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11. 发明授权

US07183296B2 Anti-HIV pyrazole derivatives 失效
标题翻译：抗HIV吡唑衍生物
公开(公告)号：US07183296B2
公开(公告)日：2007-02-27
申请号：US10766712
申请日：2004-01-27
申请人： Brian William Dymock , Philip Stephen Jones , John Herbert Merrett , Martin John Parratt
发明人： Brian William Dymock , Philip Stephen Jones , John Herbert Merrett , Martin John Parratt
IPC分类号： A61K31/415 , A61P31/18 , C07D231/18
CPC分类号： C07D401/06 , A61K31/415 , A61K31/4439 , A61K31/506 , C07D231/18 , C07D231/20 , C07D231/22 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/06 , C07D413/06
摘要： The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV infection.
摘要翻译：本发明包括具有抗HIV活性的新颖且已知的吡唑衍生物，其制备方法，药物组合物以及这些化合物在医药中的用途。特别地，式I化合物是参与病毒复制的人免疫缺陷病毒逆转录酶的抑制剂。因此，本发明的化合物可有利地用作HIV感染的治疗剂。

12. 发明申请

US20120278186A1 METHOD OF TRACKING SOFTWARE APPLICATION INTERNET DOWNLOADS 有权
标题翻译：跟踪软件应用互联网下载的方法
公开(公告)号：US20120278186A1
公开(公告)日：2012-11-01
申请号：US13287630
申请日：2011-11-02
申请人： Paul Michael Hayton , Philip Stephen Jones
发明人： Paul Michael Hayton , Philip Stephen Jones
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0277 , G06Q30/0214 , G06Q30/0242 , G06Q30/0246 , Y10S705/901 , Y10S705/908
摘要： A method of tracking software application downloads over the internet in which clicking on a web advertisement for a software application causes a user's device web browser to link to a tracking server which creates a unique identifier which is stored by the user's device browser, and also on the tracking server together with an indication of the web page including the advertisement. The user's device web browser then downloads the desired software application which includes executable code which, upon first execution, suspends the downloaded application and starts the browser, directing it to the tracking server and sending the unique identifier to the tracking server together with identification of the device and downloaded software application. The tracking server then uses the unique identifier to correlate the information on the downloaded application with the information originally stored at the time of clicking on the web advertisement.
摘要翻译：跟踪通过互联网的软件应用下载的方法，其中点击软件应用的网络广告导致用户的设备web浏览器链接到跟踪服务器，该跟踪服务器创建由用户的设备浏览器存储的唯一标识符，并且还跟踪服务器以及包括广告的网页的指示。然后，用户的设备网络浏览器下载所需的软件应用程序，其中包括可执行代码，其在第一次执行时暂停下载的应用程序并启动浏览器，将其引导到跟踪服务器，并将唯一标识符发送到跟踪服务器，设备和下载的软件应用程序。然后，跟踪服务器使用唯一标识符将下载的应用程序上的信息与在点击网络广告时原始存储的信息相关联。

13. 发明授权

US08026236B2 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives 失效
公开(公告)号：US08026236B2
公开(公告)日：2011-09-27
申请号：US12686692
申请日：2010-01-13
申请人： John Stephen Robinson , Philip Stephen Jones , Jiaqiang Cai , David Jonathan Bennett
发明人： John Stephen Robinson , Philip Stephen Jones , Jiaqiang Cai , David Jonathan Bennett
IPC分类号： A61K37/5377 , A61K31/437 , C07D471/02 , C07D413/14 , A61P19/02 , A61P17/06
CPC分类号： C07D471/04
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.

14. 发明申请

US20100184761A1 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES 失效
标题翻译： 6-苯基-1H-咪唑并[4,5-c]吡啶-4-羰基衍生物
公开(公告)号：US20100184761A1
公开(公告)日：2010-07-22
申请号：US12686692
申请日：2010-01-13
申请人： John Stephen Robinson , Philip Stephen Jones , Jiaqiang Cai , David Jonathan Bennett
发明人： John Stephen Robinson , Philip Stephen Jones , Jiaqiang Cai , David Jonathan Bennett
IPC分类号： A61K31/5377 , C07D471/02 , A61K31/437 , C07D413/14 , A61P19/02 , A61P17/06
CPC分类号： C07D471/04
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.
摘要翻译：本发明涉及具有通式I的6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物，其药物组合物包含它们，以及这些衍生物用于制备用于治疗组织蛋白酶S相关疾病如动脉粥样硬化，肥胖症，炎症和免疫疾病如类风湿性关节炎，牛皮癣，癌症和慢性疼痛如神经性疼痛的药物。

15. 发明授权

US5640505A Operational support structure for a telecommunications network 失效
标题翻译：电信网络的运营支持结构
公开(公告)号：US5640505A
公开(公告)日：1997-06-17
申请号：US524289
申请日：1995-09-06
申请人： Richard Samuel Edwin Hearn , Robert Charles Bell , Rodney Christopher Hall , Barry Sidney Farr , Stephen John Harris , Colin Grantham , Catherine Spence , Terry Fellows , Michael James Spooner , Michael William Day , Nicholas John Furley , Michael John Evans , Stephen Raymond Wells , Alan Dance , Ian Bryan Taylor , Eric Jenkin Williams , Philip Stephen Jones , Gerard Morrow , Stephen Andrew M. Wilson , John Allan Mountford , Simon Magnus Pyzer , Alistair John Lumpkin
发明人： Richard Samuel Edwin Hearn , Robert Charles Bell , Rodney Christopher Hall , Barry Sidney Farr , Stephen John Harris , Colin Grantham , Catherine Spence , Terry Fellows , Michael James Spooner , Michael William Day , Nicholas John Furley , Michael John Evans , Stephen Raymond Wells , Alan Dance , Ian Bryan Taylor , Eric Jenkin Williams , Philip Stephen Jones , Gerard Morrow , Stephen Andrew M. Wilson , John Allan Mountford , Simon Magnus Pyzer , Alistair John Lumpkin
IPC分类号： H04L12/24 , H04M3/22 , H04M3/42 , H04Q3/00 , G06F11/00
CPC分类号： H04M3/4228 , G06Q10/087 , H04L41/065 , H04L41/0672 , H04L41/5054 , H04L41/5061 , H04M3/2254 , H04Q3/0062 , H04L41/5029 , H04Q2213/1313 , H04Q2213/13535
摘要： A support structure for an operational telecommunications network deploys a set of individual technologies and provides a set of services to customers. The support structure is divided into a set of domains each of which provides a particular management function for the network. These domains include a domain for managing customer handling functions, a domain for managing the network, a domain for managing the individual technologies deployed in the network, a domain for managing instances of the individual services provided by the network, a domain for managing billing operations, a domain for managing the services provided by the network when grouped together to form a portfolio, and a domain for managing jobs performed by the human workforce for the network. Each domain has its own set of databases and systems for performing the required management operations and also interfaces to some of the other domains. Each domain is implemented by one or more tightly integrated computers. The interfaces between the domains are primarily message passing interfaces.
摘要翻译：运营电信网络的支持结构部署了一套单独的技术，并向客户提供一套服务。支持结构被分成一组域，每个域为网络提供特定的管理功能。这些域包括用于管理客户处理功能的域，用于管理网络的域，用于管理部署在网络中的各个技术的域，用于管理由网络提供的各个服务的实例的域，用于管理计费操作的域，用于管理由网络组合在一起形成组合的服务的域，以及用于管理由人力为网络执行的作业的域。每个域都有自己的一组数据库和系统，用于执行所需的管理操作，并且还与其他一些域的接口。每个域由一个或多个紧密集成的计算机实现。域之间的接口主要是消息传递接口。

16. 发明授权

US08862503B2 Method of tracking software application internet downloads 有权
标题翻译：跟踪软件应用程序互联网下载的方法
公开(公告)号：US08862503B2
公开(公告)日：2014-10-14
申请号：US13287630
申请日：2011-11-02
申请人： Paul Michael Hayton , Philip Stephen Jones
发明人： Paul Michael Hayton , Philip Stephen Jones
IPC分类号： G06Q30/00 , G06F21/10 , G06Q30/02
CPC分类号： G06Q30/0277 , G06Q30/0214 , G06Q30/0242 , G06Q30/0246 , Y10S705/901 , Y10S705/908
摘要： A method of tracking software application downloads over the internet in which clicking on a web advertisement for a software application causes a user's device web browser to link to a tracking server which creates a unique identifier which is stored by the user's device browser, and also on the tracking server together with an indication of the web page including the advertisement. The user's device web browser then downloads the desired software application which includes executable code which, upon first execution, suspends the downloaded application and starts the browser, directing it to the tracking server and sending the unique identifier to the tracking server together with identification of the device and downloaded software application. The tracking server then uses the unique identifier to correlate the information on the downloaded application with the information originally stored at the time of clicking on the web advertisement.
摘要翻译：跟踪通过互联网的软件应用下载的方法，其中点击软件应用的网络广告导致用户的设备web浏览器链接到跟踪服务器，该跟踪服务器创建由用户的设备浏览器存储的唯一标识符，并且还跟踪服务器以及包括广告的网页的指示。然后，用户的设备网络浏览器下载所需的软件应用程序，其中包括可执行代码，其在第一次执行时暂停下载的应用程序并启动浏览器，将其引导到跟踪服务器，并将唯一标识符发送到跟踪服务器，设备和下载的软件应用程序。然后，跟踪服务器使用唯一标识符将下载的应用程序上的信息与在点击网络广告时原始存储的信息相关联。

17. 发明申请

US20100062796A1 MULTI-MEDIA MESSAGING SYSTEM FOR MOBILE TELEPHONE 审中-公开
标题翻译：用于移动电话的多媒体消息传递系统
公开(公告)号：US20100062796A1
公开(公告)日：2010-03-11
申请号：US12528184
申请日：2008-03-06
申请人： Paul Michael Hayton , Philip Stephen Jones
发明人： Paul Michael Hayton , Philip Stephen Jones
IPC分类号： H04W4/12
CPC分类号： H04M1/72547 , H04M1/72544 , H04M1/72561 , H04M1/7258
摘要： A messaging system for sending formatted pages combining pictures, text, hyperlinks and other web-style content between mobile telephony devices such as mobile telephones or PDAs within a network or community of users. The display of the messages on the mobile terminals is defined by means of command set which allows users to specify message content as occupying a certain percentage of the display screen of the destination device. The command set also includes functionality allowing hyper-links within a message to be displayable as a separate list of hyperlinks on operation of a soft key on the mobile device for ease of navigation.
摘要翻译：用于在网络或用户社区内的移动电话设备（例如移动电话或PDA）之间发送格式化的页面组合图片，文本，超链接和其他网络样式内容的消息系统。移动终端上的消息的显示通过命令集定义，该命令集允许用户将消息内容指定为占用目标设备的显示屏幕的一定百分比。命令集还包括允许消息中的超链接在移动设备上的软键操作上作为单独的超链接列表显示的功能，以便于导航。

18. 发明授权

US06737429B2 Pyrrole derivatives 失效
标题翻译：吡咯衍生物
公开(公告)号：US06737429B2
公开(公告)日：2004-05-18
申请号：US09880534
申请日：2001-06-13
申请人： Brian William Dymock , Philip Stephen Jones , John Herbert Merrett , Martin John Parratt
发明人： Brian William Dymock , Philip Stephen Jones , John Herbert Merrett , Martin John Parratt
IPC分类号： A61K3144
CPC分类号： C07D401/06 , C07D207/36 , C07D401/14 , C07D409/06 , C07D417/06
摘要： Disclosed are novel pyrrole derivatives, a process for their manufacture, pharmaceutical compositions containing such compounds and the use of such compounds in the treatment of HIV mediated diseases.
摘要翻译：公开了新颖的吡咯衍生物，其制备方法，含有这些化合物的药物组合物以及这些化合物在治疗HIV介导的疾病中的用途。

19. 发明授权

US06044407A Interface for translating an information message from one protocol to another 失效
标题翻译：用于将信息消息从一个协议转换到另一个协议的接口
公开(公告)号：US06044407A
公开(公告)日：2000-03-28
申请号：US139692
申请日：1993-10-22
申请人： Philip Stephen Jones , David Scott Murray
发明人： Philip Stephen Jones , David Scott Murray
IPC分类号： H04L12/24 , H04L29/06 , G06F13/00
CPC分类号： H04L41/00 , H04L12/24 , H04L29/06
摘要： A computer implemented interface for interfacing an equipment controller to an equipment manager each arranged to respond to a reproduced text messages according to a first and second protocol, respectively. The interface comprises a number of program modules (502-514) which each receive one or more inputs and produce an output dependent on whether defined conditions are met by the inputs. A number of the outputs of the program modules constitute inputs to other program modules therefore defining a network. A number of the program modules (502-508) are of the type which is responsive to a predefined text in a respective field of an input message to produce an output to a further program module which is responsive to a further predefined text in another field which is valid in a first protocol in the context of the predefined text. The network of program modules produces a series of outputs which represent the information content of the original input message. These outputs are then passed to a further series of modules which format a translation of the input message. The defined conditions of the program modules are modifiable and in particular are modifiable in a manner which is dependent on the state of part of the equipment management system thereby providing an inherent model of the network management system for use during parsing of an input message.
摘要翻译：一种计算机实现的接口，用于将设备控制器连接到设备管理器，每个设备管理器分别根据第一和第二协议来响应于再现的文本消息。接口包括多个程序模块（502-514），每个程序模块接收一个或多个输入并且产生取决于输入是否满足定义的条件的输出。程序模块的多个输出构成其他程序模块的输入，从而定义网络。多个程序模块（502-508）是响应于输入消息的相应字段中的预定义文本的类型，以产生另一个程序模块的输出，该程序模块响应于另一个字段中的另外的预定义文本这在预定义文本的上下文中在第一协议中是有效的。程序模块的网络产生代表原始输入消息的信息内容的一系列输出。然后将这些输出传递给另一系列模块，该模块格式化输入消息的转换。程序模块的定义的条件是可修改的，并且特别地可以以取决于设备管理系统的一部分的状态的方式进行修改，从而提供网络管理系统的固有模型以在输入消息的解析期间使用。

20. 发明授权

US09115126B2 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives 有权
标题翻译： 1H- [1,2,3]三唑并[4,5-c]吡啶-4-甲腈衍生物
公开(公告)号：US09115126B2
公开(公告)日：2015-08-25
申请号：US13519924
申请日：2011-01-13
申请人： Jiaqiang Cai , David Jonathan Bennett , Philip Stephen Jones
发明人： Jiaqiang Cai , David Jonathan Bennett , Philip Stephen Jones
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/496 , A61K31/54 , A61K31/437 , A61K31/551
CPC分类号： C07D471/04
摘要： The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R1 is H or (C1-3)alkyl; R2 is halogen or (C1-4)alkyl, optionally substituted with one or more halogens; n is 1-3; X is O or CH2; U, V and W are CH; or one of U, V and W is N; Y is a group capable of interacting with the Sn . . . S2 substites of the active site of Cathepsin S; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.
摘要翻译：本发明涉及式（I）的1H- [1,2,3]三唑并[4,5-c]吡啶-4-腈衍生的组织蛋白酶S抑制剂，其中R 1是H或（C 1-3）烷基; R2是卤素或任选被一个或多个卤素取代的（C 1-4）烷基; n为1-3; X是O或CH2; U，V和W是CH; 或U，V和W之一为N; Y是能够与Sn相互作用的组。。。组织蛋白酶S活性位点的S2位点; 或其药学上可接受的盐用于包含其的药物组合物以及这些衍生物用于制备用于治疗组织蛋白酶S相关疾病如动脉粥样硬化，肥胖症，炎症和免疫疾病如类风湿病的药物中的用途关节炎，牛皮癣，癌症和慢性疼痛，如神经性疼痛。

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