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11. 发明授权

US08586707B2 Stapled peptides and method of synthesis 有权
标题翻译：装订肽和合成方法
公开(公告)号：US08586707B2
公开(公告)日：2013-11-19
申请号：US12561107
申请日：2009-09-16
申请人： Qing Lin , Mike Madden
发明人： Qing Lin , Mike Madden
IPC分类号： A61K38/00 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K1/045 , C07K1/107 , C07K1/1136
摘要： A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.
摘要翻译：一种制备缝合肽的方法。根据光化学方法[3 + 2]环加成反应制备包装螺旋缝合肽的缝合肽。螺旋缝合肽表现出增加的螺旋度，热稳定性和细胞渗透性。

12. 发明申请

US20130014289A1 GENES CONFERRING STRESS TOLERANCE IN PLANTS AND USES THEREOF 审中-公开
标题翻译：基因在植物中的应变耐力及其用途
公开(公告)号：US20130014289A1
公开(公告)日：2013-01-10
申请号：US13580935
申请日：2010-02-24
申请人： Jinsong Zhang , Shouyi Chen , Canfang Niu , Biao Ma , Wanke Zhang , Qing Lin , Sijie He
发明人： Jinsong Zhang , Shouyi Chen , Canfang Niu , Biao Ma , Wanke Zhang , Qing Lin , Sijie He
IPC分类号： A01H5/00 , A01H1/02 , A01H5/10 , C12N15/82
CPC分类号： C07K14/415 , C12N15/8271
摘要： Compositions and methods for imparting stress tolerance to plants using WRKY nucleic acid and polypeptides.
摘要翻译：使用WRKY核酸和多肽赋予植物胁迫耐受性的组合物和方法。

13. 发明申请

US20080138339A1 Anti human ovarian cancer-anti CD3 bispecific antibody 审中-公开
标题翻译：抗人卵巢癌抗CD3双特异性抗体
公开(公告)号：US20080138339A1
公开(公告)日：2008-06-12
申请号：US11895207
申请日：2007-08-22
申请人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
发明人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
IPC分类号： A61K39/395 , C12N15/11 , C07K16/18 , A61P43/00 , C12N15/00 , C12N1/20
CPC分类号： C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
摘要翻译：本发明提供了抗卵巢癌双特异性抗体。所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或其Fab片段，单CDR抗体或scFv。本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。

14. 发明申请

US20130087270A1 Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS 有权
标题翻译：聚乙二醇/聚（对苯二甲酸丁二醇酯）共聚物涂层装置，包括EVEROLIMUS
公开(公告)号：US20130087270A1
公开(公告)日：2013-04-11
申请号：US10807546
申请日：2004-03-22
申请人： Syed Faiyaz Hossainy , Yiwen Tang , Homayon Askaryar , Qing Lin , Thierry Glauser
发明人： Syed Faiyaz Hossainy , Yiwen Tang , Homayon Askaryar , Qing Lin , Thierry Glauser
IPC分类号： A61F2/82
CPC分类号： B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
摘要： Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
摘要翻译：提供了在可植入装置上制备涂层的方法，例如药物洗脱支架，其包含聚合物和缓慢溶解多晶型物质中的药物的纳米或微粒，通过使用该涂层的方法和方法制备的可植入装置。

15. 发明申请

US20080305519A1 Biochemical method for specific protein labeling 审中-公开
标题翻译：特异性蛋白标记的生物化学方法
公开(公告)号：US20080305519A1
公开(公告)日：2008-12-11
申请号：US11709949
申请日：2007-02-23
申请人： Qing Lin , Michael M. Madden
发明人： Qing Lin , Michael M. Madden
IPC分类号： C12P21/06 , C07K7/00 , C07D235/02
CPC分类号： C07K5/06026 , C07K5/0817 , C07K5/101 , C07K7/06
摘要： An improved method for protein labeling comprising the steps of providing a synthetic small molecule tag, providing a target protein to be tagged, providing at least two enzymes for catalyzing a conjugation reaction between the tag and the target protein, incubating the tag, the protein and the enzyme, and allowing the tag to conjugate to the target protein. The tag may embody at least one structural feature of an ubiquitin C-terminus, and the structural feature may comprise a recognition sequence that is recognizable by an ubiquitin activating enzyme.
摘要翻译：一种用于蛋白质标记的改进方法，包括提供合成小分子标签，提供待标记的靶蛋白的步骤，提供至少两种用于催化标签和靶蛋白之间的缀合反应的酶，孵育标签，蛋白质和酶，并使标签与靶蛋白结合。标签可以体现泛素C-末端的至少一个结构特征，并且结构特征可以包含可被泛素活化酶识别的识别序列。

16. 发明申请

US20050255115A1 Anti human ovarian cancer-anti cd3 bispecific antibody 失效
标题翻译：抗人卵巢癌抗CD3双特异性抗体
公开(公告)号：US20050255115A1
公开(公告)日：2005-11-17
申请号：US10478345
申请日：2002-05-23
申请人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
发明人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , C07K19/00 , C12N15/13 , C12N15/62 , C12N15/63 , C12P21/08 , G01N33/574 , C12N5/06
CPC分类号： C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
摘要翻译：本发明提供了抗卵巢癌双特异性抗体。所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或其Fab片段，单CDR抗体或scFv。本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。

17. 发明申请

US20050244467A1 Extended release biodegradable ocular implants 有权
标题翻译：延长释放生物降解性眼部植入物
公开(公告)号：US20050244467A1
公开(公告)日：2005-11-03
申请号：US10837355
申请日：2004-04-30
申请人： Thierry Nivaggioli , Jane Shiah , Qing Lin
发明人： Thierry Nivaggioli , Jane Shiah , Qing Lin
IPC分类号： A61K9/00 , A61K9/14 , A61K9/20 , A61K31/57 , A61F13/00
CPC分类号： A61K9/0051 , A61K9/204 , A61K31/57 , A61K31/573 , A61K47/34
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
摘要翻译：尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。植入物以治疗有效量提供活性剂的延长释放一段时间在50天至1年或更长时间之间。

18. 发明申请

US20080089228A1 Systems and Methods for Wireless Communications 有权
标题翻译：无线通信系统与方法
公开(公告)号：US20080089228A1
公开(公告)日：2008-04-17
申请号：US11680607
申请日：2007-02-28
申请人： Qing Lin , Bin Gan , Xiaoyun Jing
发明人： Qing Lin , Bin Gan , Xiaoyun Jing
IPC分类号： H04Q7/00
CPC分类号： H04L69/16 , H04L47/10 , H04L47/14 , H04L47/193 , H04L47/2441 , H04L47/2466 , H04L47/283 , H04L69/163 , H04W80/06
摘要： A method to improve TCP throughput by separating TCP acknowledgment flow from TCP normal data flow in a wireless communications environment. This method creates dedicated signaling air interface link and signaling A10 link for TCP acknowledgment flow and assigns a higher priority value to TOS field of IP packets encapsulating TCP acknowledgments than those encapsulating TCP normal data.
摘要翻译：一种通过在无线通信环境中将TCP确认流与TCP正常数据流分离来提高TCP吞吐量的方法。该方法创建用于TCP确认流的专用信令空中接口链路和信令A10链路，并且为封装TCP确认的IP分组的TOS字段的TOS字段分配比封装TCP普通数据的IP分组更高的优先级值。

19. 发明申请

US20070104000A1 Field programmable memory repair for eprom 审中-公开
标题翻译：用于eprom的现场可编程存储器修复
公开(公告)号：US20070104000A1
公开(公告)日：2007-05-10
申请号：US11589164
申请日：2006-10-30
申请人： Qing Lin , Kiran Dasoju
发明人： Qing Lin , Kiran Dasoju
IPC分类号： G11C29/00
CPC分类号： G11C29/027 , G11C29/72
摘要： The present invention according to certain embodiments is directed to a method, device and apparatus for repairing a plurality of memory locations. The present invention includes providing a plurality of memory locations, providing a plurality of fuses coupled to the memory locations and loading fuse data into a data register from a plurality of read-only memory (ROM) devices thereby creating loaded fuse data. The present invention also provides loading a programming sequence of the memory device, wherein the programming sequence includes a plurality of memory addresses, and reading the loaded fuse data from the fuse register to a plurality of memory locations corresponding to the plurality of memory addresses.
摘要翻译：根据某些实施例的本发明涉及用于修复多个存储器位置的方法，装置和装置。本发明包括提供多个存储器位置，提供耦合到存储器位置的多个熔丝，并将熔丝数据从多个只读存储器（ROM）器件加载到数据寄存器中，从而产生加载的熔丝数据。本发明还提供加载存储器件的编程序列，其中编程序列包括多个存储器地址，并将加载的熔丝数据从熔丝寄存器读取到对应于多个存储器地址的多个存储单元。

20. 发明授权

US09264373B2 Adaptive frame structure for TDD point-to-point wireless transmission 有权
标题翻译：用于TDD点对点无线传输的自适应帧结构
公开(公告)号：US09264373B2
公开(公告)日：2016-02-16
申请号：US11994491
申请日：2005-07-01
申请人： Lei Wan , Lars Robert Looström , Qing Lin
发明人： Lei Wan , Lars Robert Looström , Qing Lin
IPC分类号： H04J3/00 , H04L12/805 , H04J3/06 , H04L12/801 , H04L1/00
CPC分类号： H04L47/36 , H04J3/0682 , H04L1/0007 , H04L47/10
摘要： The present invention relates to an arrangement for point-to-point transmission over links between first and second link (end) terminals in a system implementing time division duplex (TDD) and wherein information is sent over the links in frames divided into time slots. It is adapted to determine the lengths of the frames on a per link basis using one or more link parameters, the frame length hence being variable.
摘要翻译：本发明涉及一种在实现时分双工（TDD）的系统中的第一和第二链路（终端）终端之间的链路上的点对点传输的装置，并且其中信息通过划分为时隙的帧中的链路发送。其适于使用一个或多个链路参数在每个链路的基础上确定帧的长度，因此帧长度是可变的。

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