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11. 发明申请

US20120122704A1 Differential multiplexing with pattern recognition 有权
标题翻译：差分复用与模式识别
公开(公告)号：US20120122704A1
公开(公告)日：2012-05-17
申请号：US11786260
申请日：2007-04-11
申请人： Daniel H. Atchley , John R. Hickman , Craig T. Narasaki
发明人： Daniel H. Atchley , John R. Hickman , Craig T. Narasaki
IPC分类号： C40B30/00 , C40B40/04
CPC分类号： G01N33/6845 , C12Q1/686 , C12Q1/689 , C40B30/04 , C40B40/04 , C12Q2537/143
摘要： This novel form of multiplexing allows the user to probe for multiple targets and simultaneously identify a specific target. An example of solutions provided here comprises: providing one or more assay mixes for a number of targets (the number of assay mixes is less than the number of targets); providing a number of reference patterns (each of the reference patterns is associated with one of the targets); contacting each of a number of aliquots with one of the assay mixes; generating a result pattern, based on positive or negative results; and selecting the reference pattern most similar to the result pattern, to thereby detect the target. Solutions provided here, which we term differential multiplexing with pattern recognition, may involve molecular or immunological techniques to identify one of many indicators of drug use, illness, disease, or medical condition. For example, we provide a simple method for identifying targets using combinations of real-time PCR reagent mixes and only one reporter. This is an effective and inexpensive method that can be used to identify targets with minimal reagents and supplies.
摘要翻译：这种新颖的复用形式允许用户探测多个目标并同时识别特定目标。这里提供的解决方案的一个例子包括：为多个靶标提供一个或多个测定混合物（测定混合物的数量小于靶标数目）; 提供多个参考图案（每个参考图案与目标之一相关联）; 将多个等分试样中的每一个与测定混合物之一接触; 根据积极或消极的结果产生结果模式; 并且选择与结果图案最相似的参考图案，从而检测目标。这里提供的解决方案，我们用差异复用与模式识别，可能涉及分子或免疫学技术来识别药物使用，疾病，疾病或医疗状况的许多指标之一。例如，我们提供了使用实时PCR试剂混合物和仅一位记者组合鉴定靶标的简单方法。这是一种有效且廉价的方法，可用于以最小的试剂和用量鉴定靶物。

12. 发明授权

US06170240B2 Packaging and disposal system 有权
标题翻译：包装和处理系统
公开(公告)号：US06170240B2
公开(公告)日：2001-01-09
申请号：US09162580
申请日：1998-09-29
申请人： Charles J. Jacoby , John R. Hickman , Michael J. Gallo
发明人： Charles J. Jacoby , John R. Hickman , Michael J. Gallo
IPC分类号： B65B915
CPC分类号： B65B67/1277 , B65F1/062 , B65F1/10 , B65F1/125 , B65F1/1615 , B65F2210/1675 , B65F2240/132
摘要： A packaging and disposal system for sealing waste and related materials within flexible plastic tubing for odorless and sanitary disposal. Improvements in the latch, including the addition of a transverse mounted latch spring, and improvements in the support retention springs serve to increase the ability of the device to operate efficiently and effectively and reduce the potential of accidental spills or other exposure of the waste package. The latch requires two independent motions to actuate and incorporates a transversely mounted latch spring. The reduced cross-sectional area of the retention spring design concentrates force applied to the package to increase the effective holding ability of the system.
摘要翻译：用于在柔性塑料管内密封废物和相关材料的无害化和卫生处理的包装和处理系统。闩锁的改进，包括添加横向安装的闩锁弹簧以及支撑保持弹簧的改进用于增加装置有效和有效地操作的能力，并减少意外泄漏或废物包装的其他暴露的可能性。闩锁需要两个独立的运动来致动并结合横向安装的闩锁弹簧。保持弹簧设计的减小的横截面积集中了施加到包装上的力，以增加系统的有效保持能力。

13. 发明授权

US4693399A Two-flap closure 失效
公开(公告)号：US4693399A
公开(公告)日：1987-09-15
申请号：US920566
申请日：1986-10-17
申请人： John R. Hickman , Craig C. Weidman
发明人： John R. Hickman , Craig C. Weidman
IPC分类号： B65D47/08 , A47G19/24
CPC分类号： B65D47/0847
摘要： An injection-molded thermoplastic closure with shake-and-spoon apertures and associated flaps for selectively closing and opening the apertures. The flaps are releasably retained in their closed positions by catch elements which provide retention forces that are relatively insensitive to dimensional and shape variations in the body resulting from the molding process. In one embodiment, the cap has "freeze points" and a gate location that reduce the tendency of the cap to assume an oval condition when cooled from molding temperatures. A wide sealing ledge cooperates with a central support for a liner seal positioned in the cap to seal the mouth of a container.

14. 发明授权

US4541541A Tamper-resistant closure for dispensers 失效
标题翻译：用于分配器的防撬盖
公开(公告)号：US4541541A
公开(公告)日：1985-09-17
申请号：US659234
申请日：1984-10-09
申请人： John R. Hickman , Nicholas J. Kriska , Jeffrey H. Brechtelsbauer , Bruno A. Mediate , Jordan I. Rotheiser
发明人： John R. Hickman , Nicholas J. Kriska , Jeffrey H. Brechtelsbauer , Bruno A. Mediate , Jordan I. Rotheiser
IPC分类号： B65D47/26 , B65D55/02 , B65D51/18
CPC分类号： B65D55/02 , B65D47/265
摘要： A tamperproof dispenser end closure includes a base and a rotor pivotally connected to the base by a hub. The base and rotor have webs provided with means defining respective dispensing apertures. The base and rotor are retained in a close superposed relationship to each other by the hub. Frangible means are provided which tear or break when an attempt is made to separate the base from the rotor so that the base and rotor cannot be pivotally connected again by the hub.
摘要翻译：防窜改分配器端盖包括基座和通过轮毂枢转地连接到基座的转子。基部和转子具有设置有限定相应分配孔的装置的腹板。基座和转子通过轮毂以彼此紧密的重叠关系保持。提供了当尝试将基座与转子分离以使得基座和转子不能由轮毂再次枢转地连接时，撕裂或断裂的易碎装置。

15. 发明授权

US08978999B2 Container for air freshening materials and other volatiles 有权
标题翻译：空气清新剂和其他挥发物的容器
公开(公告)号：US08978999B2
公开(公告)日：2015-03-17
申请号：US13090542
申请日：2011-04-20
申请人： Frank M. Lesniak , Kyle Brandenburg , John R. Hickman
发明人： Frank M. Lesniak , Kyle Brandenburg , John R. Hickman
IPC分类号： A61L9/12 , A61L9/04 , B65D51/16 , B65D43/24 , B65D41/04
CPC分类号： A61L9/12
摘要： A container for air freshening materials or other volatiles includes a receptacle or base and a cover that may be rotated from a closed position to multiple open positions while still engaged to the base to create vent passageway(s) between the cover and the base. A containment section of the base houses an air freshening material, such as a fragrance gel or potpourri, or a volatile, such as an insect repellant. The base further defines an alignment section adapted to rotationally and axially position the cover, an integrated sealing element, and an optional vent section. The alignment section includes a ramp and upper and lower locating elements coupled to the ramp. The alignment section engages at least one guide or a guide nub that extends from a depending arm of the cover. The guide or guide nub travels along the ramp from a first locating element when the cover is in a fully closed position to a second locating element when the cover is in a fully open position. In one of its multiple open positions, the cover is rotationally and axially displaced to specified height(s) above the container, allowing for fragrance or volatile material release.
摘要翻译：用于空气清新材料或其它挥发物的容器包括容器或底座以及可以从关闭位置旋转到多个打开位置同时仍接合到底座以在盖和底座之间形成通气通道的盖。基座的容纳部分容纳空气清新材料，例如香料凝胶或香水，或挥发性物质，例如驱虫剂。基座还限定了适于旋转和轴向地定位盖子，一体式密封元件和可选的通气部分的对准部分。对准部分包括斜坡和联接到斜坡的上和下定位元件。对准部分接合至少一个从盖的悬垂臂延伸的引导件或引导件。当盖处于完全打开位置时，当盖处于完全关闭位置到第二定位元件时，引导件或引导件沿着斜面从第一定位元件行进。在其多个打开位置中的一个位置，盖被旋转和轴向移位到容器上方的指定高度，允许香料或挥发性物质释放。

16. 再颁专利

USRE37634E1 Two-flap closure 失效
标题翻译：双瓣关闭
公开(公告)号：USRE37634E1
公开(公告)日：2002-04-09
申请号：US08731975
申请日：1996-10-23
申请人： John R. Hickman , Craig C. Weidman , Nickolas J. Kriska
发明人： John R. Hickman , Craig C. Weidman , Nickolas J. Kriska
IPC分类号： B67D300
CPC分类号： B65D47/0847
摘要： An injection-molded thermoplastic closure with shake-and-spoon apertures and associated flaps for selectively closing and opening the apertures. The flaps are releasably retained in their closed positions by catch elements which provide retention forces that are relatively insensitive to dimensional and shape variations in the body resulting from the molding process. In one embodiment, the cap has “freeze points” and a gate location that reduce the tendency of the cap to assume an oval condition when cooled from molding temperatures. A wide sealing ledge cooperates with a central support for a liner seal positioned in the cap to seal the mouth of a container.
摘要翻译：一种具有摇动和勺子孔的注射成型的热塑性封盖以及用于选择性地关闭和打开孔的相关翼片。襟翼通过卡扣元件可释放地保持在其关闭位置，捕获元件提供对由模制过程导致的主体尺寸和形状变化相对不敏感的保持力。在一个实施例中，当从成型温度冷却时，盖具有“冻结点”和浇口位置，该浇口位置减小了盖子呈现椭圆状态的倾向。宽密封凸缘与位于盖中的衬垫密封件的中心支撑件配合以密封容器的口部。

17. 外观设计

USD305206S Two flap container cap 失效
公开(公告)号：USD305206S
公开(公告)日：1989-12-26
申请号：US899935
申请日：1986-08-25
申请人： John R. Hickman , Nickolas J. Kriska
设计人： John R. Hickman , Nickolas J. Kriska

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