专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07529583B1 Therapeutic device and method using feedback from implantable pressure sensor 失效
标题翻译：使用植入式压力传感器反馈的治疗装置和方法
公开(公告)号：US07529583B1
公开(公告)日：2009-05-05
申请号：US10756188
申请日：2004-01-12
申请人： Brian P. Brockway , Brian D. Pederson , David G. Benditt
发明人： Brian P. Brockway , Brian D. Pederson , David G. Benditt
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/36564 , A61N1/36585 , A61N1/3987
摘要： Devices and methods to reduce the incidence of both false positive and false negative detection of rhythm anomalies. Implantable devices that measure vascular pressure, vascular blood flow, tissue perfusion, and/or intracardial pressure provide feedback directly to the therapeutic device to improve aberrant rhythm detection.
摘要翻译：设备和方法减少假阳性和假阴性检测发生的节律异常。测量血管压力，血管血流，组织灌注和/或心内压力的可植入装置直接向治疗装置提供反馈以改善异常心律检测。

12. 发明授权

US5027813A Rate responsive pacemaker apparatus having an electrode interface sensor 失效
标题翻译：具有电极接口传感器的速率响应起搏器装置
公开(公告)号：US5027813A
公开(公告)日：1991-07-02
申请号：US487918
申请日：1990-03-05
申请人： Brian D. Pederson , John A. Hauck
发明人： Brian D. Pederson , John A. Hauck
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A variable rate cardiac pacer apparatus is responsive to the physical activity of the patient. A source of alternating current carrier signals of a predetermined frequency is coupled to the pacer housing. At least one sensing electrode is coupled to the carrier signals. The sensing electrode and the pacer housing are structured and arranged to operate as a pair of interface sensing electrodes. A sense amplifier apparatus is coupled to the sensing electrodes for receiving and amplifying modulated electrical signals developed across the sensing electrodes. A demodulator circuit apparatus is structured and arranged to receive the amplified modulated carrier signal which is proportional to the impedance field around the sensing electrode. The frequency of the demodulated signal is proportional to the patient's rate of movement. A signal processing apparatus receives the demodulated signal and provides a processed signal proportional to impedance changes sensed at the interface. A rate control apparatus determines the rate at which the heart stimulating pulse will be generated in response to the processed signal.
摘要翻译：可变率心脏起搏器装置响应于患者的身体活动。具有预定频率的交流载波信号的源耦合到起搏器壳体。至少一个感测电极耦合到载波信号。感测电极和起搏器壳体被构造和布置成作为一对接口感测电极工作。感测放大器装置耦合到感测电极，用于接收和放大在感测电极两端产生的经调制的电信号。解调器电路装置被构造和布置成接收与感测电极周围的阻抗场成比例的放大的调制载波信号。解调信号的频率与患者的运动速率成比例。信号处理装置接收解调信号，并提供与界面处感测到的阻抗变化成比例的处理信号。速率控制装置响应于处理的信号确定将产生心脏刺激脉冲的速率。

13. 发明授权

US07167746B2 Anti-coagulation and demineralization system for conductive medical devices 有权
标题翻译：导电医疗器械的抗凝和去矿物质系统
公开(公告)号：US07167746B2
公开(公告)日：2007-01-23
申请号：US10889328
申请日：2004-07-12
申请人： Brian D. Pederson
发明人： Brian D. Pederson
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/375
摘要： A system for minimizing and/or eliminating coagulative or mineral deposits on respective blood-contacting surfaces of implanted medical devices includes an implantable system having a current generating device that is electrically coupled to at least first and second electrodes for developing a current therebetween. The at least first and second electrodes are disposed across a patient's thoracic cavity in a manner so that a particular implanted medical device having at least a portion thereof that is fabricated from an electrically conductive material is disposed in a path substantially between such electrodes, thereby focusing the generated electrical current at the electrically conductive portion of the implanted medical device for therapeutic treatment thereat.
摘要翻译：用于最小化和/或消除植入的医疗装置的各个血液接触表面上的凝结或矿物沉积物的系统包括具有电流发生装置的可植入系统，该电流产生装置电耦合至少第一和第二电极以在其间形成电流。所述至少第一和第二电极以使得具有由导电材料制成的至少一部分的特定植入医疗装置设置在基本上位于这些电极之间的路径中的方式设置在患者的胸腔上，由此聚焦在植入医疗装置的导电部分处产生的用于治疗性处理的电流。

14. 发明授权

US5284136A Dual indifferent electrode pacemaker 失效
标题翻译：双重无动于衷的电极起搏器
公开(公告)号：US5284136A
公开(公告)日：1994-02-08
申请号：US698789
申请日：1991-05-13
申请人： John A. Hauck , Brian D. Pederson
发明人： John A. Hauck , Brian D. Pederson
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/36521
摘要： An endocardial lead having first and second spaced apart electrodes resides in a patient's heart. The first electrode is a sensing electrode and the second electrode is a carrier signal driving electrode. The lead has a conductor coupling a source of alternating current carrier signals of a predetermined frequency to the second electrode. A third electrode is in electrical contact with body tissues. A cardiac pacer apparatus includes a pacer can which functions as a fourth electrode and has a plastic top wherein the third electrode is located. Said third electrode acts in cooperation with the first electrode to form a pair of sensing electrodes. The sensing electrode pair is further coupled to a sense amplifier for receiving an amplifying modulated electrical signals developed across the sensing electrode pair. A demodulator and filters circuit for demodulating the modulated carrier signal and recovering the modulating signal therefrom is connected to the output of the sense amplifier. The modulating signal is proportional to instantaneous stroke volume of the patient's heart and the demodulator and filters circuit develops a control signal therefrom called a stroke volume signal. The control signal is applied to the pulse generator so as to control the rate of stimulating pulses.
摘要翻译：具有第一和第二间隔开的电极的心内膜引线驻留在患者的心脏中。第一电极是感测电极，第二电极是载体信号驱动电极。引线具有将预定频率的交流载波信号源耦合到第二电极的导体。第三电极与身体组织电接触。心脏起搏器装置包括作为第四电极并具有第三电极所在的塑料顶部的起搏罐。所述第三电极与第一电极配合起作用以形成一对感测电极。感测电极对还被耦合到读出放大器，用于接收在感测电极对上产生的放大调制电信号。解调器和滤波器电路用于解调调制后的载波信号并从其中恢复调制信号连接到读出放大器的输出端。调制信号与患者心脏的瞬时行程体积成正比，解调器和滤波器电路产生一个控制信号，称为行程音量信号。控制信号被施加到脉冲发生器，以便控制刺激脉冲的速率。

15. 发明授权

US09844667B2 System for conditioning surfaces in vivo 有权
公开(公告)号：US09844667B2
公开(公告)日：2017-12-19
申请号：US11402463
申请日：2006-04-12
申请人： Brian D. Pederson
发明人： Brian D. Pederson
IPC分类号： A61N1/20
CPC分类号： A61N1/20
摘要： A system and method for conditioning surfaces of a body in vivo includes providing an electrical energy source, coupling the electric energy source to the surface, and delivering electropositive current from the electrical energy source to the surface so as to generate a sub-threshold current density on the surface. In preferred embodiments, the sub-threshold electropositive current density is between about 0.001 and about 1.0 mA/cm2.

16. 发明授权

US08565872B2 Anti-coagulation and demineralization system for conductive medical devices 有权
标题翻译：导电医疗器械的抗凝和去矿物质系统
公开(公告)号：US08565872B2
公开(公告)日：2013-10-22
申请号：US11617507
申请日：2006-12-28
申请人： Brian D. Pederson
发明人： Brian D. Pederson
IPC分类号： A61N1/36
CPC分类号： A61N1/08 , A61N1/375
摘要： A system for minimizing and/or eliminating coagulative or mineral deposits on respective blood-contacting surfaces of implanted medical devices includes an implantable system having a current generating device that is electrically coupled to at least first and second electrodes for developing a current therebetween. The at least first and second electrodes are disposed across a patient's thoracic cavity in a manner so that a particular implanted medical device having at least a portion thereof that is fabricated from an electrically conductive material is disposed in a path substantially between such electrodes, thereby focusing the generated electrical current at the electrically conductive portion of the implanted medical device for therapeutic treatment thereat.
摘要翻译：用于最小化和/或消除植入的医疗装置的各个血液接触表面上的凝结或矿物沉积物的系统包括具有电流发生装置的可植入系统，该电流产生装置电耦合至少第一和第二电极以在其间形成电流。所述至少第一和第二电极以使得具有由导电材料制成的至少一部分的特定植入医疗装置设置在基本上位于这些电极之间的路径中的方式设置在患者的胸腔上，由此聚焦在植入医疗装置的导电部分处产生的用于治疗性处理的电流。

17. 发明授权

US4899759A Flow-through resistivity cell 失效
标题翻译：流通电阻率单元
公开(公告)号：US4899759A
公开(公告)日：1990-02-13
申请号：US297664
申请日：1989-01-17
申请人： Brian D. Pederson , Bruce A. Tockman
发明人： Brian D. Pederson , Bruce A. Tockman
IPC分类号： A61B5/053 , G01N27/07 , G01N33/487
CPC分类号： A61B5/053
摘要： A resistivity cell formed integrally with or attached to the proximal end of a diagnostic catheter, allowing blood resistivity to be more easily and accurately measured. The cell comprises generally cylindrical body having an internal longitudinal bore of a known cross-sectional area and extending through the wall of the body are first and second pairs of longitudinally aligned electrodes. By joining a syringe to the proximal end of the assembly, a known volume of blood can be drawn into the cell. By applying an alternating current driving signal across the two outer electrodes and measuring the resistance between the two center electrodes, the blood's resistivity can be measured using the equation .rho.=AR/1. By connecting the cell directly to the vascular catheter, the need to maintain the blood sample at body temperature is alleviated.
摘要翻译：与诊断导管的近端一体地连接或附接到诊断导管的近端的电阻率电池，允许更容易且准确地测量血液电阻率。电池包括具有已知横截面积的内部纵向孔的大致圆柱体，并且延伸通过本体的壁是第一和第二对纵向对准的电极。通过将注射器连接到组件的近端，可以将已知体积的血液吸入细胞。通过在两个外部电极之间施加交流驱动信号并测量两个中心电极之间的电阻，可以使用等式rho = AR / 1来测量血液的电阻率。通过将细胞直接连接到血管导管，可以减轻在体温下维持血液样本的需要。

18. 发明授权

US4819662A Cardiac electrode with drug delivery capabilities 失效
标题翻译：心电极具有药物输送能力
公开(公告)号：US4819662A
公开(公告)日：1989-04-11
申请号：US112518
申请日：1987-10-26
申请人： Ronald W. Heil, Jr. , Robert C. Owens , Brian D. Pederson
发明人： Ronald W. Heil, Jr. , Robert C. Owens , Brian D. Pederson
IPC分类号： A61N1/05 , A61N1/00
CPC分类号： A61N1/0568
摘要： An implantable cardiac pacing lead includes a porous, platinum electrode, a flexible electrically conductive coil, and a crimp tube coupling the electrode to the distal end of the coil. A recess in the crimp tube, open to the electrode at the crimp tube distal end, houses a matrix impregnated with a therapeutic drug. The electrode is highly porous and loaded with a therapeutic drug in liquid or solid form. Immediately upon implant of the electrode at a selected myocardial location, the electrode begins dispensing the therapeutic drug. Meanwhile, the matrix begins to elute its drug at a rate more suited to chronic treatment. If desired, the recess can extend through the crimp tube to permit proximal end loading of the drug carrying matrix. A silicone plug, or an additional and proximal crimp tube section, is inserted into the recess after loading of the matrix to provide the required fluid seal. Finally, a variety of different matrices can be housed in the recess, to provide elution of different drugs and at differing rates.
摘要翻译：可植入心脏起搏引线包括多孔铂电极，柔性导电线圈和将电极耦合到线圈的远端的压接管。在压接管远端的电极开口的压接管中的凹部容纳浸有治疗药物的基质。电极是高度多孔的，并以液体或固体形式装载治疗药物。在选定的心肌位置植入电极后，电极开始分配治疗药物。同时，矩阵开始以更适合慢性治疗的速度洗脱药物。如果需要，凹槽可以延伸穿过压接管以允许携带药物的基质的近端负载。在加载基质以提供所需的流体密封之后，硅胶塞或附加的和近端的卷边管部分被插入到凹槽中。最后，可以将许多不同的基质容纳在凹槽中，以提供不同药物和不同速率的洗脱。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式