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11. 发明授权

US5968928A Excitatory amino acid antagonists: fused-azacyclic quinoxalinediones and immunoassays thereof 失效
标题翻译：兴奋性氨基酸拮抗剂：融合 - 氮杂环喹诺酮和其免疫测定
公开(公告)号：US5968928A
公开(公告)日：1999-10-19
申请号：US909471
申请日：1997-08-11
申请人： Christopher Franklin Bigge , Gerald David Nordblom , Chung Stephen Yi
发明人： Christopher Franklin Bigge , Gerald David Nordblom , Chung Stephen Yi
IPC分类号： C07D471/04 , C07D519/00 , A61K31/495 , A61K31/55 , C07D487/14
CPC分类号： C07D471/04 , Y10S436/815
摘要： The invention discloses novel fused-azacylic quinoxalinediones. These compounds may be employed as excitatory amino acid antagonists and as analogs for use in immunological assays. The invention is also directed to both a radioimmunoassay and enzyme immunoassay for detecting and quantitating 1,4,7,8,9,10,-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione PNQX and analogs thereof.
摘要翻译：本发明公开了新型稠合氮酰喹啉喹啉。这些化合物可以用作兴奋性氨基酸拮抗剂和用作免疫测定中的类似物。本发明还涉及用于检测和定量1,4,7,8,9,10-六氢-9-甲基-6-硝基吡啶并[3,4-f] - 喹喔啉-2的放射免疫测定和酶免疫测定， 3-二酮PNQX及其类似物。

12. 发明授权

US5767119A Method of treating neurodegenerative diseases using an AMPA excitatory amino and an uricosuric agent 失效
标题翻译：使用AMPA兴奋性氨基和尿酸润滑剂治疗神经变性疾病的方法
公开(公告)号：US5767119A
公开(公告)日：1998-06-16
申请号：US775637
申请日：1996-12-31
申请人： Christopher Franklin Bigge , Graham Johnson , Charles Price Taylor, Jr. , Devin Franklin Welty
发明人： Christopher Franklin Bigge , Graham Johnson , Charles Price Taylor, Jr. , Devin Franklin Welty
IPC分类号： A61K31/19 , A61K31/47 , A61K31/495 , A61K31/675 , A61K45/00 , A61K45/06 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/28 , A61P43/00 , A61K31/195 , A61K31/50
CPC分类号： A61K31/675 , A61K31/47 , A61K31/495 , A61K45/06
摘要： The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.
摘要翻译：本发明是具有尿酸润滑剂如丙磺舒等的组合物和可用于治疗有利于用兴奋性氨基酸拮抗剂治疗影响的疾病的兴奋性氨基酸拮抗剂的药物组合物。

13. 发明授权

US06703391B2 Quinoxalinedione derivatives, their preparation and use 失效
标题翻译：喹喔啉二酮衍生物，其制备和用途
公开(公告)号：US06703391B2
公开(公告)日：2004-03-09
申请号：US08443507
申请日：1995-05-18
申请人： Christopher Franklin Bigge , Thomas Charles Malone , Frank Watjen
发明人： Christopher Franklin Bigge , Thomas Charles Malone , Frank Watjen
IPC分类号： C07D48704
CPC分类号： C07D471/04 , C07D217/04 , C07D487/04 , C07F9/6561
摘要： A compound having the formula or a pharmaceutically acceptable salt thereof wherein R is hydrogen or hydroxy; R1 is hydrogen, alkyl, arylalkyl, (CH2)nOH, or (CH2)nNR7R8; R5 and R6 are each independently hydrogen, halogen, NO2, CN, CF3, SO2NR7R8, PO3R9R10, alkyl, alkenyl, alkynyl, (CH2)nCONR7R8, (CH2)nCO2R10, NHCOR11, A is a ring formed by the following: a-NR12—CHR13—CHR14-b, a-CHR13—CHR14—NR12-b, a-CHR13—NR12—CHR14-b, a-CHR14—CH2—NR12—CHR13-b, a-CHR13—NR12—CH2—CHR14-b, a-CH2—CH2—CHR13—NR12-b, a-NR12—CHR13—CHR12—CH2—CH2-b, a-CH2—CH2—NR12—CH2—CH2-b, a-CH2—CH2—CH2NR12—CH2-b, a-CH2—NR12—CH2—CH2-b a-CH2—CH2—CH2—CH2—NR12-b, a-NR12—CH2—CH2—CH2—CH2-b, The compounds are useful in the treatment of disorders responsive to the blockade of glutamic and aspartic acid receptors.
摘要翻译：具有下式的化合物或其药学上可接受的盐，其中R是氢或羟基; R 1是氢，烷基，芳基烷基，（CH 2）n OH或（CH 2）n NR 7 R 8; R 5和 R 6各自独立地为氢，卤素，NO 2，CN，CF 3，SO 2 NR 7，PO 3 R 9，烷基，烯基，炔基，（CH 2）n CONR 7 R 8 >，（CH 2）n CO 2 R 10，NHCOR 11，A是由以下形成的环：a-NR 12 -CHR 13 -CHR 14 - ，a-CHR 13 - CHR 14 -NR 12 -b，a-CHR 13 -NR 12 -CHR 14 -b，a-CHR 14 -CH 2 -NR 12 -CHR 13 - b，a-CHR 13 -NR 12 -CH 2 -CHR 14 -b，a-CH 2 -CH 2 -CHR 13 -NR 12 -b，-NR a R 12 -CHR -CH 2 -CH 2-b，a-CH 2 -CH 2 -NR 12 -CH 2 -CH 2 -B，a-CH 2 -CH 2 -CH 2 NR 12 -CH 2 -B，a-CH 2 - NR 12 -CH 2 -CH 2 -BA-CH 2 -CH 2 -CH 2 -CH 2 -NR 12 -b，a-NR 12 -CH 2 -CH 2 -CH 2 -CH 2 -B，该化合物可用于治疗的阻滞谷氨酸和天冬氨酸受体的病症。

14. 发明授权

US06197771B1 Glutamate (ampa/kainate) receptor antagonists: N-substituted fused azacycloalkylquinoxalinediones 失效
标题翻译：谷氨酸（ampa / kainate）受体拮抗剂：N-取代的稠合氮杂环烷基喹喔啉
公开(公告)号：US06197771B1
公开(公告)日：2001-03-06
申请号：US09499475
申请日：2000-02-07
申请人： Christopher Franklin Bigge , Thomas Charles Malone , Robert Michael Schelkun , Chung Stephen Yi
发明人： Christopher Franklin Bigge , Thomas Charles Malone , Robert Michael Schelkun , Chung Stephen Yi
IPC分类号： A61K3147
CPC分类号： C07D471/04 , C07D217/02 , C07D217/04 , C07D217/06
摘要： Novel N-substituted azacycloalkyl ring fused 2,3-quinoxalinediones represented by the formula: or a pharmaceutically acceptable salt thereof, are disclosed, wherein the formula variables R1, R2, X, Y, m and n are as defined herein. Also disclosed are methods of treatment using the same and intermediate compounds useful in the preparation thereof.
摘要翻译：公开了由下式表示的新型N-取代的氮杂环烷基环稠合的2,3-喹喔啉二盐或其药学上可接受的盐，其中式变量R1，R2，X，Y，m和n如本文所定义。还公开了使用可用于其制备的相同和中间体化合物的治疗方法。

15. 发明授权

US5942513A Pharmaceutical composition and a method for treating neurodegenerative diseases using a combination of a kainate excitatory amino acid antagonist and an uricosuric agent 失效
标题翻译：药物组合物和使用红藻氨酸兴奋性氨基酸拮抗剂和尿酸排泄剂的组合治疗神经变性疾病的方法
公开(公告)号：US5942513A
公开(公告)日：1999-08-24
申请号：US049495
申请日：1998-03-27
申请人： Christopher Franklin Bigge , Graham Johnson , Charles Price Taylor, Jr. , Devin Franklin Welty
发明人： Christopher Franklin Bigge , Graham Johnson , Charles Price Taylor, Jr. , Devin Franklin Welty
IPC分类号： A61K31/19 , A61K31/47 , A61K31/495 , A61K31/675 , A61K45/00 , A61K45/06 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/28 , A61P43/00 , A61K31/50
CPC分类号： A61K31/675 , A61K31/47 , A61K31/495 , A61K45/06
摘要： The present invention relates to a pharmaceutical composition containing a kainate excitatory amino acid antagonist and an uricosuric agent and to a method of treating neurodegenerative diseases using a combination of a kainate excitatory amino acid antagonist and an uricosuric agent.
摘要翻译：本发明涉及含有红藻氨酸兴奋性氨基酸拮抗剂和尿酸排泄剂的药物组合物和使用红藻氨酸兴奋性氨基酸拮抗剂和尿酸排泄剂的组合治疗神经变性疾病的方法。

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