专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20110178063A1 BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES 有权
标题翻译：作为PI3 KINASES的抑制剂的苯并噻唑衍生物
公开(公告)号：US20110178063A1
公开(公告)日：2011-07-21
申请号：US12994250
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/553 , C07D413/14 , A61K31/5377 , C07D417/14 , A61K31/541 , A61K31/5386 , C07D401/14 , A61K31/454 , A61K31/427 , A61K31/496 , A61K31/4439 , C07D471/04 , A61K31/4985 , C07D487/04 , A61K31/519 , A61P11/00 , A61P37/08 , A61P9/00 , A61P19/02 , A61P25/28 , A61P1/00 , A61P7/02 , A61P29/00
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译：本发明涉及某些新的式（I）化合物及其盐。本发明的化合物是PI3-激酶活性的抑制剂。

12. 发明申请

US20080280911A1 Cinnoline Compounds as Inhibitors of Phosphodiesterase Type IV (Pde4) 审中-公开
标题翻译：噌啉化合物作为磷酸二酯酶IV型抑制剂（Pde4）
公开(公告)号：US20080280911A1
公开(公告)日：2008-11-13
申请号：US12090491
申请日：2006-10-18
申请人： Nicola Mary Aston , John Edward Robinson , Naimisha Trivedi
发明人： Nicola Mary Aston , John Edward Robinson , Naimisha Trivedi
IPC分类号： A61K31/502 , C07D237/26 , C07D403/12 , C07D401/12 , C07D405/12 , C07D413/12 , A61P11/00
CPC分类号： C07D237/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： There are provided according to the invention novel compounds of formula (I)
摘要翻译：根据本发明提供新的式（I）化合物，

13. 发明申请

US20090270444A1 1,7-Naphthyridines 审中-公开
标题翻译： 1,7-萘啶
公开(公告)号：US20090270444A1
公开(公告)日：2009-10-29
申请号：US11718892
申请日：2005-11-17
申请人： Colin David Eldred , John Edward Robinson , Alison Judith Steel
发明人： Colin David Eldred , John Edward Robinson , Alison Judith Steel
IPC分类号： A61K31/4375 , C07D471/04 , A61P37/08
CPC分类号： C07D471/04
摘要： There are provided according to the invention novel compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein: R1 is phenyl which may be unsubstituted or substituted by one or two substituents selected from fluorine, chlorine, C1-2alkoxy-, —CN; phenyl fused to a 5-membered saturated ring containing one oxygen atom; pyridinyl which may be unsubstituted or substituted by one or two substituents selected from fluorine or chlorine; or C-linked pyrazolyl which may be unsubstituted or substituted by the substituent C1-2alkyl; R2 is C1-4alkyl; R3 is C1-2alkyl; and n is 0, 1 or 2.
摘要翻译：根据本发明，提供新的式（I）化合物及其药学上可接受的盐和溶剂化物，其中：R1是可以是未取代的或被一个或两个选自氟，氯，C 1-2烷氧基 - ， - CN; 与含有一个氧原子的5元饱和环稠合的苯基; 吡啶基，其可以是未取代的或被一个或两个选自氟或氯的取代基取代; 或C连接的吡唑基，其可以是未取代的或被取代基C 1-2烷基取代; R2是C1-4烷基; R3是C1-2烷基; n为0,1或2。

14. 发明申请

US20080146563A1 1,7-Naphthyridines as Pde4 Inhibitors 审中-公开
标题翻译： 1,7-萘乙酸作为Pde4抑制剂
公开(公告)号：US20080146563A1
公开(公告)日：2008-06-19
申请号：US11908188
申请日：2006-03-16
申请人： Colin David Eldred , John Edward Robinson
发明人： Colin David Eldred , John Edward Robinson
IPC分类号： A61K31/5377 , C07D221/04 , A61K31/4375 , A61K31/496 , A61P37/08 , A61P29/00 , C07D295/00
CPC分类号： C07D471/04
摘要： There are provided according to the invention novel compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein R1 is selected from the group consisting of C1-4alkyl, C4-6cycloalkyl(CH2)m—, methoxyC2-4alkyl, HOCH2CH2—, R3(O)2S(CH2)2—, R5R4NCO(CH2)n—, and heterocyclyl(CH2)m— wherein any nitrogen heteroatom of the heterocyclyl radical may be unsubstituted or substituted by methyl; R2 is hydrogen or methyl; R3 is methyl or NH2; R4-5 independently represent methyl, m is 0, 1 or 2; and n is 1 or 2; or R1 and R2 together with the nitrogen atom to which they are attached may form a heterocyclyl ring, which may be unsubstituted or substituted by one or two substituents selected from the group consisting of; methyl, ═O and (CH3)2N—.
摘要翻译：根据本发明提供新的式（I）化合物及其药学上可接受的盐和溶剂合物：其中R 1选自C 1-4烷基，烷基，C 4-6环烷基（CH 2 CH 2）m - ，甲氧基C 2-4烷基，（O）2 S 2（CH 2）2 - - - - （CH 2） R 2，R 5，R 5，R 5，N 2，N 2，和杂环基（CH 2 CH 2）m - ，其中杂环基的任何氮杂原子可以是未取代的或被甲基取代; R 2是氢或甲基; R 3是甲基或NH 2; R 4-5独立地表示甲基，m是0,1或2; n为1或2; 或R 1和R 2与它们所连接的氮原子一起可以形成杂环基环，其可以是未取代的或被一个或两个选自以下的取代基取代：组成; 甲基，-O和（CH 3）2 N - 。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式