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11. 发明申请

US20080279785A1 Novel synthetic agonists of toll-like receptors containing CG dinucleotide modifications 审中-公开
标题翻译：含有CG二核苷酸修饰的toll样受体的新型合成激动剂
公开(公告)号：US20080279785A1
公开(公告)日：2008-11-13
申请号：US11641590
申请日：2006-12-19
申请人： Ekambar R. Kandimalla , Malikarjuna Reddy Putta , Yukui Li , Lakshmi Bhagat , FuGang Zhu , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Malikarjuna Reddy Putta , Yukui Li , Lakshmi Bhagat , FuGang Zhu , Sudhir Agrawal
IPC分类号： A61K9/12 , C07H21/02 , A61K39/395 , A61K39/00 , C07H21/04 , A61P35/00 , A61K39/35 , A61K38/02 , A61K31/711
CPC分类号： C12N15/117 , A61K39/39 , A61K2039/55561 , C07H21/02 , C12N2310/17 , C12N2310/3183 , C12N2310/334 , C12N2310/336
摘要： The invention relates to the therapeutic use of oligonucleotides as immune modulatory agents in immunotherapy applications. More particularly, the invention provides immune modulatory oligonucleotide compositions for use in methods for generating an immune response or for treating a patient in need of immune modulation. The immune modulatory oligonucleotides of the invention preferably comprise novel pyrimidines and purines.
摘要翻译：本发明涉及在免疫治疗应用中寡核苷酸作为免疫调节剂的治疗用途。更具体地，本发明提供用于产生免疫应答的方法或用于治疗需要免疫调节的患者的免疫调节寡核苷酸组合物。本发明的免疫调节寡核苷酸优选包含新的嘧啶和嘌呤。

12. 发明授权

US08759310B2 Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 有权
标题翻译：用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物
公开(公告)号：US08759310B2
公开(公告)日：2014-06-24
申请号：US13353905
申请日：2012-01-19
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
IPC分类号： A61K48/00 , A61K49/00 , A61K39/00 , A61K45/00 , A61K47/00 , C07H21/04
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译：本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。

13. 发明申请

US20080171712A1 STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 有权
标题翻译：稳定的免疫调节剂RNA（SIMRA）化合物用于TLR7和TLR8
公开(公告)号：US20080171712A1
公开(公告)日：2008-07-17
申请号：US11697422
申请日：2007-04-06
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译：本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。

14. 发明授权

US08106173B2 Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 有权
标题翻译：用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物
公开(公告)号：US08106173B2
公开(公告)日：2012-01-31
申请号：US11697422
申请日：2007-04-06
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
IPC分类号： C07H21/02 , A61K48/00
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译：本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。

15. 发明申请

US20130202584A1 STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 有权
标题翻译：稳定的免疫调节剂RNA（SIMRA）化合物用于TLR7和TLR8
公开(公告)号：US20130202584A1
公开(公告)日：2013-08-08
申请号：US13353905
申请日：2012-01-19
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译：本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。

16. 发明申请

US20130108589A1 Method of Producing Neurons from Stem Cells, the Neurons and Uses Thereof 审中-公开
标题翻译：从干细胞，神经元及其用途产生神经元的方法
公开(公告)号：US20130108589A1
公开(公告)日：2013-05-02
申请号：US13263667
申请日：2010-07-22
申请人： Yinxue Yang , Jun Wei , Yukui Li , Libin Wang , Lijun Ma , Ting Liu , Xiaona Ma , Heng Fan , Yongzhao Zhu , Ping Ye , Yiran Jin
发明人： Yinxue Yang , Jun Wei , Yukui Li , Libin Wang , Lijun Ma , Ting Liu , Xiaona Ma , Heng Fan , Yongzhao Zhu , Ping Ye , Yiran Jin
IPC分类号： C12N5/0793 , A61K35/30 , C12N5/071
CPC分类号： C12N5/0619 , A61K35/12 , A61K35/28 , A61K35/30 , C12N5/0668 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/385 , C12N2501/41 , C12N2501/91 , C12N2502/08 , C12N2506/025 , C12N2506/1392
摘要： The present invention belongs to the field of cell transplantation. Particularly, the present invention provides a method of producing neurons for treating injuries with the loss of neuron function from stem cells, wherein the stem cell is a human derived mesenchymal stem cell, preferably human derived placental mesenchymal stem cell, bone marrow mesenchymal stem cell, adipose mesenchymal stem cell and liver mesenchymal stem cell. The present invention also provides the uses of said method and the nerve cells produced by said method in the preparation of medicines for treating injuries with the loss of neuron function and in the treatment of injuries with the loss of neuron function. The present invention further provides a method of treating injuries with the loss of neuron function.
摘要翻译：本发明属于细胞移植领域。特别地，本发明提供了一种用于从干细胞中产生神经元功能丧失来治疗损伤的神经元的方法，其中干细胞是人源间充质干细胞，优选人源性胎盘间充质干细胞，骨髓间充质干细胞，脂肪间充质干细胞和肝间充质干细胞。本发明还提供了所述方法和由所述方法产生的神经细胞在制备用于治疗神经元功能丧失的损伤和用神经元功能丧失治疗损伤的药物中的用途。本发明还提供了一种用神经元功能丧失来治疗损伤的方法。

17. 发明申请

US20070021360A1 Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase 审中-公开
标题翻译：具有反义寡核苷酸和抗炎类固醇和/或四氟酮的组合物，制剂和试剂盒，用于治疗呼吸和肺部疾病
公开(公告)号：US20070021360A1
公开(公告)日：2007-01-25
申请号：US10475684
申请日：2002-04-23
申请人： Jonathan Nyce , Jonathan Pabalan , Douglas Aguilar , Shoreh Miller , Yukui Li , Anthony Sandrasagra , Evan Katz , Lei Tang , Syed Shahabuddin
发明人： Jonathan Nyce , Jonathan Pabalan , Douglas Aguilar , Shoreh Miller , Yukui Li , Anthony Sandrasagra , Evan Katz , Lei Tang , Syed Shahabuddin
IPC分类号： A61K48/00 , A61K31/56
CPC分类号： C12N15/111 , A61K31/122 , A61K31/7088 , A61K45/06 , C12N15/113 , C12N2310/11 , C12N2320/31 , A61K2300/00
摘要： A pharmaceutical composition and formulations comprise preventative, prophylactic or therapeutic amounts of an oligo(s) anti-sense to a specific gene(s) or its corresponding mRNA(s), and a glucocorticoid and/or non-glucocorticoid steroid or a ubiquinone or their salts. The agents, composition and formulations are used for treatment of ailments associated with impaired respiration, bronchoconstriction, lung allergy(ies) or inflammation, and abnormal levels of adenosine, adenosine receptors, sensitivity to adenosine, lung surfactant and ubiquinone, such as pulmonary fibrosis, vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, COPD, RDS, ARDS, cancer, and others. The present treatment is effectively administered by itself for conditions without known therapies, as a substitute for therapies exhibiting undesirable side effects, or in combination with other treatments, e.g. before, during and after other respiratory system therapies, radiation, chemotherapy, antibody therapy and surgery, among others. Each of the agents of this invention may be administered directly into the respiratory system so that they gain direct access to the lungs, or by other effective routes of administration. A kit comprises a delivery device, the agents and instructions for its use.
摘要翻译：药物组合物和制剂包含预防性，预防性或治疗量的对特定基因或其相应的mRNA反义的寡核苷酸，以及糖皮质激素和/或非糖皮质激素类固醇或泛醌或他们的盐药物，组合物和制剂用于治疗与呼吸受阻，支气管收缩，肺过敏或炎症相关的疾病，以及腺苷，腺苷受体，对腺苷，肺表面活性剂和泛醌的敏感性的异常水平，例如肺纤维化，血管收缩，炎症，过敏，过敏性鼻炎，哮喘，阻碍呼吸，肺痛，囊性纤维化，支气管收缩，COPD，RDS，ARDS，癌症等。本治疗本身对于没有已知疗法的病症本身有效地施用，作为表现出不良副作用的治疗的替代物，或与其它治疗组合，例如，其他呼吸系统治疗，辐射，化疗，抗体治疗和手术之前，之中和之后等。本发明的每种药剂可以直接施用到呼吸系统中，使得它们直接进入肺部，或通过其它有效的给药途径。一个套件包括一个送货装置，代理商和使用说明书。

18. 发明申请

US20100272694A1 CLINIC COMPLIANT METHOD FOR BANKING HUMAN PLACENTAL MESENCHYMAL CELLS 审中-公开
标题翻译：用于储存人类细胞胚胎细胞的临床合适方法
公开(公告)号：US20100272694A1
公开(公告)日：2010-10-28
申请号：US12747307
申请日：2008-10-17
申请人： Yinxue Yang , Jun Wei , Yukui Li , Libin Wang , Ting Liu , Xiaona Ma , Guangyi Zhang
发明人： Yinxue Yang , Jun Wei , Yukui Li , Libin Wang , Ting Liu , Xiaona Ma , Guangyi Zhang
IPC分类号： A61K35/50 , C12N5/071 , C12Q1/68 , C12N5/02 , G06F19/00
CPC分类号： A61K35/50 , A01N1/0221 , A01N1/0226
摘要： The present invention relates to a method for processing human placental cell sample, a human placental cell sample obtained according to said method for processing human placental cell sample, a human placental cell bank, a method for banking human placental cells, a method for searching human placental cell sample in said human placental cell bank according to the present invention, a method for preparing human cord blood serum, use of human placental cells obtained by said method for processing human placental cell sample or human placental cell bank established by said method for banking human placental cells in treating human dysfunction and diseases due to cell injury or cell malfunction, as well as a method for treating human dysfunction and diseases due to cell injury or cell malfunction.
摘要翻译：本发明涉及一种处理人胎盘细胞样品的方法，根据所述用于处理人胎盘细胞样品的方法获得的人胎盘细胞样品，人胎盘细胞库，人类胎盘细胞的储存方法，人类检索方法根据本发明的所述人胎盘细胞库中的胎盘细胞样品，用于制备人脐带血清的方法，使用通过所述方法获得的人胎盘细胞，所述方法用于处理通过所述银行方法建立的人胎盘细胞样品或人胎盘细胞库人胎盘细胞治疗人类功能障碍和由于细胞损伤或细胞功能障碍引起的疾病，以及用于治疗人类功能障碍和由细胞损伤或细胞故障引起的疾病的方法。

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