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11. 发明授权

US09402961B2 Drug delivery device having a spring element 有权
标题翻译：具有弹簧元件的药物输送装置
公开(公告)号：US09402961B2
公开(公告)日：2016-08-02
申请号：US13885326
申请日：2011-11-28
申请人： David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , Simon Lewis Bilton , Daniel David Higgins
发明人： David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , Simon Lewis Bilton , Daniel David Higgins
IPC分类号： A61M5/315 , A61M5/19 , A61M5/20 , A61M5/24
CPC分类号： A61M5/31548 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/3157 , A61M5/31585 , A61M5/31593 , A61M2005/202
摘要： A drug delivery device having a spring element that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, and a mechanical coupling having a spring element. The variable dose setting mechanism is operably coupled to a first reservoir holding a first medicament, and the variable dose setting mechanism comprises a dose setter. The fixed dose setting mechanism is operably coupled to a second reservoir holding a second medicament. The mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter, and the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during variable dose setting. Still further, the spring element is configured to store energy during dose setting and to transfer stored energy to the fixed dose setting mechanism to assist with dispense of the fixed dose.
摘要翻译：具有提供分配辅助的弹簧元件的药物递送装置。药物递送装置包括可变剂量设定机构，固定剂量设定机构和具有弹簧元件的机械联接器。可变剂量设定机构可操作地耦合到保持第一药物的第一储存器，并且可变剂量设定机构包括剂量设定器。固定剂量设定机构可操作地联接到容纳第二药剂的第二储存器。机械耦合可操作地耦合可变剂量设定机构和固定剂量设定机构。此外，可变剂量设定机构被配置为在激活剂量设定器时设定第一药剂的可变剂量，并且固定剂量设定机构被配置为在可变剂量设定期间设定第二药剂的固定剂量。此外，弹簧元件构造成在剂量设定期间储存能量并将储存的能量转移到固定剂量设定机构以帮助分配固定剂量。

12. 发明授权

US09248239B2 Drug delivery device having linked dose dial components 有权
标题翻译：药物输送装置具有连接的剂量拨号组件
公开(公告)号：US09248239B2
公开(公告)日：2016-02-02
申请号：US13885324
申请日：2011-11-28
申请人： David Martin Leak , David Aubrey Plumptre , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell
发明人： David Martin Leak , David Aubrey Plumptre , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell
IPC分类号： A61M5/315 , A61M5/19 , A61M5/31
CPC分类号： A61M5/3155 , A61M5/19 , A61M5/31596 , A61M2005/3142
摘要： A drug delivery device for co-delivery of two medicaments. The drug delivery device has a dose setter, a first dose dial component, a second dose dial component, and a collar. The first dose dial component is configured to select a first dose of a first medicament, and the first dose dial component is operably connected to the dose setter. The second dose dial component is configured to select a second dose of a second medicament. In addition, the first dose dial component and the second dose dial component are connected to the collar. The collar is configured to be moved in a proximal direction by actuation of the dose setter. Further, when the collar is moved in a proximal direction, the first dose dial component and the second dose dial component are configured to move proximally to set a dose “A” for the first medicament with the first dose dial component and set a dose “B” for the second medicament with the second dose dial component.
摘要翻译：用于共同递送两种药物的药物递送装置。药物递送装置具有剂量设定器，第一剂量拨号部件，第二剂量拨号部件和衣领。第一剂量拨号组件被配置为选择第一药剂的第一剂量，并且第一剂量拨号组件可操作地连接到剂量设定器。第二剂量拨号组件配置成选择第二剂量的第二药剂。此外，第一剂量拨号组件和第二剂量拨号组件连接到衣领。套环构造成通过致动剂量设定器在近端方向上移动。此外，当套环沿近端方向移动时，第一剂量拨盘部件和第二剂量拨盘部件构造成向近侧移动以针对具有第一剂量拨号部件的第一药物设定剂量“A”并设定剂量“ B“用于具有第二剂量拨号组件的第二药物。

13. 发明申请

US20130245565A1 DRUG DELIVERY DEVICE HAVING A SPRING ELEMENT 有权
标题翻译：具有弹簧元件的药物递送装置
公开(公告)号：US20130245565A1
公开(公告)日：2013-09-19
申请号：US13885326
申请日：2011-11-28
申请人： David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , Simon Lewis Bilton , Daniel David Higgins
发明人： David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , Simon Lewis Bilton , Daniel David Higgins
IPC分类号： A61M5/315
CPC分类号： A61M5/31548 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/3157 , A61M5/31585 , A61M5/31593 , A61M2005/202
摘要： A drug delivery device having a spring element that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, and a mechanical coupling having a spring element. The variable dose setting mechanism is operably coupled to a first reservoir holding a first medicament, and the variable dose setting mechanism comprises a dose setter. The fixed dose setting mechanism is operably coupled to a second reservoir holding a second medicament. The mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter, and the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during variable dose setting. Still further, the spring element is configured to store energy during dose setting and to transfer stored energy to the fixed dose setting mechanism to assist with dispense of the fixed dose.
摘要翻译：具有提供分配辅助的弹簧元件的药物递送装置。药物递送装置包括可变剂量设定机构，固定剂量设定机构和具有弹簧元件的机械联接器。可变剂量设定机构可操作地耦合到保持第一药物的第一储存器，并且可变剂量设定机构包括剂量设定器。固定剂量设定机构可操作地联接到容纳第二药剂的第二储存器。机械耦合可操作地耦合可变剂量设定机构和固定剂量设定机构。此外，可变剂量设定机构被配置为在激活剂量设定器时设定第一药剂的可变剂量，并且固定剂量设定机构被配置为在可变剂量设定期间设定第二药剂的固定剂量。此外，弹簧元件构造成在剂量设定期间储存能量并将储存的能量转移到固定剂量设定机构以帮助分配固定剂量。

14. 发明授权

US09333303B2 Drug delivery device having a trigger 有权
标题翻译：具有触发器的药物输送装置
公开(公告)号：US09333303B2
公开(公告)日：2016-05-10
申请号：US13885327
申请日：2011-11-28
申请人： David Martin Leak , Malcolm Stanley Boyd
发明人： David Martin Leak , Malcolm Stanley Boyd
IPC分类号： A61M5/315 , A61M5/19 , A61M5/20
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/20 , A61M5/2066 , A61M5/31551 , A61M5/31575 , A61M5/31583 , A61M5/31585
摘要： A drug delivery device having a trigger biasing member that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism that is operably coupled to a primary reservoir holding a first medicament. The drug delivery device also includes a fixed dose setting mechanism that is operably coupled to a secondary reservoir holding a second medicament. The fixed dose setting mechanism comprises a trigger biasing member or spring. In addition, the drug delivery device includes a mechanical coupling that operably couples the variable dose setting mechanism and the fixed dose setting mechanism. During dose setting, activation of a single dose setter sets a variable dose of the first medicament. Setting of a minimum dose of the first medicament causes a fixed dose of the second medicament to be automatically set, and, during dispense, the trigger spring at least assists with the dispense of the fixed dose of the second medicament.
摘要翻译：具有提供分配辅助的触发偏置构件的药物输送装置。药物递送装置包括可变剂量设定机构，其可操作地联接到容纳第一药剂的主贮存器。药物递送装置还包括固定剂量设定机构，其可操作地连接到容纳第二药剂的次级贮存器。固定剂量设定机构包括触发偏置构件或弹簧。此外，药物递送装置包括可操作地连接可变剂量设定机构和固定剂量设定机构的机械联接器。在剂量设定期间，单次剂量设定器的激活设定第一药物的可变剂量。设置第一药物的最小剂量导致第二药物的固定剂量自动设定，并且在分配期间，触发弹簧至少有助于分配固定剂量的第二药物。

15. 发明申请

US20130253465A1 Dispense Interface Component for a Drug Delivery Device 审中-公开
标题翻译：药物输送装置的分配界面组件
公开(公告)号：US20130253465A1
公开(公告)日：2013-09-26
申请号：US13988315
申请日：2011-11-28
申请人： Marc Holtwick , Zdenek Cerman , David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , David Saunders
发明人： Marc Holtwick , Zdenek Cerman , David Martin Leak , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell , David Saunders
IPC分类号： A61M5/19
CPC分类号： A61M5/19 , A61M5/14244 , A61M5/1452 , A61M5/16827 , A61M5/20 , A61M5/2066 , A61M2005/2407 , A61M2005/247 , A61M2005/2496 , A61M2005/3125 , A61M2005/3126 , A61M2005/3128 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/6072 , A61M2205/8206
摘要： A dispense interface component for use with a drug delivery device is provided. The dispense interface component may include a main body, a first piercing portion, a second piercing portion, and a biasing element. The main body is configured for connection to the drug delivery device. The first piercing portion is for piercing a first cartridge contained within the drug delivery device, and the first piercing portion is connected to the main body. The second piercing portion is for piercing a second cartridge contained with the drug delivery device, and the second piercing portion is connected to the main body. The at least one biasing element is operably coupled to the main body, wherein the at least one biasing element is configured to, when the load on the at least one biasing element is less than or equal to a threshold load, bias (i) the first piercing portion away from the first cartridge and (ii) the second piercing portion away from the second cartridge.
摘要翻译：提供了一种用于药物输送装置的分配界面部件。分配界面部件可以包括主体，第一穿刺部分，第二穿刺部分和偏置元件。主体被配置为连接到药物输送装置。第一刺穿部分用于刺穿容纳在药物输送装置内的第一药筒，并且第一穿刺部分连接到主体。第二穿刺部分用于刺穿包含药物输送装置的第二药筒，第二穿刺部分连接到主体。所述至少一个偏置元件可操作地联接到所述主体，其中所述至少一个偏置元件构造成当所述至少一个偏置元件上的负载小于或等于阈值负载时，偏置（i）第一穿刺部分远离第一药筒，和（ii）第二穿刺部分远离第二药筒。

16. 发明申请

US20130237924A1 DRUG DELIVERY DEVICE HAVING LINKED DOSE DIAL COMPONENTS 有权
标题翻译：具有连接剂量配料的药物递送装置
公开(公告)号：US20130237924A1
公开(公告)日：2013-09-12
申请号：US13885324
申请日：2011-11-28
申请人： David Martin Leak , David Aubrey Plumptre , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell
发明人： David Martin Leak , David Aubrey Plumptre , Malcolm Stanley Boyd , Daniel Thomas De Sausmarez Lintell
IPC分类号： A61M5/315
CPC分类号： A61M5/3155 , A61M5/19 , A61M5/31596 , A61M2005/3142
摘要： A drug delivery device for co-delivery of two medicaments. The drug delivery device has a dose setter, a first dose dial component, a second dose dial component, and a collar. The first dose dial component is configured to select a first dose of a first medicament, and the first dose dial component is operably connected to the dose setter. The second dose dial component is configured to select a second dose of a second medicament. In addition, the first dose dial component and the second dose dial component are connected to the collar. The collar is configured to be moved in a proximal direction by actuation of the dose setter. Further, when the collar is moved in a proximal direction, the first dose dial component and the second dose dial component are configured to move proximally to set a dose “A” for the first medicament with the first dose dial component and set a dose “B” for the second medicament with the second dose dial component.
摘要翻译：用于共同递送两种药物的药物递送装置。药物递送装置具有剂量设定器，第一剂量拨号部件，第二剂量拨号部件和衣领。第一剂量拨号组件被配置为选择第一药剂的第一剂量，并且第一剂量拨号组件可操作地连接到剂量设定器。第二剂量拨号组件配置成选择第二剂量的第二药剂。此外，第一剂量拨号组件和第二剂量拨号组件连接到衣领。套环构造成通过致动剂量设定器在近端方向上移动。此外，当套环沿近端方向移动时，第一剂量拨盘部件和第二剂量拨盘部件构造成向近侧移动以针对具有第一剂量拨号部件的第一药物设定剂量“A”并设定剂量“ B“用于具有第二剂量拨号组件的第二药物。

17. 发明申请

US20130231613A1 DRUG DELIVERY DEVICE HAVING A TRIGGER 有权
标题翻译：具有触发器的药物递送装置
公开(公告)号：US20130231613A1
公开(公告)日：2013-09-05
申请号：US13885327
申请日：2011-11-28
申请人： David Martin Leak , Malcolm Stanley Boyd
发明人： David Martin Leak , Malcolm Stanley Boyd
IPC分类号： A61M5/315
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/20 , A61M5/2066 , A61M5/31551 , A61M5/31575 , A61M5/31583 , A61M5/31585
摘要： A drug delivery device having a trigger biasing member that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism that is operably coupled to a primary reservoir holding a first medicament. The drug delivery device also includes a fixed dose setting mechanism that is operably coupled to a secondary reservoir holding a second medicament. The fixed dose setting mechanism comprises a trigger biasing member or spring. In addition, the drug delivery device includes a mechanical coupling that operably couples the variable dose setting mechanism and the fixed dose setting mechanism. During dose setting, activation of a single dose setter sets a variable dose of the first medicament. Setting of a minimum dose of the first medicament causes a fixed dose of the second medicament to be automatically set, and, during dispense, the trigger spring at least assists with the dispense of the fixed dose of the second medicament.
摘要翻译：具有提供分配辅助的触发偏置构件的药物输送装置。药物递送装置包括可变剂量设定机构，其可操作地联接到容纳第一药剂的主贮存器。药物递送装置还包括固定剂量设定机构，其可操作地连接到容纳第二药剂的次级贮存器。固定剂量设定机构包括触发偏置构件或弹簧。此外，药物递送装置包括可操作地连接可变剂量设定机构和固定剂量设定机构的机械联接器。在剂量设定期间，单次剂量设定器的激活设定第一药物的可变剂量。第一药物的最小剂量的设定导致第二药物的固定剂量自动设定，并且在分配期间，触发弹簧至少有助于分配固定剂量的第二药物。

18. 发明授权

US09707351B2 Dose setting mechanism and method of using same 有权
公开(公告)号：US09707351B2
公开(公告)日：2017-07-18
申请号：US13878463
申请日：2011-10-11
申请人： David Martin Leak , Joseph Butler
发明人： David Martin Leak , Joseph Butler
IPC分类号： A61M5/315
CPC分类号： A61M5/31528 , A61M5/31525 , A61M5/31538 , A61M5/31551 , A61M5/31571 , A61M5/31585
摘要： The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.

19. 发明申请

US20130296802A1 Dose Setting Mechanism and Method of Setting a Dose 有权
标题翻译：剂量设定机制及设定方法
公开(公告)号：US20130296802A1
公开(公告)日：2013-11-07
申请号：US13878762
申请日：2011-10-11
申请人： David Moore , Joseph Butler , David Martin Leak
发明人： David Moore , Joseph Butler , David Martin Leak
IPC分类号： A61M5/315
CPC分类号： A61M5/31535 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/31585
摘要： A dose setting mechanism comprises a drug delivery device housing and a dual state track provided within the housing that is axially and rotationally fixed with respect to the housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A clutch is rotatable during dose setting and non-rotatable during dose delivery. A clutch plate is rotationally fixed relative to the housing; and a clutch blocker is in threaded engagement with the clutch plate and has a radial key engaged with the dual state track. The mechanism may comprise a biasing member positioned between the clutch blocker and clutch plate.
摘要翻译：剂量设定机构包括药物输送装置壳体和设置在壳体内的相对于壳体轴向和旋转地固定的双状态轨道。剂量拨号组件定位在壳体中并且可以在剂量设定和剂量递送期间旋转。离合器在剂量设定期间是可旋转的，并且在剂量递送期间不能旋转。离合器板相对于壳体旋转地固定; 并且离合器阻挡件与离合器板螺纹接合并且具有与双状态轨道接合的径向键。该机构可以包括定位在离合器阻挡件和离合器板之间的偏置构件。

20. 发明授权

US09517308B2 Dose setting mechanism and method of setting a dose 有权
标题翻译：剂量设定机制及剂量设定方法
公开(公告)号：US09517308B2
公开(公告)日：2016-12-13
申请号：US13878762
申请日：2011-10-11
申请人： David Moore , Joseph Butler , David Martin Leak
发明人： David Moore , Joseph Butler , David Martin Leak
IPC分类号： A61M5/315 , A61M5/24
CPC分类号： A61M5/31535 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/31585
摘要： A dose setting mechanism comprises a drug delivery device housing and a dual state track provided within the housing that is axially and rotationally fixed with respect to the housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A clutch is rotatable during dose setting and non-rotatable during dose delivery. A clutch plate is rotationally fixed relative to the housing; and a clutch blocker is in threaded engagement with the clutch plate and has a radial key engaged with the dual state track. The mechanism may comprise a biasing member positioned between the clutch blocker and clutch plate.
摘要翻译：剂量设定机构包括药物输送装置壳体和设置在壳体内的相对于壳体轴向和旋转地固定的双状态轨道。剂量拨号组件定位在壳体中并且可以在剂量设定和剂量递送期间旋转。离合器在剂量设定期间是可旋转的，并且在剂量递送期间不能旋转。离合器板相对于壳体旋转地固定; 并且离合器阻挡件与离合器板螺纹接合并且具有与双状态轨道接合的径向键。该机构可以包括定位在离合器阻挡件和离合器板之间的偏置构件。

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