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11. 发明申请

WO2007133831A3 HIGH THROUGHPUT GENOME SEQUENCING ON DNA ARRAYS 审中-公开
标题翻译：在DNA阵列上测序的高通量基因
公开(公告)号：WO2007133831A3
公开(公告)日：2008-02-07
申请号：PCT/US2007062825
申请日：2007-02-26
申请人： COMPLETE GENOMICS INC , DRMANAC RADOJE , CALLOW MATTHEW J , DRMANAC SNEZANA
发明人： DRMANAC RADOJE , CALLOW MATTHEW J , DRMANAC SNEZANA
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6837 , C12Q1/6874 , C12Q2531/125 , C12Q2525/151 , C12Q2521/313
摘要： The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences using adaptors interspersed in target polynucleotides. The sequence information can be new. e.g. sequencing unknown nucleic acids, re-sequencing, or genotyping. The invention preferably includes methods for inserting a plurality of adaptors at spaced locations within a target polynucleotide or a fragment of a polynucleotide. Such adaptors may serve as platforms for interrogating adjacent sequences using various sequencing chemistries, such as those that identify nucleotides by primer extension, probe ligation, and the like. Encompassed in the invention are methods and compositions for the insertion of known adaptor sequences into target sequences, such that there is an interruption of contiguous target sequence with the adaptors. By sequencing both "upstream" and "downstream" of the adaptors, identification of entire target sequences may be accomplished.
摘要翻译：本发明涉及使用分散在靶多核苷酸中的衔接子获得靶序列的核苷酸序列信息的方法和组合物。序列信息可以是新的。例如测序未知核酸，重新测序或基因分型。本发明优选地包括在多核苷酸的靶多核苷酸或片段内的间隔位置插入多个衔接子的方法。这样的衔接子可以用作使用各种测序化学品询问相邻序列的平台，例如通过引物延伸，探针连接等鉴定核苷酸的测序化学物质。在本发明中包括用于将已知衔接子序列插入靶序列的方法和组合物，使得与适配器存在连续靶序列的中断。通过对适配器的“上游”和“下游”进行排序，可以完成整个靶序列的识别。

12. 发明申请

WO0018916A3 HUMAN GENES AND GENE EXPRESSION PRODUCTS 审中-公开
公开(公告)号：WO0018916A3
公开(公告)日：2000-11-16
申请号：PCT/US9922226
申请日：1999-09-23
申请人： CHIRON CORP , HYSEQ INC
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , GIESE KLAUS , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

13. 发明申请

WO9958675A3 HUMAN GENES AND GENE EXPRESSION PRODUCTS V 审中-公开
标题翻译：人类基因和基因表达产物
公开(公告)号：WO9958675A3
公开(公告)日：2000-02-17
申请号：PCT/US9910602
申请日：1999-05-13
申请人： CHIRON CORP , HYSEQ INC
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , GIESE KLAUS , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

14. 发明申请

WO9933982A3 HUMAN GENES AND GENE EXPRESSION PRODUCTS I 审中-公开
标题翻译：人类基因和基因表达产物I
公开(公告)号：WO9933982A3
公开(公告)日：1999-12-23
申请号：PCT/US9827610
申请日：1998-12-22
申请人： CHIRON CORP , HYSEQ INC
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , GIESE KLAUS , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/50 , C12N9/76 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及新的人多核苷酸及其变体，它们的编码多肽及其变体，对应于这些多核苷酸的基因以及由这些基因表达的蛋白质。本发明还涉及采用这种新型人多核苷酸，其相应基因或基因产物（例如这些基因和蛋白质，包括探针，反义构建体和抗体）的诊断和治疗剂。

15. 发明申请

WO0102568A2 NOVEL HUMAN GENES AND GENE EXPRESSION PRODUCTS 审中-公开
标题翻译：新人类基因和基因表达产物
公开(公告)号：WO0102568A2
公开(公告)日：2001-01-11
申请号：PCT/US0018374
申请日：2000-06-30
申请人： CHIRON CORP , HYSEQ INC
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , KLINGER JULIE , KASSAM ALTAF , REINHARD CHRISTOPH , RANDAZZO FILIPPO , KENNEDY GUILIA C , POT DAVID , LAMSON GEORGE , DRMANAC RADOJE , CRKENJAKOV RADOMIR , DRMANAC SNEZANA , DICKSON MARK , LABAT IVAN , LESHKOWITIZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STRACHE-CRAIN BIRGIT
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N9/64 , C12N9/90 , C12N15/09 , C12N15/12 , C12N15/54 , C12N15/55 , C12N15/61 , C12Q1/68 , G01N33/566 , G01N33/574 , C07K16/40 , C12N15/11
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/47 , C07K14/4705 , C12N9/6424 , C12N9/90
摘要： The invention provides novel polynucleotides. The invention further provides novel members of protein families, and polynucleotides that are differentially expressed in cancer cells relative to normal cells, and in metastatic cancer cells relative to normal cells or non-metastatic cancer cells.
摘要翻译：本发明提供了新的多核苷酸。本发明还提供蛋白质家族的新成员和相对于正常细胞在癌细胞中差异表达的多核苷酸，以及相对于正常细胞或非转移性癌细胞在转移癌细胞中的多核苷酸。

16. 发明专利

AU8726901A Human genes and gene expression products XVI 未知
公开(公告)号：AU8726901A
公开(公告)日：2001-10-08
申请号：AU8726901
申请日：2001-03-27
申请人： CHIRON CORP , HYSEQ INC
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , HE ZHIJUN , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ATLAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P35/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , C07K14/00
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

19. 发明专利

CA2430794A1 HUMAN GENES AND GENE EXPRESSION PRODUCTS ISOLATED FROM HUMANPROSTATE 未知
公开(公告)号：CA2430794A1
公开(公告)日：2002-07-18
申请号：CA2430794
申请日：2001-12-07
申请人： CHIRON CORP , HYSEQ INC
发明人： KITA DAVID , GARCIA VERONICA , JONES WILLIAM LEE , LESHKOWITZ DENA , STACHE-CRAIN BIRGIT , LABAT IVAN , SCOTT ELIZABETH M , DRMANAC SNEZANA , ESCOBEDO JAIME , KASSAM ALTAF , DICKSON MARK , LAMSON GEORGE , CRKVENJAKOV RADOMIR , DRMANAC RADOJE , GARCIA PABLO DOMINGUEZ
IPC分类号： C12N15/09 , A61K31/7088 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostics and therapeutics comprising such novel human polynucleotides, their corresponding genes or gene products, including probe s, antisense nucleotides, and antibodies. The polynucleotides of the invention correspond to a polynucleotide comprising the sequence information of at lea st one of SEQ ID NOS:1-1477. The polypeptides of the invention correspond to a polypeptide comprising the amino acid sequence information of at least one o f SEQ ID NOS:1478-1568.

20. 发明专利

AU4561901A Human genes and gene expression products 未知
公开(公告)号：AU4561901A
公开(公告)日：2001-09-17
申请号：AU4561901
申请日：2001-03-09
申请人： CHIRON CORP , HYSEQ INC
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES WILLIAM LEE , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , A61K45/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/10 , G01N33/574
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

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