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11. 发明授权

US07101675B2 Modulators of regulatory proteins 失效
标题翻译：调节蛋白的调节剂
公开(公告)号：US07101675B2
公开(公告)日：2006-09-05
申请号：US10035408
申请日：2002-01-04
申请人： David Wallach , Mark P Boldin , Eugene E Varfolomeev , Zeev Pancer , Igor Mett , Tanya M Goncharov
发明人： David Wallach , Mark P Boldin , Eugene E Varfolomeev , Zeev Pancer , Igor Mett , Tanya M Goncharov
IPC分类号： G01N33/53 , C12N9/64 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/705 , C07K14/7151 , C07K14/7155 , C07K16/18 , C07K16/2878
摘要： A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.
摘要翻译：提供了由细胞内发生的调节性细胞事件的调节剂，其由含有“死亡域”基序的调节蛋白介导。 “死亡域”是调节蛋白的调节部分，并且调节剂能够与调节蛋白中包含的一个或多个“死亡域”基序相互作用并影响一种或多种调节蛋白的调节作用。调节剂优选能够与p55-TNF-R，FAS / APO1-R，NGF-R，MORT-1，RIP，TRADD或锚蛋白内的'死亡域'基序相互作用。还提供了一种制备调制剂的方法。调节剂可用于通过含有“死亡域”的蛋白调节细胞介导的功能。

12. 发明申请

US20050214886A1 TNF modulation 审中-公开
标题翻译： TNF调节
公开(公告)号：US20050214886A1
公开(公告)日：2005-09-29
申请号：US10968191
申请日：2004-10-20
申请人： David Wallach , Eva Pocsik , Erno Duda
发明人： David Wallach , Eva Pocsik , Erno Duda
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/48
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/00
摘要： Modulators such as proteins, peptides, antibodies or analogs, fragments or derivatives of any of them are provided which are capable of interacting with, or binding to, the intracellular domain of the membrane-bound form of TNF (26 KD TNF). These modulators are capable of regulating the expression, proteolytic processing, bioactivity or intracellular signaling of the 26 KD TNF and may thus be used for the treatment of diseases in which TNF plays a central role.
摘要翻译：提供了能够与膜结合形式的TNF（26KD TNF）的细胞内结构域相互作用或结合的调节剂，例如蛋白质，肽，抗体或类似物，其任何的片段或衍生物。这些调节剂能够调节26KD TNF的表达，蛋白水解加工，生物活性或细胞内信号传导，因此可用于治疗TNF起主要作用的疾病。

13. 发明授权

US06275890B1 Low latency data path in a cross-bar switch providing dynamically prioritized bus arbitration 失效
标题翻译：交叉条交换机中的低延迟数据路径提供动态优先的总线仲裁
公开(公告)号：US06275890B1
公开(公告)日：2001-08-14
申请号：US09136595
申请日：1998-08-19
申请人： William Robert Lee , David Wallach
发明人： William Robert Lee , David Wallach
IPC分类号： G06F1300
CPC分类号： G06F13/36
摘要： The present invention provides a cross-bar switch which includes a plurality of master bus ports, the master bus ports adapted to receive a plurality of master buses; a plurality of slave bus ports, the slave bus ports adapted to receive a plurality of slave buses; a manner of switching for selectively coupling the plurality of master bus ports to the plurality of slave bus ports; and a manner of configuration for prioritizing access requests by the plurality of master buses to the plurality of slave buses via the switching means. The cross-bar switch of the present invention has the capability of prioritizing requests between multiple parallel high speed buses. In a preferred embodiment, this arbitration is accomplished through Configuration Registers on the cross-bar switch. The Configuration Registers are programmable through the Device Control Register bus, which allows the cross-bar switch to be dynamically programmed and changed by a processor in a larger system. The cross-bar switch of the present invention minimizes the latency between data transfers. This improves the bandwidth and throughput on the on-chip bus.
摘要翻译：本发明提供一种交叉开关，其包括多个主总线端口，主总线端口适于接收多个主总线; 多个从属总线端口，所述从属总线端口适于接收多个从属总线; 用于选择性地将多个主总线端口耦合到多个从属总线端口的切换方式; 以及用于经由切换装置将多个主总线的访问请求优先于多个从总线的配置方式。本发明的交叉开关具有在多个并行高速总线之间优先化请求的能力。在优选实施例中，该仲裁通过交叉开关上的配置寄存器来实现。配置寄存器可通过器件控制寄存器总线进行编程，允许跨系统开关由较大系统中的处理器进行动态编程和更改。本发明的交叉开关将数据传输之间的延迟最小化。这样可以提高片上总线的带宽和吞吐量。

14. 发明授权

US06262239B1 TNF receptor-specific antibodies 失效
公开(公告)号：US06262239B1
公开(公告)日：2001-07-17
申请号：US08476862
申请日：1995-06-07
申请人： David Wallach , Jacek Bigda , Igor Beletsky , Igor Mett , Hartmut Engelmann
发明人： David Wallach , Jacek Bigda , Igor Beletsky , Igor Mett , Hartmut Engelmann
IPC分类号： C07K1628
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7151 , C07K16/4258 , C07K2319/00
摘要： Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF family, are provided together with methods of producing them. The antibodies preferably bind to the fourth cysteine rich domain of the p75 TNF receptor or to the region between said fourth cysteine rich domain and the cell membrane.

15. 发明授权

US5695953A DNA that encodes a tumor necrosis factor inhibitory protein and a recombinant method of production 失效
标题翻译：编码肿瘤坏死因子抑制蛋白的DNA和重组生产方法
公开(公告)号：US5695953A
公开(公告)日：1997-12-09
申请号：US876828
申请日：1992-04-30
申请人： David Wallach , Hartmut Engelmann , Dan Aderka , Menachem Rubinstein
发明人： David Wallach , Hartmut Engelmann , Dan Aderka , Menachem Rubinstein
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P37/06 , A61P37/08 , C07H21/04 , C07K1/16 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/525 , C07K14/715 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/28 , C07K19/00 , C12P21/00 , C12P21/08 , C12R1/19 , C12P21/06 , C07H21/00
CPC分类号： C07K14/7151 , C07K16/2866 , A61K38/00
摘要： Tumor Necrosis Factor (TNF) Inhibitory Protein is isolated and substantially purified and the DNA that encodes the TNF inhibitory protein, vectors, host cells, and a recombinant method for producing the encoded protein are also set forth. It has the ability to inhibit: (a) the binding of TNF to its receptors, and (b) the cytotoxic effect of TNF. TNF Inhibitory Protein and salts, functional derivatives and active fractions thereof can be used to antagonize the deleterious effects of TNF.
摘要翻译：分离并基本纯化肿瘤坏死因子（TNF）抑制蛋白，并且还阐述了编码TNF抑制蛋白的DNA，载体，宿主细胞和用于产生编码蛋白质的重组方法。它具有抑制：（a）TNF与其受体的结合，和（b）TNF的细胞毒性作用。 TNF抑制蛋白及其盐，功能衍生物及其活性成分可用于拮抗TNF的有害作用。

16. 发明授权

US5665859A Molecules influencing the shedding of the TNF receptor, their preparation and their use 失效
标题翻译：影响TNF受体脱落的分子，其制备及其用途
公开(公告)号：US5665859A
公开(公告)日：1997-09-09
申请号：US321668
申请日：1994-10-12
申请人： David Wallach , Cord Brakebusch , Eugene Varfolomeev , Michael Batkin
发明人： David Wallach , Cord Brakebusch , Eugene Varfolomeev , Michael Batkin
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/395 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K14/715 , C07K14/81 , C07K16/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N9/99 , C12N15/57 , C12P21/08 , C07K7/06
CPC分类号： C07K14/7151 , C07K14/71 , C12N9/6421 , A61K38/00 , C07K2319/00
摘要： Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.
摘要翻译：提供影响细胞结合的p55肿瘤坏死因子受体（p55-TNF-R）脱落的分子及其制备方法。

17. 发明授权

US5462731A Use of IL-6 for the treatment of chronic lymphocyte leukemia (CLL) and B-cell lymphomas 失效
标题翻译：使用IL-6治疗慢性淋巴细胞白血病（CLL）和B细胞淋巴瘤
公开(公告)号：US5462731A
公开(公告)日：1995-10-31
申请号：US963313
申请日：1992-10-20
申请人： Dan Aderka , Yasmin Maor , David Wallach , Michel Revel
发明人： Dan Aderka , Yasmin Maor , David Wallach , Michel Revel
IPC分类号： A61K38/00 , A61K38/17 , A61K38/20 , A61P35/00 , A61P35/02 , A61K45/05
CPC分类号： A61K38/1793 , A61K38/204
摘要： The use of interleukin-6 and/or salts, functional derivatives, muteins or active fractions thereof, in the treatment of chronic lymphocytic leukemia and B-cell lymphomas, as well as such use together with the soluble interleukin-6 receptor, to pharmaceutical compositions and to a method of treating chronic lymphocytic leukemia or B-cell lymphomas.
摘要翻译：将白细胞介素-6和/或其盐，功能衍生物，突变蛋白或其活性成分用于治疗慢性淋巴细胞性白血病和B细胞淋巴瘤，以及与可溶性白细胞介素-6受体的这种用途用于药物组合物以及治疗慢性淋巴细胞白血病或B细胞淋巴瘤的方法。

18. 发明授权

US08330026B2 Derivatives of the NF-κB inducing enzyme, their preparation and use 失效
标题翻译： NF-κB诱导酶的衍生物，其制备和用途
公开(公告)号：US08330026B2
公开(公告)日：2012-12-11
申请号：US10511314
申请日：2003-04-15
申请人： David Wallach , Parameswaran Ramakrishnan , Taisia Shmushkovich
发明人： David Wallach , Parameswaran Ramakrishnan , Taisia Shmushkovich
IPC分类号： C07K1/00
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/7155 , C12N2799/022
摘要： The invention relates to the use of NF-κB inducing kinase (NIK) and related molecules for the modulation of signal activities controlled by cytokines, and some new such molecules.
摘要翻译：本发明涉及NF-κB诱导激酶（NIK）和相关分子用于调节由细胞因子控制的信号活性以及一些新的这样的分子的使用。

19. 发明授权

US08318660B2 Method of treating a disease by administering caspase-8 有权
标题翻译：通过施用半胱天冬酶-8治疗疾病的方法
公开(公告)号：US08318660B2
公开(公告)日：2012-11-27
申请号：US12282747
申请日：2007-03-05
申请人： David Wallach , Elena Appel , Andrei Kovalenko , Rajput Akhill
发明人： David Wallach , Elena Appel , Andrei Kovalenko , Rajput Akhill
IPC分类号： A61K38/16 , A61P15/00 , C07K14/435
CPC分类号： A61K38/4873
摘要： The invention relates to caspases and to extracellular use of caspases for regulating cell functions.
摘要翻译：本发明涉及胱天蛋白酶和胞外使用胱天蛋白酶以调节细胞功能。

20. 发明授权

US07455977B2 Methods of determining the level of human TBP-II with anti-TBP-II antibody 失效
标题翻译：用抗TBP-II抗体测定人TBP-II水平的方法
公开(公告)号：US07455977B2
公开(公告)日：2008-11-25
申请号：US10632929
申请日：2003-08-04
申请人： David Wallach , Jacek Bigda , Igor Beletsky , Igor Mett , Hartmut Engelmann
发明人： David Wallach , Jacek Bigda , Igor Beletsky , Igor Mett , Hartmut Engelmann
IPC分类号： G01N33/53
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7151 , C07K2319/00 , Y02A50/412
摘要： Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed together with methods of producing them and methods of use of such antibodies in immunoassays and purification of TBP-II by affinity chromatography. A diagnostic assay for endogenous antibodies to TBP-II is also disclosed.
摘要翻译：公开了肿瘤坏死因子受体（TNF-Rs）的抗体及其制备方法以及免疫测定中使用此类抗体的方法，并通过亲和层析纯化TBP-II。还公开了对TBP-II的内源性抗体的诊断测定。

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