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11. 发明申请

US20050165005A1 Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them 失效
标题翻译：吡唑基衍生物，该方法的制备方法和中间体作为药物产品和含有它们的药物组合物
公开(公告)号：US20050165005A1
公开(公告)日：2005-07-28
申请号：US10997736
申请日：2004-11-24
申请人： Arielle Genevois-Borella , Jean-Luc Malleron , Jean Bouquerel , Gilles Doerflinger , Andrees Bohme , Gaetan Touyer , Jean-Francois Sabuco , Corrine Terrier , Serge Mignani , Michel Evers , Youssef El-Ahmad
发明人： Arielle Genevois-Borella , Jean-Luc Malleron , Jean Bouquerel , Gilles Doerflinger , Andrees Bohme , Gaetan Touyer , Jean-Francois Sabuco , Corrine Terrier , Serge Mignani , Michel Evers , Youssef El-Ahmad
IPC分类号： A61K31/41 , A61K31/416 , A61K31/435 , A61K31/454 , A61K31/55 , C07D231/12 , C07D231/14 , C07D231/20 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D453/02 , C07D453/06 , C07D487/08 , C07D43/02
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D401/04 , C07D401/06 , C07D403/06 , C07D409/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl group; A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms, R3 is an H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSO2Ra, R4 is an aryl or heteroaryl; and R5 is an H, halogen, CF3, CHF2, CH2F, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl to their racemates, enantiomers and diastereoisomers and to their mixtures, their tautomers and to their pharmaceutically acceptable salts.
摘要翻译：本发明涉及式（I）的新衍生物，其中A是（C 1 -C 6）烷基，（C 3 -C 6）烯基，（C 3 -C 6）炔基，（C 3 （C 5 -C 7）氮杂双环烷基或（C 5 -C 9）氮杂双环链烯基;（C 5 -C 7）氮杂双环烷基或（C 5 -C 9） A-R1使得R 1的氮和吡唑的1位的氮必须分开至少两个碳原子，R 3是H，卤素，OH，SH，NH 2 >，ORc，SRc，SORa，SO 2 Ra，NHCHO，NRaRb，NHC（O）Ra，NHC（S）Ra或NHSO2Ra，R4是芳基或杂芳基; 并且R 5是H，卤素，CF 3，CHF 2，CH 2 F，直链或支链（C 1 -C 6）烷基或（ C3-C7）环烷基与其外消旋体，对映异构体和非对映异构体及其混合物，它们的互变异构体及其药学上可接受的盐。

12. 发明申请

US20050182259A1 Novel process for preparing 3-fluoroquinolines 失效
标题翻译：制备3-氟喹啉的新方法
公开(公告)号：US20050182259A1
公开(公告)日：2005-08-18
申请号：US10985533
申请日：2004-11-10
申请人： Youssef El-Ahmad , Jean-Pierre Leconte , Joel Malpart , Serge Mignani , Stephane Mutti , Michel Tabart
发明人： Youssef El-Ahmad , Jean-Pierre Leconte , Joel Malpart , Serge Mignani , Stephane Mutti , Michel Tabart
IPC分类号： C07D215/18 , C07D215/38 , C07D215/12
CPC分类号： C07D215/38 , C07D215/18 , Y02P20/55
摘要： The invention relates to a novel preparation of 3-fluoroquinolines of formula (I) in which R1, R2, R3 and R4 represent: a) a fluorine; b) an alkyl optionally substituted with one to three fluorines, with OR5 in which R5 is an alkyl, a hydrogen or a hydroxyl-protecting group, or with NR′R″ in which R′ and R″ represent an alkyl, a hydrogen or an amino-protecting group; c) OR6 in which R6 represents a hydrogen, a phenol-protecting group or an alkyl, optionally substituted with a fluorine, with OR5 or with NR′R″ as defined above; d) NR′1R″1 in which R′1 and R″1 have the values of R′ et R″ or represent an alkyl substituted with a fluorine, with OR5 or NR′R″ as defined above; e) CO2Ra, in which Ra represents hydrogen, alkyl or a carboxyl-protecting group, and also novel intermediate compounds. The quinolines of formula (I) are intermediates useful in the preparation of compounds having antibacterial activity, described in particular in applications WO 02/40474 or WO 02/72572.
摘要翻译：本发明涉及式（I）的3-氟喹啉的新型制备方法，其中R 1，R 2，R 3和R 3，代表：a）氟; b）任选被一至三个氟取代的烷基，其中R 5是烷基，氢或羟基保护基或NR' 其中R'和R“表示烷基，氢或氨基保护基的”R“ c）OR 6其中R 6表示氢，苯酚保护基或任选被氟取代的烷基，OR 5或N >或如上定义的NR'R“ d）NR'1 R“1其中R'1和R”1 <1的数值为或者代表被氟取代的烷基，其具有如上定义的OR 5或NR'R“; e）其中R aa代表氢，烷基或羧基保护基，以及新的中间体化合物的CO 2 CO 2。式（I）的喹啉是可用于制备具有抗菌活性的化合物的中间体，特别在申请WO 02/40474或WO 02/72572中有所描述。

13. 发明授权

US07396934B2 Process for preparing 3-fluoroquinolines 失效
标题翻译：制备3-氟喹啉的方法
公开(公告)号：US07396934B2
公开(公告)日：2008-07-08
申请号：US10985533
申请日：2004-11-10
申请人： Youssef El-Ahmad , Jean-Pierre Leconte , Joël Malpart , Serge Mignani , Stéphane Mutti , Michel Tabart
发明人： Youssef El-Ahmad , Jean-Pierre Leconte , Joël Malpart , Serge Mignani , Stéphane Mutti , Michel Tabart
IPC分类号： C07D215/38 , C07D215/18
CPC分类号： C07D215/38 , C07D215/18 , Y02P20/55
摘要： The invention relates to a novel preparation of 3-fluoroquinolines of formula (I) in which R1, R2, R3 and R4 represent: a) a fluorine; b) an alkyl optionally substituted with one to three fluorines, with OR5 in which R5 is an alkyl, a hydrogen or a hydroxyl-protecting group, or with NR′R″ in which R′ and R″ represent an alkyl, a hydrogen or an amino-protecting group; c) OR6 in which R6 represents a hydrogen, a phenol-protecting group or an alkyl, optionally substituted with a fluorine, with OR5 or with NR′R″ as defined above; d) NR′1R″1 in which R′1 and R″1 have the values of R′ et R″ or represent an alkyl substituted with a fluorine, with OR5 or NR′R″ as defined above; e) CO2Ra, in which Ra represents hydrogen, alkyl or a carboxyl-protecting group, and also novel intermediate compounds. The quinolines of formula (I) are intermediates useful in the preparation of compounds having antibacterial activity, described in particular in applications WO 02/40474 or WO 02/72572.
摘要翻译：本发明涉及式（I）的3-氟喹啉的新型制备方法，其中R 1，R 2，R 3和R 3，代表：a）氟; b）任选被一至三个氟取代的烷基，其中R 5是烷基，氢或羟基保护基或NR' 其中R'和R“表示烷基，氢或氨基保护基的”R“ c）OR 6其中R 6表示氢，苯酚保护基或任选被氟取代的烷基，OR 5或N >或如上定义的NR'R“ d）NR'1 R“1其中R'1和R”1 <1的数值为或者代表被氟取代的烷基，其具有如上定义的OR 5或NR'R“; e）其中R aa代表氢，烷基或羧基保护基，以及新的中间体化合物的CO 2 CO 2。式（I）的喹啉是可用于制备具有抗菌活性的化合物的中间体，特别在申请WO 02/40474或WO 02/72572中有所描述。

14. 发明授权

US06806277B2 Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them 失效
标题翻译：醌基丙基哌啶衍生物，制备方法和中间体，以及包括它们的组合物
公开(公告)号：US06806277B2
公开(公告)日：2004-10-19
申请号：US10622655
申请日：2003-07-18
申请人： Eric Bacqué , Jean-Luc Malleron , Serge Mignani , Michel Tabart
发明人： Eric Bacqué , Jean-Luc Malleron , Serge Mignani , Michel Tabart
IPC分类号： A61K3147
CPC分类号： C07D401/06 , C07D409/12
摘要： Quinolylpropylpiperidine derivatives of general formula (I) in which: R1 is NH2, alkylamino, dialkylamino, hydroxyamino, alkyl(alkyloxy)amino or alkyloxyamino, R2 is a carboxyl, carboxymethyl or hydroxymethyl radical, R3 is alkyl (1 to 6C) substituted by phenylthio which can itself carry 1 to 3 substituents selected from halogen, OH, alkyl, alkyloxy, CF3, OCF3, COOH, alkyloxycarbonyl, CN and NH2, by cycloalkylthio (3 to 7 members) or by heteroarylthio (5 to 6 members) comprising 1 to 4 heteroatoms selected from N, S and O and optionally itself substituted [by halogen, OH, alkyl, alkyloxy, CF3, OCF3, ═O, COOH, alkyloxycarbonyl, CN or NH2] or R3 is propargyl substituted by phenyl which can itself carry 1 to 3 substituents selected from halogen, OH, alkyl, alkyloxy, CF3, OCF3, COOH, alkyloxycarbonyl, CN and NH2 or substituted by cycloalkyl comprising 3 to 7 members or substituted by 5- to 6-membered heteroaryl comprising 1 to 4 heteroatoms chosen from N, O or S and optionally itself substituted by halogen, OH, alkyl, alkyloxy, CF3, OCF3, ═O, COOH, alkyloxycarbonyl, CN or NH2, and R4 is alkyl (1 to 6C), alkenyl-CH2—, alkynyl-CH2— (3 to 7C), cycloalkyl or (cycloalkyl)alkyl, in their diastereoisomeric forms or their mixtures, and their pharmaceutically acceptable salts. These novel derivatives are particularly advantageous antimicrobial agents.
摘要翻译：通式（I）的喹啉基丙基哌啶衍生物，其中：R1是NH2，烷基氨基，二烷基氨基，羟基氨基，烷基（烷氧基）氨基或烷氧基氨基，R2是羧基，羧甲基或羟甲基，R3是被苯硫基取代的（1-6）其可以自身携带1至3个选自卤素，OH，烷基，烷氧基，CF 3，OCF 3，COOH，烷氧基羰基，CN和NH 2的取代基，被环烷硫基（3至7个成员）或通过杂芳硫基（5至6个成员）包含1至 4个选自N，S和O的杂原子，并且任选地本身被[由卤素，OH，烷基，烷氧基，CF 3，OCF 3，= O，COOH，烷氧基羰基，CN或NH 2]取代的R 3或被苯基取代的苯基，被选自卤素，OH，烷基，烷氧基，CF 3，OCF 3，COOH，烷氧基羰基，CN和NH 2的3个取代基，或被包含3至7个成员的环烷基或被包含1至4个选自 N，O或S，以及任选的其自身取代基 CN，NH 2，R 4是烷基（1-6），链烯基-CH 2 - ，炔基-CH 2 - （3至7C），环烷基（C 1 -C 6）烷基，烷氧基羰基，或（环烷基）烷基，其非对映异构体形式或其混合物及其药学上可接受的盐。这些新型衍生物是特别有利的抗微生物剂。

15. 发明授权

US06451821B1 Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase 失效
标题翻译：使用2-氨基噻唑啉衍生物作为诱导型无合成酶的抑制剂
公开(公告)号：US06451821B1
公开(公告)日：2002-09-17
申请号：US09878814
申请日：2001-06-08
申请人： Jean-Christophe Carry , Dominique Damour , Claude Guyon , Serge Mignani , Antony Bigot , Eric Bacque , Michel Tabart
发明人： Jean-Christophe Carry , Dominique Damour , Claude Guyon , Serge Mignani , Antony Bigot , Eric Bacque , Michel Tabart
IPC分类号： A61K3144
CPC分类号： C07D417/06 , A61K31/426 , A61K31/4439 , C07D277/18
摘要： The present invention relates to the use of 2-aminothiazoline derivatives of formula: in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk—NH2, —CH2—R3, —CH2—S—R4 or phenyl radical substituted with a nitro or —NH— C (═NH) CH3 radical, or R1 is an alkyl radical and R2 is a hydrogen atom, R3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, as inhibitors of inducible NO-synthase.
摘要翻译：本发明涉及下式的2-氨基噻唑啉衍生物的用途：其中R1是氢原子或烷基，R2是烷基，-alk-NH2，-CH2-R3，-CH2-S-R4或被硝基或-NH- C（= NH）CH 3基取代的苯基，或R 1是烷基，R 2是氢原子，R 3是（3-6C）环烷基，吡啶基，吡啶基N-氧化物，噻吩基，噻唑基，咪唑基，吡嗪基，三唑基或苯基或被硝基，羟基或羧基取代的苯基，R4表示吡啶基或吡啶基N-氧化物基，alk表示亚烷基或其药学上可接受的盐，作为诱导型NO合成酶。

16. 发明授权

US06699895B2 2-aminothiazoline derivatives and process for preparing the same 失效
标题翻译： 2-氨基噻唑啉衍生物及其制备方法
公开(公告)号：US06699895B2
公开(公告)日：2004-03-02
申请号：US10159498
申请日：2002-05-31
申请人： Jean-Christophe Carry , Dominique Damour , Claude Guyon , Serge Mignani , Antony Bigot , Eric Bacque , Michel Tabart
发明人： Jean-Christophe Carry , Dominique Damour , Claude Guyon , Serge Mignani , Antony Bigot , Eric Bacque , Michel Tabart
IPC分类号： C07D41706
CPC分类号： C07D417/06 , A61K31/426 , A61K31/4439 , C07D277/18
摘要： The present invention relates to a class of 2-aminothiazoline derivatives of formula I: in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, —CH2—R3, —CH2—S—R4 or phenyl radical substituted with a nitro or —NH—C(═NH)CH3 radical, or R1 is an alkyl radical and R2 is a hydrogen atom, R3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, which are useful as inhibitors of inducible NO-synthase.
摘要翻译：本发明涉及一类式I的2-氨基噻唑啉衍生物：其中R1是氢原子或烷基，R2是烷基，-alk-NH2，-CH2-R3，-CH2-S-R4 或被硝基或-NH-C（= NH）CH 3基团取代的苯基，或R 1是烷基，R 2是氢原子，R 3是（3-6C）环烷基，吡啶基，吡啶基N-氧化物，噻吩基，噻唑基，咪唑基，吡嗪基，三唑基或苯基或被硝基，羟基或羧基取代的苯基，R4表示吡啶基或吡啶基N-氧化物基，alk表示亚烷基或其药学上可接受的盐，它们是可用作诱导型NO合成酶的抑制剂。

17. 发明授权

US06762196B2 Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible no-synthase 失效
标题翻译：使用2-氨基-4-吡啶基甲基 - 噻唑啉衍生物作为诱导型无合成酶的抑制剂
公开(公告)号：US06762196B2
公开(公告)日：2004-07-13
申请号：US10290624
申请日：2002-11-08
申请人： Eric Bacque , Antony Bigot , Jean-Christophe Carry , Serge Mignani , Baptiste Ronan , Michel Tabart
发明人： Eric Bacque , Antony Bigot , Jean-Christophe Carry , Serge Mignani , Baptiste Ronan , Michel Tabart
IPC分类号： A61K314436
CPC分类号： C07D213/40 , C07D213/55 , C07D213/64 , C07D213/89 , C07D417/06 , C07F7/1804
摘要： The present invention relates to the use of 2-amino-4-pyridylmethyl thiazoline derivatives of formula (I) wherein either R1═R2═Cl or (C1-C4)alkyl, or hydroxy; or (C1-C4)alkoxy or at least one of R1 or R2 is a hydrogen and the other is a (C1-C4)alkyl, hydroxy, (C1-C4)alkoxy or chlorine or pharmaceutically acceptable salts thereof as inhibitors of inducible NO-synthase.
摘要翻译：本发明涉及式（I）的2-氨基-4-吡啶基甲基噻唑啉衍生物，其中R 1 = R 2 = Cl或（C 1 -C 4）烷基或羟基; 或（C1-C4）烷氧基，或R1或R2中的至少一个为氢，另一个为（C 1 -C 4）烷基，羟基，（C 1 -C 4）烷氧基或氯或其药学上可接受的盐作为诱导型NO -Synthase。

18. 发明授权

US06392042B1 Polyhydroxyalkylpyrazine derivatives, their preparation and medicaments comprising them 失效
标题翻译：聚羟基烷基吡嗪衍生物，其制备方法和包含它们的药物
公开(公告)号：US06392042B1
公开(公告)日：2002-05-21
申请号：US09480965
申请日：2000-01-14
申请人： Georges Bashiardes , Jean-Christophe Carry , Michel Evers , Bruno Filoche , Serge Mignani
发明人： Georges Bashiardes , Jean-Christophe Carry , Michel Evers , Bruno Filoche , Serge Mignani
IPC分类号： C07D24100
CPC分类号： C07D241/12 , A61K31/495
摘要： A pharmaceutical composition containing at least one stereoisomer of at least one compound selected from: Or a salt thereof with an organic or inorganic acid.
摘要翻译：含有至少一种选自下列化合物的至少一种立体异构体的药物组合物：或其盐与有机或无机酸。

19. 发明授权

US07348434B2 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them 失效
标题翻译： 4-取代喹啉衍生物，其制备方法和中间体以及含有它们的药物组合物
公开(公告)号：US07348434B2
公开(公告)日：2008-03-25
申请号：US10913222
申请日：2004-08-06
申请人： Antony Bigot , Serge Mignani , Baptiste Ronan , Michel Tabart , Fabrice Viviani
发明人： Antony Bigot , Serge Mignani , Baptiste Ronan , Michel Tabart , Fabrice Viviani
IPC分类号： C07D215/38
CPC分类号： C04B35/632 , C07D401/12
摘要： The invention relates to 4-substituted quinoline derivatives of general formula: which are active as antimicrobials, in which: X1, X2, X3, X4 and X5 represent >C—R′1 to >C—R′5 respectively, or alternatively at most one represents nitrogen, Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being a hydrogen or alkyl, m is 0, 1 or 2 and n is 0 or 1, R2 represents a radical R, —CO2R, —CH2CO2R, —CH2—CH2CO2R, —CONH2, —CH2—CONH2, —CH2—CH2—CONH2, —CH2OH, —CH2—CH2OH, —CH2—NH2—CH2—CH2—NH2 or —CH2—CH2—CH2—NH2, R being as defined above, R3 represents phenyl, heteroaryl or alk-Ro3, where alk is alkyl and Ro3 represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.
摘要翻译：本发明涉及以下通式的4-取代喹啉衍生物：其作为抗微生物剂是有活性的，其中：X 1，X 2，X 3 ，X 4和X 5分别表示C-R 1至C-R'5 R 2如上所定义，R 3表示苯基，杂芳基或烷基-R（R 2）其中烷基是烷基和R 3表示各种基团，其中适当地含有它们的对映异构体或非对映异构形式或其混合物中的氧，硫或胺，和/或在合适的情况下在顺式或顺式抗体形式或它们的混合物及其盐。

20. 发明授权

US06399613B1 Pyrazine derivatives, their preparation and medicaments containing them 失效
标题翻译：吡嗪衍生物，其制剂和含有它们的药物
公开(公告)号：US06399613B1
公开(公告)日：2002-06-04
申请号：US09483984
申请日：2000-01-14
申请人： Georges Bashiardes , Jean-Christophe Carry , Michel Evers , Bruno Filoche , Serge Mignani
发明人： Georges Bashiardes , Jean-Christophe Carry , Michel Evers , Bruno Filoche , Serge Mignani
IPC分类号： A61K3150
CPC分类号： C07D213/81 , C07D213/38 , C07D213/82 , C07D241/12 , C07D241/24
摘要： The invention concerns pyrazine derivatives of formula (1) in which a pharmaceutical composition comprising at least one compound of formula: in which R represents a nitrogen atom, R1 and R3 each represent the same radical selected from the group consisting of —CO—NR5R6, —CO—N(CH(CH2OH)2)2, —CO—N(CH2OH)2, —CO—N(CH2—CH(CH2OH)2)2, —CO—N(CH2—(CHOH)n—CH2OH)2 in which n is equal to 0, 1, 2, 3 or 4, —CH2—O—R6, —NR5—CO—R6, —CH2—NR5R6, —CH2—N(CH2OH)2, —CH2—N(CH2—(CHOH)y—CH2OH)2 in which y is equal to 0, 1, 2, 3 or 4, —CH2—N(CH(CH2OH)2)2 and —CH2—N(CH2—CH(CH2OH)2)2 and R2 and R4 each represents a hydrogen atom, R5 represents a hydrogen atom or an alkyl radical, R6 represents a radical —CH2—(CHOH)m—CH2OH in which m is equal to 0, 1, 2, 3 or 4, -alk-O-alk-CH2OH, -alk-O-alk, —CH(CH2OH)2, —C(CH2OH)3, —C(CH3) (CH2OH)2, —CH2—CH(CH2OH)2 or —CH(CH2OH)—(CHOH)x—CH2OH in which x is equal to 1, 2, 3 or 4, alk represents an alkyl radical, the alkyl radicals containing, unless otherwise stated, 1 to 6 carbon atoms in a straight or branched chain, stereoisomers thereof and salts thereof with an inorganic or organic acid and their preparation.
摘要翻译：本发明涉及式（1）的吡嗪衍生物，其中包含至少一种下式的化合物的药物组合物：其中R表示氮原子，R1和R3各自表示选自-CO-NR5R6， - CO-N（CH（CH 2 OH）2）2，-CO-N（CH 2 OH）2，-CO-N（CH 2 -CH（CH 2 OH）2）2，-CO-N（CH 2 - （CHOH）n -CH 2 OH） 2，其中n等于0,1,2,3或4，-CH 2 -O-R 6，-NR 5 -CO-R 6，-CH 2 -NR 5 R 6，-CH 2 -N（CH 2 OH）2，-CH 2 -N（ CH 2 - （CHOH）y -CH 2 OH）2，其中y等于0,1,2,3或4，-CH 2 -N（CH（CH 2 OH）2）2和-CH 2 -N（CH 2 -CH（CH 2 OH） 2）2，R 2和R 4各自表示氢原子，R 5表示氢原子或烷基，R 6表示基团-CH 2 - （CHOH）m -CH 2 OH，其中m等于0,1,2,3或 4，-alk-O-烷基-CH 2 OH，-OCO-烷基，-CH（CH 2 OH）2，-C（CH 2 OH）3，-C（CH 3）（CH 2 OH）2，-CH 2 -CH（CH 2 OH）2 或-CH（CH 2 OH） - （CHOH）x-CH 2 OH，其中x等于1,2,3或4，alk表示烷基，除非另有说明，烷基含有1至6个碳原子其直链或支链的立体异构体和其与无机或有机酸的盐及其制备方法。

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