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11. 发明专利

DOP2007000091A USO DE COMPLEJOS METÁLICOS QUE CONTIENEN PERFLUOROALQUILO COMO MEDIO DE CONTRASTE PARA EL DIAGNÓSTICO DE ENFERMEDAD DE ALZHEIMER 未知
公开(公告)号：DOP2007000091A
公开(公告)日：2008-01-31
申请号：DO2007000091
申请日：2007-05-08
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC
发明人： MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , MEDING JOERG
摘要： La invención se refiere al uso de complejos metálicos que contienen al menos un radical alquilo perfluorado y al menos un radical de agente quelante y al menos un equiva-lente de ion metálico de los números atómicos 21-29, 31-33, 37-39, 42-44, 49 ó 57-83, así como sus sales para la pro-ducción de un agente diagnóstico para visualizar placas con contenido de amiloides.

12. 发明专利

CA2615434A1 COMPLEXES CONTAINING PERFLUOROALKYL, THEIR USE AS CONTRAST MEDIA FOR NMR, X-RAY AND RADIO DIAGNOSIS AND RADIOTHERAPY 未知
公开(公告)号：CA2615434A1
公开(公告)日：2007-01-25
申请号：CA2615434
申请日：2006-07-11
申请人： EPIX PHARM INC , BAYER SCHERING PHARMA AG
发明人： MISSELWITZ BERND , SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS , MEDING JOERG
IPC分类号： C07D257/02 , A61B5/055 , A61K31/555 , A61K49/04 , A61K49/10 , A61P43/00 , C07D405/12 , C07H15/00
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with an N-alkyl group of general formula 1, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography.

13. 发明专利

AU2006272025A1 Complexes containing perfluoroalkyl, method for the production and use thereof 未知
公开(公告)号：AU2006272025A1
公开(公告)日：2007-01-25
申请号：AU2006272025
申请日：2006-07-11
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC
发明人： ZORN LUDWIG , WEINMANN HANNS-JOACHIM , MEDING JORG , BRUMBY THOMAS , MISSELWITZ BERND , SCHMITT-WILLICH HERIBERT , PLATZEK JOHANNES , SCHIRMER HEIKO
IPC分类号： C07D257/02 , A61K49/06
摘要： The invention relates to objects which are characterised in the claims, that is, metal complexes containing perfluoroalky, comprising radicals of general formula I containing nitrogen, to a method for the production and use thereof in the NMR field and x-ray diagnosis, radiodiagnosis and radiotherapy, in addition to lymphography in the MRT field and for blood pool imaging.

14. 发明专利

CA2660717A1 METHODS FOR LYMPH SYSTEM IMAGING 未知
公开(公告)号：CA2660717A1
公开(公告)日：2008-02-21
申请号：CA2660717
申请日：2007-08-16
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC
发明人： JACQUES VINCENT , CARAVAN PETER D , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM
IPC分类号： A61B5/055
摘要： Methods and contrast agents for imaging the lymph system are provided. Th e methods allow the diagnosis and staging of diseases of the lymph system, s uch as cancer and infections.

15. 发明专利

DE102007002726A1 未知
公开(公告)号：DE102007002726A1
公开(公告)日：2008-07-31
申请号：DE102007002726
申请日：2007-01-18
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC
发明人： SCHMITT-WILLICH HERIBERT , SCHIRMER HEIKO , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , CARAVAN PETER
IPC分类号： C07K5/08 , A61K49/12 , C07C237/00 , C08G69/00
摘要： The invention relates to novel cascade polymer complexes, to compositions comprising these compounds, to the use of the complexes in NMR diagnosis, and to processes for preparing these compounds and compositions. The complex-forming cascade polymer complexes according to the invention can be described by general formula I: R-L-A-{X-[Y-(Z-{W-K w } z ) y ] x } a-1 (I) where R=is an HSA-binding unit, L=is a linker or a bond, A=is a nitrogen-containing cascade core of base multiplicity a, X and Y are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity x and y, respectively, Z and W=are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity z and w, respectively, K is the residue of a complexing agent, a=is numbers 2 to 12, and x, y, z and w are independently of one another the numbers 1 to 4, with the proviso that exactly one multiplicity of the base multiplicity a of the cascade core A represents exactly one point of linkage to L, and with the proviso that the cascade polymer complexes comprise in the complexing agent residue K in total at least 4 ions of an element of atomic number 20 to 29, 39, 42 to 44 or 57 to 83 and comprise where appropriate cations of inorganic and/or organic bases, amino acids or amino amides.

16. 发明专利

UY30332A1 USO DE COMPLEJOS METALICOS QUE CONTIENEN PERFLUOROALQUILO COMO MEDIO DE CONTRASTE PARA EL DIAGNOSTICO DE ENFERMEDAD DE ALZHEIMER 未知
公开(公告)号：UY30332A1
公开(公告)日：2008-01-02
申请号：UY30332
申请日：2007-05-07
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC
发明人： MEDING JOERG , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM
IPC分类号： C07H23/00 , A61K31/555 , A61K49/10 , C07D257/02
摘要： La invencion se refiere al uso de complejos metálicos que contienen al menos un radical alquilo perfluorado y al menos un radical de agente quelante y al menos un equivalente de ion metálico de los numeros atomicos 21-29, 31-33,37-39, 42-44, 49 o 57-83, así como sus sales para la produccion de un agente diagnostico para visualizar placas con contenido de amiloides.

17. 发明申请

WO2007051739A3 X-RAY SYSTEM FOR THE CREATION OF DIAGNOSTIC X-RAY IMAGES USING CONTRAST MEDIA 审中-公开
标题翻译：利用容器应用创建诊断性X射线表征的X射线系统
公开(公告)号：WO2007051739A3
公开(公告)日：2007-06-21
申请号：PCT/EP2006067741
申请日：2006-10-25
申请人： SIEMENS AG , BAYER SCHERING PHARMA AG , PIETSCH HUBERTUS , WEINMANN HANNS-JOACHIM , GRASRUCK MICHAEL , STIERSTORFER KARL , FLOHR THOMAS , SUESS CHRISTOPH
发明人： PIETSCH HUBERTUS , WEINMANN HANNS-JOACHIM , GRASRUCK MICHAEL , STIERSTORFER KARL , FLOHR THOMAS , SUESS CHRISTOPH
IPC分类号： A61B6/00 , A61B5/107 , A61B6/03 , A61B6/06 , A61K49/00
CPC分类号： A61K49/04 , A61B5/1075 , A61B6/032 , A61B6/06 , A61B6/4014 , A61B6/4035 , A61B6/4241 , A61B6/4266 , A61B6/4441 , A61B6/481 , A61B6/482 , A61B6/488 , A61B6/504 , A61B6/542 , A61B6/545 , A61B6/583
摘要： The invention relates to an x-ray system comprising a selecting means for finding the best combination between the contrast medium and the energy spectrum of an x-radiation used for a scan so as to optimize the noise-to-contrast ratio, a method for creating X-ray images with the aid of contrast media by taking into account an optimal combination between the contrast medium and the energy spectrum of an X-radiation used for a scan, and the use of a lanthanide-containing complex for producing a contrast medium used for optimizing the combination between the contrast medium and the radiation in order to obtain a maximum contrast-to-noise ratio in an X-ray image.
摘要翻译：本发明涉及一种具有选择剂用于造影剂和X射线的能量光谱的最佳组合的X射线系统用于扫描的噪声 - 对比度比的优化，用于产生X表示与造影剂的辅助下，考虑到的造影剂的最佳组合的方法和 X辐射和用于扫描使用镧系元素的复合物的造影剂的制备中的能谱，以优化造影剂和辐射的组合，以实现在X射线表示的最大对比度噪声比。

18. 发明申请

WO2007009638A3 COMPLEXES CONTAINING PERFLUOROALKYL, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：全氟烷基复合物，方法生产及其用途
公开(公告)号：WO2007009638A3
公开(公告)日：2007-04-26
申请号：PCT/EP2006006777
申请日：2006-07-11
申请人： SCHERING AG , EPIX PHARM INC , SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
发明人： SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
IPC分类号： C07D257/02 , A61K49/06
CPC分类号： C07D257/02
摘要： The invention relates to objects which are characterised in the claims, that is, metal complexes containing perfluoroalky, comprising radicals of general formula I containing nitrogen, to a method for the production and use thereof in the NMR field and x-ray diagnosis, radiodiagnosis and radiotherapy, in addition to lymphography in the MRT field and for blood pool imaging.
摘要翻译：本发明涉及一种特征在于在权利要求中，即含有全氟烷金属络合物与通式I的含氮基团的主题，其制备方法以及它们在NMR和X射线诊断，放射诊断和放射治疗，使用过程以及在MRT-淋巴和血液池显像，

19. 发明公开

EP2053968A4 METHODS FOR LYMPH SYSTEM IMAGING 审中-公开
标题翻译：法用于说明淋巴系统
公开(公告)号：EP2053968A4
公开(公告)日：2015-10-21
申请号：EP07841011
申请日：2007-08-16
申请人： EPIX PHARM INC , BAYER PHARMA AG
发明人： JACQUES VINCENT , CARAVAN PETER D , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , G01R33/5601

20. 发明申请

WO2008022263A2 METHODS FOR LYMPH SYSTEM IMAGING 审中-公开
标题翻译：淋巴系统成像方法
公开(公告)号：WO2008022263A2
公开(公告)日：2008-02-21
申请号：PCT/US2007076109
申请日：2007-08-16
申请人： EPIX PHARM INC , SCHERING AG , JACQUES VINCENT , CARAVAN PETER D , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM
发明人： JACQUES VINCENT , CARAVAN PETER D , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM
IPC分类号： A61B5/055 , A61P35/00
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , G01R33/5601
摘要： Methods and contrast agents for imaging the lymph system are provided. The methods allow the diagnosis and staging of diseases of the lymph system, such as cancer and infections.
摘要翻译：提供了用于使淋巴系统成像的方法和造影剂。该方法可以诊断和分期淋巴系统疾病，如癌症和感染。

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