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11. 发明公开

EP1817055A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权转让
标题翻译： OVR110抗体组合物及使用方法
公开(公告)号：EP1817055A2
公开(公告)日：2007-08-15
申请号：EP05848912.1
申请日：2005-11-10
申请人： Diadexus, Inc.
发明人： PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , BURCHAM, Timothy, S. , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
IPC分类号： A61K39/395 , C07K16/30 , C12N5/12 , G01N33/53
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/2827 , C07K16/3015 , C07K2317/34 , C07K2317/732 , C07K2317/77
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.

12. 发明公开

EP1841793A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：EP1841793A2
公开(公告)日：2007-10-10
申请号：EP06717739.4
申请日：2006-01-09
申请人： Diadexus, Inc.
发明人： PAPKOFF, Jackie , SHROYER, Kenneth, R.
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： G01N33/574 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/30
摘要： The invention provides isolated anti-head and neck, ovarian, pancreatic, lung, endometrial or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti- Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti- Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti- Ovr110 antibodies. The invention encompasses a method of producing the anti- Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell by contacting the cancer cell with an anti- Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal by administering a therapeutically effective amount of the anti- Ovr110 antibody to the mammal.

13. 发明授权

EP1841793B1 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：EP1841793B1
公开(公告)日：2010-03-31
申请号：EP06717739.4
申请日：2006-01-09
申请人： Diadexus, Inc.
发明人： PAPKOFF, Jackie , SHROYER, Kenneth, R.
IPC分类号： C07K16/00 , A61K39/395 , G01N33/574
CPC分类号： G01N33/574 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/30

14. 发明授权

EP1817055B1 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权转让
标题翻译： OVR110抗体组合物及使用方法
公开(公告)号：EP1817055B1
公开(公告)日：2012-12-26
申请号：EP05848912.1
申请日：2005-11-10
申请人： Diadexus, Inc.
发明人： PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , BURCHAM, Timothy, S. , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , C12N5/12 , G01N33/53 , A61P35/00 , A61P37/00
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/2827 , C07K16/3015 , C07K2317/34 , C07K2317/732 , C07K2317/77

15. 发明授权

EP1633784B1 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物及使用方法
公开(公告)号：EP1633784B1
公开(公告)日：2011-07-13
申请号：EP04760956.5
申请日：2004-05-10
申请人： Diadexus, Inc.
发明人： PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30
CPC分类号： C07K16/3069 , A61K47/6855 , A61K47/6869 , C07K16/3015 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.

16. 发明公开

EP2104513A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物及其使用方法
公开(公告)号：EP2104513A2
公开(公告)日：2009-09-30
申请号：EP07868854.6
申请日：2007-11-27
申请人： Diadexus, Inc.
发明人： PAPKOFF, Jackie , DIEDRICH, Gundo , LIU, Shu-Hui , NOWAKOWSKI, Agnes
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.

17. 发明公开

EP1633784A2 OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE 有权
标题翻译： OVR110抗体组合物和使用方法
公开(公告)号：EP1633784A2
公开(公告)日：2006-03-15
申请号：EP04760956.5
申请日：2004-05-10
申请人： Diadexus, Inc.
发明人： PILKINGTON, Glenn , KELLER, Gilbert-Andre , LI, Wenlu , CORRAL, Laura , SIMON, Iris , PAPKOFF, Jackie
IPC分类号： C07K16/00 , C12P21/08 , G01N33/53 , G01N33/48 , A61K39/395 , A61K39/44
CPC分类号： C07K16/3069 , A61K47/6855 , A61K47/6869 , C07K16/3015 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译：本发明提供了分离的抗卵巢癌，胰腺癌，肺癌或乳腺癌抗原（Ovr110）抗体，其在体内与哺乳动物的Ovr110结合后内化。本发明还包括包含抗Ovr110抗体和载体的组合物。这些组合物可以在制造物品或套件中提供。本发明的另一个方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供了产生抗Ovr110抗体的细胞。本发明包括生产抗Ovr110抗体的方法。本发明的其他方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，所述方法包括施用治疗有效量的抗Ovr110抗体给哺乳动物。

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