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11. 发明专利

AU2009267844B2 Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer 未知
公开(公告)号：AU2009267844B2
公开(公告)日：2014-11-20
申请号：AU2009267844
申请日：2009-07-09
申请人： BIOMERIEUX SA
发明人： BUSSERET SANDRINE , ROLLAND DOMINIQUE , CHARRIER JEAN-PHILIPPE , BEAULIEU CORINNE , ATAMAN-ONAL YASEMIN , CHOQUET-KASTYLEVSKY GENEVIEVE
IPC分类号： G01N33/574 , C07K7/00
摘要： The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the protein disulfide isomerase tumor marker in a biological sample from a patient suspected of being affected by colorectal cancer through the use of at least one anti-PDI monoclonal antibody against a PDI epitope selected from among the epitopes of sequence SEQ ID NO:1, SEQ ID NO:2 with a similar aromatic amino acid in the three-dimensional PDI structure, and SEQ ID NO:3, said method being useful in the early diagnosis, screening, therapeutic follow-up, prognosis, and relapse diagnosis in the field of colorectal cancer.

12. 发明专利

AU2008285556B2 Apolipoprotein AI assay method for the in vitro diagnosis of colorectal cancer 未知
公开(公告)号：AU2008285556B2
公开(公告)日：2014-08-14
申请号：AU2008285556
申请日：2008-07-10
申请人： BIOMERIEUX SA
发明人： POIRIER FLORENCE , CHARRIER JEAN-PHILIPPE , ATAMAN-ONAL YASEMIN , CHOQUET-KASTYLEVSKY GENEVIEVE
IPC分类号： G01N33/574
摘要： The invention relates to a method for the

13. 发明专利

ES2912907T3 Polipéptidos mutados de HEV y sus usos para la evaluación de anticuerpos anti-HEV 未知
公开(公告)号：ES2912907T3
公开(公告)日：2022-05-30
申请号：ES16815613
申请日：2016-11-29
申请人： BIOMERIEUX SA
发明人： ATAMAN-ONAL YASEMIN , DANIEL SOIZIC , GOUTAGNY NADÈGE , LUCIANI FRANÇOISE
IPC分类号： C07K14/08 , C07K14/005 , G01N33/576
摘要： Un polipéptido apto para unirse a anticuerpos anti-HEV, escogido de: - un polipéptido que comprende al menos la secuencia 394-660 de una proteína p-ORF2 del virus de la hepatitis E que tiene una longitud de 660 aminoácidos de largo, y en el que los tres aminoácidos en las posiciones 627, 630 y 638 son diferentes de la cisteína; en el que dicha proteína p-ORF2 de 660 aminoácidos de largo tiene una identidad de secuencia de al menos 89% con la SEQ ID Nº 11, y dicha secuencia 394-660 tiene una identidad de secuencia de al menos 90% con la SEQ ID Nº 26; y - un polipéptido que comprende una secuencia análoga a SEQ ID Nº 26, que tiene una identidad de secuencia de al menos 90% con SEQ ID Nº 26, y que proviene de una proteína p-ORF2 del virus de la hepatitis E de una longitud diferente de 660 aminoácidos, y que tiene una identidad de secuencia de al menos 89% con SEQ ID Nº 11, y en la que los tres aminoácidos que corresponden a las tres cisteínas de las posiciones 627, 630 y 638 de SEQ ID Nº 11 son diferentes de la cisteína.

14. 发明专利

AU2009267844A1 Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer 未知
公开(公告)号：AU2009267844A1
公开(公告)日：2010-01-14
申请号：AU2009267844
申请日：2009-07-09
申请人： BIOMERIEUX SA
发明人： BEAULIEU CORINNE , CHOQUET-KASTYLEVSKY GENEVIEVE , ATAMAN-ONAL YASEMIN , CHARRIER JEAN-PHILIPPE , ROLLAND DOMINIQUE , BUSSERET SANDRINE
IPC分类号： G01N33/574 , C07K7/00

15. 发明专利

CA2693096A1 APOLIPOPROTEIN AI ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER 未知
公开(公告)号：CA2693096A1
公开(公告)日：2009-02-12
申请号：CA2693096
申请日：2008-07-10
申请人： BIOMERIEUX SA
发明人： ATAMAN-ONAL YASEMIN , CHARRIER JEAN-PHILIPPE , CHOQUET-KASTYLEVSKY GENEVIEVE , POIRIER FLORENCE
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/68
摘要： La présente invention concerne un procédé de diagnostic in vitro du cancer colorectal par détermination de la présence du marqueur tumoral Apolipoprotéine AI par dosage immunologique dans un échantillon biologique issu d'un patient suspecté d'être atteint du cancer colorectal, étant entendu que le dosage n'est pas turbidimé trique, ledit procédé pouvant être utilisé tant dans le diagnostic précoce, le dépistage, le suivi thérapeutique, le pronostic, que dans le diagnostic des rechutes dans le cadre du cancer colorectal.

16. 发明专利

AU2008285559A1 Apolipoprotein AII assay method for the in vitro diagnosis of colorectal cancer 未知
公开(公告)号：AU2008285559A1
公开(公告)日：2009-02-12
申请号：AU2008285559
申请日：2008-07-10
申请人： BIOMERIEUX SA
发明人： POIRIER FLORENCE , CHARRIER JEAN-PHILIPPE , ATAMAN-ONAL YASEMIN , CHOQUET-KASTYLEVSKY GENEVIEVE
IPC分类号： G01N33/574
摘要： The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Apolipoprotein AII tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer.

17. 发明专利

RU2764198C2 СПОСОБ ПОЛУЧЕНИЯ АНТИТЕЛ ПРОТИВ АМН И ИХ ПРИМЕНЕНИЕ 未知
公开(公告)号：RU2764198C2
公开(公告)日：2022-01-14
申请号：RU2019101062
申请日：2017-06-16
申请人： BIOMERIEUX SA
发明人： ATAMAN-ONAL YASEMIN , CHEUCLE SYLVIE , COMBE MAXIME , DANIEL SOIZIC , OTTONE SOPHIE
IPC分类号： C07K16/26 , G01N33/53 , G01N33/74
摘要： Изобретениеотноситсяк областибиотехнологии, вчастностик способуполученияантителпротив AMH млекопитающих. Указанныйспособпредусматриваетиммунизациюживотногополипептидом AMH илиполинуклеотидом, кодирующимуказанныйполипептид AMH, получениегибридомизклетоклимфоидногоорганаживотного, получившегоиммуноген, отборгибридом, секретирующихантитела, распознающиеполипептид AMH, иполучениеантитела. Изобретениеэффективнодляполученияантител, которыераспознаюттольконелинейныеэпитопыв конкретнойзоне AMH, причемэтиантителапозволяютпроводитьстабильныйи надежныйанализ AMH, которыйможноиспользоватьв обычноймедицинскойпрактикеи которыйявляетсянадежным, точными воспроизводимымнезависимоотпреаналитическихусловийилиусловияхраненияобразца. 5 з.п. ф-лы, 4 ил., 11 табл., 9 пр.

18. 发明专利

AU2017285276A1 Method for preparing anti-AMH antibodies and uses of same 未知
公开(公告)号：AU2017285276A1
公开(公告)日：2019-01-31
申请号：AU2017285276
申请日：2017-06-16
申请人： BIOMERIEUX SA
发明人： ATAMAN-ONAL YASEMIN , CHEUCLE SYLVIE , COMBE MAXIME , DANIEL SOIZIC , OTTONE SOPHIE
IPC分类号： C07K16/26 , G01N33/53
摘要： The present invention relates to a method for preparing mammalian anti-AMH antibodies comprising the steps of: (i) immunising an animal with a polypeptide of AMH or a polynucleotide coding for this polypeptide of AMH, said polypeptide of AMH comprising at least the 99 amino acids of sequence SEQ ID N°1 or of a sequence having at least 75% identity with sequence SEQ ID N°1, and at most the 560 amino acids of sequence SEQ ID N°2 or of a sequence having at least 75% identity with sequence SEQ ID N°2, (ii) preparing hybridomas from cells of a lymphoid organ of the animal having received the immunogen, (iii) selecting hybridomas secreting antibodies recognising a polypeptide of AMH comprising at least the 99 amino acids of sequence SEQ ID N°1 or of a sequence having at least 75% identity with sequence SEQ ID N°1, and at most the 255 amino acids of sequence SEQ ID N°8 or of a sequence having at least 75% identity with sequence SEQ ID N°8, but recognising neither (a) a polypeptide of AMH comprising at least the 131 amino acids of sequence SEQ ID N°13 or of a sequence having at least 75% identity with sequence SEQ ID N°13 and at most the 20,156 amino acids of sequence SEQ ID N°11 or of a sequence having at least 75% identity with sequence SEQ ID N°11, nor (b) any linear epitope located in sequence SEQ ID N°1 or a sequence having at least 75% identity with sequence SEQ ID N°1, and (iv) producing the antibodies. The invention also relates to antibodies, antibody fragments and the use of same for assaying AMH, particularly in fertility.

19. 发明专利

AU2008285557B2 Method for the assay of liver fatty acid-binding protein, ACE and CA19-9 for the in vitro diagnosis of colorectal cancer 未知
公开(公告)号：AU2008285557B2
公开(公告)日：2014-07-03
申请号：AU2008285557
申请日：2008-07-10
申请人： BIOMERIEUX SA
发明人： CHARRIER JEAN-PHILIPPE , ATAMAN-ONAL YASEMIN , PONS SYLVIE , BEAULIEU CORINNE , CHOQUET-KASTYLEVSKY GENEVIEVE , ROLLAND DOMINIQUE
IPC分类号： G01N33/574
摘要： The invention relates to a method for the

20. 发明专利

AU2010231255B2 Method for assaying prodefensin-A6 for the in vitro diagnosis of colorectal cancer 未知
公开(公告)号：AU2010231255B2
公开(公告)日：2015-07-16
申请号：AU2010231255
申请日：2010-04-01
申请人： BIOMERIEUX SA
发明人： ATAMAN-ONAL YASEMIN , BEAULIEU CORINNE , BUSSERET SANDRINE , CHARRIER JEAN-PHILIPPE , CHOQUET-KASTYLEVSKY GENEVIEVE , ROLLAND DOMINIQUE
IPC分类号： C07K16/44 , G01N33/574 , G01N33/577
摘要： The present invention relates to a method for the

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