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11. 发明授权

US4853379A Stable hydrocortisone-based composition for use in local corticotherapy 失效
标题翻译：稳定的氢化可的松组合物用于局部皮质激素治疗
公开(公告)号：US4853379A
公开(公告)日：1989-08-01
申请号：US918978
申请日：1986-10-15
申请人： Braham Shroot , Carole Le Foyer de Costil , Liliane Ayache
发明人： Braham Shroot , Carole Le Foyer de Costil , Liliane Ayache
IPC分类号： A61K31/12 , A61K8/00 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/40 , A61K8/63 , A61K9/08 , A61K9/107 , A61K31/57 , A61K31/575 , A61K31/60 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/18 , A61P17/00 , A61Q5/00 , A61Q5/02
CPC分类号： A61K47/14 , A61K31/57 , A61K47/08 , A61K47/186 , A61K9/0014 , Y10S424/13 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/975
摘要： A stable hydrocortisone-based composition comprises hydrocortisone solubilized in a mixture of an aliphatic alcohol, propyleneglycol and dimethyl coco-benzylammonium chloride.
摘要翻译：稳定的基于氢化可的松的组合物包含溶解在脂族醇，丙二醇和二甲基椰子 - 苄基氯化铵的混合物中的氢化可的松。

12. 发明授权

US4826969A Bicyclic naphthalenic derivatives, a process for preparing the same and human or veterinary medicines and cosmetic compositions containing said derivatives 失效
标题翻译：双环萘衍生物，其制备方法以及含有所述衍生物的人或兽用药物和化妆品组合物
公开(公告)号：US4826969A
公开(公告)日：1989-05-02
申请号：US918507
申请日：1986-10-14
申请人： Jean Maignan , Gerard Lang , Gerard Malle , Serge Restle , Braham Shroot
发明人： Jean Maignan , Gerard Lang , Gerard Malle , Serge Restle , Braham Shroot
IPC分类号： C07C63/36 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/42 , A61K8/49 , A61K31/045 , A61K31/11 , A61K31/12 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/445 , A61K31/585 , A61P17/00 , A61P35/00 , A61P43/00 , A61Q5/00 , A61Q19/00 , C07C20060101 , C07C33/34 , C07C33/36 , C07C33/38 , C07C41/00 , C07C43/178 , C07C43/30 , C07C45/00 , C07C45/30 , C07C47/445 , C07C47/546 , C07C47/56 , C07C47/57 , C07C49/83 , C07C49/86 , C07C51/00 , C07C63/49 , C07C63/66 , C07C65/17 , C07C65/26 , C07C65/36 , C07C67/00 , C07C69/76 , C07C213/00 , C07C215/28 , C07C217/48 , C07C223/02 , C07C229/38 , C07C233/12 , C07C233/64 , C07C233/65 , C07C235/66 , C07C235/84 , C07C237/30 , C07C239/00 , C07C251/48 , C07C259/10 , C07C323/59 , C07D295/18 , C07H15/18 , C07H15/20 , C07C149/243
CPC分类号： C07C323/59 , A61K31/585 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/42 , A61Q19/00 , A61Q5/00 , C07C229/38 , C07C235/66 , C07C235/84 , C07C251/48 , C07C259/10 , C07C33/34 , C07C45/30 , C07C47/56 , C07C47/57 , C07C49/83 , C07C49/86 , C07C63/49 , C07C63/66 , C07C65/17 , C07C65/26 , C07C65/36 , C07C69/76 , C07C2102/10
摘要： A bicyclic naphthalenic compound has the formula ##STR1## wherein A represents methylene or dimethylene, substituted or not by lower alkyl,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or lower alkyl, orR.sub.1 and R.sub.3 taken together form a methylene or dimethylene bridge when A represents dimethylene,R' represents hydrogen, OH, alkoxy having 1-4 carbon atoms, acyloxy having 1-4 carbon atoms or amino,R" represents hydrogen or alkoxy having 1-4 carbon atoms, orr' and R" taken together form an oxo, methano or hydroxyimino group,R represents --CH.sub.2 OH or --COR.sub.5,R.sub.5 represents hydrogen, --OR.sub.6 or ##STR2## R.sub.6 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl optionally substituted, the residue of a sugar or ##STR3## p is 1, 2 or 3, and r' and r", each independently, represent hydrogen, lower alkyl, monohydroxyalkyl optionally interrupted by a heteroatom, polyhydroxyalkyl, aryl or benzyl optionally substituted, the residue of an amino acid, an aminoester or an aminated sugar, or r' and r" together form with the nitrogen atom to which they are attached, a heterocycle substituted or not, and the salts of said compounds of formula (I) or the optional isomers thereof.
摘要翻译：双环萘化合物具有下式（I）其中A表示亚甲基或二亚甲基，被低级烷基取代或不被低级烷基取代，R 1，R 2，R 3和R 4表示氢或低级烷基，或者R 1和R 3一起形成亚甲基或当A表示二亚甲基时，R'表示氢，OH，具有1-4个碳原子的烷氧基，具有1-4个碳原子的酰氧基或氨基，R“表示氢或具有1-4个碳原子的烷氧基，或者r'和 R“一起形成氧代，亚甲基或羟基亚氨基，R表示-CH 2 OH或-COR 5，R 5表示氢，-OR 6或R 6表示氢，具有1-20个碳原子的烷基，单羟基烷基，多羟基烷基，芳基或任选取代的芳烷基，糖或者P的残基是1,2或3，并且r'和r“各自独立地代表氢，低级烷基，任选被杂原子中间的一羟基烷基，多羟基烷基，芳基或苄基任选取代，氨基酸的残基，氨基酯或胺化的糖，或者r'和r“与它们所连接的氮原子一起形成，取代或未被取代的杂环，以及所述式（I）化合物的盐或其任选的异构体。

13. 发明授权

US4810694A Benzonorbornene derivatives process, for their preparation and medicinal and cosmetic compositions comprised thereof 失效
标题翻译：苯并降冰片烯衍生物方法，用于其制备及其药物和化妆品组合物
公开(公告)号：US4810694A
公开(公告)日：1989-03-07
申请号：US817605
申请日：1986-01-10
申请人： Jean R. Maignan , Braham Shroot , Serge A. Restle
发明人： Jean R. Maignan , Braham Shroot , Serge A. Restle
IPC分类号： C07C17/263 , A61K8/00 , A61K8/25 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K31/00 , A61K31/015 , A61K31/03 , A61K31/045 , A61K31/05 , A61K31/075 , A61K31/085 , A61K31/11 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/70 , A61K31/7024 , A61P3/02 , A61P17/00 , A61P29/00 , A61P37/00 , A61P37/08 , A61Q19/00 , C07C1/00 , C07C13/605 , C07C17/00 , C07C17/12 , C07C25/22 , C07C27/00 , C07C33/18 , C07C39/17 , C07C41/00 , C07C43/20 , C07C51/00 , C07C63/34 , C07C63/49 , C07C67/00 , C07C69/76 , C07C69/94 , C07C209/00 , C07C211/30 , C07C231/00 , C07C231/12 , C07C233/65 , C07C235/42 , C07C237/28 , C07H13/08 , A61K7/06 , A61K31/33
CPC分类号： A61K8/368 , A61K8/37 , A61K8/42 , A61Q19/00 , A61Q5/008 , C07C17/12 , A61Q5/00 , Y10S514/844 , Y10S514/859 , Y10S514/863 , Y10S514/864 , Y10S514/88
摘要： The invention relates to a compound of formula (I) ##STR1## in which formula: R.sub.1, R.sub.3 and R.sub.4 denote, independently of each other a hydrogen atom, a C.sub.1 -C.sub.8 alkyl radical, a C.sub.1 -C.sub.8 alkoxy radical, a C.sub.1 -C.sub.8 acryloxy radical or a hydroxy ra dical;R, R' and R" denote, independently of each other, either one of the meanings given above for R.sub.1, R.sub.3 and R.sub.4, or a halogen atom, or a primary, secondary or tertiary amino radical,A having various meanings.The invention also relates to a process for the preparation of compounds of formula (I) and to medicinal and cosmetic compositions in which they are present.
摘要翻译：本发明涉及式（I）化合物其中式R1，R3和R4彼此独立地表示氢原子，C1-C8烷基，C1-C8烷氧基， C1-C8丙烯酰氧基或羟基; R，R'和R“彼此独立地表示对于R 1，R 3和R 4或卤素原子或具有各种含义的伯，仲或叔氨基A的含义之一。本发明还涉及制备式（I）化合物的方法及其存在的药物和化妆品组合物。

14. 发明授权

US4677123A Pharmaceutical and cosmetic compositions containing as an active ingredient 1,8-dihydroxy-10-phenyl-9-anthrone and a process for preparation thereof 失效
标题翻译：含有作为活性成分的1,8-二羟基-10-苯基-9-蒽酮的药物和化妆品组合物及其制备方法
公开(公告)号：US4677123A
公开(公告)日：1987-06-30
申请号：US753906
申请日：1985-07-11
申请人： Braham Shroot , Gerard Lang , Jean Maignan
发明人： Braham Shroot , Gerard Lang , Jean Maignan
IPC分类号： C07C49/747 , A61K8/00 , A61K8/30 , A61K8/33 , A61K31/12 , A61K31/122 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , A61Q17/04 , C07C45/00 , C07C49/737 , C07C67/00
CPC分类号： C07C49/737
摘要： Pharmaceutical or cosmetic composition containing as the active component 1,8-dihydroxy-10-phenyl-9-anthrone, and a process for preparing said active component.
摘要翻译：含有活性成分1,8-二羟基-10-苯基-9-蒽酮的药物或化妆品组合物及其制备方法。

15. 发明授权

US4558069A 1,8-Dihydroxy-9-anthrones derivatives substituted in the 10-position by an unsaturated radical used in human medicine 失效
标题翻译：通过用于人类医学中的不饱和基团在10位上被取代的1,8-二羟基-9-蒽酮衍生物
公开(公告)号：US4558069A
公开(公告)日：1985-12-10
申请号：US615734
申请日：1984-05-31
申请人： Braham Shroot , Jean Maignan , Gerard Lang
发明人： Braham Shroot , Jean Maignan , Gerard Lang
IPC分类号： C07C59/90 , A61K31/12 , A61K31/34
CPC分类号： C07C59/90 , Y10S514/859 , Y10S514/863
摘要： 1,8-dihydroxy-9-anthrone derivatives, substituted in the 10-position by an unsaturated radical, are described which have utility as ingredients in human and veterinary pharmaceutical and cosmetic preparations and which are compounds of the structural formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a --CO.sub.2 R'.sub.2 radical,R.sub.2 and R'.sub.2 identical or different, represent a hydrogen atom, a linear or branched chain alkyl radical having 1 to 6 carbon atoms, a cycloalkyl radical having 4 to 6 carbon atoms or a benzyl radical,or R.sub.1 and R.sub.2 taken together form a radical --CO--, andn is 0 or 1,with the proviso that when n is 0 and R.sub.1 is --CO.sub.2 R'.sub.2, R.sub.2 and R'.sub.2 do not simultaneously represent the radical CH.sub.3,and the isomers of the compounds of formula (I) and mixtures thereof.
摘要翻译：在10位被不饱和基团取代的1,8-二羟基-9-蒽酮衍生物被描述为具有作为人类和兽医药物和化妆品制剂中的成分的作用，并且是结构式为“IMAGE”（I ）其中R1表示氢原子或-CO2R'2基团，R2和R'2相同或不同，表示氢原子，具有1至6个碳原子的直链或支链烷基，环烷基具有4至6个碳原子或苄基，或者R 1和R 2一起形成基团-CO-，n为0或1，条件是当n为0且R 1为-CO 2 R'2时，R 2和R'2为同时代表基团CH 3，和式（I）化合物的异构体及其混合物。

16. 发明授权

US4137312A Epoxy substituted cephalosporin derivatives 失效
标题翻译：环氧取代头孢菌素衍生物
公开(公告)号：US4137312A
公开(公告)日：1979-01-30
申请号：US838830
申请日：1977-10-03
申请人： Barry C. Ross , Braham Shroot
发明人： Barry C. Ross , Braham Shroot
IPC分类号： A61K31/545 , C07D501/24 , C07D501/34 , C07D501/46
CPC分类号： C07D501/20 , C07D501/24
摘要： A series of novel 7-(D-.alpha.-acylaminoarylacetamido)-.DELTA..sup.3 -cephem derivatives have been prepared wherein the acyl moiety contains an epoxy group immediately adjacent to the carbonyl carbon atom. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-negative and Gram-positive bacteria. Preferred members include 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]-3-(1-methyl-1,2,3,4-tetrazol-5-ylthiomethyl)-.alpha..sup.3 -cephem-4-carboxylic acid and 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]cephalosporanic acid. Alternate methods of preparation are provided for these compounds and the principal synthetic route is described in detail.
摘要翻译：已经制备了一系列新颖的7-（D-α-酰基氨基芳基乙酰氨基）-TATA 3-头孢烯衍生物，其中酰基部分含有紧邻羰基碳原子的环氧基。这些化合物可用作抗菌剂，用于治疗由革兰氏阴性菌和革兰氏阳性菌引起的疾病。优选的成员包括7- [D-α - （顺式-2-羧基环氧乙烷-3-甲酰氨基）苯基乙酰氨基] -3-（1-甲基-1,2,3,4-四唑-5-基硫甲基）-α3-头孢烯 -4-羧酸和7- [D-α-（顺式-2-羧基环氧乙烷-3-甲酰氨基）苯基乙酰胺基]头孢烷酸。为这些化合物提供了替代的制备方法，并详细描述了主要合成路线。

17. 发明授权

US4064241A 7[(Carboxyoxiran-3-carboxamido)phenylacetamido]cephalosporin derivatives 失效
标题翻译： 7 {8（羧基氧环己烷-3-甲酰氨基）苯乙酰氨基{9头孢菌素衍生物
公开(公告)号：US4064241A
公开(公告)日：1977-12-20
申请号：US628543
申请日：1975-11-03
申请人： Barry Clive Ross , Braham Shroot
发明人： Barry Clive Ross , Braham Shroot
IPC分类号： C07D303/48 , C07D501/20 , C07D501/24 , C07D501/36 , A61K31/545
CPC分类号： C07D501/20 , C07D303/48 , C07D501/24
摘要： A series of novel 7-(D-.alpha.-acylaminoarylacetamido)-.DELTA..sup.3 -cephem derivatives have been prepared wherein the acyl moiety contains an epoxy group immediately adjacent to the carbonyl carbon atom. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-negative and Gram-positive bacteria. Preferred members include 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]-3-(1-methyl-1,2,3,4-tetrazol-5-ylthiomethyl)-.DELTA..sup.3 -cephem-4-carboxylic acid and 7-[D.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]cephalosporanic acid. Alternate methods of preparation are provided for these compounds and the principal synthetic route is described in detail.
摘要翻译：已经制备了一系列新颖的7-（D-α-酰基氨基芳基乙酰氨基）-TATA 3-头孢烯衍生物，其中酰基部分含有紧邻羰基碳原子的环氧基。这些化合物可用作抗菌剂，用于治疗由革兰氏阴性菌和革兰氏阳性菌引起的疾病。优选的成员包括7- [D-α - （顺式-2-羧基环氧乙烷-3-甲酰胺基）苯基乙酰胺基] -3-（1-甲基-1,2,3,4-四唑-5-基硫甲基）-TATA 3 - 头孢烯 -4-羧酸和7- [Dα-（顺式-2-羧基环氧乙烷-3-甲酰氨基）苯基乙酰胺基]头孢烷酸。为这些化合物提供了替代的制备方法，并详细描述了主要合成路线。

18. 发明授权

US5310959A Eicosatriynoic acid esters and amides and methods of preparation 失效
标题翻译：二十碳三烯酸酯和酰胺及其制备方法
公开(公告)号：US5310959A
公开(公告)日：1994-05-10
申请号：US61268
申请日：1993-05-17
申请人： Braham Shroot , Christopher Hensby , Jean Maignan , Gerard Lang , Serge Restle , Michel Colin
发明人： Braham Shroot , Christopher Hensby , Jean Maignan , Gerard Lang , Serge Restle , Michel Colin
IPC分类号： A61K8/00 , A61K8/11 , A61K8/30 , A61K8/33 , A61K8/36 , A61K8/37 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/16 , A61K31/165 , A61K31/195 , A61K31/20 , A61K31/202 , A61K31/22 , A61K31/23 , A61K31/40 , A61K31/445 , A61K31/495 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q5/00 , A61Q19/00 , C07C17/26 , C07C51/353 , C07C57/18 , C07C57/68 , C07C67/00 , C07C69/606 , C07C231/00 , C07C231/02 , C07C233/02 , C07C233/09 , C07C233/16 , C07C233/20 , C07D295/16 , C07D295/18 , C07D295/185 , C07D317/20 , C12N9/99 , C07C231/100
CPC分类号： A61K8/375 , A61K8/42 , A61Q19/00 , A61Q19/004 , C07C17/26 , C07C57/18 , C07C57/68 , C07D295/185 , C07D317/20 , Y10S514/886
摘要： Processes for preparing 5,8,11-eicosatriynoic acid as well as esters and amides thereof involves initially preparing the acid by reacting 1-decyne with 1,4-dihalo-2-butyne in the presence of a strong base to form 1-halo-2,5-tetradecadiyne which is then reacted with 5-hexynoic acid so as to form 5,8,11-eicosatriynoic acid. This acid can then be converted to the acid chloride form and reacted with an alcohol to form an ester or converted to a potassium salt and reacted with a halide also to form an ester, or after conversion to an acid chloride reacted with an amine in the presence of a tertiary amine to form an amide, or the acid can be reacted with carbonyldiimidazole in the presence of a solvent and excess amine to form an amide.
摘要翻译：制备5,8,11-二十碳三烯酸及其酯和酰胺的方法包括首先在强碱存在下使1-癸炔与1,4-二卤-2-丁炔反应制备酸，以形成1-卤代 -2,5-十四碳二炔，然后与5-己炔酸反应，形成5,8,11-二十碳三烯酸。然后将该酸转化为酰氯形式并与醇反应形成酯或转化成钾盐，并与卤化物反应形成酯，或在转化为与胺反应后的酰氯中存在叔胺以形成酰胺，或者酸可以与羰基二咪唑在溶剂和过量胺的存在下反应形成酰胺。

19. 发明授权

US5260295A Aromatic heterocyclic derivatives and their therapeutic and cosmetic use 失效
标题翻译：芳香杂环衍生物及其治疗和美容用途
公开(公告)号：US5260295A
公开(公告)日：1993-11-09
申请号：US696708
申请日：1991-05-07
申请人： Braham Shroot , Jacques Eustache , Jean-Michel Bernardon
发明人： Braham Shroot , Jacques Eustache , Jean-Michel Bernardon
IPC分类号： A61C9/00 , C07C59/64 , C07D209/10 , C07D235/18 , C07D263/56 , C07D263/57 , C07D277/66 , C07D307/79 , C07D333/54 , C07D405/04 , A61K31/42 , A61K31/395 , C07D263/34 , C07D417/12
CPC分类号： C07D263/57 , A61C9/00 , C07C59/64 , C07D209/10 , C07D235/18 , C07D277/66 , C07D307/79 , C07D333/54 , C07D405/04 , Y10S514/845 , Y10S514/846 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/912
摘要： Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents (i)--CH.sub.3, (ii)--CH.sub.2 OH or (iii) ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.7 is branched alkyl having 4-12 atoms.
摘要翻译：芳族杂环衍生物具有下式（其中R 1表示（i）-CH 3，（ii）-CH 2 OH或（iii）其中R 3表示氢，-OR 4，其中R 4表示氢，具有1-20个碳原子的烷基或单或多羟基烷基或R 3表示其中r'和r“表示氢，低级烷基或一起形成杂环，R 2表示氢或-CH 3，Ar表示（A）（C）（D）其中R6是氢或具有1-10个碳原子的烷基，R7代表具有4-12个碳原子的烷基或环烷基，Y是CH或氮原子，X代表氧，硫或（ⅰ）当Y为CH且X为氧或硫时Ar为C以外，（ⅱ）当Y为氮且X为氧时，R为氢，低级烷基或低级烷氧基羰基， Ar不是（C）或（D），其中R6是具有1-4个碳原子的烷基，R7是具有4-12个原子的支链烷基。

20. 发明授权

US5200550A Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions 失效
标题翻译：双芳香酯，其制备方法及其在人体或兽医学和化妆品组合物中的用途
公开(公告)号：US5200550A
公开(公告)日：1993-04-06
申请号：US553087
申请日：1990-07-17
申请人： Braham Shroot , Jean-Michel Bernardon
发明人： Braham Shroot , Jean-Michel Bernardon
IPC分类号： A61K31/235 , A61K8/00 , A61K8/30 , A61K8/33 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61P11/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61Q5/00 , A61Q19/00 , C07C67/14 , C07C69/00 , C07C69/76 , C07C69/773 , C07C69/78 , C07C69/88 , C07C69/94 , C07C309/42 , C07C309/58 , C07C311/29 , C07C317/22 , C07C317/44 , C07C323/62
CPC分类号： C07C323/62 , C07C69/94 , C07C2103/74
摘要： Bi-aromatic esters have the formula ##STR1## wherein R.sub.1 represents H, OH, --CH.sub.3, --CH.sub.2 OH, --CH(OH)CH.sub.3, --COOR.sub.9, ##STR2## or SO.sub.2 R.sub.10 ; R.sub.9 represents H, C.sub.1 -C.sub.6 alkyl or monoor polyhydroxyalkyl; R.sub.10 represents OH, C.sub.1 -C.sub.6 alkyl or ##STR3## r' and r" represent H, C.sub.1 -C.sub.6 alkyl, aryl, aralkyl, mono or polyhydroxyalkyl, or r' and r" taken together form a heterocycle; R.sub.2 represents H, C.sub.1 -C.sub.6 alkyl, OR.sub.9, F or --CF.sub.3 ; R.sub.3, R.sub.4 and R.sub.5 represent H, F, OH, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --COOH or --CH.sub.2 OH; R.sub.6 and R.sub.8 represent H, .alpha.-substituted C.sub.3 -C.sub.15 alkyl, .alpha.,.alpha.'-disubstituted C.sub.4 -C.sub.12 alkyl, C.sub.3 -C.sub.12 cycloalkyl, C.sub.5 -C.sub.12 mono or polycyclic cycloalkyl whose linking carbon is trisubstituted, --SR.sub.11, --SO.sub.2 R.sub.11 or --SOR.sub.11 ; R.sub.11 represents C.sub.1 -C.sub.6 alkyl or cycloalkyl; R.sub.6 and R.sub.8 cannot simultaneously represent H; R.sub.7 represents H, C.sub.1 -C.sub.6 alkyl, alkenyl, alkenyloxy, OR.sub.12 or SR.sub.13 ; R.sub.12 represents H, C.sub.1 -C.sub.6 alkyl or alkenyl; R.sub.3 represents H, C.sub.1 -C.sub.6 alkyl or aralkyl; with the proviso that when R.sub.1 represents ##STR4## and R.sub.2 represents H then: (i) either R.sub.3 and R.sub.4 are other than H or --CH.sub.3, (ii) or R.sub.7 is other than OR.sub.12 and R.sub.6 or R.sub.8 is cycloalkyl having more than 7 carbon atoms, (iii) or R.sub.7 is OR.sub.12 but R.sub.6 and R.sub.8 are other than H, (iv) or R.sub.7 is OR.sub.12 but R.sub.5 is other than H.The bi-aromatic esters are employed in human and veterinary medicine and in cosmetic compositions.
摘要翻译：双芳族酯具有式（I）其中R 1表示H，OH，-CH 3，-CH 2 OH，-CH（OH）CH 3，-COOR 9，或SO 2 R 10; R9表示H，C1-C6烷基或单或多羟基烷基; R 10表示OH，C 1 -C 6烷基或R 3'，R“表示H，C 1 -C 6烷基，芳基，芳烷基，单或多羟基烷基，或r'和r”一起形成杂环; R 2表示H，C 1 -C 6烷基，OR 9，F或-CF 3; R3，R4和R5表示H，F，OH，-CH3，-OCH3，-CF3，-COOH或-CH2OH; R 6和R 8表示H，α-取代的C 3 -C 15烷基，α，α'-二取代的C 4 -C 12烷基，C 3 -C 12环烷基，连接碳是三取代的C 5 -C 12单环或多环环烷基，-SR 11，-SO 2 R 11或 - SOR11; R11表示C1-C6烷基或环烷基; R6和R8不能同时代表H; R7表示H，C1-C6烷基，烯基，烯氧基，OR12或SR13; R12表示H，C1-C6烷基或烯基; R3表示H，C1-C6烷基或芳烷基; 条件是当R1表示且R2表示H时：（i）R3和R4不是H或-CH3，（ii）或R7不是OR12，R6或R8是大于7的环烷基碳原子，（iii）或R7是OR12，但R6和R8不是H，（iv）或R7是OR12，但R5不是H.双芳族酯用于人类和兽医学和化妆品组合物中。

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