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11. 发明授权

US06168914A System and method for solid-phase parallel synthesis of a combinatorial collection of compounds 失效
标题翻译：用于固相合并化合物组合收集的系统和方法
公开(公告)号：US06168914A
公开(公告)日：2001-01-02
申请号：US09216093
申请日：1998-12-18
申请人： David A. Campbell , Valery V. Antonenko , Harold E. Selick , Robert M. Gavin , Satoru Ida , Arthur H. Muir
发明人： David A. Campbell , Valery V. Antonenko , Harold E. Selick , Robert M. Gavin , Satoru Ida , Arthur H. Muir
IPC分类号： C12O100
CPC分类号： B01J19/0046 , B01J2219/00313 , B01J2219/00319 , B01J2219/00353 , B01J2219/00391 , B01J2219/00423 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00664 , B01J2219/00689 , C40B60/14 , Y10T436/25
摘要： The invention provides a system and method for synthesizing chemicals onto supports in a parallel manner to produce a combinatorial collection of compounds. The system includes a plurality of middle plates, with each middle plate defining a plurality of reaction zones arranged in a two dimensional array. The reaction zones are adapted to receive a solid support, such as a sheet of membrane, and the middle plates are stackable on each other to form a three dimensional array of reaction zones. The system also includes a pair of end plates, where the middle plates are located between the end plates, and where the end plates include an array of fluid guides corresponding to the array of reaction zones, to allow for selective routing of reagents through the reaction zones.
摘要翻译：本发明提供了一种用于以平行方式将化学物质合成到载体上以产生化合物组合收集的系统和方法。该系统包括多个中间板，每个中间板限定以二维阵列排列的多个反应区。反应区适于接收诸如膜片的固体支持物，并且中间板彼此堆叠以形成反应区域的三维阵列。该系统还包括一对端板，其中中间板位于端板之间，并且其中端板包括对应于反应区阵列的流体引导阵列，以允许试剂选择性地穿过反应区域。

12. 发明授权

US5874589A Methods for synthesizing diverse collections of tetramic acids and derivatives thereof 失效
标题翻译：用于合成各种收集的四聚酸及其衍生物的方法
公开(公告)号：US5874589A
公开(公告)日：1999-02-23
申请号：US896799
申请日：1997-07-18
申请人： David A. Campbell , Todd T. Romoff
发明人： David A. Campbell , Todd T. Romoff
IPC分类号： C07D211/40 , C07D207/00
CPC分类号： C07D211/40
摘要： Disclosed are methods for synthesizing very large collections of diverse diverse tetramic acids, tetronic acids, pentamic acids, pentonic acids, and derivatives thereof and synthetic compound libraries comprising compounds prepared by such methods.
摘要翻译：公开了用于合成多种不同的四元酸，四氢酸，戊酰酸，戊烯酸及其衍生物的非常大的收集物的方法，以及包含通过这些方法制备的化合物的合成化合物文库。

13. 发明授权

US5362899A Chiral synthesis of alpha-aminophosponic acids 失效
标题翻译： α-氨基磷酸的手性合成
公开(公告)号：US5362899A
公开(公告)日：1994-11-08
申请号：US120007
申请日：1993-09-09
申请人： David A. Campbell
发明人： David A. Campbell
IPC分类号： C07F9/40
CPC分类号： C07F9/4006
摘要： A stereospecific method of preparing alpha-aminophosphonic acids and derivatives thereof is provided. A protected amino acid is converted to a acyl aroyl or diacyl peroxide which spontaneously rearranges to form an alpha-amino ester. This rearrangement occurs stereospecifically with retention of configuration. The ester is subsequently converted to an appropriate leaving group and displaced with a phosphite yielding a chiral alpha-aminophosphonic acid or derivative.Alpha-aminophosphonic acids are useful for the synthesis of peptide analogs that possess a phosphonate linkage in the place of an amide linkage. This substitution can impart protease resistance in therapeutic peptides thereby increasing the serum half-life.
摘要翻译：提供了制备α-氨基膦酸及其衍生物的立体特异性方法。被保护的氨基酸被转化为酰基芳酰基或二酰基过氧化物，其自发重排以形成α-氨基酯。这种重排立体特异性地保留配置。随后将酯转化为合适的离去基团，并用亚磷酸酯置换，得到手性α-氨基膦酸或衍生物。 α-氨基膦酸可用于合成具有代替酰胺键的膦酸酯键的肽类似物。该取代可以在治疗性肽中赋予蛋白酶抗性，从而增加血清半衰期。

14. 发明授权

US5084092A Method of separating metals from catalyst material 失效
标题翻译：从催化材料中分离金属的方法
公开(公告)号：US5084092A
公开(公告)日：1992-01-28
申请号：US232984
申请日：1988-08-16
申请人： David A. Campbell , Nicholas P. Wilkinson
发明人： David A. Campbell , Nicholas P. Wilkinson
IPC分类号： B01J38/00 , C22B7/00 , C22B11/02 , C22B26/10 , C22B26/20
CPC分类号： C22B26/10 , C22B11/026 , C22B26/20 , C22B7/009 , Y02P10/214
摘要： A method of separating metals from carbon-supported catalyst materials comprises the steps of combusting the carbon at a temperature insufficient to cause volatisation of the metal followed by reduction with hydrogen of any oxidised metal and washing with acid or water.

15. 发明授权

US4693893A Vaccines for equine influenza 失效
标题翻译：马流感疫苗
公开(公告)号：US4693893A
公开(公告)日：1987-09-15
申请号：US596447
申请日：1984-04-03
申请人： David A. Campbell
发明人： David A. Campbell
IPC分类号： A01N63/00 , A61K39/145 , C12N7/00 , C12N7/02 , C12N7/04 , A61K39/155 , A61K39/295
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/5256 , A61K2039/552 , A61K2039/55505 , A61K2039/55544 , C12N2760/16134 , C12N2760/16151
摘要： It is known that the human influenza virus strain A/Puerto Rico/8/34 grows particularly well in eggs and that reassorted viruses having it as a parent may also grow well in eggs. It has now been found that certain reassortants of A/PR/8/34 and equine influenza viruses, namely those which comprise the RNA7 segment from A/PR/8/34, will grow in cell culture, even though the parent equine influenza vius will not.Thus the specification describes and claims: reassorted viruses comprising genes for surface antigens of equine influenza viruses and the RNA7 segment from A/PR/8/34; methods of obtaining such viruses by reassortment; methods of propagating such reassorted viruses in cell culture, especially Vero cells; vaccines against equine influenza comprising such reassorted viruses; and methods of vaccinating equines against influenza.
摘要翻译：已知人类流感病毒株A /波多黎各/ 8/34在卵中生长特别好，并且将其作为亲本的病毒重新配制也可以在鸡蛋中生长良好。现在已经发现，A / PR / 8/34和马流感病毒的某些重配体，即包含A / PR / 8/34的RNA7片段的重组将在细胞培养物中生长，即使母体马流感病毒将不会。因此，本说明书描述和权利要求：重新组合的病毒，其包含马流感病毒表面抗原的基因和来自A / PR / 8/34的RNA7区段; 通过重配获得此类病毒的方法; 在细胞培养物中繁殖这种重配病毒的方法，特别是Vero细胞; 针对马流感疫苗的疫苗，包括重新接种的病毒; 和针对流感的马接种疫苗的方法。

16. 发明申请

US20080182995A1 PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV 有权
标题翻译：吡咯啉化合物和选择性抑制DIPEPTIDYL PEPTIDASE-IV的方法
公开(公告)号：US20080182995A1
公开(公告)日：2008-07-31
申请号：US11930337
申请日：2007-10-31
申请人： David A. Campbell , David T. Winn , Juan Manuel Betancort
发明人： David A. Campbell , David T. Winn , Juan Manuel Betancort
IPC分类号： C07F5/02 , C07D207/00
CPC分类号： C07F5/025
摘要： The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.
摘要翻译：本发明涉及显示选择性，有效的二肽基肽酶IV抑制活性的吡咯烷基氨基乙酰基吡咯烷硼酸化合物。这些化合物可用于治疗可以通过抑制DPP-IV调节或归一化的疾病，包括那些以血糖控制受损为特征的糖尿病和相关病症。化合物可以单独施用或与另外一种显示用于治疗这些和其它疾病的药理活性的药物一起施用。

17. 发明申请

US20060135553A1 Imidazole derivatives 审中-公开
标题翻译：咪唑衍生物
公开(公告)号：US20060135553A1
公开(公告)日：2006-06-22
申请号：US11262394
申请日：2005-10-28
申请人： David A. Campbell , Juan M. Betancort
发明人： David A. Campbell , Juan M. Betancort
IPC分类号： A61K31/4745 , A61K31/444 , C07D471/02 , C07D403/14
CPC分类号： C07D403/12 , C07D235/06 , C07D401/12
摘要： Certain imidazole-containing compounds are useful for treating and/or preventing of various disease conditions, by way of methodology for modulating tyrosine kinases and angiogenesis. Illustrative of such conditions are inflammatory diseases and diseases characterized by abnormal cellular proliferation.
摘要翻译：通过用于调节酪氨酸激酶和血管生成的方法，某些含咪唑化合物可用于治疗和/或预防各种疾病状况。这些病症的说明是炎性疾病和以细胞增殖异常为特征的疾病。

18. 发明授权

US06598905B2 Hose coupling 失效
公开(公告)号：US06598905B2
公开(公告)日：2003-07-29
申请号：US09753135
申请日：2000-12-29
申请人： David A. Campbell , Fred G. Schroeder , David Urueta
发明人： David A. Campbell , Fred G. Schroeder , David Urueta
IPC分类号： F16L33207
CPC分类号： F16L33/2076 , Y10T29/49435 , Y10T29/49927
摘要： A coupling and methods for assembling and using the coupling for connecting a hose with a tube, pipe or other hose in an automotive refrigerant system. The coupling comprises a connector member connected to a tube, pipe or hose, the connector member having at least one circumferential groove into which at least one sealing member is disposed. A hose is fitted over the connector member and covers the sealing member. A collar is disposed over the hose and the at least one sealing member and is deformed such that the hose is brought into engagement with the at least one sealing member and the at least one sealing member and hose occupy substantially 100% of the volume of the at least one circumferential groove.

19. 发明授权

US5929278A Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use 失效
标题翻译：金属蛋白酶抑制剂，包含其的药物组合物及其使用方法
公开(公告)号：US5929278A
公开(公告)日：1999-07-27
申请号：US81466
申请日：1998-05-19
申请人： David A. Campbell , Dinesh V. Patel , Xiao-Yi Xiao
发明人： David A. Campbell , Dinesh V. Patel , Xiao-Yi Xiao
IPC分类号： C07C323/60 , C07K5/06 , C07K5/072 , C07C321/00
CPC分类号： C07C323/60 , C07K5/06043 , C07K5/06095 , C07C2101/14
摘要： Disclosed are novel inhibitors of metalloproteases, in particular matrix metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.
摘要翻译：公开了金属蛋白酶，特别是基质金属蛋白酶的新型抑制剂。所公开的抑制剂是巯基酮和巯基醇化合物，其可用于治疗或控制涉及组织分解的疾病状态或病症的方法，例如关节病，皮肤病学条件，骨吸收，炎性疾病和肿瘤侵袭以及促进的伤口愈合。

20. 发明授权

US5840698A Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use 失效
标题翻译：胶原酶-1和暴露溶血素-1金属蛋白酶抑制剂，包含其的药物组合物及其使用方法
公开(公告)号：US5840698A
公开(公告)日：1998-11-24
申请号：US549346
申请日：1995-10-27
申请人： David A. Campbell , Dinesh V. Patel , Xiao-Yi Xiao
发明人： David A. Campbell , Dinesh V. Patel , Xiao-Yi Xiao
IPC分类号： A61K38/00 , C07C323/60 , C07D209/48 , C07K5/06 , A61K38/06
CPC分类号： C07D209/48 , C07C323/60 , C07K5/06043 , A61K38/00
摘要： Disclosed are novel inhibitors of collagenase-1 and stromelysin-I metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.
摘要翻译：公开了胶原酶-1和基质溶蛋白-I金属蛋白酶的新型抑制剂。所公开的抑制剂是巯基酮和巯基醇化合物，其可用于治疗或控制涉及组织分解的疾病状态或病症的方法，例如关节病，皮肤病学条件，骨吸收，炎性疾病和肿瘤侵袭以及促进的伤口愈合。

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