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11. 发明申请

US20160070436A1 PLANNING, NAVIGATION AND SIMULATION SYSTEMS AND METHODS FOR MINIMALLY INVASIVE THERAPY 有权
标题翻译：计划，导航和模拟系统以及最小的入侵治疗方法
公开(公告)号：US20160070436A1
公开(公告)日：2016-03-10
申请号：US14769668
申请日：2014-03-14
申请人： Monroe M. THOMAS , Gal SELA , Cameron PIRON , Joshua RICHMOND , Murugathas YUWARAJ , Wes HODGES , Simon ALEXANDER , David GALLOP , William LAU , Sheryl THINGVOLD , Kelly DYER
发明人： Monroe M. Thomas , Gal Sela , Cameron Piron , Joshua Richmond , Murugathas Yuwaraj , Wes Hodges , Simon Alexander , David Gallop , William Lau , Sheryl Thingvold , Kelly Dyer
IPC分类号： G06F3/0481 , G06T1/60 , A61B19/00 , G06T11/20 , G06F3/0484 , G06T7/00 , G06T17/00
CPC分类号： G06T19/003 , A61B5/0042 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/501 , A61B8/00 , A61B8/0808 , A61B34/10 , A61B34/20 , A61B2034/105 , A61B2034/107 , A61B2034/2051 , A61B2034/2055 , A61B2090/3735 , A61B2090/378 , G06F3/04815 , G06F3/04842 , G06F3/04847 , G06T1/60 , G06T7/0012 , G06T11/20 , G06T17/00 , G06T19/20 , G06T2200/04 , G06T2200/24 , G06T2207/10088 , G06T2207/20101 , G06T2207/30016 , G06T2207/30241 , G06T2210/41 , G06T2219/028
摘要： Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery.
摘要翻译：这里公开了用于微创治疗的计划，导航和模拟系统和方法，其中规划方法和系统使用患者特定的术前图像。规划系统允许从术前图像开发多条路径，并根据手术的期望手术结果评估路径，并且导航系统允许基于微创端口的外科手术，以及特定情况下的开颅手术的脑部手术。

12. 发明申请

US20160005169A1 SYSTEM AND METHOD FOR DETECTING TISSUE AND FIBER TRACT DEFORMATION 有权
标题翻译：用于检测组织和纤维束变形的系统和方法
公开(公告)号：US20160005169A1
公开(公告)日：2016-01-07
申请号：US14769507
申请日：2014-03-14
申请人： Gal SELA , Simon ALEXANDER , Cameron PIRON , Joshua RICHMOND , Michael WOOD , Murugathas YUWARAJ , David GALLOP , Wes HODGES , Monrore M. THOMAS
发明人： Gal Sela , Simon Alexander , Cameron Piron , Joshua Richmond , Michael Wood , Murugathas Yuwaraj , David Gallop , Wes Hodges , Monroe M. Thomas
IPC分类号： G06T7/00 , A61B5/00
CPC分类号： G06T7/0012 , A61B5/0066 , A61B5/055 , A61B34/10 , A61B90/11 , A61B2034/105 , G06T2207/30012 , G09B23/30
摘要： Disclosed herein is a method for producing an evolvable tissue model of a patient and, using this model, modelling physical transformations of the tissue (e.g. deformation) of the tissue model by interacting the tissue model with influence models which model interactions with the tissue such as surgical instruments, pressure, swelling, temperature changes etc. The model is produced from a set of input data of the tissue which includes directional information of the tissue. The directional information is used to produce an oriented tissue map. A tissue model is then produced from the oriented tissue map such that the tissue model reflects the directionality of the tissue component. When the tissue model is subjected to an influence that causes tissue deformation over a period of time, the tissue model directionally deforms over the period of time in a manner which reflects a trajectory of the influence interacting with the directionality of the tissue component.
摘要翻译：本文公开了一种用于产生患者的可演化组织模型的方法，并且使用该模型通过将组织模型与模型与组织相互作用的影响模型相互作用来模拟组织模型的物理变化（例如变形），例如手术器械，压力，肿胀，温度变化等。该模型由组织的一组输入数据产生，包括组织的方向信息。方向信息用于产生定向组织图。然后从定向组织图生成组织模型，使得组织模型反映组织成分的方向性。当组织模型受到在一段时间内引起组织变形的影响时，组织模型以反映与组织部件的方向性相互作用的影响的轨迹的方式在一段时间内定向变形。

13. 发明申请

US20160000515A1 SYSTEM AND METHOD FOR DYNAMIC VALIDATION, CORRECTION OF REGISTRATION FOR SURGICAL NAVIGATION 审中-公开
标题翻译：用于动态鉴定的系统和方法，用于手术导航的注册更正
公开(公告)号：US20160000515A1
公开(公告)日：2016-01-07
申请号：US14775759
申请日：2014-03-14
申请人： Gal Sels , Cameron Piron , Michael Wood , Joshua Richmond , Murugathas Yuwaraj , Stephen McFadyen , Monroe M. Thomas , Wes Hodges , Simon Alexander
发明人： Gal Sela , Cameron Piron , Michael Wood , Joshua Richmond , Murugathas Yuwaraj , Stephen McFadyen , Monroe M. Thomas , Wes Hodges , Simon Alexander , David Gallop
IPC分类号： A61B19/00
摘要： Disclosed herein is a system and method for dynamic validation, correction of registration for surgical navigation during medical procedures on a patient which involves confirmation of registration between one or more previously registered virtual objects, such as surgical tools etc. in a common coordinate frame of a surgical navigation system and an operating room, and intra-operatively acquired imaging during the medical procedure in the common coordinate frame. The method includes displaying intra-operatively acquired imaging of the surgical field containing the one or more real objects corresponding to the one or more previously registered virtual objects, with the real objects being tracked by a tracking system. The method overlaying a virtual image containing the previously registered virtual objects onto the intra-operatively acquired imaging, from the point of view of the intra-operatively acquired imaging, and detecting for any misalignment between any one of the one or more previously registered virtual objects contained in the virtual image and its corresponding real object contained in the intra-operatively acquired imaging.
摘要翻译：本文公开了一种用于动态验证的系统和方法，用于在患者的医疗过程期间对外科导航的注册进行校正，其涉及确认一个或多个先前登记的虚拟对象之间的注册，诸如外科手术工具等手术导航系统和手术室，以及在公共坐标系中的医疗过程期间的手术内获取的成像。该方法包括显示手术区域的操作中获取的成像，所述成像包含与一个或多个先前注册的虚拟对象相对应的一个或多个实际对象，其中所述实际对象由跟踪系统跟踪。从操作中获取的成像的角度，将包含先前登记的虚拟对象的虚拟图像重叠到操作中获取的成像上的方法，以及检测一个或多个先前注册的虚拟对象中的任何一个之间的任何未对准包含在虚拟图像中及其对应的实际对象中，包含在操作中获取的成像中。

14. 发明授权

US09913733B2 Intra-operative determination of dimensions for fabrication of artificial bone flap 有权
公开(公告)号：US09913733B2
公开(公告)日：2018-03-13
申请号：US15110161
申请日：2014-08-20
申请人： Cameron Piron , Murugathas Yuwaraj
发明人： Cameron Piron , Murugathas Yuwaraj
IPC分类号： A61F2/46 , A61F2/28 , A61B6/03 , A61B5/00 , A61B5/055 , A61B5/06 , A61B5/107 , A61B34/00 , A61B34/20 , G05B19/4097 , A61F2/30
CPC分类号： A61F2/4601 , A61B5/0035 , A61B5/0037 , A61B5/0042 , A61B5/0066 , A61B5/055 , A61B5/064 , A61B5/1072 , A61B5/1079 , A61B6/03 , A61B6/032 , A61B6/037 , A61B6/505 , A61B6/5229 , A61B8/0841 , A61B17/00491 , A61B17/0642 , A61B17/86 , A61B34/00 , A61B34/10 , A61B34/20 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2034/108 , A61B2034/2051 , A61B2034/2055 , A61B2034/2065 , A61B2034/2068 , A61B2090/363 , A61B2090/365 , A61B2090/3735 , A61F2/28 , A61F2/2875 , A61F2/30942 , A61F2/46 , A61F2002/2835 , A61F2002/30948 , A61F2002/4632 , G05B19/4097 , G05B2219/35134 , G05B2219/49007
摘要： Methods and systems for calculating dimensions for fabricating an artificial bone flap. Intra-operative data indicating dimensions of an opening in a portion of the patient's skull are obtained. 3D dimensions of the opening are calculated using the intra-operative data, registered to a reference image. The calculated 3D dimensions are provided for fabricating the artificial bone flap by a fabrication system.

15. 发明申请

US20080306696A1 Methods for Resolving Convoluted Peaks in a Chromatogram 有权
标题翻译：解决色谱峰的方法
公开(公告)号：US20080306696A1
公开(公告)日：2008-12-11
申请号：US12159213
申请日：2007-02-06
申请人： Alexandre M. Izmailov , Murugathas Yuwaraj
发明人： Alexandre M. Izmailov , Murugathas Yuwaraj
IPC分类号： G06F19/00
CPC分类号： G01N30/8624 , G01N30/8631
摘要： The present invention relates to methods for resolving convoluted peaks in a chromatogram into one or more constituent peaks using peak resolution values. The peaks methods of the invention determine empirical peak resolution values of “well-defined” or “isolated” peaks in the data, then extrapolate these empirical resolution values to peaks in neighboring regions to predict the number of constituent peaks at a given peak position. Predicted peak resolution values are compared to observed peak resolution values of low-resolution or convoluted peaks to determine the number of constituent peaks in the convoluted peaks. These methods enable extension of the region of data that can used for identifying nucleotide sequences, and increase base-calling accuracy in the low-resolution region (end region) of data.
摘要翻译：本发明涉及使用峰值分辨率将色谱图中的卷曲峰分解成一个或多个组成峰的方法。本发明的峰方法确定数据中“明确”或“隔离”峰的经验峰分辨率值，然后将这些经验分辨率值推算到相邻区域中的峰值，以预测在给定峰位置处的构成峰的数量。将预测的峰值分辨率值与观察到的低分辨率或卷积峰值的峰值分辨率进行比较，以确定卷积峰值中的组成峰数。这些方法能够扩展可用于识别核苷酸序列的数据区域，并增加数据的低分辨率区域（结束区域）中的基本呼叫精度。

16. 发明授权

US10245071B2 System for illumination during a corridor based procedure 有权
公开(公告)号：US10245071B2
公开(公告)日：2019-04-02
申请号：US15515654
申请日：2014-12-23
申请人： Michael Frank Gunter Wood , Cameron Anthony Piron , Murugathas Yuwaraj , Joshua Lee Richmond
发明人： Michael Frank Gunter Wood , Cameron Anthony Piron , Murugathas Yuwaraj , Joshua Lee Richmond
IPC分类号： A61B1/32 , A61B17/34 , A61B90/30 , A61B17/00 , A61B34/20
摘要： A system for illumination during a corridor based procedure is provided, comprising: a light source; and, an optical probe comprising: a tube having a distal end, a proximal end and one or more sidewalls there between, the optical probe and the light source arranged so that light from the light source is received by the one or more sidewalls, the one or more sidewalls configured to convey the light to the distal end, the distal end configured to receive the light and illuminate a sample adjacent thereto.

17. 发明授权

US09799114B2 Method, system and apparatus for quantitative surgical image registration 有权
公开(公告)号：US09799114B2
公开(公告)日：2017-10-24
申请号：US15514111
申请日：2014-11-27
申请人： Cameron Anthony Piron , Murugathas Yuwaraj
发明人： Cameron Anthony Piron , Murugathas Yuwaraj
IPC分类号： G06T7/00 , A61B34/10 , A61B5/00 , A61B5/055 , A61B6/03 , A61B8/08 , A61B6/00
CPC分类号： G06T7/0012 , A61B5/0035 , A61B5/0066 , A61B5/0075 , A61B5/055 , A61B6/032 , A61B6/5247 , A61B8/06 , A61B8/12 , A61B8/485 , A61B8/5223 , A61B8/5261 , A61B34/10 , A61B34/20 , A61B2034/2055 , A61B2090/365 , A61B2090/3735 , A61B2505/05 , G06T7/33 , G06T2207/10076 , G06T2207/10081 , G06T2207/10088 , G06T2207/10101 , G06T2207/30016 , G06T2207/30101 , G09B23/30
摘要： A method in a computing device for quantitative surgical image registration includes: prior to a surgical procedure, obtaining, using a first imaging modality, a preoperative image of patient tissue and a plurality of preoperative measurements of a material property of the patient tissue. The preoperative measurements correspond to respective points in the preoperative image. The method includes storing the preoperative image and the preoperative measurements, and during the surgical procedure, using a second imaging modality, capturing an intraoperative image of the patient tissue and a second plurality of intraoperative measurements of the material property of the patient tissue. The intraoperative measurements correspond to respective points in the intraoperative image. The method includes comparing the first and second pluralities of measurements to determine a transformation for registering the preoperative image and the intraoperative image; and storing the transformation in association with one of the intraoperative image and the preoperative image.

18. 发明授权

US07720612B2 Methods for resolving convoluted peaks in a chromatogram 有权
标题翻译：解决色谱图中的卷积峰的方法
公开(公告)号：US07720612B2
公开(公告)日：2010-05-18
申请号：US12159213
申请日：2007-02-06
申请人： Alexandre M. Izmailov , Murugathas Yuwaraj
发明人： Alexandre M. Izmailov , Murugathas Yuwaraj
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N30/8624 , G01N30/8631
摘要： The present invention relates to methods for resolving convoluted peaks in a chromatogram into one or more constituent peaks using peak resolution values. The peaks methods of the invention determine empirical peak resolution values of “well-defined” or “isolated” peaks in the data, then extrapolate these empirical resolution values to peaks in neighboring regions to predict the number of constituent peaks at a given peak position. Predicted peak resolution values are compared to observed peak resolution values of low-resolution or convoluted peaks to determine the number of constituent peaks in the convoluted peaks. These methods enable extension of the region of data that can used for identifying nucleotide sequences, and increase base-calling accuracy in the low-resolution region (end region) of data.
摘要翻译：本发明涉及使用峰值分辨率将色谱图中的卷曲峰分解成一个或多个组成峰的方法。本发明的峰方法确定数据中“明确”或“隔离”峰的经验峰分辨率值，然后将这些经验分辨率值推算到相邻区域中的峰值，以预测在给定峰位置处的构成峰的数量。将预测的峰值分辨率值与观察到的低分辨率或卷积峰值的峰值分辨率进行比较，以确定卷积峰值中的组成峰数。这些方法能够扩展可用于识别核苷酸序列的数据区域，并增加数据的低分辨率区域（结束区域）中的基本呼叫精度。

19. 发明授权

US10552959B2 System and method for using imaging quality metric ranking 有权
公开(公告)号：US10552959B2
公开(公告)日：2020-02-04
申请号：US15903237
申请日：2018-02-23
申请人： Cameron Anthony Piron , Murugathas Yuwaraj
发明人： Cameron Anthony Piron , Murugathas Yuwaraj
IPC分类号： G06T7/00 , A61N5/10 , G16H30/40 , A61B5/00
摘要： A method and system is provided for storing and analyzing clinical imaging data. The method includes obtaining patient images from two or more modalities, registering the images, determining position information of a voxel, calculating and assigning a quality metric for the voxel, storing the voxel information and at least one searchable header as imaging data in a computer memory, and modifying or maintaining treatment based on the imaging data. The system includes a memory and a processor, the processor configured to obtain images from two or more modalities, register and store the image set in memory, calculate a quality metric for a voxel in the image set, store the voxel quality metric with the image set in the memory, and modify or maintain treatment based on the calculated qualitative metric.

20. 发明授权

US10074177B2 Method, system and apparatus for quantitative surgical image registration 有权
公开(公告)号：US10074177B2
公开(公告)日：2018-09-11
申请号：US15789360
申请日：2017-10-20
申请人： Cameron Anthony Piron , Murugathas Yuwaraj
发明人： Cameron Anthony Piron , Murugathas Yuwaraj
IPC分类号： G06T7/00 , A61B34/10 , A61B5/00 , A61B5/055 , A61B6/03 , A61B8/08 , A61B6/00
CPC分类号： G06T7/0012 , A61B5/0035 , A61B5/0066 , A61B5/0075 , A61B5/055 , A61B6/032 , A61B6/5247 , A61B8/06 , A61B8/12 , A61B8/485 , A61B8/5223 , A61B8/5261 , A61B34/10 , A61B34/20 , A61B2034/2055 , A61B2090/365 , A61B2090/3735 , A61B2505/05 , G06T7/33 , G06T2207/10076 , G06T2207/10081 , G06T2207/10088 , G06T2207/10101 , G06T2207/30016 , G06T2207/30101 , G09B23/30
摘要： A method in a computing device for quantitative surgical image registration includes: prior to a surgical procedure, obtaining, using a first imaging modality, a preoperative image of patient tissue and a plurality of preoperative measurements of a material property of the patient tissue. The preoperative measurements correspond to respective points in the preoperative image. The method includes storing the preoperative image and the preoperative measurements, and during the surgical procedure, using a second imaging modality, capturing an intraoperative image of the patient tissue and a second plurality of intraoperative measurements of the material property of the patient tissue. The intraoperative measurements correspond to respective points in the intraoperative image. The method includes comparing the first and second pluralities of measurements to determine a transformation for registering the preoperative image and the intraoperative image; and storing the transformation in association with one of the intraoperative image and the preoperative image.

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