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11. 发明申请

US20120118041A1 SYSTEM AND METHOD FOR TESTING GAS MIGRATION PROCESS IN COAL-ROCK MASS 有权
标题翻译：用于测试煤岩质量气体移动过程的系统和方法
公开(公告)号：US20120118041A1
公开(公告)日：2012-05-17
申请号：US13386050
申请日：2010-07-15
申请人： Manchao He , Chunguang Wang , Haijiang Zhang , Dejian Li
发明人： Manchao He , Chunguang Wang , Haijiang Zhang , Dejian Li
IPC分类号： G01N30/02 , G01N7/00
CPC分类号： G01N7/14 , G01N7/16 , G01N2015/0866
摘要： A system and method for testing gas migration process in the coal and rock mass are disclosed. The method includes the following steps: selecting a cylindrical coal sample, applying an axial pressure and a radial pressure to the coal sample under a sealing state, and/or increasing temperature, to desorb gas absorbed by the coal sample; guiding the gas desorbed from the coal sample by a guiding passage, detecting gas flow rate and pressure, analyzing gas composition and content, and achieving a data statistics. The method provides a theory and data basis for researching the forming and occurring process of gas outburst accident in coal mine. The system is simple and easy to use, and is suitable for migration research of the gas absorbed in the deep coal-rock mass.
摘要翻译：公开了一种用于测试煤和岩体中气体迁移过程的系统和方法。该方法包括以下步骤：选择圆柱形煤样，在密封状态和/或升高温度下向煤样施加轴向压力和径向压力，以解吸煤样吸收的气体; 通过引导通道引导从煤样中解吸的气体，检测气体流量和压力，分析气体组成和含量，并实现数据统计。该方法为煤矿瓦斯突出事故形成和发生过程的研究提供了理论和数据依据。该系统简单易用，适用于深层煤岩吸收气体的迁移研究。

12. 发明授权

US07678804B2 Pyrimidine derivatives for treatment of hyperproliferative disorders 失效
标题翻译：嘧啶衍生物用于治疗过度增殖性疾病
公开(公告)号：US07678804B2
公开(公告)日：2010-03-16
申请号：US11078681
申请日：2005-03-10
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y表示芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。

13. 发明授权

US07582645B2 Pyrimidine derivatives for treatment of hyperproliferative disorders 失效
标题翻译：嘧啶衍生物用于治疗过度增殖性疾病
公开(公告)号：US07582645B2
公开(公告)日：2009-09-01
申请号：US10573227
申请日：2004-10-08
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/506 , A61K31/505 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。

14. 发明申请

US20080124782A1 METHOD FOR PRODUCING A MULTIFUNCTIONAL ENZYME 失效
标题翻译：生产多功能酶的方法
公开(公告)号：US20080124782A1
公开(公告)日：2008-05-29
申请号：US11933076
申请日：2007-10-31
申请人： Raili Myllyla , Jari Heikkinen , Maija Risteli , Chunguang Wang
发明人： Raili Myllyla , Jari Heikkinen , Maija Risteli , Chunguang Wang
IPC分类号： C12N9/10 , C07H21/04
CPC分类号： C12N9/48 , C07K14/78 , C12N9/1048
摘要： This invention relates to a multifunctional enzyme having lysyl hydroxylase and glycosyltransferase activity and to the use of the enzyme in glycosylating hydroxylysine residues. In particular this invention relates to a method for producing glycosyltransferase activity, which comprises that a nucleotide sequence encoding lysyl hydroxylase and glycosyltransferase activity is introduced and expressed in a chosen host and the protein product is recovered from the host cell or from the culture medium.
摘要翻译：本发明涉及具有赖氨酰羟化酶和糖基转移酶活性的多功能酶以及该酶在糖基化羟赖氨酸残基中的用途。特别地，本发明涉及一种生产糖基转移酶活性的方法，其包括将编码赖氨酰羟化酶和糖基转移酶活性的核苷酸序列引入并在选择的宿主中进行表达，并从宿主细胞或培养基中回收蛋白质产物。

15. 发明授权

US08418526B2 System and method for testing gas migration process in coal-rock mass 有权
标题翻译：煤岩瓦斯迁移过程的系统和方法
公开(公告)号：US08418526B2
公开(公告)日：2013-04-16
申请号：US13386050
申请日：2010-07-15
申请人： Manchao He , Chunguang Wang , Haijiang Zhang , Dejian Li
发明人： Manchao He , Chunguang Wang , Haijiang Zhang , Dejian Li
IPC分类号： G01N7/00
CPC分类号： G01N7/14 , G01N7/16 , G01N2015/0866
摘要： A system and method for testing gas migration process in the coal and rock mass are disclosed. The method includes the following steps: selecting a cylindrical coal sample, applying an axial pressure and a radial pressure to the coal sample under a sealing state, and/or increasing temperature, to desorb gas absorbed by the coal sample; guiding the gas desorbed from the coal sample by a guiding passage, detecting gas flow rate and pressure, analyzing gas composition and content, and achieving a data statistics. The method provides a theory and data basis for researching the forming and occurring process of gas outburst accident in coal mine. The system is simple and easy to use, and is suitable for migration research of the gas absorbed in the deep coal-rock mass.
摘要翻译：公开了一种用于测试煤和岩体中气体迁移过程的系统和方法。该方法包括以下步骤：选择圆柱形煤样，在密封状态和/或升高温度下向煤样施加轴向压力和径向压力，以解吸煤样吸收的气体; 通过引导通道引导从煤样中解吸的气体，检测气体流量和压力，分析气体组成和含量，并实现数据统计。该方法为煤矿瓦斯突出事故形成和发生过程的研究提供了理论和数据依据。该系统简单易用，适用于深层煤岩吸收气体的迁移研究。

16. 发明申请

US20100075967A1 PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗高反应性疾病的吡嗪衍生物
公开(公告)号：US20100075967A1
公开(公告)日：2010-03-25
申请号：US12550010
申请日：2009-08-28
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianging Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianging Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： A61K31/5377 , C07D401/12 , C07D239/02 , C07D413/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。

17. 发明授权

US07582646B2 Pyrimidine derivatives for treatment of hyperproliferative disorders 有权
公开(公告)号：US07582646B2
公开(公告)日：2009-09-01
申请号：US11078681
申请日：2005-03-10
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

18. 发明申请

US20070117817A1 Pyrimidine derivatives for treatment of hyperproliferative disorders 失效
标题翻译：嘧啶衍生物用于治疗过度增殖性疾病
公开(公告)号：US20070117817A1
公开(公告)日：2007-05-24
申请号：US10573227
申请日：2004-10-08
申请人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yin , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion
发明人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yin , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion
IPC分类号： A61K31/513 , A61K31/506 , C07D403/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。

19. 发明申请

US20110098301A1 Pyrimidine Derivatives for Treatment of Hyperproliferative Disorders 审中-公开
标题翻译：嘧啶衍生物治疗过度增殖性疾病
公开(公告)号：US20110098301A1
公开(公告)日：2011-04-28
申请号：US11886132
申请日：2006-03-09
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/506 , C07D401/14 , C07D239/48 , C07D403/12 , C07D413/14 , A61K31/496 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14
摘要： Pyrimidine derivatives of formula pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.
摘要翻译：公开并要求保护含有这些化合物的配方药物组合物的嘧啶衍生物和使用这些化合物治疗过度增殖性疾病如癌症的方法。

20. 发明申请

US20100249159A1 RHO-KINASE INHIBITORS 审中-公开
公开(公告)号：US20100249159A1
公开(公告)日：2010-09-30
申请号：US12726660
申请日：2010-03-18
申请人： Dhanapalan Nagarathnam , Chunguang Wang
发明人： Dhanapalan Nagarathnam , Chunguang Wang
IPC分类号： A61K31/517 , C07D403/12 , A61P35/00 , A61P11/06 , A61P9/10 , A61P15/10 , A61P19/10 , A61P25/00 , A61P27/06 , A61P7/02
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

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