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11. 发明授权

US08158681B2 Nutraceutical and pharmaceutical compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders 失效
标题翻译：营养品和药物组合物及其用于治疗，共同治疗或预防炎症性疾病的用途
公开(公告)号：US08158681B2
公开(公告)日：2012-04-17
申请号：US12279510
申请日：2007-02-13
申请人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
发明人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
IPC分类号： A61K31/20 , A61K31/085 , A61K31/192 , A61P19/02 , C07C43/23 , C07C65/28
CPC分类号： C07C43/23 , C07C65/28 , C07D311/58
摘要： The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.
摘要翻译：本发明涉及新的甲氧基化芳族化合物。它还涉及包含甲氧基化芳族化合物的新型组合物以及这些组合物作为药物，特别是作为治疗，共同治疗或预防炎症性疾病的药物的用途。

12. 发明申请

US20100093843A1 NOVEL NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF CARTILAGE DEGRADATION OR CARTILAGE DAMAGE IN JOINTS 审中-公开
标题翻译：新型营养和药物组合物及其用于治疗，共同治疗或预防接合物降解或损伤的接头的药物组合物及其用途
公开(公告)号：US20100093843A1
公开(公告)日：2010-04-15
申请号：US12438405
申请日：2007-09-12
申请人： Joseph Schwager , Daniel Raederstorff , Goede Schueler
发明人： Joseph Schwager , Daniel Raederstorff , Goede Schueler
IPC分类号： A61K31/352 , C07D311/86 , A61P19/00
CPC分类号： A61K31/352
摘要： The invention relates to novel nutraceutical and pharmaceutical compositions comprising at least a compound of the general formula (I), wherein R1 and R2 are independently from each other C1-8-alk(en)yl and R3 and R4 are independently from each other hydroxy or C1-8-alkyloxy, as well as to the use of these compositions for the treatment, co-treatment or prevention of joint disorders.
摘要翻译：本发明涉及至少包含通式（I）化合物的新型营养药物和药物组合物，其中R1和R2彼此独立地为C1-8-烷（烯）基，R3和R4彼此独立为羟基或C 1-8烷氧基，以及这些组合物用于治疗，共同治疗或预防关节疾病的用途。

13. 发明申请

US20090176873A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20090176873A1
公开(公告)日：2009-07-09
申请号：US11920346
申请日：2006-05-24
申请人： Ann Fowler , Daniel Raederstorff , Goede Schuler , Joseph Schwager
发明人： Ann Fowler , Daniel Raederstorff , Goede Schuler , Joseph Schwager
IPC分类号： A61K31/365 , C07D307/87 , A61P19/02
CPC分类号： A61K31/343
摘要： The present invention relates to the use of compounds of the formula (I) wherein the clotted line is an optional bond; R1 is butyl or butyryl if R2 is hydroxyl but is butyl if R2 is hydrogen; or R1 and R2 taken together are 1-butylidene optionally substituted by hydroxyl, methyl, or 3-(α,β-dimethylacrylyloxy)-pentylidenyl; X is a residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is X1, X4 or X5 if the dotted line signifies a bond in formula (I) above; R3 is hydroxyl or butyryl; and n is 1 or 2, as agents for the prevention, control and treatment of conditions requiring modulation of inflammation in mammals. In another aspect, the present invention relates to the use of compounds of the formula (I) as active ingredients in the manufacture of medicaments/compositions for the prevention, control and treatment of conditions requiring modulation of inflammation. The compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the management of pain, fever and injuries, especially sport injuries. Moreover, the compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the maintenance and regeneration of articular cartilage.
摘要翻译：本发明涉及式（I）化合物的用途，其中凝血线是任选的键; 如果R2是羟基，R1是丁基或丁酰基，如果R2是氢，则是丁基; 或者R 1和R 2一起是被羟基，甲基或3-（α，β-二甲基丙烯酰氧基） - 戊酰基任选取代的1-亚丁基; X是选自X1，X2，X3，X4和X5的残基; 其中如果式（I）中的虚线不存在，X是X 2，X 3或X 5; 如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R3是羟基或丁酰基; 和n为1或2，作为预防，控制和治疗需要调节哺乳动物炎症的病症的药剂。另一方面，本发明涉及式（I）化合物作为活性成分在制备用于预防，控制和治疗需要调节炎症的病症的药物/组合物中的用途。如上定义的式（I）化合物也可用于治疗疼痛，发烧和损伤，特别是运动损伤（用于制造组合物）。此外，如上定义的式（I）化合物也可用于维持和再生关节软骨（用于制备组合物）。

14. 发明申请

US20080319071A1 Novel Nutraceutical and Pharmaceutical Compositions and Use Thereof for the Treatment, Co-Treatment or Prevention of Inflammatory Disorders 失效
标题翻译：新型营养和药物组合物及其用途，用于治疗，共同治疗或预防炎性疾病
公开(公告)号：US20080319071A1
公开(公告)日：2008-12-25
申请号：US12279510
申请日：2007-02-13
申请人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
发明人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
IPC分类号： A61K31/20 , C07C65/28 , A61K31/085 , A61P19/02 , C07C43/23 , A61K31/192
CPC分类号： C07C43/23 , C07C65/28 , C07D311/58
摘要： The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.
摘要翻译：本发明涉及新的甲氧基化芳族化合物。它还涉及包含甲氧基化芳族化合物的新型组合物以及这些组合物作为药物，特别是作为治疗，共同治疗或预防炎症性疾病的药物的用途。

15. 发明授权

US07582674B2 Nutraceutical compositions and use thereof 有权
标题翻译：营养组合物及其用途
公开(公告)号：US07582674B2
公开(公告)日：2009-09-01
申请号：US10558042
申请日：2004-05-18
申请人： Daniel Raederstorff , Joseph Schwager , Volker Spitzer , Peter Weber
发明人： Daniel Raederstorff , Joseph Schwager , Volker Spitzer , Peter Weber
IPC分类号： A61K31/35 , A61K31/355 , A61K31/05
CPC分类号： A23G3/36 , A21D2/14 , A21D2/36 , A21D13/02 , A21D13/80 , A23C9/1315 , A23C9/1322 , A23G3/368 , A23G9/32 , A23G9/366 , A23L2/52 , A23L33/105 , A23L33/12 , A23L33/15 , A23V2002/00 , A61K31/202 , A61K31/353 , A61K31/355 , A61K2300/00 , A23V2250/1882 , A23V2250/187 , A23V2250/1868 , A23V2250/1874 , A23V2250/712 , A23V2250/714 , A23V2250/2116
摘要： Compositions including, as the active ingredients, resveratrol, a derivative, metabolite or analogue thereof, and at least one additional component selected from epigallocatechin gallate (EGCG), genestein, vitamin E, polyunsaturated fatty acids, gamma-linolenic acid and vitamin K are disclosed. Also disclosed, are methods of making such compositions including admixing resveratrol, a derivative, metabolite or analogue thereof, and at least one additional component selected from EGCG, genestein, vitamin E, polyunsaturated fatty acids, gamma-linolenic acid and vitamin K are disclosed. Methods for the treatment or prevention of inflammatory diseases including administering to a subject in need of such treatment resveratrol, a derivative, metabolite or analogue thereof, in combination with at least one additional component selected from epigallocatechin gallate (EGCG), genestein, vitamin E, polyunsaturated fatty acids, gamma-linolenic acid and vitamin K are also disclosed.
摘要翻译：公开了包含作为活性成分的白藜芦醇，衍生物，代谢物或类似物以及至少一种选自表没食子儿茶素没食子酸酯（EGCG），依那斯汀，维生素E，多不饱和脂肪酸，γ-亚麻酸和维生素K的另外组分的组合物。还公开了公开了制备这样的组合物的方法，包括混合白藜芦醇，衍生物，代谢物或其类似物，以及至少一种选自EGCG，genestein，维生素E，多不饱和脂肪酸，γ-亚麻酸和维生素K的其它组分。用于治疗或预防炎性疾病的方法，包括向需要这种治疗的受试者施用白藜芦醇，其衍生物，代谢物或类似物，与至少一种选自表没食子儿茶素没食子酸酯（EGCG），依达孕酮，维生素E，多不饱和脂肪酸，γ-亚麻酸和维生素K也被公开。

16. 发明申请

US20090186942A1 NOVEL NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：新型营养和药物组合物及其用于治疗，并发治疗或预防炎症性疾病的组合物
公开(公告)号：US20090186942A1
公开(公告)日：2009-07-23
申请号：US12279516
申请日：2007-02-13
申请人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
发明人： Daniel Raederstorff , Joseph Schwager , Goede Schueler
IPC分类号： A61K31/192 , C07C65/03 , A61P29/00
CPC分类号： A61K31/05 , A61K31/60
摘要： The invention relates to novel compositions comprising a phenolic compound as well as to the use of these compositions as a medicament, in particular for the manufacture of a nutraceutical or pharmaceutical composition for the treatment, co-treatment or prevention of inflammatory disorders, such as arthritis, asthma, inflammatory bowel diseases, inflammatory diseases of the skin (e.g., psoriasis, eczema, atopic dermatitis, sunburn) and chronic inflammatory disorders, such as atherosclerosis, heart diseases, metabolic syndrome X, cancer, Alzheimer's disease and pre-stages thereof such as mild cognitive impairment. Also, the invention relates to the use of a cosmetic composition comprising a phenolic compound for the cosmetic treatment, co-treatment or prevention of inflammation of the skin, in particular for the cosmetic treatment, co-treatment or prevention of sunburn or of impure skin.
摘要翻译：本发明涉及包含酚类化合物的新型组合物以及这些组合物作为药物的用途，特别是用于制备用于治疗，共同治疗或预防炎症性疾病如关节炎的营养药物或药物组合物，哮喘，炎症性肠病，皮肤炎性疾病（例如牛皮癣，湿疹，特应性皮炎，晒伤）和慢性炎症性疾病如动脉粥样硬化，心脏病，代谢综合征X，癌症，阿尔茨海默氏病及其前期阶段作为轻度认知障碍。此外，本发明涉及包含酚类化合物的化妆品组合物在美容治疗，共同治疗或预防皮肤炎症中的用途，特别是用于美容治疗，共同治疗或预防晒伤或不纯的皮肤。

17. 发明授权

US08680147B2 Compositions 失效
标题翻译：组合
公开(公告)号：US08680147B2
公开(公告)日：2014-03-25
申请号：US12515332
申请日：2007-11-21
申请人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
发明人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
IPC分类号： A61K31/192 , C07C63/33 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention relates to novel composition for the treatment, co-treatment or prevention of inflammatory disorders comprising an effective amount of carnosic acid 12-methylether.
摘要翻译：本发明涉及用于治疗，共同治疗或预防炎性疾病的新型组合物，其包含有效量的鼠尾草酸12-甲基醚。

18. 发明申请

US20100298427A1 Anti-inflammatory compositions and their use 审中-公开
标题翻译：抗炎组合物及其用途
公开(公告)号：US20100298427A1
公开(公告)日：2010-11-25
申请号：US12801646
申请日：2010-06-18
申请人： Ann Fowler , Daniel Raederstorff , Goede Schuler , Joseph Schwager
发明人： Ann Fowler , Daniel Raederstorff , Goede Schuler , Joseph Schwager
IPC分类号： A61K31/365 , A61P19/02 , A61P19/04 , A61P17/02 , A61P17/06 , A61P11/06 , A61P19/10 , A61P35/00 , A61P9/10 , A61P25/16 , A61P25/28 , A61P25/24 , C07D307/88 , A61P29/00
CPC分类号： A61K31/343
摘要： The present invention relates to the use of compounds of the formula (I) wherein the clotted line is an optional bond; R1 is butyl or butyryl if R2 is hydroxyl but is butyl if R2 is hydrogen; or R1 and R2 taken together are 1-butylidene optionally substituted by hydroxyl, methyl, or 3-(α,β-dimethylacrylyloxy)-pentylidenyl; X is a residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is X1, X4 or X5 if the dotted line signifies a bond in formula (I) above; R3 is hydroxyl or butyryl; and n is 1 or 2, as agents for the prevention, control and treatment of conditions requiring modulation of inflammation in mammals. In another aspect, the present invention relates to the use of compounds of the formula (I) as active ingredients in the manufacture of medicaments/compositions for the prevention, control and treatment of conditions requiring modulation of inflammation. The compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the management of pain, fever and injuries, especially sport injuries. Moreover, the compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the maintenance and regeneration of articular cartilage.
摘要翻译：本发明涉及式（I）化合物的用途，其中凝血线是任选的键; 如果R2是羟基，R1是丁基或丁酰基，如果R2是氢，则是丁基; 或R 1和R 2一起是可任意被羟基，甲基或3-（α，b-二甲基丙烯酰氧基） - 戊酰基取代的1-亚丁基; X是选自X1，X2，X3，X4和X5的残基; 其中如果式（I）中的虚线不存在，X是X 2，X 3或X 5; 如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R3是羟基或丁酰基; 和n为1或2，作为预防，控制和治疗需要调节哺乳动物炎症的病症的药剂。另一方面，本发明涉及式（I）化合物作为活性成分在制备用于预防，控制和治疗需要调节炎症的病症的药物/组合物中的用途。如上定义的式（I）化合物也可用于治疗疼痛，发烧和损伤，特别是运动损伤（用于制造组合物）。此外，如上定义的式（I）化合物也可用于维持和再生关节软骨（用于制备组合物）。

19. 发明申请

US20100056634A1 NOVEL COMPOSITIONS 失效
标题翻译：新组合
公开(公告)号：US20100056634A1
公开(公告)日：2010-03-04
申请号：US12515332
申请日：2007-11-21
申请人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Chirstof Wehrli
发明人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Chirstof Wehrli
IPC分类号： A61K31/192 , C07C63/33 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention relates to novel composition for the treatment, co-treatment or prevention of inflammatory disorders comprising an effective amount of carnosic acid 12-methylether.
摘要翻译：本发明涉及用于治疗，共同治疗或预防炎性疾病的新型组合物，其包含有效量的鼠尾草酸12-甲基醚。

20. 发明申请

US20100056615A1 USE OF TRICYCLIC DITERPENES AND THEIR DERIVATIVES FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS AND/OR JOINT DISORDERS 审中-公开
标题翻译：治疗，治疗或预防感染性疾病和/或联合疾病的三环磷酸酯及其衍生物的使用
公开(公告)号：US20100056615A1
公开(公告)日：2010-03-04
申请号：US12515329
申请日：2007-11-21
申请人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
发明人： Daniel Raederstorff , Goede Schueler , Joseph Schwager , Christof Wehrli
IPC分类号： A61K31/335 , C07C59/00 , C07C35/42 , C07C69/76 , C07C49/403 , A61K31/192 , A61K31/045 , A61K31/215 , A61K31/122 , A61P29/00 , A61P17/00 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention refers to the use of at least one tricyclic diterpenes for the manufacture of a nutraceutical or pharmaceutical for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders.
摘要翻译：本发明涉及至少一种三环二萜用于制备用于治疗，共同治疗或预防炎症性疾病和/或关节病症的营养药物或药物的用途。

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