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11. 发明申请

WO0007545A8 NOVEL APOPTOSIS PROTEINS 审中-公开
标题翻译：新的细胞凋亡蛋白
公开(公告)号：WO0007545A8
公开(公告)日：2000-05-25
申请号：PCT/US9917776
申请日：1999-08-06
申请人： RIGEL PHARMACEUTICALS INC , LUO YING , HUANG BETTY C B , SHEN MARY , YU PEI WEN
发明人： LUO YING , HUANG BETTY C B , SHEN MARY , YU PEI WEN
IPC分类号： G01N33/50 , A61K38/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C40B40/02 , C40B50/06 , G01N33/15 , A61K
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及新的凋亡多肽，例如涉及调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。本发明进一步提供了鉴定调节Apop1，Apop2和Apop3的生物学活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。

12. 发明申请

WO2011163303A3 SENSOR SYSTEMS HAVING MULTIPLE PROBES AND ELECTRODE ARRAYS 审中-公开
标题翻译：具有多个探头和电极阵列的传感器系统
公开(公告)号：WO2011163303A3
公开(公告)日：2012-03-22
申请号：PCT/US2011041357
申请日：2011-06-22
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , CHIU CHIA-HUNG , RAMACHANDRAN MEENA , DANGUI-PATEL NANDITA , ROSE JEFFERSON , RAO ASHWIN K , WANG HSIFU , LUO YING
发明人： GOTTLIEB REBECCA K , CHIU CHIA-HUNG , RAMACHANDRAN MEENA , DANGUI-PATEL NANDITA , ROSE JEFFERSON , RAO ASHWIN K , WANG HSIFU , LUO YING
IPC分类号： C12Q1/00 , A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/1486 , A61B5/0017 , A61B5/14503 , A61B5/14532 , A61B5/726 , C12Q1/001 , G01N27/307
摘要： Embodiments of the invention provide amperometric analyte sensors having multiple related structural elements (e.g. sensor arrays comprising a working, counter and reference electrode) and algorithms designed for use with such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施方案提供了具有多个相关结构元件（例如包括工作，计数器和参考电极的传感器阵列）和设计用于与这种传感器一起使用的算法的电流分析物传感器。虽然本发明的实施方案可以在各种情况下使用，但是本发明的典型实施方案包括用于糖尿病管理的葡萄糖传感器。

13. 发明申请

WO03040409A9 NOVEL GERMINAL CENTER KINASE PROTEINS, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：新型终端中心激酶蛋白，组合物和使用方法
公开(公告)号：WO03040409A9
公开(公告)日：2004-03-04
申请号：PCT/US0233845
申请日：2002-10-21
申请人： RIGEL PHARMACEUTICALS INC , LEO CINDY , LUO YING , XU XIANG , YU SIMON
发明人： LEO CINDY , LUO YING , XU XIANG , YU SIMON
IPC分类号： C07H21/04 , C12N9/12 , C12Q1/48 , C12Q1/68 , G01N33/50 , A01N43/04 , A61K31/07
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
摘要翻译：本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。提供了编码能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质和蛋白质的核酸。还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

14. 发明申请

WO0129072A9 P15 CELL CYCLE PROTEINS ASSOCIATED WITH PCNA, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：与PCNA相关的P15 细胞周期蛋白，组合物和使用方法
公开(公告)号：WO0129072A9
公开(公告)日：2002-08-01
申请号：PCT/US0041296
申请日：2000-10-18
申请人： RIGEL PHARMACEUTICALS INC , LUO YING , YU PEIWEN , HUANG BETTY
发明人： LUO YING , YU PEIWEN , HUANG BETTY
IPC分类号： G01N33/50 , C07K14/47 , C07K16/18 , C12N15/09 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/566 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K14/4738
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。本发明进一步提供了用于鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。

15. 发明申请

WO0121654A3 SYK KINASE-ASSOCIATED CELL CYCLE PROTEINS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： SYK激酶相关细胞周期蛋白，组合物和使用方法
公开(公告)号：WO0121654A3
公开(公告)日：2002-03-07
申请号：PCT/US0026338
申请日：2000-09-25
申请人： RIGEL PHARMACEUTICALS INC , LUO YING , MANCEBO HELENA
发明人： LUO YING , MANCEBO HELENA
IPC分类号： G01N33/50 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/48 , G01N33/15 , G01N33/566 , G01N33/68
CPC分类号： C07K14/47
摘要： The present invention is directed to polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

16. 发明申请

WO0164913A2 CELL CYCLE PROTEINS ASSOCIATED WITH RAD9, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：与RAD9相关的细胞周期蛋白，组合物和使用方法
公开(公告)号：WO0164913A2
公开(公告)日：2001-09-07
申请号：PCT/US0106849
申请日：2001-03-02
申请人： RIGEL PHARMACEUTICALS INC , XU XIANG , LUO YING
发明人： XU XIANG , LUO YING
IPC分类号： C07K14/47 , C12N9/16 , C12N15/55 , G01N33/50 , G01N33/68 , C12N9/64
CPC分类号： C07K14/4738 , C12N9/16 , C12Y301/03016 , G01N33/5011 , G01N33/6872 , G01N2333/4739 , G01N2333/8114
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

17. 发明申请

WO2007146477A3 METHOD AND APPARATUS FOR ADAPTIVE HIERARCHICAL PROCESSING OF PRINT IMAGES 审中-公开
标题翻译：用于打印图像的自适应分层处理的方法和设备
公开(公告)号：WO2007146477A3
公开(公告)日：2008-06-05
申请号：PCT/US2007065595
申请日：2007-03-30
申请人： MOTOROLA INC , LO PETER Z , LUO YING
发明人： LO PETER Z , LUO YING
IPC分类号： G06K9/00
CPC分类号： G06K9/0008 , G06K9/036
摘要： Print image processing includes generating (402, 408) a first direction image and a multi-resolution hierarchy tree (MRT) having a plurality of direction measures, and adjusting (4120 at least one direction measure based on whether it is associated with a singularity area or a non-singularity area of the MRT, to output (418) a final first direction image used for further print image processing. The MRT direction images include the first direction image having a highest resolution and at least one other direction image having a lower resolution. Each direction measure is determined from a direction measure, in a higher resolution direction image, which is selected based on image quality and distance from the boundary between print areas and non-print areas. Upon determining the final first direction image, a consistency measure can be computed and compared to a consistency metric and the method iteratively performed until the consistency measure satisfies the consistency metric.
摘要翻译：打印图像处理包括生成（402,408）第一方向图像和具有多个方向测量值的多分辨率分层树（MRT），以及基于其是否与奇异区域相关联来调整（4120）至少一个方向测量或MRT的非奇异区域，以输出（418）用于进一步的打印图像处理的最终的第一方向图像。MRT方向图像包括具有最高分辨率的第一方向图像和具有较低分辨率的至少一个其他方向图像分辨率，每个方向测量是根据方向测量确定的，在更高分辨率的方向图像中，根据图像质量以及与打印区域和非打印区域之间的边界的距离来选择更高分辨率的方向图像;在确定最终的第一方向图像时，度量可以被计算并且与一致性度量进行比较，并且该方法迭代地执行，直到一致性度量满足一致性度量。

18. 发明申请

WO0121799A9 TRAF4 ASSOCIATED CELL CYCLE PROTEINS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： TRAF4相关细胞周期蛋白，组合物和使用方法
公开(公告)号：WO0121799A9
公开(公告)日：2002-08-08
申请号：PCT/US0040987
申请日：2000-09-25
申请人： RIGEL PHARMACEUTICALS INC , LUO YING , XU XIANG
发明人： LUO YING , XU XIANG
IPC分类号： G01N33/50 , A61K31/711 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K14/4738
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

19. 发明申请

WO0129072A3 P15 CELL CYCLE PROTEINS ASSOCIATED WITH PCNA, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： P15 与PCNA相关的细胞周期蛋白，组合物和使用方法
公开(公告)号：WO0129072A3
公开(公告)日：2002-01-17
申请号：PCT/US0041296
申请日：2000-10-18
申请人： RIGEL PHARMACEUTICALS INC , LUO YING , YU PEIWEN , HUANG BETTY
发明人： LUO YING , YU PEIWEN , HUANG BETTY
IPC分类号： G01N33/50 , C07K14/47 , C07K16/18 , C12N15/09 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/566 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K14/4738
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

20. 发明申请

WO0007545A9 NOVEL APOPTOSIS PROTEINS 审中-公开
标题翻译：新型疫苗蛋白
公开(公告)号：WO0007545A9
公开(公告)日：2000-07-13
申请号：PCT/US9917776
申请日：1999-08-06
申请人： RIGEL PHARMACEUTICALS INC , LUO YING , HUANG BETTY C B , SHEN MARY , YU PEI WEN
发明人： LUO YING , HUANG BETTY C B , SHEN MARY , YU PEI WEN
IPC分类号： G01N33/50 , A61K38/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C40B40/02 , C40B50/06 , G01N33/15 , A61K
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及新的凋亡多肽，例如参与调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明进一步提供了用于鉴定调节Apop1，Apop2和Apop3的生物活性的新组合物的方法，以及这些组合物在诊断和治疗疾病中的用途。

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