专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US5344960A Catalyst for carbonylating naphthalene mono- and disulfonates and process using said catalyst 失效
标题翻译：用于羰基化萘单和二磺酸盐并使用所述催化剂进行处理的催化剂
公开(公告)号：US5344960A
公开(公告)日：1994-09-06
申请号：US163114
申请日：1993-12-06
申请人： Giuseppe Cometti , Annick Du Vosel , Franco Francalanci , Roberto Santi
发明人： Giuseppe Cometti , Annick Du Vosel , Franco Francalanci , Roberto Santi
IPC分类号： B01J31/22 , B01J31/18 , B01J31/20 , C07B61/00 , C07C51/10 , C07C67/00 , C07C69/76 , B01J31/00
CPC分类号： B01J31/20 , B01J31/181 , C07C51/10 , B01J2531/845
摘要： A cobalt based catalyst, and the method for preparing it, are disclosed. The catalyst is obtained from the reaction between NaCo(CO).sub.4 and s-trichloro triazine and is advantageously used in the processes of carbonylation of naphthalene mono- and disulfonates in order to yield naphthalene esters and acids.
摘要翻译：公开了一种钴基催化剂及其制备方法。催化剂是由NaCo（CO）4和s-三氯三嗪之间的反应获得的，有利地用于萘单和二磺酸萘的羰基化方法中，以产生萘酯和酸。

12. 发明授权

US5248601A Process for preparing L(-)-carnitine chloride 失效
标题翻译：制备L（ - ） - 肉碱氯化物的方法
公开(公告)号：US5248601A
公开(公告)日：1993-09-28
申请号：US595670
申请日：1990-10-09
申请人： Franco Francalanci , Marco Ricci , Pietro Cesti , Carlo Venturello
发明人： Franco Francalanci , Marco Ricci , Pietro Cesti , Carlo Venturello
IPC分类号： C12P17/02 , C12P41/00
CPC分类号： C12P17/02 , C12P41/005
摘要： A biotechnological process for preparing L(-)-carnitine chloride, having the formula ##STR1## comprising: (a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having the formula ##STR2## wherein R is an alkyl group having from 1 to 10 carbons or a benzyl group, with an enzyme capable of selectively hydrolyzing enantiomer S(-);(b) separating the enantiomer S(-) from non-reacted ester which is present in predominantly the R(+) form;(c) reacting the non-reacted ester obtained in step (b) with an enzyme capable of quantitatively hydrolyzing the R(+) form to obtain thereby a salt of 3,4-epoxybutyric acid in the R(+) form having the formula ##STR3## wherein X is Na, K, or Li; (d) reacting the salt obtained in step (c) with a molar excess of trimethylamine; and(e) treating the reaction product of step (d) with HCl to remove excess trimethylamine and to obtain thereby the L(-)-carnitine chloride of formula (I).
摘要翻译：用于制备具有式（I）的L（ - ） - 肉碱氯化物的生物技术方法包括：（a）使具有式（IMA）的（R，S）-3,4-环氧丁酸的外消旋酯与式（II）其中R为具有1至10个碳原子的烷基或苄基，具有能够选择性水解对映体S（ - ）的酶; （b）从主要为R（+）形式存在的未反应的酯分离对映体S（ - ）; （c）将步骤（b）中获得的未反应的酯与能够定量水解R（+）形式的酶反应，从而得到具有式（B）的R（+）形式的3,4-（环己基）（III）其中X是Na，K或Li; （d）使步骤（c）中获得的盐与摩尔过量的三甲胺反应; 和（e）用HCl处理步骤（d）的反应产物以除去过量的三甲胺，从而得到式（I）的L（ - ） - 肉碱氯化物。

13. 发明授权

US5103029A Process for preparing 4-demethoxydaunomycinone 失效
标题翻译：制备4-去甲基联苯胺的方法
公开(公告)号：US5103029A
公开(公告)日：1992-04-07
申请号：US333951
申请日：1989-04-06
申请人： Walter Cabri , Silvia de Bernardinis , Franco Francalanci , Sergio Penco
发明人： Walter Cabri , Silvia de Bernardinis , Franco Francalanci , Sergio Penco
IPC分类号： C07D317/26 , B01J31/02 , B01J31/24 , C07B61/00 , C07C45/00 , C07C46/00 , C07C50/38 , C07C67/00 , C07H15/252
CPC分类号： C07C46/00 , Y02P20/55
摘要： 4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound, in an appropriate reducing environment, with a catalytic amount of a transition metal complex, preferably palladium or nickel with 1,3 diphenylphosphinopropane or 1,1'-bis (diphenylphosphino) ferrocene, and eliminating the 13-dioxolanyl group by treatment with trifluoroacetic acid.

14. 发明授权

US5015745A Process for the preparation of 4-demethoxydaunomycinone, the aglycone of 4-demethoxy-daunorubicin 失效
标题翻译： 4-脱甲氧基多霉素酮的制备方法，4-脱甲氧基柔红霉素的糖苷配基
公开(公告)号：US5015745A
公开(公告)日：1991-05-14
申请号：US306559
申请日：1989-02-06
申请人： Silvia De Bernardinis , Walter Cabri , Tiziano Martinengo , Franco Francalanci
发明人： Silvia De Bernardinis , Walter Cabri , Tiziano Martinengo , Franco Francalanci
IPC分类号： C07D317/20 , C07C45/00 , C07C46/00 , C07C50/38 , C07C67/00 , C07C225/32 , C07C241/00 , C07C245/20 , C07D317/26 , C07D317/28 , C07H15/252
CPC分类号： C07C50/38 , C07C46/00 , C07C2103/46 , Y02P20/55
摘要： 4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyl-daunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound with an amine, removing the amino protecting group from the resultant 4-demethyl-4-(protected amino)-13-dioxolanyl-daunomycinone, diazotizing the thus-freed 4-amino group and reducing under mild conditions the resulting diazonium compound.

15. 发明授权

US4980291A Process for the enzymatic separation of the optical isomers of racemic .alpha.-alkyl-substituted primary alcohols 失效
标题翻译：用于酶分离外消旋的α-烷基取代的伯醇的光学异构体的方法
公开(公告)号：US4980291A
公开(公告)日：1990-12-25
申请号：US307913
申请日：1989-02-09
申请人： Daniele Bianchi , Pietro Cesti , Franco Francalanci , Walter Cabri
发明人： Daniele Bianchi , Pietro Cesti , Franco Francalanci , Walter Cabri
IPC分类号： C12P7/62 , C12P41/00
CPC分类号： C12P41/004 , C12P7/62
摘要： Biotechnological resolution by means of enzymatic transesterification of the relevant racemic mixture of the optical isomers of .alpha.-alkyl-substituted primary alcohols having the formula (I): ##STR1## wherein: R represents a linear or branched (C.sub.1 -C.sub.20)-alkyl or alkenyl group or an aryl group, also substituted or condensed with other groups, in particular a group of formula (II) or (III): ##STR2## wherein: R.sup.ii represents a (C.sub.1 -C.sub.8)-alkyl group, a (C.sub.1 -C.sub.4)-alkenyl group, an alkoxy, phenyl, phenoxy, benzoyl, or heterocyclic group;R.sup.iii represents a hydrogen or halogen atom;R.sup.iv represents a (C.sub.1 -C.sub.4)-alkyl group, and whereinR.sup.i represents a (C.sub.1 -C.sub.4)-alkyl group either equal to, or different from, R,in the presence of an enzyme either free or immobilized on a support capable of selectively causing the S isomer to be esterified, with the R isomer being left substantially unchanged, said isomers being then separated according to techniques known from the prior art. The process is used in the synthesis of antiinflammatory agents.

16. 发明授权

US4865771A Process for preparing L(-)-carnitine chloride from 3,4-epoxybutyric esters and novel intermediate compounds 失效
标题翻译：从3,4-环氧丁酸酯和新型中间体化合物制备L（ - ） - 肉碱氯化物的方法
公开(公告)号：US4865771A
公开(公告)日：1989-09-12
申请号：US25351
申请日：1987-03-13
申请人： Franco Francalanci , Marco Ricci , Pietro Cesti , Carlo Venturello
发明人： Franco Francalanci , Marco Ricci , Pietro Cesti , Carlo Venturello
IPC分类号： C07D303/40 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/08 , C07C227/18 , C07C229/22 , C12P13/00 , C12P17/02 , C12P41/00 , C12R1/06 , C12R1/07 , C12R1/38 , C12R1/645 , C12R1/72
CPC分类号： C12P41/005 , C12P17/02
摘要： A process for preparing L(-)-carnitine chloride having the formula: ##STR1## comprising the steps of: (a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having the formula: ##STR2## wherein R is an alkyl group having from 1-10 carbons, or a benzyl group, with an enzyme capable of selectively hydrolyzing enantiomer S(-),(b) separating said enantiomer S(-), from non-reacted ester, which is predominantly in the R(+) form;(c) reacting (1) the non-reacted ester obtained in step (b) with trimethylamine hydrochlorid or (2) the trimethylamine, to obtain thereby an ester having the formula: ##STR3## (d) hydrolyzing the ester obtain in step (c) in the presence of HCl to obtain thereby the L(-)-carnitine chloride having formula (I).The present invention is also directed to a novel class of compounds comprising R(+) enantiomers of the esters of 3,4-epoxybutyric acid.
摘要翻译：一种具有下式的制备L（ - ） - 肉碱氯化物的方法：（I）包括以下步骤：（a）使具有下式的（R，S）-3,4-环氧丁酸的外消旋酯：（II）其中R是具有1-10个碳原子的烷基或苄基，具有能够选择性水解对映异构体S（ - ）的酶，（b）将所述对映异构体S（ - ）与非 - 主要是R（+）形式的酯; （c）使（1）步骤（b）中获得的未反应的酯与三甲胺盐酸盐或（2）三甲胺反应，从而得到具有下式的酯：（Ⅳ）（d）水解该酯在步骤（c）中，在HCl存在下得到具有式（I）的L（ - ） - 肉碱氯化物。本发明还涉及包含3,4-环氧丁酸的酯的R（+）对映异构体的新一类化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式