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11. 发明申请

US20120114628A1 COSMETIC AND THERAPEUTIC USE OF PROTEINS OF DJ-1 TYPE FOR TREATING SKIN DRYNESS 有权
标题翻译： DJ-1型蛋白质治疗皮肤干燥的化妆和治疗方法
公开(公告)号：US20120114628A1
公开(公告)日：2012-05-10
申请号：US13130710
申请日：2009-11-19
申请人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
发明人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
IPC分类号： A61K38/48 , A61K8/64 , A61K31/375 , A61K31/455 , G01N33/566 , C12Q1/68 , A61K38/02 , A61K38/17 , A61K38/08 , A61K38/10 , A61K31/7088 , A61K31/713 , A61K8/49 , A61P17/00 , A61Q19/00 , A61K8/73
CPC分类号： A61K38/1709 , A61K8/64 , A61Q19/007
摘要： The present invention relates to the use, especially the cosmetic and/or therapeutic use, of the protein DJ-1, of polypeptides derived from this protein or of analogues thereof, of a nucleic acid sequence coding for such a polypeptide or of a modulator of the activity, stability or expression of such a polypeptide, especially for preventing and/or treating the signs of skin dryness. The invention also relates to the use of the protein DJ-1, of polypeptides derived from this protein or of analogues thereof or of a nucleic acid sequence coding for such a polypeptide, as a marker for evaluating the state of dryness of an epithelium.
摘要翻译：本发明涉及编码这种多肽或调节剂的核酸序列的衍生自该蛋白质或其类似物的多肽蛋白质DJ-1的用途，特别是化妆品和/或治疗用途这种多肽的活性，稳定性或表达，特别是用于预防和/或治疗皮肤干燥症状。本发明还涉及蛋白质DJ-1来自该蛋白质或其类似物的多肽或编码这种多肽的核酸序列作为评价上皮干燥状态的标记物的用途。

12. 发明申请

US20070014748A1 Urea compounds that promote desquamation 有权
标题翻译：促进脱屑的尿素化合物
公开(公告)号：US20070014748A1
公开(公告)日：2007-01-18
申请号：US11485506
申请日：2006-07-13
申请人： Dominique Bernard , Lucie Simonetti , Pascale Pelletier
发明人： Dominique Bernard , Lucie Simonetti , Pascale Pelletier
IPC分类号： A61K8/65 , A61K8/40
CPC分类号： A61Q19/00 , A61K8/42 , A61K8/66 , A61K31/17 , A61K2800/28 , A61K2800/88 , A61Q5/006
摘要： The invention relates to the use of at least one urea derivative of the following formula (I) in a composition containing a physiologically acceptable medium, as agent intended for stimulating desquamation of the skin and/or the mucous membranes. It also relates to a method of cosmetic treatment and cosmetic agents containing it.
摘要翻译：本发明涉及至少一种下述式（I）的尿素衍生物在含有生理学上可接受的培养基的组合物中作为用于刺激皮肤和/或粘膜脱屑的试剂。它还涉及一种美容治疗方法和含有它的美容剂。

13. 发明申请

US20110098230A1 COSMETIC USE OF ANNEXIN II-TYPE PROTEINS FOR TREATING DRYNESS OF THE SKIN 审中-公开
标题翻译：用于治疗皮肤干燥的新型II型蛋白质的化妆品用途
公开(公告)号：US20110098230A1
公开(公告)日：2011-04-28
申请号：US12936320
申请日：2009-04-02
申请人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
发明人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
IPC分类号： A61K38/16 , A61K38/08 , A61K38/10 , A61Q19/00
CPC分类号： A61Q19/007 , A61K8/64
摘要： The present invention relates to the use, in particular cosmetic and/or therapeutic use, of annexin II, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of a modulator of the activity, the stability or the expression of such a polypeptide, in particular for preventing and/or treating the signs of skin dryness.The invention also relates to the use of annexin II, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide, as a marker for evaluating a state of dryness of an epithelium.
摘要翻译：本发明涉及膜联蛋白II的用途，特别是化妆品和/或治疗用途，其衍生自该蛋白质或其类似物的多肽编码这种多肽或活性调节剂的核酸序列，其稳定性或这种多肽的表达，特别是用于预防和/或治疗皮肤干燥症状。本发明还涉及膜联蛋白II来自该蛋白质或其类似物的多肽或编码这种多肽的核酸序列作为评价上皮干燥状态的标记物的用途。

14. 发明申请

US20100179200A1 2-OXOTHIAZOLIDINE 4-CARBOXYLIC ACID COMPOUNDS FOR PROMOTING DESQUAMATION OF THE SKIN 审中-公开
标题翻译：用于促进皮肤脱屑的2-氧杂环丁烷4-羧酸化合物
公开(公告)号：US20100179200A1
公开(公告)日：2010-07-15
申请号：US12683088
申请日：2010-01-06
申请人： Jean-Baptiste GALEY , Dominique Bernard , Lucie Simonetti
发明人： Jean-Baptiste GALEY , Dominique Bernard , Lucie Simonetti
IPC分类号： A61K31/426 , A61P17/00
CPC分类号： A61Q19/00 , A61K8/49 , A61K2800/28 , A61Q19/08
摘要： 2-oxothiazolidine-4-carboxylic acid compounds having the structural formula (I): are suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating aging of the skin.
摘要翻译：具有结构式（I）的2-氧代噻唑烷-4-羧酸化合物：适于促进皮肤脱皮和/或刺激表皮更新和/或抵抗皮肤老化。

15. 发明授权

US09316653B2 Use of soluble forms of the Desmoglein I protein for the purposes of screening for anti-ageing active agents 有权
标题翻译：使用可溶形式的脱骨髓蛋白I蛋白质用于筛选抗衰老活性剂
公开(公告)号：US09316653B2
公开(公告)日：2016-04-19
申请号：US12687601
申请日：2010-01-14
申请人： Mark Donovan , Lucie Simonetti , Dominique Bernard
发明人： Mark Donovan , Lucie Simonetti , Dominique Bernard
IPC分类号： G01N31/00 , G01N33/53 , G01N33/68 , A61K8/64 , A61Q19/08
CPC分类号： G01N33/6881 , A61K8/64 , A61Q19/08 , G01N2333/705 , G01N2333/795
摘要： The invention relates to the use of one or more complexed or noncomplexed, soluble peptide form(s) of Desmoglein I, as a marker for evaluating the effectiveness of active agents and/or of treatments, in particular anti-ageing active agents and/or treatments, with regard to an epidermis.
摘要翻译：本发明涉及使用一种或多种络合或非复合的可溶形式的脱骨髓蛋白I的肽形式作为评估活性剂和/或治疗的有效性的标志物，特别是抗衰老活性剂和/或治疗，关于表皮。

16. 发明授权

US08785397B2 Cosmetic use of apolipoprotein D type proteins 有权
标题翻译：化妆品使用载脂蛋白D型蛋白
公开(公告)号：US08785397B2
公开(公告)日：2014-07-22
申请号：US12602246
申请日：2008-06-20
申请人： Dominique Bernard , Isabelle Castiel , Lucie Simonetti
发明人： Dominique Bernard , Isabelle Castiel , Lucie Simonetti
IPC分类号： A61K38/16 , A61K8/64 , G01N33/68
CPC分类号： G01N33/92 , A61K8/64 , A61K38/1709 , A61Q17/00 , A61Q19/08 , C07K14/775 , G01N2500/04 , G01N2500/10
摘要： The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation.The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis.
摘要翻译：本发明的主题是使用来自该蛋白质或其类似物的多肽的载脂蛋白D的化妆品和/或治疗用途，编码这种多肽的核酸序列或调节活性或这种多肽的表达，特别是用于刺激末端上皮分化。本发明还涉及来自该蛋白质或其类似物的多肽的蛋白质载脂蛋白D或编码这种多肽的核酸序列作为评估表皮状态的标记物的用途。

17. 发明申请

US20110038830A1 COSMETIC USE OF PLAKOGLOBIN-TYPE PROTEINS 审中-公开
标题翻译： PLAKOGLOBIN型蛋白质的化学使用
公开(公告)号：US20110038830A1
公开(公告)日：2011-02-17
申请号：US12809385
申请日：2008-12-19
申请人： Dominique Bernard , Lucie Simonetti , Isabelle Castel
发明人： Dominique Bernard , Lucie Simonetti , Isabelle Castel
IPC分类号： A61K8/64 , A61K38/17 , A61K38/19 , A61K38/10 , A61K38/45 , C12Q1/68 , G01N33/566 , G01N33/68 , A61Q19/08 , A61Q19/00 , A61P17/00
CPC分类号： G01N33/6881 , A61K8/606 , A61K8/64 , A61K38/17 , A61Q19/08 , G01N33/5008
摘要： The present invention relates to the use, in particular cosmetic and/or therapeutic use, of plakoglobin, of polypeptides derived from this protein or of analogs thereof, of a nucleic sequence encoding such a polypeptide or of an agent for modulating the activity, the stability or the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation. The invention also relates to the use of plakoglobin, of polypeptides derived from this protein or of analogs thereof, or of a nucleic sequence encoding such a polypeptide, as a marker for evaluating a state of an epithelium.
摘要翻译：本发明涉及编码这种多肽或调节活性的试剂的核酸序列的来源于该蛋白质或其类似物的多肽使用，特别是化学和/或治疗用的嗜铬蛋白的用途，稳定性或这种多肽的表达，特别是用于刺激末端上皮分化。本发明还涉及来自该蛋白质或其类似物的多肽，或编码这种多肽的核酸序列的蛋白激酶作为评价上皮状态的标记物的用途。

18. 发明申请

US20060127343A1 Administration of urea compounds for combating signs of cutaneous aging 有权
标题翻译：管理尿素化合物，防止皮肤老化迹象
公开(公告)号：US20060127343A1
公开(公告)日：2006-06-15
申请号：US11260139
申请日：2005-10-28
申请人： Dominique Bernard , Lucie Simonetti
发明人： Dominique Bernard , Lucie Simonetti
IPC分类号： A61K8/42
CPC分类号： A61Q19/08 , A61K8/42
摘要： Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.
摘要翻译：防止和/或减少皮肤和/或粘膜老化的迹象，通过向需要这种治疗的个体施用化妆品/药物组合物来刺激角质层蛋白水解酶的活性其包含如此有效量的至少一种具有下式（I）的羟基化脲化合物：其中：可以相同或不同的基团R 1，R 2，R 3和R 4各自为氢原子，可以含有1至5个羟基的C 1 -C 4烷基或C 2 -C 6 -C 6羟烷基基团，其中R 1至R 4基团中的至少一个表示配制到其生理学上可接受的介质中的羟烷基或其盐，溶剂化物或异构体。

19. 发明授权

US08609117B2 Compositions comprising jasmonic acid derivatives and use of the derivatives 有权
标题翻译：包含茉莉酸衍生物的组合物和衍生物的用途
公开(公告)号：US08609117B2
公开(公告)日：2013-12-17
申请号：US12728580
申请日：2010-03-22
申请人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
发明人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
IPC分类号： A61K31/557
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; —R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1是选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; -R2选自包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其任选被1至5个选自-OR“，-OCOR”，“ -SR“'，-SCOR”，NR“'R”'， - NHCOR''，卤素，-CN，-COOR“和-COR”'，其中R“ 和R“'可以相同或不同，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

20. 发明授权

US08481594B2 Compositions comprising jasmonic acid derivatives and use of these derivatives 有权
标题翻译：包含茉莉酸衍生物的组合物和这些衍生物的用途
公开(公告)号：US08481594B2
公开(公告)日：2013-07-09
申请号：US12406570
申请日：2009-03-18
申请人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
发明人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
IPC分类号： A61K31/122 , A61K31/60
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein;R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein;as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1为选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; R 2选自包含1至18个碳原子的饱和和不饱和的，直链的，支链的和环状的烃基，其任选被1-5个相同或不同的选自-OR“，-OCOR” - ， - ，“NR”，“R”“，”-NHCOR“，卤素，-CN，-COOR”和-COR“，其中R”'和R“ 其可以相同或不同，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

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