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11. 发明申请

US20110182848A1 GRANULOCYTE COLONY STIMULATING FACTOR 审中-公开
标题翻译： GRANULOCYTE COLONY刺激因子
公开(公告)号：US20110182848A1
公开(公告)日：2011-07-28
申请号：US12671987
申请日：2008-07-31
申请人： Peter Artymiuk , Richard Ross , Jon Sayers
发明人： Peter Artymiuk , Richard Ross , Jon Sayers
IPC分类号： A61K38/19 , C07K14/535 , C07H21/04 , C12N15/63 , C12N5/16 , A61P37/04 , C12N1/00 , C12N5/14
CPC分类号： C07K14/535 , C07K14/715 , C07K2319/00
摘要： We disclose granulocyte colony stimulating factor fusion polypeptides; nucleic acid molecules encoding said polypeptides and methods of treatment that use said proteins.
摘要翻译：我们公开了粒细胞集落刺激因子融合多肽; 编码所述多肽的核酸分子和使用所述蛋白质的治疗方法。

12. 发明授权

US07485713B2 Polypeptides comprising growth hormone receptor extracellular domain and glycosylphosphatidylinositol 失效
标题翻译：包含生长激素受体细胞外结构域和糖基磷脂酰肌醇的多肽
公开(公告)号：US07485713B2
公开(公告)日：2009-02-03
申请号：US10492403
申请日：2002-10-11
申请人： Richard Ross
发明人： Richard Ross
IPC分类号： C07H21/04 , C07K14/71 , C07K19/00 , C12N15/12 , C12N15/64 , C12N15/63 , C12N1/15 , C12N1/11 , C12N5/10 , A61K38/17
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to polypeptides which comprise a receptor binding domain of a cytokine and a domain which includes a signal sequence for the attachment of glycosylphosphatidylinositol (GPI) anchors. The invention also relates to methods to manufacture the polypeptides, nucleic acids molecules encoding the polypeptides and therapeutic compositions comprising the polypeptides.
摘要翻译：本发明涉及包含细胞因子的受体结合结构域和包含用于连接糖基磷脂酰肌醇（GPI）锚的信号序列的结构域的多肽。本发明还涉及制备多肽的方法，编码多肽的核酸分子和包含多肽的治疗组合物。

13. 发明申请

US20070173149A1 WATER- AND OIL-REPELLENT FLUOROACRYLATES 失效
标题翻译：水和油的氟代丙烯酸酯
公开(公告)号：US20070173149A1
公开(公告)日：2007-07-26
申请号：US11688074
申请日：2007-03-19
申请人： Gregg CALDWELL , John Clark , David Kinning , Alan Kirk , Thomas Klun , Ramesh Kumar , Roger Mader , George Moore , Zai-Ming Qiu , Richard Ross
发明人： Gregg CALDWELL , John Clark , David Kinning , Alan Kirk , Thomas Klun , Ramesh Kumar , Roger Mader , George Moore , Zai-Ming Qiu , Richard Ross
IPC分类号： B32B27/04 , C08L31/00 , C08F8/30 , C07C271/14
CPC分类号： C08F220/38 , C07C271/20 , C07C271/28 , C07C311/09 , Y10T442/2287
摘要： Fluoroacrylates comprise the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: CnF2n+1—X—OH wherein: n=1 to 4, R=hydrogen or an alkyl group of 1 to 4 carbon atoms, m=2 to 8, Rf=CnF2n+1, y=0 to 6, and q=1 to 8; (b) at least one unbranched symmetric diusocyanate; and (c) at least one hydroxy-terminated alkyl (meth)acrylate or 2-fluoro acrylate monomer having 2 to about 30 carbon atoms in its alkylene portion.
摘要翻译：氟代丙烯酸酯包括以下反应产物：（a）至少一种由下式表示的含氟醇：<？in-line-formula description =“In-line Formulas”end =“lead”？> C

14. 发明申请

US20050214762A1 Polypeptide variants 审中-公开
标题翻译：多肽变体
公开(公告)号：US20050214762A1
公开(公告)日：2005-09-29
申请号：US10502344
申请日：2003-01-24
申请人： Richard Ross , Peter Artymiuk , Jon Sayers
发明人： Richard Ross , Peter Artymiuk , Jon Sayers
IPC分类号： C12N15/09 , A61K38/00 , A61K38/19 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P5/06 , A61P7/06 , A61P9/12 , A61P13/12 , A61P19/02 , A61P19/10 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , C07K14/52 , C07K14/575 , C07K14/61 , C07K14/715 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/10 , C12N15/62 , C12N15/63 , C12P21/02 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/61 , A61K38/00 , C07K14/5759 , C07K2319/00
摘要： The invention relates to the provision of oligomeric polypeptides (dimers, trimmers, etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptides linker molecules. The linker molecules optionally comprise protease sensitive sites to modulate the release of biologically active cytokines when administered to a human or animal subject.
摘要翻译：本发明涉及提供包含通过柔性多肽连接分子连接的细胞因子的配体结合结构域的寡聚多肽（二聚体，微调剂等）。连接分子任选地包含蛋白酶敏感位点，以在施用于人或动物受试者时调节生物活性细胞因子的释放。

15. 发明授权

US06513600B2 Apparatus and method for packing or anchoring an inner tubular within a casing 失效
标题翻译：用于在内壳内包装或固定内管的装置和方法
公开(公告)号：US06513600B2
公开(公告)日：2003-02-04
申请号：US09746406
申请日：2000-12-21
申请人： Richard Ross
发明人： Richard Ross
IPC分类号： E21B33128
CPC分类号： E21B33/1212 , E21B33/1277
摘要： The present invention provides an apparatus and method for sealing and/or anchoring against the inside surface of an outer tubular. In one embodiment, a radially expandable sleeve has at least one radially expandable separate rings located there about. The at least one ring is capable of radical expansion without appreciable deformation of the at least one edge for improved engagement between the at least one edge and the inside surface of the outer tubular. In another embodiment, the present invention provides an inflatable metal to metal seal packer that is able to accommodate out of round casing.
摘要翻译：本发明提供一种用于密封和/或锚定抵抗外管的内表面的装置和方法。在一个实施例中，径向可扩张的套筒具有位于其周围的至少一个可径向扩张的分离环。所述至少一个环能够自由扩张，而不会有至少一个边缘的明显变形，以改善外管的至少一个边缘和内表面之间的接合。在另一个实施例中，本发明提供一种能够容纳在圆形外壳内的可膨胀的金属到金属密封封隔器。

16. 发明授权

US4050651A Wing and reduced airspeed system for jet aircraft 失效
标题翻译：飞机和飞机降低空速系统
公开(公告)号：US4050651A
公开(公告)日：1977-09-27
申请号：US699391
申请日：1976-06-24
申请人： Ronald D. Neal , Richard Ross , Joseph N. Hein
发明人： Ronald D. Neal , Richard Ross , Joseph N. Hein
IPC分类号： B64C3/14 , B64C13/16 , B64C3/10
CPC分类号： B64C13/16 , B64C3/14 , B64C2003/146
摘要： A thin, high performance swept wing of the tapered type with an improved leading edge characterized by (1) camber that increases from a minimum near the wing root to a maximum near the wing tip, and (2) substantially a constant leading edge radius extending substantially across the wing span which defines a "blunt" contour. The wing in combination with a T-tail aircraft with a stick shaker/pusher activated by a rate of change of angle of attack sensor and optionally a strake between the leading edge and a wing tip tank which intrinsically combine to define a system that enhances aircraft performance by reducing minimum airspeed without impairing aircraft performance at high subsonic Mach (M) numbers.
摘要翻译：一种具有改进的前缘的锥形型薄型高性能扫掠翼，其特征在于（1）弧角从翼根附近的最小值增加到翼尖附近的最大值，以及（2）基本上恒定的前缘半径延伸基本上穿过限定“钝”轮廓的机翼跨度。机翼与T型尾翼飞行器结合，其中具有通过迎角传感器的变化速率和可选地在前缘和翼尖坦克之间的行程的活塞式摇动器/推动器，其固有地组合以限定增强飞行器的系统通过降低最小空速而不损害高亚音速马赫（M）数量下的飞机性能的性能。

17. 发明授权

US08790046B2 High pressure slurry nozzle 有权
标题翻译：高压浆喷嘴
公开(公告)号：US08790046B2
公开(公告)日：2014-07-29
申请号：US13484038
申请日：2012-05-30
申请人： Richard Ross
发明人： Richard Ross
IPC分类号： B05B1/00 , E02D17/18
CPC分类号： E02D31/002 , B05B13/005 , B05B15/62 , B05B15/63 , B05B15/652 , E02D3/12 , Y10T137/9464
摘要： An embankment system comprises a source of pressurized sand/concrete slurry and a delivery conduit in fluid communication with the pressurized sand/concrete slurry source. The embankment system further comprises an elongate nozzle having an inlet and an outlet, with the inlet operatively associated with a distal end of the delivery conduit. A tube formed of a sheet material having an open end and a closed end is operatively associated with the nozzle outlet to receive the pressurized sand/concrete slurry through the open end, such that the tube is continuously filled with the pressurized sand/concrete slurry between the closed end and the open end.
摘要翻译：堤防系统包括加压砂/混凝土浆料源和与加压砂/混凝土浆料源流体连通的输送管道。堤防系统还包括具有入口和出口的细长喷嘴，入口与输送导管的远端可操作地相关联。由具有开口端和闭合端的片材形成的管与喷嘴出口可操作地相关联，以通过开口端接收加压砂/混凝土浆料，使得管连续地填充有加压砂/混凝土浆料封闭端和开口端。

18. 发明授权

US08470559B2 Growth hormone fusion proteins 失效
标题翻译：生长激素融合蛋白
公开(公告)号：US08470559B2
公开(公告)日：2013-06-25
申请号：US13620004
申请日：2012-09-14
申请人： Richard Ross , Peter Artymiuk , Jon Sayers
发明人： Richard Ross , Peter Artymiuk , Jon Sayers
IPC分类号： A61K38/27 , C07K14/61 , C07K14/72 , C12N15/18 , C12N1/21 , C12N5/10 , C12N15/63
CPC分类号： C07K14/61 , C07K14/71 , C07K2319/31 , C12N15/62
摘要： We disclose growth hormone [GH] fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone deficiency that use said fusion proteins. The GH fusion proteins comprise human GH covalently linked to the extracellular domain of Growth Hormone Receptor [GHR] either as a direct in-frame translational fusion or via a flexible peptide linker. The GH/GHR fusion proteins have exceptional pharmacokinetics and are potent growth hormone receptor agonists. The GH/GHR fusion proteins form head to tail dimers.
摘要翻译：我们公开了增加体内稳定性和活性的生长激素[GH]融合蛋白; 编码所述蛋白质的核酸分子和使用所述融合蛋白的生长激素缺乏症的治疗方法。 GH融合蛋白包括与生长激素受体[GHR]的细胞外结构域共价连接的人GH，作为直接的帧内翻译融合或通过柔性肽接头。 GH / GHR融合蛋白具有特殊的药代动力学，是有效的生长激素受体激动剂。 GH / GHR融合蛋白形成头对尾二聚体。

19. 发明申请

US20110230401A1 INSULIN FUSION POLYPEPTIDES 审中-公开
标题翻译：胰岛素融合多糖
公开(公告)号：US20110230401A1
公开(公告)日：2011-09-22
申请号：US13002039
申请日：2009-07-02
申请人： Peter Artymiuk , Richard Ross
发明人： Peter Artymiuk , Richard Ross
IPC分类号： A61K38/28 , C07H21/04 , C07K14/62 , C12N15/63 , A61P3/10 , C12N5/10 , C12N1/00
CPC分类号： C07K14/62 , A61K38/00 , C07K14/72
摘要： We disclose insulin fusion polypeptides and dimers; nucleic acid molecules encoding said polypeptides and methods of treatment that use said polypeptides/dimers.
摘要翻译：我们公开胰岛素融合多肽和二聚体; 编码所述多肽的核酸分子和使用所述多肽/二聚体的治疗方法。

20. 发明申请

US20110152187A1 INSULIN-LIKE GROWTH FACTOR FUSION PROTEINS 审中-公开
标题翻译：胰岛素样生长因子融合蛋白
公开(公告)号：US20110152187A1
公开(公告)日：2011-06-23
申请号：US12672000
申请日：2008-08-05
申请人： Peter Artymiuk , Richard Ross , Jon Sayers
发明人： Peter Artymiuk , Richard Ross , Jon Sayers
IPC分类号： A61K38/30 , C07K14/475 , C12N15/18 , C12N15/63 , C12N5/00 , A61P5/00 , A61P3/10 , A61P17/02
CPC分类号： C07K14/65 , A61K38/00 , C07K14/72 , C07K2319/00 , C07K2319/32 , C07K2319/74 , G01N2030/8827 , G01N2030/8831
摘要： This disclosure relates to insulin-like growth factor fusion polypeptides; nucleic acid molecules encoding said polypeptides and methods of treatment that use said polypeptides.
摘要翻译：本公开涉及胰岛素样生长因子融合多肽; 编码所述多肽的核酸分子和使用所述多肽的治疗方法。

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