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11. 发明申请

US20110212032A1 POLYMER PARTICLES FOR NIR/MR BIMODAL MOLECULAR IMAGING AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用于NIR / MR双模分子成像的聚合物颗粒及其制备方法
公开(公告)号：US20110212032A1
公开(公告)日：2011-09-01
申请号：US12672185
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik LIm , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik LIm , Jung Hyun Han
IPC分类号： A61K49/12 , C12Q1/02
CPC分类号： C08J5/005 , A61K49/0002 , A61K49/0034 , A61K49/0067 , A61K49/0093 , A61K49/1824 , B82Y30/00 , C08J3/12 , C08J3/2053 , C08J3/215 , C08J2367/02 , G01R33/0213 , G01R33/1269 , G01R33/281 , G01R33/4808 , G01R33/5601
摘要： The present invention relates to polymer particles showing magnetic properties and fluorescent properties simultaneously and a preparation method thereof More specifically, relates to polymer particles for near infrared (NIR)/magnetic resonance (MR) bimodal molecular imaging, contain a magnetic nanomaterial and an NIR fluorescent material, and a preparation method thereof The disclosed polymer particles show magnetic properties and fluorescent properties simultaneously, and thus are useful as contrast agents for NIR/MR bimodal molecular imaging.
摘要翻译：本发明涉及同时显示磁特性和荧光特性的聚合物颗粒及其制备方法更具体地，涉及用于近红外（NIR）/磁共振（MR）双峰分子成像的聚合物颗粒，其含有磁性纳米材料和NIR荧光材料及其制备方法所公开的聚合物颗粒同时显示磁性和荧光特性，因此可用作NIR / MR双峰分子成像的造影剂。

12. 发明申请

US20100233094A1 PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME 有权
标题翻译：含有量子纳米粒子的全氟烷纳米乳液及其制备方法
公开(公告)号：US20100233094A1
公开(公告)日：2010-09-16
申请号：US12738394
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
IPC分类号： A61B5/055
CPC分类号： C09K11/565 , C09K11/02 , C09K11/883
摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
摘要翻译：本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

13. 发明申请

US20100040693A1 SILICA CAPSULES HAVING NANO-HOLES OR NANO-PORES ON THEIR SURFACES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：在其表面上具有纳米孔或纳米孔的二氧化硅颗粒及其制备方法
公开(公告)号：US20100040693A1
公开(公告)日：2010-02-18
申请号：US12376798
申请日：2007-08-01
申请人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim
发明人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim
IPC分类号： A61K9/14 , B32B5/16 , H01F1/00 , G02F1/361 , A61K38/43 , A61K38/02 , C09K11/06
CPC分类号： B01J13/02 , A61K9/5115 , A61K9/5192 , Y10T428/2982
摘要： The present invention relates to silica capsules having nano-holes or nano-pores on the surface thereof, and preparation methods thereof. More specifically, relates to silica capsules having holes with a size ranging from a few nanometers (nm) to a few hundreds of nanometers (nm), on the surface thereof, multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles, and preparation methods thereof. According to the present invention, the silica capsules having holes on the surface thereof can be prepared by making an emulsion system using two fluids having different surface tensions, and selectively evaporating only one fluid of the two fluids during a process of forming a silica layer. In addition, the multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles can be prepared by loading various multifunctional nanoparticles into the two fluids.
摘要翻译：本发明涉及在其表面具有纳米孔或纳米孔的二氧化硅胶囊及其制备方法。更具体地，涉及具有尺寸范围从几纳米（nm）到几百纳米（nm）的孔的二氧化硅胶囊，其表面上含有磁性纳米颗粒和光学纳米颗粒的多功能硅胶胶囊及其制备方法。根据本发明，其表面上具有孔的二氧化硅胶囊可以通过制备使用具有不同表面张力的两种流体的乳液体系，并且在形成二氧化硅层的过程中仅选择性地蒸发两种流体的一种流体来制备。另外，含有磁性纳米粒子和光学纳米粒子的多功能二氧化硅胶囊可以通过将各种多功能纳米粒子加载到两种流体中来制备。

14. 发明申请

US20090318376A1 High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby 审中-公开
标题翻译：通过筛选caspase3和XIAP结合抑制剂之间的结合抑制剂的高通量筛选方法
公开(公告)号：US20090318376A1
公开(公告)日：2009-12-24
申请号：US12304766
申请日：2006-06-12
申请人： Bong Hyun Chung , Kwang-Hee Son , Moonil Kim , Kyoungsook Park , Byoung-Mog Kwon , Hyun Jung Junn , Dong Cho Han , Sun-Hee Jeon
发明人： Bong Hyun Chung , Kwang-Hee Son , Moonil Kim , Kyoungsook Park , Byoung-Mog Kwon , Hyun Jung Junn , Dong Cho Han , Sun-Hee Jeon
IPC分类号： A61K31/702 , G01N33/573 , C07H15/24
CPC分类号： A61K31/702 , G01N33/574 , G01N2333/96469 , G01N2500/02
摘要： The present invention relates to a high throughput screening method of a binding inhibitor between caspase3 and xIAP and chromomycin screened using the same, and more specifically, the present invention provides a method for screening anticancer substance, the method comprising the steps of reacting caspase3 or xIAP and candidate inhibitors of the binding between caspase3 and xIAP on a biochip for detecting caspase3:xIAP interaction, and selecting a candidate substance inhibiting the binding of caspase3 to xIAP as an anticancer substance, and an anticancer agent inhibiting caspase3:xIAP binding, which is screened by the above method. According to present invention, it is possible to develop a target-oriented anticancer agent focused on xIAP and caspase3, apoptosis-related proteins and thus it can be applied to tailored medication and combination therapy. Moreover, glycoside antibiotic chromomycin, screened by the present invention has inhibitory activity of the binding between xIAP and caspase3 involved in apoptosis, so that it can be used as a therapeutic agent for myelogenous leukemia and solid tumors.
摘要翻译：本发明涉及使用其筛选的胱天蛋白酶3和xIAP之间的结合抑制剂的高通量筛选方法，更具体地说，本发明提供了筛选抗癌物质的方法，所述方法包括以下步骤：使半胱天冬酶3或xIAP 以及用于检测胱天蛋白酶3：xIAP相互作用的生物芯片上的半胱天冬酶3和xIAP之间的结合的候选抑制剂，并且选择抑制半胱天冬酶3与作为抗癌物质的xIAP的结合的候选物质，以及抑制胱天蛋白酶3的抗癌剂：xIAP结合通过上述方法。根据本发明，可以开发聚焦于xIAP和caspase3的靶向抗癌剂，凋亡相关蛋白，因此可以应用于定制药物和联合治疗。此外，通过本发明筛选的糖苷抗生素chromomycin具有抑制参与凋亡的xIAP和半胱天冬酶3之间的结合的活性，因此可以用作骨髓性白血病和实体瘤的治疗剂。

15. 发明授权

US5712113A Signal sequences for secretion of heterologous proteins from yeast 失效
标题翻译：从酵母中分泌异源蛋白质的信号序列
公开(公告)号：US5712113A
公开(公告)日：1998-01-27
申请号：US353751
申请日：1994-12-12
申请人： Bong Hyun Chung , Soo Wan Nam , Byung Moon Kim , Sun Ah Yang , Young Hoon Park
发明人： Bong Hyun Chung , Soo Wan Nam , Byung Moon Kim , Sun Ah Yang , Young Hoon Park
IPC分类号： C12N15/09 , C07K14/47 , C12N1/19 , C12N9/24 , C12N15/00 , C12N15/56 , C12N15/81 , C12P21/02 , C12R1/645 , C12R1/865 , C12P21/06
CPC分类号： C12Y302/01007 , C07K14/4721 , C12N15/81 , C12N15/815 , C12N9/2402 , C07K2319/00 , C07K2319/02
摘要： Secretion signal peptides of inulinases derived from Kluyveromyces marxianus, which makes a heterologous protein produced in a yeast cell be secreted almost completely into the extracellular medium; nucleotide sequences encoding said secretion signal peptides; expression and secretion vectors comprising nucleotide sequences encoding said secretion signal peptides; recombinant yeast cells transformed with said expression and secretion vectors; and a process for producing heterologous proteins by culturing said recombinant yeast cells.
摘要翻译：衍生自马克斯克鲁维酵母的菊粉酶的分泌信号肽，其使得在酵母细胞中产生的异源蛋白质几乎完全分泌到细胞外培养基中; 编码所述分泌信号肽的核苷酸序列; 包含编码所述分泌信号肽的核苷酸序列的表达和分泌载体; 用所述表达和分泌载体转化的重组酵母细胞; 以及通过培养所述重组酵母细胞产生异源蛋白质的方法。

16. 发明授权

US09326940B2 Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same 有权
标题翻译：用于高效包封核酸和亲水性阴离子化合物的不对称脂质体及其制备方法
公开(公告)号：US09326940B2
公开(公告)日：2016-05-03
申请号：US13697705
申请日：2010-11-12
申请人： Myung Kyu Lee , Abbas Mokhtarieh Amir , Bong Hyun Chung , Jong Min Choi
发明人： Myung Kyu Lee , Abbas Mokhtarieh Amir , Bong Hyun Chung , Jong Min Choi
IPC分类号： A61K9/127 , A61K31/122 , A61K31/70 , A61K31/713
CPC分类号： A61K9/1272 , A61K9/1271 , A61K9/1277 , A61K31/122 , A61K31/70 , A61K31/713
摘要： The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.
摘要翻译：本发明涉及用于核酸和亲水性阴离子化合物的高包封效率的不对称脂质体及其制备方法，具体涉及由具有小头基团作为内部脂质和中性的阳离子脂质组成的不对称脂质体或具有大头基的聚乙二醇化脂质作为外部脂质，其中核酸和/或阴离子化合物包封在内部脂质中。根据本发明，可以制备其中核酸和亲水性阴离子化合物以高效率包封的不对称脂质体，因此可以用于各种目的，例如基因治疗和递送亲水性阴离子药物其难以作为前药制备，并且药物递送，成像等可以通过将荧光对比剂包封在脂质体中来进行。

17. 发明申请

US20120059326A1 Microneedle Unit Capable of Controlling Fluid Delivery 有权
标题翻译：能够控制流体输送的微针单元
公开(公告)号：US20120059326A1
公开(公告)日：2012-03-08
申请号：US13263306
申请日：2010-04-08
申请人： Bong Hyun Chung , Nyeon Sik Eum
发明人： Bong Hyun Chung , Nyeon Sik Eum
IPC分类号： A61M5/32 , A61M5/00
CPC分类号： A61M37/0015 , A61M5/178 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061
摘要： Provided is a microneedle unit comprising a case having a space accommodating a fluid and a fluid channel through which the fluid is discharged, a microneedle coupled to a lower portion of the case, a base cover disposed at the lower portion of the case, having a hole through which the microneedle passes, and being vertically movable, a guide pin coupled to the base cover and configured to open and close the fluid channel, and an elastic member configured to impart a restoring force such that the base cover is moved upward by an external pressure and then returns downward again. Therefore, the microneedle unit, which is provided to deliver a fluid into the skin with no pain and no scar, can control injection of the fluid using the guide pin, and repeatedly and conveniently control injection of the fluid using the elastic member.
摘要翻译：提供了一种微针单元，其包括具有容纳流体的空间和流体被排出的流体通道的壳体，连接到壳体的下部的微针，设置在壳体的下部的底盖，具有所述微针通过所述孔并且可垂直移动;引导销，其联接到所述基座盖并且构造成打开和关闭所述流体通道;以及弹性构件，其构造成赋予恢复力，使得所述底盖向上移动一个外部压力再次向下返回。因此，提供用于将流体输送到皮肤中而没有疼痛和无疤痕的微针单元可以使用导销来控制流体的注入，并且使用弹性构件重复且方便地控制流体的注入。

18. 发明申请

US20110171269A1 METHOD FOR MANUFACTURING UNIFORM SIZE POLYMERIC NANOPARTICLES CONTAINING POORLY SOLUBLE DRUGS 有权
标题翻译：制造含有不溶性药物的均匀聚合物纳米颗粒的方法
公开(公告)号：US20110171269A1
公开(公告)日：2011-07-14
申请号：US12990540
申请日：2009-04-30
申请人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
IPC分类号： A61K9/00 , A61K31/235 , A61P1/16 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/1652 , A61K9/5153 , A61K31/235 , A61K31/343 , A61K31/513 , A61K31/519 , A61K31/5415 , A61K31/573 , A61K31/585 , A61K31/704 , A61K31/7048 , B01D65/00 , C08J3/03 , Y10S516/929
摘要： The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.
摘要翻译：本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将可生物降解聚合物溶解在非挥发性物质中的第一步骤极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小而均匀的聚合物纳米颗粒可生物降解聚合物和难溶性物质的溶液，并且使用低机械能条件和在乳化过程中分批添加分散体。本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐且稳定地释放并保持在恒定的密度。

19. 发明申请

US20110020225A1 POROUS POLYMER PARTICLES IMMOBILIZED WITH CHARGED MOLECULES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用充电分子固定的多孔聚合物颗粒及其制备方法
公开(公告)号：US20110020225A1
公开(公告)日：2011-01-27
申请号：US12672517
申请日：2008-08-05
申请人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
IPC分类号： A61K49/00 , A61K9/14 , A61P31/00
CPC分类号： A61K9/5031 , A61K49/0034 , A61K49/0054 , A61K49/0056 , A61K49/0089 , C08J3/12 , C08J2367/04
摘要： The present invention relates to porous polymer particles containing a charged molecule immobilized therein and a method for preparing the same. According to the disclosed invention, porous particles can be prepared using a biocompatible polymer and, at the same time, a charged molecule can be immobilized in the pores of the porous particles, such that various charged molecules can be loaded in the porous particles. In addition, various kinds of drugs or functional materials can be loaded into the porous particles of the present invention by electrostatic attraction and absorption or adsorption by a capillary phenomenon occurring due to porous properties.
摘要翻译：本发明涉及含有固定在其中的带电分子的多孔聚合物颗粒及其制备方法。根据所公开的发明，可以使用生物相容性聚合物制备多孔颗粒，并且同时可以将带电分子固定在多孔颗粒的孔中，使得各种带电分子可以负载在多孔颗粒中。此外，通过由于多孔性质而发生的毛细管现象的静电吸引和吸收，可以将各种药物或功能材料装载到本发明的多孔颗粒中。

20. 发明申请

US20100256397A1 WATER SOLUBLE PHOTOCHROMIC COMPOUNDS FOR LABELING OF BIOMOLECULES AND METHOD FOR DETECTING BIOMOLECULES USING THE SAME 有权
标题翻译：用于生物分子标记的水溶性光致变色化合物和使用该分析物检测生物分子的方法
公开(公告)号：US20100256397A1
公开(公告)日：2010-10-07
申请号：US12739601
申请日：2008-08-21
申请人： Bong Hyun Chung , Sang Jeon Chung , Suh Hyun Lee , Im Sik Chung , Hyun Kyu Park , Chang Soo Lee
发明人： Bong Hyun Chung , Sang Jeon Chung , Suh Hyun Lee , Im Sik Chung , Hyun Kyu Park , Chang Soo Lee
IPC分类号： C07D409/06
CPC分类号： G01N33/533 , A61K49/0021 , A61K49/006 , C09B11/24
摘要： The present invention relates to water-soluble photochromic compounds for labeling biomolecules and a method of detecting biomolecules using the same. More specifically, relates to water-soluble photochromic compounds for labeling biomolecules, in which a functional group rendering photochromic molecules water-soluble is linked to a functional group capable of binding to biomolecules, and a method of detecting biomolecules using the same. Because the disclosed water-soluble photochromic compounds exhibit the color corresponding to the wavelength of visible light range, they allow signals to be easily detected not only with an UV-VIS spectrophotometer but also visually. Accordingly, the photochromic compounds can be advantageously used in sensors for diagnosing diseases.
摘要翻译：本发明涉及用于标记生物分子的水溶性光致变色化合物和使用其的生物分子的检测方法。更具体地，涉及用于标记生物分子的水溶性光致变色化合物，其中使可溶于水的光致变色分子的官能团与能够结合生物分子的官能团连接，以及使用该生物分子检测生物分子的方法。由于所公开的水溶性光致变色化合物表现出与可见光范围波长相对应的颜色，所以它们不仅可以用UV-VIS分光光度计而且可视地容易地检测信号。因此，光致变色化合物可有利地用于诊断疾病的传感器中。

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