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11. 发明申请

US20100240663A1 HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS 失效
标题翻译：杂质作为钾通道调节剂
公开(公告)号：US20100240663A1
公开(公告)日：2010-09-23
申请号：US12706574
申请日：2010-02-16
申请人： Thomas Eugene Christos , George S. Amato , Robert N. Atkinson , Maria Graciela Barolli , Lilli Ann Wolf-Gouveia , Mark J. Suto
发明人： Thomas Eugene Christos , George S. Amato , Robert N. Atkinson , Maria Graciela Barolli , Lilli Ann Wolf-Gouveia , Mark J. Suto
IPC分类号： A61K31/5025 , C07D471/04 , A61K31/437 , C07D487/04 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/18 , A61P25/08 , A61P27/00 , C12N5/02
CPC分类号： C07D487/04 , A61K31/5025 , C07D471/04
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.
摘要翻译：提供了通过电压依赖钾通道调节钾离子通量可用于治疗疾病的化合物，组合物和方法。更具体地说，本发明提供了可用于治疗中枢性或周围神经系统疾病（例如偏头痛，共济失调，帕金森病，双相情感障碍，三叉神经痛，痉挛状态，情绪障碍，脑肿瘤，精神病症）的杂环，组合物和方法，癫痫，癫痫，癫痫，癫痫发作，视网膜变性，听力和视力丧失，阿尔茨海默病，年龄相关记忆丧失，学习缺陷，焦虑，神经元变性和运动神经元疾病，维持膀胱控制或治疗尿失禁）和神经保护剂（例如，为了预防中风等）通过调节与指示的病症的发作或复发相关的钾通道。

12. 发明授权

US07244744B2 Piperidines 失效
标题翻译：哌啶子
公开(公告)号：US07244744B2
公开(公告)日：2007-07-17
申请号：US10286662
申请日：2002-11-01
申请人： Michael F. Gross , Robert N. Atkinson , Matthew S. Johnson
发明人： Michael F. Gross , Robert N. Atkinson , Matthew S. Johnson
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D401/04 , A61K31/00 , A61K31/4439 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译：提供的化合物，组合物和方法可用于通过电压依赖性钠通道抑制钠离子通量来治疗疾病。更具体地说，本发明提供取代的哌啶和含有这些化合物的组合物。还提供了使用本发明化合物治疗中枢性或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与所述病症的发作或复发有关的钠通道。本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。

13. 发明授权

US07223782B2 Pyrazole-amides and -sulfonamides 失效
标题翻译：吡唑酰胺和磺酰胺
公开(公告)号：US07223782B2
公开(公告)日：2007-05-29
申请号：US10286304
申请日：2002-11-01
申请人： Robert N. Atkinson , Michael F. Gross
发明人： Robert N. Atkinson , Michael F. Gross
IPC分类号： A61K31/4155 , C07D231/12 , C07D231/14
CPC分类号： C07D231/14 , C07D231/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译：提供的化合物，组合物和方法可用于通过电压依赖性钠通道抑制钠离子通量来治疗疾病。更具体地，本发明提供了可用于治疗中枢性或周围神经系统疾病，特别是疼痛和慢性疼痛的吡唑酰胺和磺酰胺，组合物和方法，其通过阻断与指定条件的发作或复发有关的钠通道。本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。

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