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11. 发明公开

EP3449927A1 PHARMACEUTICAL FORMULATIONS COMPRISING CHONDROITIN SULFATE AND HYALURONIC ACID DERIVATIVES 有权
公开(公告)号：EP3449927A1
公开(公告)日：2019-03-06
申请号：EP18200663.5
申请日：2013-03-27
申请人： Fidia Farmaceutici S.p.A.
发明人： CAMPISI, Monica , CARPANESE, Giancarlo , CORSA, Vincenza , ZANELLATO, Anna Maria
IPC分类号： A61K31/728 , A61K31/737 , A61P19/02 , A61P13/10 , A61K9/00 , A61K47/00
摘要： The present invention relates to pharmaceutical formulations containing a combination of specific high-molecular weight hyaluronic acid derivatives and chondroitin sulfate to be used in the treatment of osteoarthritis, of subchondral damage, osteoporosis, synovitis, tenosynovitis, tendinitis, tendinosis, as an intra-articular washing liquid and as a viscous substitute of synovial fluid following osteochondral surgery. These formulations are also suitable for the treatment of interstitial cystitis.

12. 发明授权

EP2279006B1 THERAPEUTIC USE OF PHARMACEUTICAL PREPARATIONS CONTAINING ANTITUMORAL DRUGS BOUND TO HYALURONIC ACID IN THE TREATMENT OF NEOPLASIAS 有权
标题翻译：药物制剂的治疗应用抗肿瘤，要透明质酸约束的药品，在治疗肿瘤
公开(公告)号：EP2279006B1
公开(公告)日：2014-10-22
申请号：EP09734556.5
申请日：2009-04-21
申请人： FIDIA FARMACEUTICI S.p.A.
发明人： CAMPISI, Monica , RENIER, Davide , PIERIMARCHI, Pasquale , SERAFINO, Annalucia
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/61
摘要： The present invention describes the new use in the oncologic field of bioconjugates as differentiating agents obtained by the conjugation between hyaluronic acid (HA) and a chemotherapeutic product (identified hereafter with the trade-name ONCOFID®) among which, in particular, Irinotecan, Doxorubicin, Paclitaxel, Cis-platinum and 5-Fluorouracyl (5-FU) for treating primary tumors and metastasis. In particular, the biological behavior is described in terms of action mechanism, efficacy and tolerability of pharmaceutical preparations of derivative of ONCOFID® soluble in water. More specifically, the invention relates to the surprising biological and pharmacological effect demonstrated by formulations based on ONCOFID-S (HA-SN38 conjugates) and ONCOFID-D (HA-Doxorubicin conjugates) in promoting the differentiation of tumoral cells towards a untransformed phenotype, compared with the reference drug Irinotecan (or CPT11 whose active form is represented by SN38) and Doxorubicin.

13. 发明公开

EP3790599A1 WOUND DRESSING FOR TREATMENT OF DAMAGED SKIN 有权
公开(公告)号：EP3790599A1
公开(公告)日：2021-03-17
申请号：EP19730943.8
申请日：2019-05-06
申请人： Fidia Farmaceutici S.p.A.
发明人： CAMPISI, Monica , GENNARI, Giovanni
IPC分类号： A61L15/28 , A61L15/44

14. 发明授权

EP2953656B1 PHOTOCROSSLINKED HYALURONIC ACID DERIVATIVES, AND THE PREPARATION PROCESS AND USE THEREOF 有权
标题翻译： LIGHT CONNECTED透明质酸衍生物和方法进行生产及其用途
公开(公告)号：EP2953656B1
公开(公告)日：2016-11-09
申请号：EP14708662.3
申请日：2014-02-04
申请人： Fidia Farmaceutici S.p.A.
发明人： CAMPISI, Monica , DE LUCCHI, Ottorino , BENINATTO, Riccardo , BORSATO, Giuseppe
IPC分类号： A61L27/20 , A61L27/36 , A61L27/38 , A61K31/728 , C08B37/08
CPC分类号： A61L27/20 , A61K47/61 , A61K47/6903 , A61L27/26 , A61L27/3804 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/64 , A61L2400/16 , A61L2430/06 , C08B37/0072 , C08L5/08
摘要： Disclosed are photocrosslinked hyaluronic acid (HA) derivatives consisting of HA, a bifunctional polyethylene glycol (PEG) spacer which is triethylene glycol, and a photoreactive compound selected from a coumarin derivative and propiophenone.

15. 发明公开

EP2279006A1 THERAPEUTIC USE OF NEW PHARMACEUTICAL PREPARATIONS CONTAINING ANTITUMORAL DRUGS BOUND TO HYALURONIC ACID IN THE TREATMENT OF NEOPLASIAS 有权
标题翻译：药物制剂的治疗应用抗肿瘤，要透明质酸约束的药品，在治疗肿瘤
公开(公告)号：EP2279006A1
公开(公告)日：2011-02-02
申请号：EP09734556.5
申请日：2009-04-21
申请人： FIDIA FARMACEUTICI S.p.A.
发明人： CAMPISI, Monica , RENIER, Davide , PIERIMARCHI, Pasquale , SERAFINO, Annalucia
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/61
摘要： The present invention describes the new use in the oncologic field of bioconjugates as differentiating agents obtained by the conjugation between hyaluronic acid (HA) and a chemotherapeutic product (identified hereafter with the trade-name ONCOFID®) among which, in particular, Irinotecan, Doxorubicin, Paclitaxel, Cis-platinum and 5-Fluorouracyl (5-FU) for treating primary tumors and metastasis. In particular, the biological behavior is described in terms of action mechanism, efficacy and tolerability of pharmaceutical preparations of derivative of ONCOFID® soluble in water. More specifically, the invention relates to the surprising biological and pharmacological effect demonstrated by formulations based on ONCOFID-S (HA-SN38 conjugates) and ONCOFID-D (HA-Doxorubicin conjugates) in promoting the differentiation of tumoral cells towards a untransformed phenotype, compared with the reference drug Irinotecan (or CPT11 whose active form is represented by SN38) and Doxorubicin.
摘要翻译：本发明描述的生物缀合物中作为鉴别由透明质酸（HA）之间的共轭获得试剂的肿瘤学领域中哪个的新用途和化疗产物（具有商品名ONCOFID®下文标识的），特别地，伊立替康，多柔比星，紫杉醇，顺铂和5-氟尿嘧啶（5-FU），用于治疗原发性肿瘤和转移。特别地，所述生物行为在的作用机理，药效和在水中ONCOFID®可溶性衍生物的药物制剂的耐受性来描述。更具体地，本发明涉及到由在电视节目预告婷基于ONCOFID-S（HA-SN38缀合物）和ONCOFID-D（HA-阿霉素缀合物）的肿瘤细胞的分化朝向未转化表型的式蒸发散实例阐述了令人惊奇的生物学和药理学作用，相比与参考药物依立替康（或CPT11其活性形式是由SN38表示）和多柔比星。

16. 发明公开

EP4135773A1 PROCESS FOR THE SYNTHESIS OF A CONJUGATE OF HYALURONIC ACID AND PACLITAXEL 审中-实审
公开(公告)号：EP4135773A1
公开(公告)日：2023-02-22
申请号：EP21724037.3
申请日：2021-04-15
申请人： Fidia Farmaceutici S.p.A.
发明人： CAMPISI, Monica , GUARISE, Cristian , PIZZOCARO, Carlo
IPC分类号： A61K47/61 , C08B37/08 , A61P35/00

17. 发明公开

EP3758762A1 MULTILAYER COMPOSITE MATERIAL 审中-实审
公开(公告)号：EP3758762A1
公开(公告)日：2021-01-06
申请号：EP19712844.0
申请日：2019-02-26
申请人： Fidia Farmaceutici S.p.A.
发明人： GENNARI, Giovanni , CAMPISI, Monica , ZANELLATO, Anna Maria
IPC分类号： A61L15/26 , A61L15/28 , A61L15/44

18. 发明公开

EP2953656A1 PHOTOCROSSLINKED HYALURONIC ACID DERIVATIVES, AND THE PREPARATION PROCESS AND USE THEREOF 有权
标题翻译： LIGHT CONNECTED透明质酸衍生物和方法进行生产及其用途
公开(公告)号：EP2953656A1
公开(公告)日：2015-12-16
申请号：EP14708662.3
申请日：2014-02-04
申请人： Fidia Farmaceutici S.p.A.
发明人： CAMPISI, Monica , DE LUCCHI, Ottorino , BENINATTO, Riccardo , BORSATO, Giuseppe
IPC分类号： A61L27/20 , A61L27/36 , A61L27/38 , A61K31/728 , C08B37/08
CPC分类号： A61L27/20 , A61K47/61 , A61K47/6903 , A61L27/26 , A61L27/3804 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/64 , A61L2400/16 , A61L2430/06 , C08B37/0072 , C08L5/08
摘要： Disclosed are photocrosslinked hyaluronic acid (HA) derivatives consisting of HA, a bifunctional polyethylene glycol (PEG) spacer which is triethylene glycol, and a photoreactive compound selected from a coumarin derivative and propiophenone.

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