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11. 发明授权

US08669244B2 Cucurbitane-triterpenoid compounds, pharmaceutical composition, use and preparation method thereof 有权
标题翻译：葫芦巴三萜类化合物，药物组合物及其制备方法
公开(公告)号：US08669244B2
公开(公告)日：2014-03-11
申请号：US13173200
申请日：2011-06-30
申请人： Ching-Jang Huang , Yueh-Hsiung Kuo , Chin Hsu
发明人： Ching-Jang Huang , Yueh-Hsiung Kuo , Chin Hsu
IPC分类号： A61K31/585 , A61K31/56 , C07J71/00 , C07J9/00
CPC分类号： C07J9/00 , A61K31/575 , A61K31/58 , A61K31/585 , A61K36/42 , A61K2236/00 , C07J71/0005
摘要： Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I): wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the R1 is oxygen; while a single bond is formed between C8 and C9, R2 is carbonyl group (—C═O), methyl hydroxyl group (—CH(OH)), methyl ketone or methyl dimethoxy group (—CH(OCH3)2); and wherein while R1 is oxygen (—O—) and R2 is carbonyl group (—C═O) or methyl hydroxyl group (—CH(OH)), a single bond is formed between R1 (—O—) and C19 of R2 such that R1 and R2 are formed tetrahydro-2H-pyran-2-one or hemiacetal ring.
摘要翻译：公开了用于激活雌激素受体活性的葫芦巴 - 三萜化合物及其药物组合物的用途及制备方法。葫芦巴 - 三萜化合物以式（I）表示：其中C5和C10之间形成单键或双键，在C8和C9之间形成单键或双键; 当在C5和C10之间形成单键时，R1是氧; 而在C8和C9之间形成单键，R2是羰基（-C = O），甲基羟基（-CH（OH）），甲基酮或甲基二甲氧基（-CH（OCH 3）2））。并且其中当R 1是氧（-O-）和R 2是羰基（-C = O）或甲基羟基（-CH（OH））时，在R 2（-O-）和C 19之间形成单键使得R1和R2形成四氢-2H-吡喃-2-酮或半缩醛环。

12. 发明申请

US20120190632A1 ANTI-BACTERIAL INFECTION, INFLAMMATION, AND LEUKEMIA COMPOSITION AND USE THEREOF 有权
标题翻译：抗细菌感染，炎症和淋巴液组合物及其用途
公开(公告)号：US20120190632A1
公开(公告)日：2012-07-26
申请号：US13354496
申请日：2012-01-20
申请人： Lih-Geeng Chen , Yen-Hsu Chen , Chin Hsu , Hsin-Ju Chien , Shih-Han Kao , Yu-Wei Chang , Wan-Chun Huang
发明人： Lih-Geeng Chen , Yen-Hsu Chen , Chin Hsu , Hsin-Ju Chien , Shih-Han Kao , Yu-Wei Chang , Wan-Chun Huang
IPC分类号： A61K31/7034 , A61P29/00 , A61P35/02 , A61P31/04
CPC分类号： A61K31/7024 , A61K31/43 , A61K31/431 , A61K31/65 , A61K45/06 , A61K2300/00
摘要： A method of inhibiting the growth of Gram-positive bacteria comprising administering an effective amount of Tellimagrandin II, its pharmaceutically acceptable salt, enantiomer, isomer or tautomer to a subject is provided. The Gram-positive bacteria comprise methicillin-resistant Staphylococcus aureus. A method of treating sepsis comprising administering an effective amount of Tellimagrandin II, its pharmaceutically acceptable salt, enantiomer, isomer or tautomer to a subject is also provided. A method of treating leukemia comprising administering an effective amount of Tellimagrandin II, its pharmaceutically acceptable salt, enantiomer, isomer or tautomer to a subject is further provided.
摘要翻译：提供抑制革兰氏阳性菌生长的方法，其包括向受试者施用有效量的特利马格兰汀II，其药学上可接受的盐，对映体，异构体或互变异构体。革兰氏阳性菌包含耐甲氧西林金黄色葡萄球菌。还提供了治疗败血症的方法，其包括向受试者施用有效量的特利马格兰汀II，其药学上可接受的盐，对映体，异构体或互变异构体。进一步提供一种治疗白血病的方法，其包括向受试者施用有效量的特利马格兰汀II，其药学上可接受的盐，对映体，异构体或互变异构体。

13. 发明授权

US07902384B2 Estrogenic-active compounds and application thereof 有权
标题翻译：雌激素活性化合物及其应用
公开(公告)号：US07902384B2
公开(公告)日：2011-03-08
申请号：US12418490
申请日：2009-04-03
申请人： Ching-Jang Huang , Ssu-Ching Wang , Yueh-Hsiung Kuo , Yong-Han Hong , Bi-Fong Lin , Chin Hsu
发明人： Ching-Jang Huang , Ssu-Ching Wang , Yueh-Hsiung Kuo , Yong-Han Hong , Bi-Fong Lin , Chin Hsu
IPC分类号： C07D315/00
CPC分类号： C07D307/83 , A23L33/105 , A61K31/343 , C07D309/30
摘要： The present invention relates to compounds having estrogenic activity selected from the group consisting of Loliolide, (4S,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one, (4R,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one and analogues thereof. The compounds of the present invention are selective estrogen receptor modulator, which can selectively activate ERβ and simultaneously express high estrogenic activity, and also can be applied as medical or food compositions to improve estrogen deficiency-related symptoms.
摘要翻译：本发明涉及具有选自下组的雌激素活性的化合物：（L，R），（4S，6S）-4-羟基-6-十九烷基 - 四氢吡喃-2-酮，（4R，6S）-4-羟基-6 - 十二烷基 - 四氢 - 吡喃-2-酮及其类似物。本发明的化合物是选择性雌激素受体调节剂，其可以选择性地激活ER和bgr; 同时表现出较高的雌激素活性，也可用作医药或食品组合物，以改善与雌激素缺乏有关的症状。

14. 发明申请

US20070138723A1 Clamping device having replaceable clamping members 审中-公开
标题翻译：夹紧装置具有可更换夹紧件
公开(公告)号：US20070138723A1
公开(公告)日：2007-06-21
申请号：US11311027
申请日：2005-12-19
申请人： Chin Hsu , Mei Hsiao
发明人： Chin Hsu , Mei Hsiao
IPC分类号： B23Q3/02
CPC分类号： B25B7/04 , B25B5/06 , B25B5/163 , B25B7/14 , B25B7/16
摘要： A clamping device includes two handles pivotally connected with each other and each having a first end and a second end, and two clamping members each detachably mounted on the first end of a respective one of the two handles by a quick release mechanism. Thus, the clamping members are detachably mounted on the handles by the quick release mechanism, so that the handles can co-operate with clamping members of different specifications and shapes according to different requirements, thereby facilitating a user operating the clamping device to clamp workpieces of different specifications and sizes.
摘要翻译：夹紧装置包括彼此枢转地连接并具有第一端和第二端的两个手柄，以及两个夹紧构件，每个夹紧构件通过快速释放机构可拆卸地安装在两个手柄中的相应一个的第一端上。因此，夹紧构件通过快速释放机构可拆卸地安装在手柄上，使得手柄可以根据不同要求与不同规格和形状的夹紧构件配合，从而便于使用者操作夹紧装置以夹紧不同规格和尺寸。

15. 发明申请

US20070102248A1 Clamping device having stepless braking effect 失效
标题翻译：夹紧装置具有无级制动效果
公开(公告)号：US20070102248A1
公开(公告)日：2007-05-10
申请号：US11268864
申请日：2005-11-08
申请人： Chin Hsu
发明人： Chin Hsu
IPC分类号： B61H13/00
CPC分类号： B25B7/18 , B25B5/06 , B25B7/04
摘要： A clamping device includes two clamping members pivotally connected with each other and each having a first end and a second end, and a braking mechanism mounted between the second ends of the two clamping members to provide a stepless braking effect to the two clamping members. Thus, the braking mechanism provides a stepless braking effect to the two clamping members, so that the two clamping members are movable toward each other freely so as to shorten and adjust the open angle of the holding portion successively to hold a workpiece and are not movable outward relative each other to stop an outward movement of the two clamping members instantaneously so as to fix the holding portion to clamp the workpiece.
摘要翻译：夹紧装置包括彼此枢转地连接并且各自具有第一端和第二端的两个夹紧构件，以及安装在两个夹紧构件的第二端之间的制动机构，以向两个夹紧构件提供无级制动作用。因此，制动机构对两个夹紧构件提供无级制动作用，使得两个夹紧构件能够彼此自由移动，以便缩短和保持保持部分的开放角度以保持工件并且不可移动彼此相对地立即停止两个夹紧构件的向外移动，以便固定保持部分以夹紧工件。

16. 发明申请

US20050168925A1 Separable and foldable tablet PC assembly 审中-公开
标题翻译：可分离和可折叠的平板电脑组件
公开(公告)号：US20050168925A1
公开(公告)日：2005-08-04
申请号：US10766826
申请日：2004-01-30
申请人： Yung Fang , Shiou Lin , Chen Chang , Chin Hsu , Chiang Kuang
发明人： Yung Fang , Shiou Lin , Chen Chang , Chin Hsu , Chiang Kuang
IPC分类号： G06F1/16
CPC分类号： G06F1/1632 , G06F1/1626
摘要： A separable and foldable Tablet PC assembly has a data-inputting device, a combining seat which is pivotally connecting on the data-inputting device, and a slate-like Tablet PC which is received in the combining seat. The combining seat has a base portion, two guiding arms extending upwardly from two sides of the base portion, and a pair of connectors mounted opposite one another on the base portion. The slate-like Tablet PC has a receiving cavity in a bottom thereof and a mating connector on a bottom thereof and corresponding to one of the connectors of the combining seat.
摘要翻译：可分离和可折叠的平板电脑组件具有数据输入装置，在数据输入装置上枢转连接的组合座以及容纳在组合座中的平板式平板电脑。组合座具有基部，从基部的两侧向上延伸的两个引导臂和在基部上彼此相对安装的一对连接器。板状平板PC在其底部具有接收腔，并且在其底部具有对应于组合座的连接器中的一个的配合连接器。

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