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11. 发明授权

US08445546B2 Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures 有权
标题翻译：包含电荷稳定的含气体纳米结构的电动改性流体
公开(公告)号：US08445546B2
公开(公告)日：2013-05-21
申请号：US12773825
申请日：2010-05-04
申请人： Anthony B. Wood , Richard L. Watson , Gregory J. Archambeau
发明人： Anthony B. Wood , Richard L. Watson , Gregory J. Archambeau
IPC分类号： B01F3/04
CPC分类号： C12N5/0602 , A61K9/0014 , A61K9/0073 , A61K33/00 , A61K41/0004 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29B7/401
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized gas-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized, at least in part, with molecular gas (e.g., oxygen).
摘要翻译：提供了电动改变的流体（例如，富氧（例如，富氧）电动流体），其包含电荷稳定的含气体纳米结构的离子水溶液，其量足以在与电池接触时提供调制细胞膜电位和细胞膜电导率中的至少一种。进一步提供制备电动改性的离子水性液体组合物的方法。特定方面提供调节或调节与细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G蛋白偶联受体（GPCR））和细胞间结合（例如，细胞间接合）中的至少一种调节相关的细胞内信号转导。，紧密连接处，间隙连接处，扎胶粘合剂和粘胶）。其它实施方案包括产生电动改变的流体的特定方法。电动改变的流体组合物和制备流体的方法包括任选以溶剂化电子的形式的电动改变的离子水性流体，至少部分地用分子气体（例如氧）稳定。

12. 发明申请

US20120039884A1 COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于治疗心血管疾病的组合物和方法
公开(公告)号：US20120039884A1
公开(公告)日：2012-02-16
申请号：US13209154
申请日：2011-08-12
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K33/00 , A61P35/00 , A61P29/00 , A61P25/00 , A61K33/24 , A61P25/16 , A61P37/02 , A61P9/10 , A61K39/395 , A61P11/00 , A61P25/18
CPC分类号： A61K33/00 , A61K9/0009 , A61K9/0019 , A61K9/08 , A61K31/58 , A61K33/40 , A61K2300/00
摘要： Provided are methods for treating cardiovascular diseases and related conditions and symptoms (e.g., cardiac arrhythmia, vascular disease, myocardial infarction, congestive heart failure, myocarditis, atherosclerosis, and restenosis), comprising administering to a subject in need thereof a therapeutically effective amount of an electrokinetically altered aqueous fluid as described herein. In particular aspects, the electrokinetically altered aqueous fluids comprise an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures predominantly having an average diameter of less than about 100 nanometers and sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity. Provided are routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions, along with use of the electrokinetically altered aqueous fluids in surgical contexts, including but not limited to cardiovascular related surgeries. Additionally provided are methods for measuring biological activity of electrokinetically altered fluids.
摘要翻译：提供了治疗心血管疾病及相关病症和症状（例如心律失常，血管疾病，心肌梗塞，充血性心力衰竭，心肌炎，动脉粥样硬化和再狭窄）的方法，包括向有需要的受试者施用治疗有效量的如本文所述的电动改变的含水流体。在特定方面，电动改变的含水流体包含电荷稳定的含氧纳米结构的离子水溶液，其主要具有小于约100纳米的平均直径，并且足以提供细胞膜电位和细胞膜电导率中的至少一种的调节。提供用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的给药途径或制剂，以及在外科环境中使用电动改变的含水流体，包括但不限于心血管相关手术另外提供了用于测量电动改变的流体的生物活性的方法。

13. 发明申请

US20100311167A1 ELECTROKINETICALLY-ALTERED FLUIDS COMPRISING CHARGE-STABILIZED GAS-CONTAINING NANOSTRUCTURES 有权
标题翻译：包含充电稳定性气体纳米结构的电动液态流体
公开(公告)号：US20100311167A1
公开(公告)日：2010-12-09
申请号：US12773825
申请日：2010-05-04
申请人： Anthony B. Wood , Richard L. Watson , Gregory J. Archambeau
发明人： Anthony B. Wood , Richard L. Watson , Gregory J. Archambeau
IPC分类号： C12N5/071
CPC分类号： C12N5/0602 , A61K9/0014 , A61K9/0073 , A61K33/00 , A61K41/0004 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29B7/401
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized gas-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized, at least in part, with molecular gas (e.g., oxygen).
摘要翻译：提供了电动改变的流体（例如，富氧（例如，富氧）电动流体），其包含电荷稳定的含气体纳米结构的离子水溶液，其量足以在与电池接触时提供调制细胞膜电位和细胞膜电导率中的至少一种。进一步提供制备电动改性的离子水性液体组合物的方法。特定方面提供调节或调节与细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G蛋白偶联受体（GPCR））和细胞间结合（例如，细胞间接合）中的至少一种调节相关的细胞内信号转导。，紧密连接处，间隙连接处，扎胶粘合剂和粘胶）。其它实施方案包括产生电动改变的流体的特定方法。电动改变的流体组合物和制备流体的方法包括任选以溶剂化电子的形式的电动改变的离子水性流体，至少部分地用分子气体（例如氧）稳定。

14. 发明申请

US20100310664A1 COMPOSITIONS AND METHODS FOR TREATING INSULIN RESISTANCE AND DIABETES MELLITUS 有权
标题翻译：用于治疗胰岛素抵抗和糖尿病的组合物和方法
公开(公告)号：US20100310664A1
公开(公告)日：2010-12-09
申请号：US12768615
申请日：2010-04-27
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K31/58 , A61K9/14 , A61K31/138 , A61P3/10 , A61P29/00
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/08 , A61K9/14 , A61K31/138 , A61K31/45 , A61K31/58 , A61K41/00 , A61K41/0004 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating diabetes and diabetes-associated conditions or disorders (e.g., insulin resistance), or symptoms thereof. Provided are electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动改变的流体（富含气体的电动液体），其包含足以提供细胞膜电位和细胞膜电导率中的至少一种的调节的电荷稳定的含氧纳米结构的离子水溶液，以及治疗组合物和用于治疗糖尿病和糖尿病相关病症或障碍（例如，胰岛素抵抗）的方法或其症状。提供任选与其它治疗剂组合的电动学改变的碘含量水性流体。特定方面提供调节或调节与所述炎症反应相关的细胞内信号转导，通过调节细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G-蛋白偶联受体（GPCR））和细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

15. 发明申请

US20100310609A1 COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的组合物和方法
公开(公告)号：US20100310609A1
公开(公告)日：2010-12-09
申请号：US12771476
申请日：2010-04-30
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K33/00 , A61K9/00 , A61K31/58 , A61P25/28
CPC分类号： A61K31/56 , A61K31/58 , A61K33/00 , A61K38/13 , A61K38/215 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient for treating an inflammatory neurodegenerative condition or disease (e.g., multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD)) or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential and/or conductance, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动改变的流体（富含气体的电动液），其包含足以用于治疗炎症性神经变性病症或疾病（例如，多发性硬化（MS））帕金森氏病（多发性硬化症（MS））的电荷稳定的含氧纳米结构的离子水溶液 PD），阿尔茨海默病（AD））或其至少一种症状。电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。特定方面提供通过调节细胞膜，膜电位和/或电导中的至少一种调节或调节与所述炎症反应相关的细胞内信号转导，膜蛋白例如膜受体，包括但不限于G-蛋白偶联受体（ GPCR）和细胞间结（例如，紧密连接，间隙连接，zona adherins和desmasomes）。其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

16. 发明申请

US20100098687A1 COMPOSITIONS AND METHODS FOR TREATING THYMIC STROMAL LYMPHOPOIETIN (TSLP)-MEDIATED CONDITIONS 审中-公开
标题翻译：用于治疗THYMIC STROLLLYMPHOPOIETIN（TSLP）的受控条件的组合物和方法
公开(公告)号：US20100098687A1
公开(公告)日：2010-04-22
申请号：US12603873
申请日：2009-10-22
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K39/395 , A61K33/14 , A61P25/28 , A61P11/06 , A61P19/02 , A61P35/00 , A61P25/16
CPC分类号： C12N13/00
摘要： Provided are methods for treating a TSLP-mediated or TSLPR-mediated disease or condition, comprising administration of an electrokinetically altered aqueous fluid comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures substantially having an average diameter of less than about 100 nanometers and stably configured in the ionic aqueous fluid in an amount sufficient for treating a TSLP-mediated or TSLPR-mediated disease or condition. The charge-stabilized oxygen-containing nanostructures are preferably stably configured in the fluid in an amount sufficient to provide for modulation of cellular membrane potential and/or conductivity. Certain aspects comprising modulation or down-regulation of TSLP expression and/or activity have utility for treating TSLP-mediated or TSLPR-mediated diseases or conditions as disclosed herein (e.g., disorders of the immune system, allergic inflammation, allergic airway inflammation, DC-mediated inflammatory Th2 responses, atopic dermatitis, atopic eczema, asthma, obstructive airways disease, chronic obstructive pulmonary disease, and food allergies, inflammatory arthritis, rheumatoid arthritis, psoriasis, IgE-mediated disorders, and rhino-conjunctivitis).
摘要翻译：提供了用于治疗TSLP介导的或TSLPR介导的疾病或病症的方法，包括施用电动改变的含水流体，其包含基本上具有小于约100纳米的平均直径的电荷稳定的含氧纳米结构的离子水溶液，稳定地配置在离子水性液体中，其量足以用于治疗TSLP介导的或TSLPR介导的疾病或病症。电荷稳定的含氧纳米结构优选地稳定地配置在流体中，其量足以提供细胞膜电位和/或电导率的调节。包括TSLP表达和/或活性的调节或下调的某些方面具有用于治疗如本文所公开的TSLP介导的或TSLPR介导的疾病或病症（例如，免疫系统的紊乱，过敏性炎症，过敏性气道炎症，DC- 介导的炎性Th2应答，特应性皮炎，特应性湿疹，哮喘，阻塞性气道疾病，慢性阻塞性肺疾病和食物过敏，炎症性关节炎，类风湿性关节炎，牛皮癣，IgE介导的病症和犀 - 结膜炎）。

17. 发明申请

US20100004189A1 COMPOSITIONS AND METHODS FOR TREATING CYSTIC FIBROSIS 审中-公开
公开(公告)号：US20100004189A1
公开(公告)日：2010-01-07
申请号：US12434560
申请日：2009-05-01
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K31/7052 , A61K31/7036 , A61K31/58 , A61K31/546 , A61K31/5383 , A61K31/496 , A61K31/40 , A61K31/137
CPC分类号： C12N13/00 , G01N33/6872
摘要： Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating cystic fibrosis or a symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered fluids optionally in combination with other therapeutic agents (e.g., antibiotics, albuterol, budesonide, etc.). Particular embodiments comprise use and/or synergy with tobramycin for treating bacterial infection, and use and/or synergy with a bronchiodilator. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (like, membrane receptors, including but not limited to G protein coupled receptors, and intercellular junctions).

18. 发明申请

US20090227018A1 COMPOSITIONS AND METHODS FOR MODULATING CELLULAR MEMBRANE-MEDIATED INTRACELLULAR SIGNAL TRANSDUCTION 审中-公开
标题翻译：用于调节细胞膜介导的细胞内信号转导的组合物和方法
公开(公告)号：US20090227018A1
公开(公告)日：2009-09-10
申请号：US12256774
申请日：2008-10-23
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： C12N5/08 , C12N5/00
CPC分类号： C12N13/00 , G01N33/6872
摘要： Particular aspects of the present invention provide compositions and methods for modulating intracellular signal transduction, including modulation of at least one of membrane structure, membrane potential or membrane conductivity, membrane proteins or receptors, ion channels, and calcium dependant cellular messaging systems, comprising use of the inventive electrokinetically generated solutions to impart electrochemical and/or conformational changes in membranous structures (e.g., membrane and/or membrane proteins, receptors or other components) including but not limited to G-protein coupled receptors (GPCRs) and/or G-proteins, and intracellular junctions. In particular embodiments, the electrokinetically generated solutions or compositions are gas-enriched and/or comprise other therapeutic agents. Other embodiments include particular therapeutic methods comprising administration or formulations of the therapeutic compositions, and in various combination treatments.
摘要翻译：本发明的特定方面提供用于调节细胞内信号转导的组合物和方法，包括调节膜结构，膜电位或膜电导率，膜蛋白或受体，离子通道和钙依赖性细胞消化系统中的至少一种，包括使用本发明的电动产生的溶液以在膜结构（例如膜和/或膜蛋白，受体或其它组分）中包括但不限于G蛋白偶联受体（GPCR）和/或G-蛋白质来赋予电化学和/或构象变化，和细胞内结。在具体实施方案中，电动产生的溶液或组合物是富气和/或包含其它治疗剂。其它实施方案包括特定的治疗方法，其包括治疗组合物的施用或制剂，以及各种组合治疗。

19. 发明授权

US09745567B2 Compositions and methods for treating multiple sclerosis 有权
公开(公告)号：US09745567B2
公开(公告)日：2017-08-29
申请号：US12430728
申请日：2009-04-27
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , C12N13/00
CPC分类号： C12N13/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.

20. 发明授权

US08980325B2 Compositions and methods for treating digestive disorders 有权
标题翻译：用于治疗消化系统疾病的组合物和方法
公开(公告)号：US08980325B2
公开(公告)日：2015-03-17
申请号：US12432571
申请日：2009-04-29
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61F13/00 , A61K33/00 , A61K45/06
CPC分类号： A61K9/0087 , A61K33/00 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating digestive disorders or at least one symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said digestive disorders by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids and therapeutic compositions.
摘要翻译：提供了电动改变的流体（例如，富含气体（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供调制细胞膜电位和细胞膜电导率中的至少一种，以及用于治疗消化系统疾病或其至少一种症状的治疗组合物和方法。电动改变的流体组合物和方法包括任选与其它治疗剂组合的电动改变的碘代水性流体。特定方面提供通过调节细胞膜，膜电位，膜蛋白例如膜受体（包括但不限于G-蛋白偶联受体（GPCR））中的至少一种来调节或调节与所述消化系统疾病相关的细胞内信号转导和细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。其它实施方案包括用于电动改变的流体和治疗组合物的特定给药途径或制剂。

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