一种可植入瓣膜假体。瓣膜假体包括框架，该框架限定沿着纵向轴线在近端框架端和远端框架端之间延伸的内腔，以及定位在内腔内并且具有附接到框架的远侧边缘的第一瓣膜小叶和没有帧。第一阀瓣包括从近侧边缘向远侧延伸的第一和第二狭缝，并且在第一和第二狭缝之间限定第一瓣膜叶片的自由部分。第一阀瓣可在第一位置和第二位置之间移动，该第一位置允许流体沿第一，顺流方向和第二位置流动，从而限制第二逆向方向的流动。

13. 发明授权

US08382822B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08382822B2
公开(公告)日：2013-02-26
申请号：US12574870
申请日：2009-10-07
申请人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
发明人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0021 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095
摘要： A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶片结构，其包括一个或多个小叶，每个小叶的外边缘沿着沿着通过可扩张的第二通道推动抵靠通道的蛇形路径接合身体通道的内周框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

14. 发明授权

US08192479B2 Method and device for vascular therapy 有权
标题翻译：用于血管治疗的方法和装置
公开(公告)号：US08192479B2
公开(公告)日：2012-06-05
申请号：US12324484
申请日：2008-11-26
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61F2/06 , A61F2/01 , A61M29/00
CPC分类号： A61M29/02 , A61M2025/0024 , A61M2025/0096 , A61M2025/0188
摘要： Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device can have a middle region with a plurality of members. The members can expand radially outward away from a longitudinal axis of the tubular frame, which can urge the sleeve to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.
摘要翻译：提供医疗装置以及治疗和制造这种装置的方法，用于在体内血管局部施用血管治疗。医疗装置包括可扩张的管状框架和套筒。医疗装置可用于局部递送用于撕裂体血管的体内容器或填塞物中的治疗剂，同时允许灌注植入的医疗装置的远端的流体或血液流。医疗装置的管状框架可以具有带有多个构件的中间区域。构件可以从管状框架的纵向轴线径向向外膨胀，这可以促使套筒接触身体容器的壁。在扩展构型中，当套管抵靠身体血管壁时，该装置的一部分允许流体流动继续。

15. 发明授权

US08100962B2 Flow-deflecting prosthesis for treating venous disease 有权
标题翻译：用于治疗静脉疾病的流变假体
公开(公告)号：US08100962B2
公开(公告)日：2012-01-24
申请号：US12350456
申请日：2009-01-08
申请人： Charles W. Agnew , Ram H. Paul, Jr.
发明人： Charles W. Agnew , Ram H. Paul, Jr.
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016
摘要： A flow-deflecting medical device comprising a support structure and at least one flow-deflecting member attached to the support structure. The flow-deflecting member is at least partially evertible between a first position and a second position. In the first position, antegrade flow contacts the antegrade surface of the flow-deflecting member, urging the flow-deflecting member proximally in the body vessel, such that antegrade flow is substantially uninterrupted. In the second position, retrograde flow contacts the retrograde surface of the flow-deflecting member, urging the flow-deflecting member distally in the body vessel, such that retrograde flow is received and redirected by the flow-deflecting member. Also provided is a method for treating a body vessel valve-related condition comprising implanting a flow-deflecting medical device proximal to a native valve.
摘要翻译：一种流动偏转医疗装置，其包括支撑结构和附接到所述支撑结构的至少一个流动偏转构件。流动偏转构件在第一位置和第二位置之间至少部分可逆。在第一位置，顺行流动接触流动偏转构件的顺行表面，在身体容器中向近侧推动流动偏转构件，使得顺行流动基本上不中断。在第二位置，逆行流动接触流动偏转构件的逆行表面，将流体偏转构件向远侧推动到体内容器中，从而逆流被接收并由流动偏转构件重定向。还提供了一种用于治疗体内血管相关病症的方法，包括在靠近天然瓣膜的位置植入偏转转向的医疗装置。

16. 发明授权

US08092522B2 Artificial valve prostheses with a free leaflet portion 有权
标题翻译：具有自由叶片部分的人造瓣膜假体
公开(公告)号：US08092522B2
公开(公告)日：2012-01-10
申请号：US12030945
申请日：2008-02-14
申请人： Ram H. Paul, Jr. , Gary B. Shirley
发明人： Ram H. Paul, Jr. , Gary B. Shirley
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2220/005 , A61F2220/0058 , A61F2250/0036
摘要： An implantable valve prosthesis including a frame defining a lumen extending between a proximal frame end and a distal frame end and a leaflet positioned within the lumen and having a distal edge attached to the frame and a proximal edge free of the frame. The leaflet includes a first and a second slit extending distally from the proximal edge and defining a free portion of the leaflet between the first and second slits. The leaflet is movable between a position that allows fluid flow in an antegrade direction and a second position that restricts flow in a retrograde direction.
摘要翻译：一种可植入瓣膜假体，其包括限定在近端框架端和远端框架端之间延伸的内腔的框架，以及定位在内腔内并具有附接到框架的远侧边缘和没有框架的近侧边缘的小叶。小叶包括从近侧边缘向远侧延伸并且在第一和第二狭缝之间限定小叶的自由部分的第一狭缝和第二狭缝。小叶可以在允许流体沿顺行方向流动的位置和限制沿逆行方向的流动的第二位置之间移动。

17. 发明授权

US5399165A Lockable connector, a drainage catheter utilizing the connector, and method of use 失效
标题翻译：可锁定连接器，使用连接器的排水导管及其使用方法
公开(公告)号：US5399165A
公开(公告)日：1995-03-21
申请号：US259353
申请日：1994-06-13
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61M1/00 , A61M25/00 , A61M25/01 , A61M25/04 , A61M25/18 , A61M37/00
CPC分类号： A61M25/0147 , A61M25/0152 , A61M2025/0163 , A61M25/04
摘要： A drainage catheter with a distal member end that is lockable in a desired loop configuration for retaining the catheter in a body cavity such as the bladder. The lockable drainage catheter includes a flexible tension member for drawing the distal member end into a loop. The tension member extends through a lockable connector positioned about the proximal member end. The lockable connector includes a resilient material sleeve with a sleeve passage extending longitudinally therethrough for positioning the tension member therein. The sleeve is positioned in a passage of the connector adjacent a channel wherein a pivotedly attached lever is positioned. When the lever is pivoted toward the connector into a fixed position, a cam surface of the lever compresses the sleeve and locks thereabout to maintain the loop formed in the distal member end.
摘要翻译：具有远端构件端部的排水导管，其能够锁定在期望的环形结构中，用于将导管保持在诸如膀胱的体腔中。可锁定排水导管包括用于将远端构件端拉入环的柔性张紧构件。张紧构件延伸穿过围绕近端构件端定位的可锁定连接器。可锁定连接器包括弹性材料套筒，其具有纵向延伸穿过的套筒通道，用于将张紧构件定位在其中。套筒定位在连接器邻近通道的通道中，其中枢轴连接的杆被定位。当杠杆朝向连接器枢转到固定位置时，杠杆的凸轮表面压缩套筒并锁定在其上以保持形成在远端构件端部的环。

18. 发明公开

US20240058094A1 MRI Compatible Interventional Medical Devices and Related Methods 审中-公开
公开(公告)号：US20240058094A1
公开(公告)日：2024-02-22
申请号：US18234440
申请日：2023-08-16
申请人： Ram H. Paul, Jr. , Sean D. Chambers , David Gross , Neal Fearnot , Jesse Roll , Joshua F. Krieger , Carl A. Cook
发明人： Ram H. Paul, Jr. , Sean D. Chambers , David Gross , Neal Fearnot , Jesse Roll , Joshua F. Krieger , Carl A. Cook
IPC分类号： A61B90/00 , A61B5/055 , A61L31/02 , A61L31/14
CPC分类号： A61B90/39 , A61B5/055 , A61L31/022 , A61L31/14 , A61B2090/3954 , A61M2025/09075
摘要： The disclosure relates to methods of imaging a portion of a body vessel using magnetic resonance imaging (MRI), methods of performing interventional medical treatment under MRI, interventional medical devices, such as wire guides, useful in performing treatment under MRI, and methods of making interventional medical devices. A method of imaging a portion of a body vessel of a patient using MRI includes advancing through a body vessel an end of a wire guide comprising a continuous metal core member and a continuous jacket disposed over the entire core member through a body vessel and scanning the portion of the patient that is positioned within an MRI scanner and that includes a portion of the body vessel within which the end of the wire guide is disposed. A secondary medical device, such as a catheter, can be disposed over the wire guide and manipulated in the method.

19. 发明授权

US08506621B2 Flow-deflecting medical device 有权
标题翻译：流量偏转医疗器械
公开(公告)号：US08506621B2
公开(公告)日：2013-08-13
申请号：US13355959
申请日：2012-01-23
申请人： Charles W. Agnew , Ram H. Paul, Jr.
发明人： Charles W. Agnew , Ram H. Paul, Jr.
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016
摘要： The disclosure relates to a flow-deflecting medical device comprising a support structure and two flow-deflecting members attached to the support structure. The first flow-deflecting member is movable to a position in which it contacts and substantially seals against the second flow-deflecting member.
摘要翻译：本发明涉及一种流动偏转医疗装置，其包括支撑结构和附接到支撑结构的两个流动偏转构件。第一流动偏转构件可移动到其接触并基本上密封第二流动偏转构件的位置。

20. 发明授权

US08500772B2 Distal protection device 有权
标题翻译：远端保护装置
公开(公告)号：US08500772B2
公开(公告)日：2013-08-06
申请号：US11688430
申请日：2007-03-20
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0093
摘要： The present invention provides, in certain aspects, devices and methods for protecting the body from downstream embolization. In one embodiment, a distal protection device comprises a shaft and a jacket with the shaft being received within the jacket. The device also includes a filter, which is supported by a wire cone that has one end attached to the jacket and an opposite end attached to the shaft. The shaft is rotatable relative to the jacket to reduce the size of the cone for capturing embolic debris within the wire cone. The invention also provides such devices in combination with instruments (e.g., balloon stent catheters) for treating stenosis and other similar conditions.
摘要翻译：本发明在某些方面提供了用于保护身体免受下游栓塞的装置和方法。在一个实施例中，远侧保护装置包括轴和夹套，所述轴被容纳在护套内。该装置还包括一个过滤器，该过滤器由电线锥体支撑，其中一端连接到护套上，另一端连接到轴上。轴可相对于护套旋转以减小用于捕获线锥内的栓塞碎片的锥体的尺寸。本发明还提供了用于治疗狭窄和其他类似病症的器械（例如气囊支架导管）的这种装置。

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