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11. 发明授权

US06833068B2 Passive injection control for microfluidic systems 有权
公开(公告)号：US06833068B2
公开(公告)日：2004-12-21
申请号：US10341870
申请日：2003-01-13
申请人： Phillip H. Paul , Don W. Arnold , David W. Neyer
发明人： Phillip H. Paul , Don W. Arnold , David W. Neyer
IPC分类号： B01D1508
CPC分类号： B01J20/283 , B01J20/285 , B01L3/502746 , B01L2200/0605 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N30/10 , G01N30/16 , G01N30/466 , G01N30/6095 , G01N2030/162 , G01N2030/285 , G01N2030/324
摘要： Apparatus for eliminating siphoning, “dead” regions, and fluid concentration gradients in microscale analytical devices. In its most basic embodiment, the present invention affords passive injection control for both electric field-driven and pressure-driven systems by providing additional fluid flow channels or auxiliary channels disposed on either side of a sample separation column. The auxiliary channels are sized such that volumetric fluid flow rate through these channels, while sufficient to move the sample away from the sample injection region in a timely fashion, is less than that through the sample separation channel or chromatograph.

12. 发明授权

US08685218B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US08685218B2
公开(公告)日：2014-04-01
申请号：US13046496
申请日：2011-03-11
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

13. 发明授权

US06460420B1 Flowmeter for pressure-driven chromatography systems 有权
标题翻译：用于压力驱动色谱系统的流量计
公开(公告)号：US06460420B1
公开(公告)日：2002-10-08
申请号：US09548474
申请日：2000-04-13
申请人： Phillip H. Paul , Don W. Arnold
发明人： Phillip H. Paul , Don W. Arnold
IPC分类号： G01F137
CPC分类号： G01N30/36 , B01D15/14 , B01D15/163 , G01F1/36 , G01N2030/324
摘要： A flowmeter for accurately measuring the flowrate of fluids in high pressure chromatography systems. The flowmeter is a porous bed of a material, the porous bed having a porosity in the range of about 0.1 to 0.6 and a pore size in the range of about 50 nm to 1 &mgr;m, disposed between a high pressure pumping means and a chromatography column. The flowmeter is provided with pressure measuring means at both the inlet and outlet of the porous bed for measuring the pressure drop through the porous bed. This flowmeter system provides not only the ability to measure accurately flowrates in the range of &mgr;L/min to nL/min but also to provide a signal that can be used for a servo loop or feedback control system for high pressure pumping systems.
摘要翻译：一种用于精确测量高压色谱系统中流体流量的流量计。流量计是材料的多孔床，多孔床的孔隙率在约0.1至0.6范围内，孔径在约50nm至1μm的范围内，设置在高压泵送装置和色谱柱之间。流量计在多孔床的入口和出口处设有压力测量装置，用于测量通过多孔床的压降。该流量计系统不仅提供了在muL / min至nL / min的范围内精确测量流量的能力，而且提供了可用于高压泵送系统的伺服回路或反馈控制系统的信号。

14. 发明申请

US20100199750A1 Microfludic Analysis System and Method 审中-公开
标题翻译：微流体分析系统与方法
公开(公告)号：US20100199750A1
公开(公告)日：2010-08-12
申请号：US12367407
申请日：2009-02-06
申请人： Don W. Arnold , Nicole E. Hebert , Patrick Leung , David W. Wyrick , Phillip H. Paul
发明人： Don W. Arnold , Nicole E. Hebert , Patrick Leung , David W. Wyrick , Phillip H. Paul
IPC分类号： G01N30/02 , G01N27/26
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2300/021 , B01L2300/18
摘要： A microfluidic processing system having a manifold with at least one inlet; at least one outlet; and a plurality of microfluidic chip holders. A fluidic jumper is coupled to one of the chip holders and at least two fluidic elements are coupled to at least one of the chip holders. The fluidic jumper controls the fluidic path through the system.
摘要翻译：一种具有至少一个入口的歧管的微流体处理系统; 至少一个出口; 和多个微流体芯片保持器。流体跳线耦合到芯片保持器中的一个，并且至少两个流体元件耦合到至少一个芯片保持器。流体跳线控制通过系统的流体路径。

15. 发明授权

US07465382B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US07465382B2
公开(公告)日：2008-12-16
申请号：US10246284
申请日：2002-09-17
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04 , B01L11/00
CPC分类号： G05D7/0682 , G01N30/32 , G01N30/34 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

16. 发明授权

US07220592B2 Particulate processing system 有权
标题翻译：颗粒加工系统
公开(公告)号：US07220592B2
公开(公告)日：2007-05-22
申请号：US10295482
申请日：2002-11-15
申请人： David J. Rakestraw , Don W. Arnold , Phillip H. Paul
发明人： David J. Rakestraw , Don W. Arnold , Phillip H. Paul
IPC分类号： G01N33/48
CPC分类号： G01N33/54313 , G01N15/1459 , G01N21/05 , G01N21/64 , G01N27/447 , G01N2015/1497 , G01N2021/0346 , G01N2035/00564 , Y10T436/117497
摘要： A system for simultaneously processing a plurality of particles, e.g. beads or cells. A liquid sample containing the particles is delivered to a processing chamber in which the particles are positioned on particle retainers which lie in a plane. The particle retainers are sized to receive only one particle, so that the particles do not overlap. The system can make use of positioning fluid for forcing the particles into the particle retainers. The positioned particles can, for example, be processed by interrogating the particles with a light of a preselected wavelength, and analyzing signals received from the particles.
摘要翻译：用于同时处理多个颗粒的系统，例如，珠子或细胞。将含有颗粒的液体样品输送到处理室，其中颗粒位于位于平面中的颗粒保持器上。颗粒保持器的尺寸被设计成仅接收一个颗粒，使得颗粒不重叠。该系统可以利用定位流体来迫使颗粒进入颗粒保持器。定位的颗粒可以例如通过用预选波长的光询问颗粒并分析从颗粒接收的信号来处理颗粒。

17. 发明授权

US06994826B1 Method and apparatus for controlling cross contamination of microfluid channels 有权
标题翻译：用于控制微流体通道交叉污染的方法和装置
公开(公告)号：US06994826B1
公开(公告)日：2006-02-07
申请号：US09669862
申请日：2000-09-26
申请人： Ernest F. Hasselbrink, Jr. , Jason E. Rehm , Phillip H. Paul , Don W. Arnold
发明人： Ernest F. Hasselbrink, Jr. , Jason E. Rehm , Phillip H. Paul , Don W. Arnold
IPC分类号： B01L3/02 , G01N27/447 , G01N27/453
CPC分类号： B01L3/502746 , B01L2200/0605 , B01L2300/0861 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/086
摘要： A method for controlling fluid flow at junctions in microchannel systems. Control of fluid flow is accomplished generally by providing increased resistance to electric-field and pressure-driven flow in the form of regions of reduced effective cross-sectional area within the microchannels and proximate a channel junction. By controlling these flows in the region of a microchannel junction it is possible to eliminate sample dispersion and cross contamination and inject well-defined volumes of fluid from one channel to another.
摘要翻译：一种用于控制微通道系统中接合处流体流动的方法。流体流动的控制通常通过以微通道内和接近通道连接处的有效截面积减小的区域形式的电场和压力驱动流提供增加的阻力来实现。通过控制这些在微通道连接区域中的这些流动，可以消除样品分散和交叉污染，并将明确定义的体积从一个通道注入另一个通道。

18. 发明授权

US06532802B2 Flowmeter for pressure-driven chromatography systems 有权
公开(公告)号：US06532802B2
公开(公告)日：2003-03-18
申请号：US10155102
申请日：2002-05-23
申请人： Phillip H. Paul , Don W. Arnold
发明人： Phillip H. Paul , Don W. Arnold
IPC分类号： G01N3000
CPC分类号： G01N30/36 , B01D15/14 , B01D15/163 , G01F1/36 , G01N2030/324
摘要： A flowmeter for accurately measuring the flowrate of fluids in high pressure chromatography systems. The flowmeter is a porous bed of a material, the porous bed having a porosity in the range of about 0.1 to 0.6 and a pore size in the range of about 50 nm to 1 &mgr;m, disposed between a high pressure pumping means and a chromatography column. The flowmeter is provided with pressure measuring means at both the inlet and outlet of the porous bed for measuring the pressure drop through the porous bed. This flowmeter system provides not only the ability to measure accurately flowrates in the range of &mgr;L/min to nL/min but also to provide a signal that can be used for a servo loop or feedback control system for high pressure pumping systems.

19. 发明授权

US06290909B1 Sample injector for high pressure liquid chromatography 有权
标题翻译：高压液相色谱仪样品注射器
公开(公告)号：US06290909B1
公开(公告)日：2001-09-18
申请号：US09548475
申请日：2000-04-13
申请人： Phillip H. Paul , Don W. Arnold , David W. Neyer
发明人： Phillip H. Paul , Don W. Arnold , David W. Neyer
IPC分类号： G01N3002
CPC分类号： G01N30/22 , G01N30/6095 , G01N2030/285 , Y10T436/2575
摘要： Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.
摘要翻译：用于在压力下将具有明确定义的体积的样品驱动到色谱柱中的装置和方法。传统的高压取样阀被由一对与公共接头串联连接的一对注射器部件组成的样品注射器代替。注射器组件是多孔电介质材料的容器，其被构造成提供样品的电渗流入结点。在适当的时间，连接到公共接头的来自高压源（可以是电动泵）的压力脉冲将一部分样品（其尺寸由公共接头的死体积确定）驱动到色谱中色谱柱用于随后的分离和分析。该装置可以在用于微量分析应用的基板上制造。

20. 发明授权

US08795493B2 Flow control systems 有权
标题翻译：流量控制系统
公开(公告)号：US08795493B2
公开(公告)日：2014-08-05
申请号：US12567482
申请日：2009-09-25
申请人： David W. Neyer , Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
发明人： David W. Neyer , Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
IPC分类号： G05D7/06
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.
摘要翻译：流量控制器，其使用静水压力和电渗流量的组合来控制流体的流动。其流量取决于流体静力压力和电渗流量的驱动流体（1204）可以（a）直接用作可操作装置（例如色谱仪）中的工作流体，或（b）将工作流体（1203））从存储容器（625）移动到可操作装置（1301）或（a）和（b）中。驱动流体（1204）可以由一种或多种流体组成。部分或全部驱动流体（1204）通过电渗装置（100），以增加或减少由静水压力引起的流速。

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