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11. 发明公开

EP1874818A2 TGF BETA 1 SPECIFIC ANTIBODIES 有权
标题翻译： TGF-β-1特异性抗体
公开(公告)号：EP1874818A2
公开(公告)日：2008-01-09
申请号：EP06750860.6
申请日：2006-04-20
申请人： ELI LILLY AND COMPANY
发明人： DAVIES, Julian , DICKINSON, Craig, Duane , HUANG, Lihua , JONES, Bryan, Edward , MARQUIS, David, Matthew , ROWLINSON, Scott, William , TANG, Ying , VAILLANCOURT, Peter, Edward , WATKINS, Jeffry, Dean
IPC分类号： C07K16/22 , G01N33/68 , G01N33/577
CPC分类号： C07K16/22 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K2317/55 , C07K2317/74 , C07K2317/92
摘要： Antibodies specific for mature TGF Beta 1 over mature TGF Beta 2 and mature TGF Beta 3 are provided. The antibodies are characterized by CDR3 of the heavy- chain GYRX1X2X3Y wherein Xl is W or A, X2 is F or L, X3 is A, E or Y.

12. 发明公开

EP1587904A2 GLYCOSYLATION MODIFIED IL-20 审中-公开
标题翻译：糖基化修饰的IL-20
公开(公告)号：EP1587904A2
公开(公告)日：2005-10-26
申请号：EP03791607.9
申请日：2003-08-14
申请人： ELI LILLY AND COMPANY
发明人： GREALISH, Patrick, Francis , ROWLINSON, Scott, William
IPC分类号： C12N1/00
CPC分类号： C07K14/54 , A61K38/00 , C07K2319/91
摘要： This invention relates to glycosylation-modified IL-20 polypeptides which preferentially signal through one of the multiple IL-20 receptor complexes and maintain at least one activity associated with wild type IL-20 while decreasing or eliminating at least one other activity associated with wild type IL-20. The N-linked consensus glycosylation sites are engineered into IL-20 at one or more sites which correspond to an N-linked consensus glycosylation site that exists in wild type IL-19 or IL-24. The invention also relates to polynucleotides encoding the polypeptides of the invention, vectors and host cells comprising a polynucleotide of the invention, and therapeutic methods for using the polypeptides and polynucleotides of the invention.
摘要翻译：本发明涉及糖基化修饰的IL-20多肽，其优先通过多种IL-20受体复合物之一发出信号并维持至少一种与野生型IL-20相关的活性，同时降低或消除至少一种与野生型相关的其他活性 IL-20。 N-连接的共有糖基化位点在对应于存在于野生型IL-19或IL-24中的N-连接共有糖基化位点的一个或多个位点处被工程化为IL-20。本发明还涉及编码本发明多肽的多核苷酸，包含本发明多核苷酸的载体和宿主细胞，以及使用本发明多肽和多核苷酸的治疗方法。

13. 发明公开

EP1419250A2 LP MAMMALIAN PROTEINS; RELATED REAGENTS 审中-公开
标题翻译： LP哺乳动物蛋白，及相关试剂
公开(公告)号：EP1419250A2
公开(公告)日：2004-05-19
申请号：EP02718810.1
申请日：2002-01-28
申请人： ELI LILLY AND COMPANY
发明人： BHATT, Ramesh, Rajani , CALLEY, John, Nels , HEUER, Josef, Georg , KELEHER, Gerald, Patrick , LANCASTER, Joanne, Sloan , LI, Qingqin , LU, Deshun , MILLS, Bradley, Jay , MISHRA, Santosh, Kumar , PERKINS, Douglas, Raymond , ROWLINSON, Scott, William , SMITH, Rosamund, Carol , SU, Eric, Wen , WANG, He , ZHI, Yu
IPC分类号： C12N15/12 , C07K14/47 , C12Q1/68 , C07K16/18 , G01N33/53
CPC分类号： C07K14/47
摘要： Isolated nucleic acid molecules encoding polypeptides froma human, reagents related thereto (including purified polypeptidesspecific antibodies) are provided. Methods of using said reagentsand diagnostic kits are also provided.

14. 发明授权

EP1966243B1 TGF-BETA BINDING ANTIBODIES 有权
标题翻译： TGF-β抗体
公开(公告)号：EP1966243B1
公开(公告)日：2012-02-15
申请号：EP06840328.6
申请日：2006-12-20
申请人： ELI LILLY AND COMPANY
发明人： JONES, Bryan, Edward , PANCOOK, James, D. , ROWLINSON, Scott, William
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-βl, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.

15. 发明公开

EP1511511A2 USE OF IL-19, IL-22 AND IL-24 TO TREAT HEMATOPOIETIC DISORDERS 审中-公开
标题翻译： IL-19，IL-22和IL-24在治疗造血功能障碍USE
公开(公告)号：EP1511511A2
公开(公告)日：2005-03-09
申请号：EP02806634.8
申请日：2002-10-24
申请人： ELI LILLY AND COMPANY
发明人： ROWLINSON, Scott, William
IPC分类号： A61K38/19 , A61K38/20
CPC分类号： A61K38/20
摘要： The present invention relates to a method of using a mammalian gene sequence and polypeptides encoded thereby to treat mammalian hematopoietic disorders.

16. 发明公开

EP1434783A2 LP MAMMALIAN PROTEINS; RELATED REAGENTS 审中-公开
标题翻译： LP-哺乳动物蛋白; 相关试剂
公开(公告)号：EP1434783A2
公开(公告)日：2004-07-07
申请号：EP02719036.2
申请日：2002-03-01
申请人： ELI LILLY AND COMPANY
发明人： AMEGADZIE, Bernard, Yaovi , BASINSKI, Margret, Barbara , CHEN, Dayue , HUANG, Chongxi , KELEHER, Gerald, Patrick , PERKINS, Douglas, Raymond , ROSTECK, Paul, Robert, Junior , ROWLINSON, Scott, William , SANKHAVARAM, Patanjali, Raghavacharya , SENO, Eugene, Thomas , SU, Eric, Wen , ZHI, Yu
IPC分类号： C07H21/02 , C07H21/04 , C07K14/00 , C12N15/09
CPC分类号： C07K14/47
摘要： Isolated nucleic acid molecules encoding polypeptides from a human, reagents related thereto (including purified polypeptides specific antibodies) are provided. Methods of using said reagents and diagnostic kits are also provided.

17. 发明授权

EP1874818B1 TGF BETA 1 SPECIFIC ANTIBODIES 有权
标题翻译： TGF-β-1特异性抗体
公开(公告)号：EP1874818B1
公开(公告)日：2011-04-13
申请号：EP06750860.6
申请日：2006-04-20
申请人： ELI LILLY AND COMPANY
发明人： DAVIES, Julian , DICKINSON, Craig, Duane , HUANG, Lihua , JONES, Bryan, Edward , MARQUIS, David, Matthew , ROWLINSON, Scott, William , TANG, Ying , VAILLANCOURT, Peter, Edward , WATKINS, Jeffry, Dean
IPC分类号： C07K16/22 , G01N33/68 , G01N33/577
CPC分类号： C07K16/22 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K2317/55 , C07K2317/74 , C07K2317/92
摘要： Antibodies specific for mature TGF Beta 1 over mature TGF Beta 2 and mature TGF Beta 3 are provided. The antibodies are characterized by CDR3 of the heavy- chain GYRX1X2X3Y wherein Xl is W or A, X2 is F or L, X3 is A, E or Y.

18. 发明公开

EP1966243A1 TGF-BETA BINDING COMPOSITIONS 有权
标题翻译： TGF-β抗体
公开(公告)号：EP1966243A1
公开(公告)日：2008-09-10
申请号：EP06840328.6
申请日：2006-12-20
申请人： ELI LILLY AND COMPANY
发明人： JONES, Bryan, Edward , PANCOOK, James, D. , ROWLINSON, Scott, William
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-βl, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.

19. 发明公开

EP1646655A2 TGF-BETA1 LIGANDS 审中-公开
标题翻译： TGF-β1配体
公开(公告)号：EP1646655A2
公开(公告)日：2006-04-19
申请号：EP04776554.0
申请日：2004-07-06
申请人： ELI LILLY AND COMPANY
发明人： BRADLEY, Heidi, Marie , KIKLY, Kristine, Kay , LANCASTER, Joanne, Sloan , ROWLINSON, Scott, William
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73
摘要： Isolated and/or recombinant binding compositions, reagents related thereto are provided. Methods of using said reagents and diagnostic kits are also provided.

20. 发明公开

EP1439850A1 SOLUBLE PROTEINS THAT INHIBIT CYTOKINE SIGNAL TRANSDUCTION PATHWAYS 审中-公开
标题翻译：可溶性蛋白细胞因子信号传输路径INHIBIT
公开(公告)号：EP1439850A1
公开(公告)日：2004-07-28
申请号：EP02778287.9
申请日：2002-10-09
申请人： ELI LILLY AND COMPANY
发明人： BALDWIN, David, Bruce , ROWLINSON, Scott, William
IPC分类号： A61K38/00 , A61K38/16 , C07K14/47 , C07K14/705
CPC分类号： C07K14/7155 , A61K38/00
摘要： This invention provides methods using secreted IL10-related cytokine receptor subunits, and variants and fusions and combinations thereof for treating and preventing, inflammatory system, immune system, and cardiovascular system disorders as well as hematopoiesis disorders and cancer.

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