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11. 发明申请

WO2009061378A3 VARIANTS OF BACILLUS LICHENIFORMIS ALPHA-AMYLASE WITH INCREASED THERMOSTABILITY AND/OR DECREASED CALCIUM DEPENDENCE 审中-公开
标题翻译： BACILLUS LICHENIFORMIS ALPHA-AMYLASE具有增加的热稳定性和/或降低钙依赖性的变体
公开(公告)号：WO2009061378A3
公开(公告)日：2009-06-25
申请号：PCT/US2008012410
申请日：2008-11-03
申请人： DANISCO US INC GENENCOR DIV , SHAW ANDREW , RAMER SANDRA , POWER SCOTT D , SHETTY JAYARAMA K , PAULSON BRADLEY , SHARMA VIVEK , WARD DONALD
发明人： SHAW ANDREW , RAMER SANDRA , POWER SCOTT D , SHETTY JAYARAMA K , PAULSON BRADLEY , SHARMA VIVEK , WARD DONALD
IPC分类号： C11D3/386 , C12N9/28 , C12N15/75 , D06L4/40
CPC分类号： C11D3/38609 , C11D3/38618 , C12N9/2417 , Y02E50/16 , Y02E50/17
摘要： Variants of B. licheniformis alpha-amylase exhibit improved enzymatic performance, including increased themostability and reduced calcium dependence. Compositions comprising the variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal. The nucleic acids encoding the variants are also disclosed.
摘要翻译：地衣芽孢杆菌α-淀粉酶的变体表现出改善的酶性能，包括增加其稳定性和减少的钙依赖性。包含变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洗，洗衣，纺织品退浆，烘烤和生物膜除去的方法。还公开了编码变体的核酸。

12. 发明申请

WO2009061380A2 VARIANTS OF BACILLUS sp. TS-23 ALPHA-AMYLASE WITH ALTERED PROPERTIES 审中-公开
标题翻译： BACILLUS sp。具有改性特性的TS-23 ALPHA-AMYLASE
公开(公告)号：WO2009061380A2
公开(公告)日：2009-05-14
申请号：PCT/US2008012412
申请日：2008-11-03
申请人： DANISCO US INC GENENCOR DIV , SHAW ANDREW , RAMER SANDRA , POWER SCOTT D , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN E , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMAN CASPER , WEYLER WALTER , KRAGH KARSTEN M , GOYAL MANSI , GRAYCAR THOMAS , HUANG VICTORIA
发明人： SHAW ANDREW , RAMER SANDRA , POWER SCOTT D , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN E , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMAN CASPER , WEYLER WALTER , KRAGH KARSTEN M , GOYAL MANSI , GRAYCAR THOMAS , HUANG VICTORIA
IPC分类号： C11D3/386 , C12N9/28 , C12N15/75
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417
摘要： Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing / cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
摘要翻译：芽孢杆菌的变种 TS-23菌株α-淀粉酶表现出改善的酶性能，包括增加其稳定性，降低钙依赖性，提高洗涤/清洁性能和烘烤能力。包含这些变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洗，洗衣，纺织品退浆，烘烤和生物膜除去的方法。

13. 发明申请

WO2009134670A3 NEW CHIMERIC ALPHA-AMYLASE VARIANTS 审中-公开
标题翻译：新的二甲基氨基酸变体
公开(公告)号：WO2009134670A3
公开(公告)日：2010-04-15
申请号：PCT/US2009041498
申请日：2009-04-23
申请人： DANISCO US INC GENENCOR DIV , POWER SCOTT D , SHAW ANDREW
发明人： POWER SCOTT D , SHAW ANDREW
IPC分类号： C12N15/62 , A23L29/00 , A23L29/20 , C07K14/00 , C12N5/00 , C12N15/00
CPC分类号： C12N9/96 , A23L29/06 , C11D3/38618 , C12N9/2417 , C12P19/14 , Y02E50/17
摘要： Chimeric alpha amylases having the characteristics of high thermostability and good performance in starch degradation, especially high-temperature liquefaction processes, are provided. The alpha-amylases are chimeras of AmyL and AmyS enzymes, and are useful in starch degradation processes. Methods of making the chimeric enzymes, and methods of using the chimeric alpha-amylases for liquefaction, cleaning starch residue from a surface, and treating woven material to remove coatings. Kits for practicing the methods are provided. Polynucleotides encoding the chimeric amylases, vectors, and expression hosts also are provided.
摘要翻译：提供了具有高淀粉降解特性，特别是高温液化工艺的高热稳定性和良好性能的嵌合α淀粉酶。 α-淀粉酶是AmyL和AmyS酶的嵌合体，并且可用于淀粉降解过程。制备嵌合酶的方法，以及使用嵌合α-淀粉酶液化的方法，从表面清洗淀粉残渣，以及处理织造材料以除去涂层。提供实践方法的工具包。还提供了编码嵌合淀粉酶，载体和表达宿主的多核苷酸。

14. 发明申请

WO2009061380A4 VARIANTS OF BACILLUS sup. TS-23 ALPHA-AMYLASE WITH ALTERED PROPERTIES 审中-公开
标题翻译： BACILLUS的变种sup。具有改性特性的TS-23 ALPHA-AMYLASE
公开(公告)号：WO2009061380A4
公开(公告)日：2009-11-05
申请号：PCT/US2008012412
申请日：2008-11-03
申请人： DANISCO US INC GENENCOR DIV , SHAW ANDREW , RAMER SANDRA , POWER SCOTT D , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN E , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMAN CASPER , WEYLER WALTER , KRAGH KARSTEN M , GOYAL MANSI , GRAYCAR THOMAS , HUANG VICTORIA
发明人： SHAW ANDREW , RAMER SANDRA , POWER SCOTT D , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN E , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMAN CASPER , WEYLER WALTER , KRAGH KARSTEN M , GOYAL MANSI , GRAYCAR THOMAS , HUANG VICTORIA
IPC分类号： C11D3/386 , C12N9/28 , C12N15/75
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417
摘要： Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing / cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
摘要翻译：芽孢杆菌的变种 TS-23菌株α-淀粉酶表现出改善的酶性能，包括增加其稳定性，降低钙依赖性，提高洗涤/清洁性能和烘烤能力。包含这些变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洗，洗衣，纺织品退浆，烘烤和生物膜除去的方法。

15. 发明专利

JP2014221074A ポリペプチド审中-公开
标题翻译：多肽
公开(公告)号：JP2014221074A
公开(公告)日：2014-11-27
申请号：JP2014152584
申请日：2014-07-28
申请人：デュポンニュートリションバイオサイエンシーズエーピーエス , Dupont Nutrition Biosciences Aps , デュポンニュートリションバイオサイエンシーズエーピーエス , ダニスコ・ユーエス・インコーポレイテッドDanisco US Inc. , Danisco Us Inc , ダニスコ・ユーエス・インコーポレイテッドDanisco US Inc.
发明人： BERG CASPER TUNE , DERKX PATRICK M F , FIORESI CAROL , GERRITSE GIJSBERT , KELLET-SMITH ANJA HEMMINGEN , KRAGH KARSTEN MATHIAS , LIU WEI , SHAW ANDREW , SOERENSEN BO SPANGE , THOUDAHL CHARLOTTE REFDAHL
IPC分类号： C12N15/09 , A21D2/26 , A23K1/16 , A23K1/165 , A23L1/30 , C07K14/21 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/26
CPC分类号： C12Y302/0106 , A21D8/042 , A23K20/189 , A23L7/107 , A23L29/35 , A23V2002/00 , C12N9/2417 , A23V2300/21
摘要：【課題】経時変化に伴い澱粉の顆粒中に生じるアミロペプチンの結晶化に伴う、パンの硬化を防止する、ポリペプチド(詳細にはアミラーゼポリペプチド)及びこれらをコードする核酸、並びに食品を製造する際の非マルトース生成エキソアミラーゼとしてのそれらの使用を提供。【解決手段】非マルトース生成エキソアミラーゼ活性を有する親ポリペプチドから誘導可能なPS4改変体ポリペプチドであって、Pseudomonas saccharophiliaエキソアミラーゼの特定の配列の位置番号、121、161、223、146、157、158、198、229、303、309、316、353、26、70、145、188、272、339からなる群から選択される1つ以上の位置でのアミノ酸突然変異を含むPS4改変体ポリペプチド。【選択図】なし
摘要翻译：要解决的问题：提供一种防止由于淀粉颗粒随时间产生的支链淀粉结晶而导致的面包硬化的多肽（特别是淀粉酶多肽），也提供编码它们的核酸，并且其用作非产麦芽糖内切淀粉酶食品制造。解决方案：公开了可衍生自具有非麦芽糖脱色酶活性的亲本多肽的PS4变体多肽，其在选自以下的一个或多个位置具有氨基酸突变：121,161,223,146,157,158 ，198,229,303,306,309,316,353,26,70014,188,272和339，参考规定的糖酵母假单胞菌素外切酶序列的位置编号。

16. 发明申请

WO2008153934A3 METHODS FOR IMPROVING PROTEIN PERFORMANCE 审中-公开
标题翻译：改善蛋白质性能的方法
公开(公告)号：WO2008153934A3
公开(公告)日：2009-02-05
申请号：PCT/US2008007113
申请日：2008-06-06
申请人： DANISCO US INC GENENCOR DIV , AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JR JAMES T , SHAW ANDREW
发明人： AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JR JAMES T , SHAW ANDREW
IPC分类号： C12N15/10 , C12N15/01 , C12N15/52
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681 , C12N9/2411 , C12N9/2417 , C12N15/1034 , C12Y302/01001 , C12Y304/21062
摘要： The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes {e.g., metalloproteases or serine proteases) to obtain enzyme variants that demonstrate improved performance in detergent formulations as compared to the starting or parent enzyme.
摘要翻译：本发明提供了在某些感兴趣的环境条件下工程化蛋白质以优化其性能的方法。在一些实施方案中，本发明提供了工程化酶以在特定环境条件下优化其催化活性的方法。在一些优选的实施方案中，本发明提供用于改变酶（例如金属蛋白酶或丝氨酸蛋白酶）的净表面电荷和/或表面电荷分布的方法，以获得与起始或母体相比在洗涤剂配方中表现出改善的性能的酶变体酶。

17. 发明申请

WO2008153935A2 METHODS FOR IMPROVING PROTEIN PROPERTIES 审中-公开
标题翻译：改善蛋白质性质的方法
公开(公告)号：WO2008153935A2
公开(公告)日：2008-12-18
申请号：PCT/US2008007114
申请日：2008-06-06
申请人： DANISCO US INC GENENCOR DIV , AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JR JAMES T , SHAW ANDREW
发明人： AEHLE WOLFGANG , CASCAO-PEREIRA LUIS GUSTAVO , KELLIS JAMES T JR , SHAW ANDREW
IPC分类号： C07K14/435
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681 , C12N9/2411 , C12N9/2417 , C12N15/1034 , C12Y302/01001 , C12Y304/21062
摘要： The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity and/or stability under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their storage stability, particularly under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes (e.g., metalloproteases) to obtain enzyme variants that demonstrate improved performance and/or stability in detergent formulations as compared to the starting or parent enzyme.
摘要翻译：本发明提供了在某些感兴趣的环境条件下工程化蛋白质以优化其性能的方法。在一些实施方案中，本发明提供了工程化酶以在特定环境条件下优化其催化活性的方法。在一些优选实施方案中，本发明提供了工程化酶以在不利的环境条件下优化其催化活性和/或稳定性的方法。在一些优选的实施方案中，本发明提供了工程化酶优化其储存稳定性的方法，特别是在不利的环境条件下。在一些优选的实施方案中，本发明提供了用于改变酶（例如金属蛋白酶）的净表面电荷和/或表面电荷分布以获得酶变体的方法，所述酶变体与洗涤剂配方相比起始或以后可以改善洗涤剂配方的性能和/或稳定性亲本酶。

18. 发明专利

JP2012070751A Polypeptide 有权
标题翻译：多肽
公开(公告)号：JP2012070751A
公开(公告)日：2012-04-12
申请号：JP2011258176
申请日：2011-11-25
申请人： Danisco As , Danisco Us Inc , ダニスコエイ/エス , ダニスコ・ユーエス・インコーポレイテッドDanisco US Inc.
发明人： BERG CASPER TUNE , DERKX PATRICK M F , FIORESI CAROL , GERRITSE GIJSBERT , KELLET-SMITH ANJA HEMMINGEN , KRAGH KARSTEN MATHIAS , LIU WEI , SHAW ANDREW , SOERENSEN BO SPANGE , THOUDAHL CHARLOTTE REFDAHL
IPC分类号： C12N15/09 , A21D2/26 , A21D13/00 , A23K1/16 , A23L1/03 , A23L1/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/26
CPC分类号： C12Y302/0106 , A21D8/042 , A23K20/189 , A23L7/107 , A23L29/35 , A23V2002/00 , C12N9/2417 , A23V2300/21
摘要： PROBLEM TO BE SOLVED: To provide polypeptides, especially amylase polypeptides, and nucleic acids encoding these, and their uses as non-maltogenic exoamylases in producing food products.SOLUTION: A PS4 variant polypeptide derivable from a parent polypeptide having non-maltogenic exoamylase activity comprises an amino acid mutation at one or more positions selected from the group consisting of 121, 161, 223, 146, 157, 158, 198, 229, 303, 309, 316, 353, 26, 70, 145, 188, 272 and 339, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence having an amino acid sequence comprising a specific sequence.
摘要翻译：待解决的问题：提供多肽，特别是淀粉酶多肽，以及编码这些多肽的核酸，以及它们在制备食品中作为非麦芽糖外消旋酶的用途。解决方案：可衍生自具有非麦芽糖胞外淀粉酶活性的亲本多肽的PS4变体多肽包含在选自以下的一个或多个位置的氨基酸突变：121,161,223,146,157,158,198， 229,303,309,316,353,26,70,205,188,272和339，参考具有包含特定序列的氨基酸序列的假单胞菌属嗜酸芽胞弧菌外消旋酶序列的位置编号。版权所有（C）2012，JPO＆INPIT

19. 发明专利

JP2013078334A Production of thermolysin and variant thereof and use in liquid detergent 有权
标题翻译：生产热变性蛋白酶及其变体，并用于液体洗涤剂
公开(公告)号：JP2013078334A
公开(公告)日：2013-05-02
申请号：JP2012278814
申请日：2012-12-21
申请人： Danisco Us Inc , ダニスコ・ユーエス・インク
发明人： ESTELL DAVID A , HOMMES RONALDUS W J , LIU AMY D , SHAW ANDREW
IPC分类号： C12N15/09 , C11D3/386 , C11D7/42 , C11D17/08 , C12N9/52
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38618 , C11D3/38636 , C12Y304/24027
摘要： PROBLEM TO BE SOLVED: To provide methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved stability and/or catalytic activity.SOLUTION: There is provided an isolated thermolysin variant that is a variant of Geobacillus caldoproteolyticus or Geobacillus stearothermophilus. The thermolysin can be used in cleaning and other applications including detergents. The present invention provides the methods and compositions comprising thermolysin formulated and engineered to resist detergent-induced inactivation.

20. 发明专利

JP2013135683A Alpha-amylase with altered property 有权
标题翻译：具有改性物质的ALPHA-AMYLASE
公开(公告)号：JP2013135683A
公开(公告)日：2013-07-11
申请号：JP2013031943
申请日：2013-02-21
申请人： Danisco Us Inc , ダニスコ・ユーエス・インク
发明人： SHAW ANDREW , RAMER SANDRA , POWER SCOTT D , SHETTY JAYARAMA K , PAULSON BRADLEY , SHARMA VIVEK , WARD DONALD , CASCAO-PEREIRA LUIS G , KELLIS JAMES T
IPC分类号： C12N15/09 , C12N1/21 , C12N9/28 , C12P19/14
CPC分类号： C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
摘要： PROBLEM TO BE SOLVED: To provide improved alpha-amylase variants suitable for specific uses, such as starch liquefaction and textile desizing agent.SOLUTION: There are provided: a composition comprising variants of alpha-amylase having at least 95% homology to an amino acid sequence of a parent AmyS-like alpha-amylase, and altered properties having a substitution at a specified amino acid position and having a melting point higher by 5-10°C relative to a parent AmyS-like alpha-amylase; a composition comprising other enzymes such as phytase in the composition; and a method for using the composition and a kit by the composition.
摘要翻译：要解决的问题：提供适合于特定用途的改进的α-淀粉酶变体，例如淀粉液化和纺织品脱浆剂。溶液：提供：包含与氨基酸具有至少95％同源性的α-淀粉酶变体的组合物亲本AmyS样α-淀粉酶的序列，以及相对于母体AmyS样α-淀粉酶在特定氨基酸位置具有取代并具有高于5-10℃的熔点的改变的性质; 组合物中包含其它酶如植酸酶的组合物; 以及通过该组合物使用该组合物和试剂盒的方法。

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