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    • 16. 发明授权
    • Method and system for administering therapeutic and diagnostic agents
    • 用于治疗和诊断药物的方法和系统
    • US4863713A
    • 1989-09-05
    • US877327
    • 1986-06-23
    • David A. GoodwinClaude MearesMichael McCall
    • David A. GoodwinClaude MearesMichael McCall
    • A61K51/00A61K47/48A61K51/10
    • B82Y5/00A61K47/48753A61K51/1093A61K2123/00
    • A method and system for localizing a diagnostic or therapeutic agent to an internal target site. The system includes (1) an epitopic compound, (2) a binding protein which is effective to bind specifically with the compound and capable of localizing selectively at the target tissue, when administered parenterally, and (3) a clearing agent which can bind to and cross-link the binding protein, to form a protein aggregate which is readily cleared from the subject's bloodstream. In practicing the method of the invention, the binding protein is administered to the subject parenterally, and allowed to localize at the target site, typically within 1-4 days. This is followed by a chase with the clearing agent to remove circulating, but not target-localized binding protein. When the epitopic compound is administered, binding of the compound to the localized binding protein, and rapid clearance of unbound compound by the kidneys, results in selective localization of the compound at the target site.
    • 用于将诊断或治疗剂定位到内部靶位点的方法和系统。 该系统包括(1)表位化合物,(2)能够与该化合物特异性结合并能够在肠胃外给药时能够在靶组织上选择性定位的结合蛋白,和(3)可结合 并交联结合蛋白,以形成容易从受试者的血液中清除的蛋白质聚集体。 在实施本发明的方法中,将结合蛋白经胃肠外施用给受试者,并且通常在1-4天内允许在靶位点定位。 其次是用清除剂去除循环但不是靶向定位的结合蛋白。 当施用表位化合物时,化合物与局部结合蛋白的结合以及肾脏中未结合的化合物的快速清除导致化合物在靶位点的选择性定位。