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11. 发明申请

US20120295270A1 METHODS OF USING IMPROVED POLYMERASES 有权
标题翻译：使用改进聚合物的方法
公开(公告)号：US20120295270A1
公开(公告)日：2012-11-22
申请号：US13560075
申请日：2012-07-27
申请人： Yan Wang , Peter Vander Horn , Lei Xi
发明人： Yan Wang , Peter Vander Horn , Lei Xi
IPC分类号： G01N21/64
CPC分类号： C12N15/10 , C07K14/195 , C07K2319/00 , C07K2319/80 , C12N9/1252 , C12N15/62 , C12P19/34 , C12Q1/686 , C12Y207/07007
摘要： This invention provides for methods of sequencing and performing polymerase reactions using an improved generation of nucleic acid polymerases. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the processivity of the polymerase.
摘要翻译：本发明提供使用改进的核酸聚合酶的产生来测序和进行聚合酶反应的方法。改进是以提高聚合酶的持续性的方式将序列非特异性核酸结合结构域与酶的融合。

12. 发明申请

US20060051749A1 Polymorphism and haplotype scoring by differential amplification of polymorphisms 审中-公开
标题翻译：多态性差异扩增多态性和单倍型评分
公开(公告)号：US20060051749A1
公开(公告)日：2006-03-09
申请号：US10496702
申请日：2002-11-27
申请人： Yan Wang , Lei Xi , Michael Finney , Fan Chen
发明人： Yan Wang , Lei Xi , Michael Finney , Fan Chen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q2561/113 , C12Q2545/114 , C12Q2537/143 , C12Q2535/125 , C12Q2531/113
摘要： The current invention provides a method of performing DNA polymorphism assays. The assay combines allele-specific PCR with technology used for quantitative PCR. The method can be used to score the presence of absence of particular polymorphisms in a DNA sample. In a further aspect of the invention, the method is used to score the presence or absence of particular haplotypes in a DNA sample.
摘要翻译：本发明提供了进行DNA多态性测定的方法。该测定将等位基因特异性PCR与用于定量PCR的技术相结合。该方法可用于评估DNA样品中特定多态性缺失的存在。在本发明的另一方面，该方法用于评估DNA样品中特定单元型的存在或不存在。

13. 发明授权

US08232078B2 Methods of using improved polymerases 有权
标题翻译：使用改良聚合酶的方法
公开(公告)号：US08232078B2
公开(公告)日：2012-07-31
申请号：US10306827
申请日：2002-11-27
申请人： Yan Wang , Peter Vander Horn , Lei Xi
发明人： Yan Wang , Peter Vander Horn , Lei Xi
IPC分类号： C12P19/34 , C12N9/12
CPC分类号： C12N15/10 , C07K14/195 , C07K2319/00 , C07K2319/80 , C12N9/1252 , C12N15/62 , C12P19/34 , C12Q1/686 , C12Y207/07007
摘要： This invention provides for methods of sequencing and performing polymerase reactions using an improved generation of nucleic acid polymerases. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the processivity of the polymerase.
摘要翻译：本发明提供使用改进的核酸聚合酶的产生来测序和进行聚合酶反应的方法。改进是以提高聚合酶的持续性的方式将序列非特异性核酸结合结构域与酶的融合。

14. 外观设计

USD1051109S1 TV antenna 有权
公开(公告)号：USD1051109S1
公开(公告)日：2024-11-12
申请号：US29954104
申请日：2024-07-25
申请人： Yan Wang
设计人： Yan Wang
摘要： FIG. 1 is a top perspective view of a TV antenna showing my new design.
FIG. 2 is a bottom perspective view thereof.
FIG. 3 is a front view thereof
FIG. 4 is a rear view thereof.
FIG. 5 is a left side view thereof.
FIG. 6 is a right side view thereof.
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.
The broken lines illustrate portions of the TV antenna that form no part of the claimed design.

15. 外观设计

USD1051026S1 Car storage box 有权
公开(公告)号：USD1051026S1
公开(公告)日：2024-11-12
申请号：US29958462
申请日：2024-08-20
申请人： Yan Wang
设计人： Yan Wang
摘要： FIG. 1 is a front perspective view of a car storage box, showing my new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is an enlarged left plane view;
FIG. 6 is an enlarged right plane view;
FIG. 7 is a top view thereof;
FIG. 8 is a bottom view thereof;
FIG. 9 is a perspective view showing the car storage box in a use state;
FIG. 10 is an enlarged detail view of area 10 in FIG. 1; and,
FIG. 11 is an enlarged detail view of area 11 in FIG. 2.
The broken lines in the drawings illustrate the portions of the car storage box, which form no part of the claimed design.
The dash-dot-dash broken lines encircling the enlarged views are for annotative purposes only and form no part of the claim thereof.

16. 发明授权

US11952603B2 Method for reducing or inactivating viral and microbial content in the processes for the manufacture of pancreatin 有权
公开(公告)号：US11952603B2
公开(公告)日：2024-04-09
申请号：US16108930
申请日：2018-08-22
申请人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
发明人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
IPC分类号： C12N9/92 , A61K9/00 , A61K31/327 , A61K35/39 , A61K38/46 , C12N7/00 , C12N9/94
CPC分类号： C12N9/94 , A61K9/00 , A61K31/327 , A61K35/39 , A61K38/46 , C12N7/00 , C12N2750/10063 , C12N2750/14363 , C12N2770/32263 , A61K35/39 , A61K2300/00 , A61K38/46 , A61K2300/00 , A61K31/327 , A61K2300/00
摘要： A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.

17. 外观设计

USD985153S1 Decoration light 有权
公开(公告)号：USD985153S1
公开(公告)日：2023-05-02
申请号：US29770167
申请日：2021-02-10
申请人： Yan Wang
设计人： Yan Wang

18. 发明授权

US11579086B2 Method for correcting interference of multicolor fluorescence channels 有权
公开(公告)号：US11579086B2
公开(公告)日：2023-02-14
申请号：US17496262
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
IPC分类号： C12Q1/686 , G01N21/64 , B01L9/00
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.

19. 发明申请

US20220026363A1 Method for Analyzing digital PCR Data Using Multicolor Fluorescence Reader 有权
公开(公告)号：US20220026363A1
公开(公告)日：2022-01-27
申请号：US17496285
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
IPC分类号： G01N21/64 , B01L9/00 , C12Q1/686
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.

20. 发明申请

US20220026362A1 Method for Correcting Interference of Multicolor Fluorescence Channels 有权
公开(公告)号：US20220026362A1
公开(公告)日：2022-01-27
申请号：US17496262
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
IPC分类号： G01N21/64 , B01L9/00 , C12Q1/686
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.

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