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11. 发明授权

US08420605B2 Hydrogel compositions 有权
标题翻译：水凝胶组合物
公开(公告)号：US08420605B2
公开(公告)日：2013-04-16
申请号：US11470962
申请日：2006-09-07
申请人： Rein Vincent Ulijn , Vineetha Jayawarna , Andrew Smith , Julie Elizabeth Gough
发明人： Rein Vincent Ulijn , Vineetha Jayawarna , Andrew Smith , Julie Elizabeth Gough
IPC分类号： A61K38/08 , A61K38/06 , A61K38/07 , A61K38/05
CPC分类号： A61K38/07 , A61K9/0014 , A61K38/05 , A61K38/06 , A61K38/08 , A61K47/42
摘要： Hydrogel compositions comprise an aqueous dispersion phase and a plurality of peptides, or derivatives, or analogues thereof. Each peptide comprises at least two amino acid residues and an aromatic stacking ligand and the hydrogel is formed by self-assembly of said peptides in said aqueous dispersion medium. The aqueous dispersion phase is physiologically acceptable and may have a pH of 6 to 8, as may the hydrogel itself. The hydrogel may be used for cell culture or for treatment of medical conditions characterized by tissue loss/damage.
摘要翻译：水凝胶组合物包含水性分散相和多种肽或其衍生物或类似物。每个肽包含至少两个氨基酸残基和芳族叠层配体，并且通过所述肽在所述水性分散介质中的自组装形成所述水凝胶。水分散相在生理上是可接受的，并且可以具有6至8的pH，如水凝胶本身。水凝胶可用于细胞培养或用于治疗以组织损失/损伤为特征的医学病症。

12. 发明申请

US20120256920A1 System and Method for Fusing Computer Assisted Detection in a Multi-Modality, Multi-Dimensional Breast Imaging Environment 审中-公开
标题翻译：多模式多维乳腺成像环境中计算机辅助检测融合的系统与方法
公开(公告)号：US20120256920A1
公开(公告)日：2012-10-11
申请号：US13440219
申请日：2012-04-05
申请人： Julian Marshall , John LaViola , Andrew Smith
发明人： Julian Marshall , John LaViola , Andrew Smith
IPC分类号： G06T17/00
CPC分类号： A61B6/12 , A61B6/025 , A61B6/0414 , A61B6/4417 , A61B6/463 , A61B6/466 , A61B6/469 , A61B6/502 , A61B6/5247 , A61B6/563 , A61B6/566 , A61B8/0825 , A61B8/0841 , A61B8/0866 , A61B8/4254 , A61B8/4263 , A61B8/466 , A61B8/469 , A61B8/483 , A61B8/486 , A61B8/5261
摘要： A multi-modality cancer screening and diagnosis system fuses CAD information obtained by imaging an immobilized patient using multiple different image acquisition systems to provide a single fused CAD data set. Combining the CAD results of multiple modalities into a single, rich, data set allows the strengths of each imaging modality to be leveraged to improve the sensitivity and specificity of breast cancer diagnosis. The CAD results may be used, together with fused image data, to train a CAD algorithm which may be used to directly process a fused multi-mode image data set.
摘要翻译：多模式癌症筛查和诊断系统通过使用多个不同的图像采集系统对固定的患者进行成像而获得的CAD信息融合以提供单个融合的CAD数据集。将多种模态的CAD结果结合到单一，丰富的数据集中，可以利用每种成像模式的优势来提高乳腺癌诊断的敏感性和特异性。可以将CAD结果与融合图像数据一起使用以训练可用于直接处理融合多模式图像数据集的CAD算法。

13. 发明申请

US20120219111A1 INTEGRATED MULTI-MODE MAMMOGRAPHY/TOMOSYNTHESIS X-RAY SYSTEM AND METHOD 有权
标题翻译：综合多模式人机界面/ TOMOSYNTHESIS X射线系统及方法
公开(公告)号：US20120219111A1
公开(公告)日：2012-08-30
申请号：US13462342
申请日：2012-05-02
申请人： Kenneth Defreitas , Tom Farbizio , Baori Ren , Chris Ruth , Ian Shaw , Andrew Smith , Jay Stein
发明人： Kenneth Defreitas , Tom Farbizio , Baori Ren , Chris Ruth , Ian Shaw , Andrew Smith , Jay Stein
IPC分类号： A61B6/04
CPC分类号： A61B6/4417 , A61B6/025 , A61B6/107 , A61B6/4291 , A61B6/4452 , A61B6/482 , A61B6/502 , G06T2207/30068
摘要： A system for multi-mode breast x-ray imaging which comprises a compression arm assembly for compressing and immobilizing a breast for x-ray imaging, an x-ray tube assembly, and an x-ray image receptor is provided. The system is configured for a plurality of imaging protocols and modes.
摘要翻译：提供了一种用于多模式乳房x射线成像的系统，其包括用于压缩和固定用于X射线成像的乳房的压缩臂组件，X射线管组件和x射线图像接收器。该系统被配置用于多个成像协议和模式。

14. 发明申请

US20120066672A1 Systems and Methods for Implementing Upgradeable Subscriber-Controlled Managed Package Components in a Multi-Tenant Environment 审中-公开
标题翻译：在多租户环境中实现可升级的订户控制的管理包组件的系统和方法
公开(公告)号：US20120066672A1
公开(公告)日：2012-03-15
申请号：US13048516
申请日：2011-03-15
申请人： Andrew Smith , Danil Dvinov , Timothy P. Kral
发明人： Andrew Smith , Danil Dvinov , Timothy P. Kral
IPC分类号： G06F9/44
CPC分类号： G06F8/65
摘要： Systems and methods for installing and upgrading application packages to an application platform include mechanisms for allowing subscribers to make changes to components contained in managed installed packages, while allowing for upgrades of such components. The mechanisms give the subscriber the choice of using developer provided components (the ones that belong to the original package), or creating their own. This also allows developers to package the components, knowing that subscribers won't be limited to using only what's packaged, but rather will be able to make changes if they wish. Information about multiple versions of the same installed managed component is stored and managed with different ownership (e.g., one version belongs to a developer, the other to the subscriber) while in the context of a subscriber organization.
摘要翻译：用于将应用程序包安装和升级到应用程序平台的系统和方法包括允许用户对包含在受管理的安装包中的组件进行更改的机制，同时允许升级这些组件。这些机制使用户可以选择使用开发人员提供的组件（属于原始软件包的组件）或创建自己的组件。这也允许开发人员打包组件，知道用户不会被限制为仅使用打包的内容，而是可以根据需要进行更改。关于相同安装的被管理组件的多个版本的信息在订户组织的上下文中以不同的所有权存储和管理（例如，一个版本属于开发者，另一个版本属于订户）。

15. 发明申请

US20110296380A1 METHODS AND SYSTEMS FOR PRESENTING DIFFERENT VERSIONS OF AN APPLICATION 有权
标题翻译：用于呈现应用程序不同版本的方法和系统
公开(公告)号：US20110296380A1
公开(公告)日：2011-12-01
申请号：US12971320
申请日：2010-12-17
申请人： Danil Dvinov , Andrew Smith
发明人： Danil Dvinov , Andrew Smith
IPC分类号： G06F9/44
CPC分类号： G06F8/71
摘要： Methods and systems for presenting different versions of an application are described. In one example, a selection of a version of application code is received. Such a selection may include a simultaneous selection of all versions. Information about the selected version is retrieved. A description of features contained within the selected version is presented and then a version summary for each listed feature is displayed, together with the description of features, to indicate the versions of the application code that contain the respective feature.
摘要翻译：描述用于呈现应用的不同版本的方法和系统。在一个示例中，接收到应用代码版本的选择。这样的选择可以包括同时选择所有版本。检索有关所选版本的信息。将介绍所选版本中包含的功能，然后显示每个列出的功能的版本摘要以及功能说明，以指示包含相应功能的应用程序代码的版本。

16. 发明申请

US20110190302A1 Aryl-Phenyl-Sulfonamide-Phenylene Compounds and Their Use 有权
标题翻译：芳基 - 苯基磺酰胺 - 亚苯基化合物及其用途
公开(公告)号：US20110190302A1
公开(公告)日：2011-08-04
申请号：US13063950
申请日：2009-09-18
申请人： Iain Robert Greig , Rose Mary Sheridan , Raymond Fisher , Matthew John Tozer , Juha Andrew Clase , Andrew Smith , Andrew Robert Tuffnell , Robert Jurgen Van 't Hof
发明人： Iain Robert Greig , Rose Mary Sheridan , Raymond Fisher , Matthew John Tozer , Juha Andrew Clase , Andrew Smith , Andrew Robert Tuffnell , Robert Jurgen Van 't Hof
IPC分类号： A61K31/5375 , C07C311/21 , C07D303/36 , C07D295/135 , C07C255/58 , C07D263/14 , A61K31/18 , A61K31/245 , A61K31/196 , A61K31/336 , A61K31/421 , A61P29/00 , A61P19/02 , A61P17/06 , A61P11/00 , A61P9/10 , A61P35/00 , A61P35/02 , A61P19/08 , A61P19/10
CPC分类号： C07D303/36 , C07C311/21 , C07C311/39 , C07C2601/02 , C07D239/26 , C07D239/30 , C07D263/20 , C07D295/135
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-phenylene compounds of the following formula (I) (collectively referred to herein as “APSAP compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及下列通式（I）的某些芳基 - 苯基 - 亚磺酰氨基 - 亚苯基化合物（本文统称为“APSAP化合物”）。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内在治疗例如炎症和/或关节破坏和/或骨丢失中的用途; 由免疫系统的过度和/或不适当和/或延长的激活介导的疾病; 炎性和自身免疫性疾病，例如类风湿性关节炎，牛皮癣，牛皮癣关节炎，慢性阻塞性肺病（COPD），动脉粥样硬化，炎性肠病，强直性脊柱炎等; 与骨丢失相关的疾病，例如与类风湿性关节炎中的过度破骨细胞活性相关的骨丢失，骨质疏松症，癌症相关的骨病，佩吉特氏病等; 和癌症，如血液恶性肿瘤，实体瘤等。

17. 发明申请

US20110172189A1 Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use 有权
标题翻译：芳基 - 苯基磺酰氨基 - 环烷基化合物及其用途
公开(公告)号：US20110172189A1
公开(公告)日：2011-07-14
申请号：US13063956
申请日：2009-09-18
申请人： Iain Robert Greig , Rose Mary Sheridan , Raymond Fisher , Matthew John Tozer , Juha Andrew Clase , Andrew Smith , Andrew Robert Tuffnell , Robert Jurgen Van 't Hof
发明人： Iain Robert Greig , Rose Mary Sheridan , Raymond Fisher , Matthew John Tozer , Juha Andrew Clase , Andrew Smith , Andrew Robert Tuffnell , Robert Jurgen Van 't Hof
IPC分类号： A61K31/69 , C07C311/20 , A61K31/18 , C07D239/30 , A61K31/505 , C07D213/61 , A61K31/4418 , C07F5/02 , C07D265/30 , A61K31/5375 , C07D207/04 , A61K31/40 , A61K31/235 , A61P35/00 , A61P19/00 , A61P1/00 , A61P29/00 , A61P7/00 , A61P17/06
CPC分类号： A61K31/18 , A61K31/44 , A61K31/4418 , A61K31/505 , C07C311/20 , C07C311/28 , C07C311/29 , C07D207/04 , C07D213/34 , C07D213/52 , C07D213/61 , C07D239/26 , C07D239/30 , C07D295/135
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc. Formula (I).
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及下列通式的某些芳基 - 苯基 - 亚磺酰氨基 - 环烷基化合物（在本文中统称为“APSAC化合物”）。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内在治疗例如炎症和/或关节破坏和/或骨丢失中的用途; 由免疫系统的过度和/或不适当和/或延长的激活介导的疾病; 炎性和自身免疫性疾病，例如类风湿性关节炎，牛皮癣，牛皮癣关节炎，慢性阻塞性肺病（COPD），动脉粥样硬化，炎性肠病，强直性脊柱炎等; 与骨丢失相关的疾病，例如与类风湿性关节炎中的过度破骨细胞活性相关的骨丢失，骨质疏松症，癌症相关的骨病，佩吉特氏病等; 和癌症，如血液恶性肿瘤，实体肿瘤等。式（I）。

18. 发明授权

US07909222B2 Endoscopic stapling devices and methods 有权
公开(公告)号：US07909222B2
公开(公告)日：2011-03-22
申请号：US12052997
申请日：2008-03-21
申请人： David Cole , Andrew Smith
发明人： David Cole , Andrew Smith
IPC分类号： A61B17/068
CPC分类号： A61B17/072 , A61B17/064 , A61B17/115 , A61B17/32053 , A61B2017/00539 , A61B2017/00818 , A61B2017/07271 , A61B2017/306 , A61F5/0013 , A61F5/0083
摘要： Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.

19. 发明申请

US20100299664A1 SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR PUSHING AN APPLICATION UPDATE BETWEEN TENANTS OF A MULTI-TENANT ON-DEMAND DATABASE SERVICE 审中-公开
标题翻译：系统，方法和计算机程序产品，用于推动多重使用需求数据库服务的收入之间的应用程序更新
公开(公告)号：US20100299664A1
公开(公告)日：2010-11-25
申请号：US12784666
申请日：2010-05-21
申请人： James Taylor , Andrew Smith , Craig Weissman
发明人： James Taylor , Andrew Smith , Craig Weissman
IPC分类号： G06F9/44
CPC分类号： G06F16/2379 , G06F8/65
摘要： In accordance with embodiments, there are provided mechanisms and methods for pushing an application update between tenants of a multi-tenant on-demand database service. These mechanisms and methods for pushing an application update between tenants of a multi-tenant on-demand database service can enable tenants providing the application update to force instances of the application utilized by other tenants to be updated. This may allow the tenants providing the application update to ensure that instances of the application utilized by other tenants are updated.
摘要翻译：根据实施例，提供了用于在多租户按需数据库服务的租户之间推送应用更新的机制和方法。用于在多租户点播数据库服务的租户之间推送应用更新的这些机制和方法可以使得提供应用更新的租户能够迫使由其他租户使用的应用的实例被更新。这可以允许提供应用程序更新的租户确保更新其他租户使用的应用程序的实例。

20. 发明申请

US20100299663A1 SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR VERSIONING AND DEPRECATION OF COMPONENTS OF AN APPLICATION 失效
标题翻译：系统，方法和计算机程序产品用于应用程序的组件的编辑和删除
公开(公告)号：US20100299663A1
公开(公告)日：2010-11-25
申请号：US12784668
申请日：2010-05-21
申请人： Craig Weissman , Andrew Smith
发明人： Craig Weissman , Andrew Smith
IPC分类号： G06F9/44
CPC分类号： G06F8/71
摘要： In accordance with embodiments, there are provided mechanisms and methods for versioning components of an application. These mechanisms and methods for versioning components of an application can ensure that an updated application maintains backwards compatibility, such that the application developer may maintain a single application while supporting multiple prior versions of the application.
摘要翻译：根据实施例，提供了用于对应用的组件进行版本化的机制和方法。用于版本化应用程序组件的这些机制和方法可以确保更新的应用程序维护向后兼容性，使得应用程序开发人员可以在支持应用程序的多个先前版本的同时维护单个应用程序。

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