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11. 发明申请

US20110054183A1 Method For Manufacturing Aryl Carboxamides 有权
标题翻译：芳基酰胺制备方法
公开(公告)号：US20110054183A1
公开(公告)日：2011-03-03
申请号：US12990892
申请日：2009-05-06
申请人： Wolfgang Reichert , Christopher Koradin , Sebastian Peer Smidt , Volker Maywald , Bernd Wolf , Michael Rack , Thomas Zierke , Michael Keil
发明人： Wolfgang Reichert , Christopher Koradin , Sebastian Peer Smidt , Volker Maywald , Bernd Wolf , Michael Rack , Thomas Zierke , Michael Keil
IPC分类号： C07D213/82 , C07D231/14
CPC分类号： C07C231/02 , C07C2601/14 , C07D213/82 , C07D231/14 , C07D231/16 , C07C233/65 , C07C233/75
摘要： A process for preparing arylcarboxamides of the formula (I) whereAr =a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, Ci-C4-alkyl and C1-C4-haloalkyl;M =thienyl or phenyl, which may bear a halogen substituent;Q =direct bond, cyclopropylene, fused bicycio[2.2.1]heptane or bicyclo[2.2.1]heptene ring;R1 =hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl;by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base,a) the acid chloride (II) is initially charged,b) a pressure of from 0 to 700 mbar is established,c) the arylamine (III) is metered in in an approximately stoichiometric amount andd) the product of value is isolated.
摘要翻译：制备式（I）的芳基甲酰胺的方法，其中Ar =单 - 三取代的苯基，吡啶基或吡唑基环，其中取代基选自卤素，C 1 -C 4烷基和C 1 -C 4卤代烷基; M =噻吩基或苯基，其可以带有卤素取代基; Q =直接键合，亚环丙基，稠合二环[2.2.1]庚烷或双环[2.2.1]庚烯环; R1 =氢，卤素，C1-C6-烷基，C1-C4-烷氧基，C1-C4-卤代烷氧基，一至三取代的苯基，其中取代基选自卤素和三氟甲硫基，或环丙基; 通过使式（II）的酰氯与芳基胺（III）在合适的非水溶剂中反应，其中在没有辅助碱的情况下，a）最初加入酰氯（II），b）建立0至700毫巴，c）芳基胺（III）以约化学计量的量计量，并且d）分离产物的值。

12. 发明申请

US20110046371A1 PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS 有权
标题翻译：制备2-（氨基乙基）-4,4-二氟-3-氧代丁酸酯的方法
公开(公告)号：US20110046371A1
公开(公告)日：2011-02-24
申请号：US12990359
申请日：2009-04-30
申请人： Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
发明人： Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
IPC分类号： C07D295/145 , C07D211/34 , C07D265/30 , C07D231/14
CPC分类号： C07D231/14 , C07C229/30 , C07D295/145
摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3-oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.
摘要翻译：本发明涉及式（I）的二氟甲基取代的吡唑-4-基羧酸及其酯，2-（氨基亚甲基）-4,4-二氟-3-氧代苦味酯的方法，其中R 1，R 2和 R 3彼此独立地是C 1 -C 6 - 烷基，C 1 -C 6 - 卤代烷基，C 2 -C 6 - 烯基，C 3 -C 10 - 环烷基或苄基或NR 2 R 3是5-至10-元杂环基，式（I）的化合物，其中适当的3-氨基丙烯酸酯与二氟乙酰氟反应，以及在制备二氟甲基取代的吡唑-4-基羧酸及其酯的方法中使用式（I）的化合物。

13. 发明授权

US09062012B2 Process for manufacturing 4-substituted amino-benzoxazinones 有权
标题翻译：制备4-取代氨基 - 苯并恶嗪酮的方法
公开(公告)号：US09062012B2
公开(公告)日：2015-06-23
申请号：US14365774
申请日：2012-12-20
申请人： Bernd Wolf , Joachim Gebhardt , Uwe Josef Vogelbacher , Maximilian Dochnahl , Michael Rack , Michael Keil , Timo Frassetto , Volker Maywald
发明人： Bernd Wolf , Joachim Gebhardt , Uwe Josef Vogelbacher , Maximilian Dochnahl , Michael Rack , Michael Keil , Timo Frassetto , Volker Maywald
IPC分类号： C07D265/36 , C07D413/04
CPC分类号： C07D265/36 , C07D413/04
摘要： The present invention relates to a process for manufacturing 4-substituted amino-benzoxazinones of formula (I), by reacting a NH-benzoxazinone of formula (II) with a compound of formula (III); wherein the variables are defined according to the description.
摘要翻译：本发明涉及式（I）的4-取代氨基 - 苯并恶嗪酮的制备方法，其中式（II）的N-苯并恶嗪酮与式（III）的化合物反应; 其中根据描述定义变量。

14. 发明申请

US20110004002A1 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates 有权
标题翻译：制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法
公开(公告)号：US20110004002A1
公开(公告)日：2011-01-06
申请号：US12919842
申请日：2009-02-27
申请人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
发明人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
IPC分类号： C07D231/14 , C07C69/66
CPC分类号： C07D231/14 , C07C67/343 , C07C69/72
摘要： A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting where M is a sodium or potassium ion, and without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
摘要翻译：由烷基4,4-二氟乙酰乙酸酯（I）的粗反应混合物制备R为甲基或乙基的2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI）的方法，通过a）使M 钠离子或钾离子，无另外的溶剂以形成烯醇化物（Ⅴ）b）通过酸从烯醇化物（Ⅴ）中释出相应的4,4-二氟乙酰乙酸烷基酯（Ⅰ），c）除去由阳离子M形成的盐和酸阴离子作为固体，以及d）将（I）从粗反应混合物中分离出来，转化为2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI），以及（VI）用于制备1-甲基-3-二氟甲基 - 吡唑-3-基羧酸酯VII

15. 发明授权

US08586750B2 Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters 有权
标题翻译：卤素取代的2-（氨基亚甲基）-3-氧代丁酸酯的制备方法
公开(公告)号：US08586750B2
公开(公告)日：2013-11-19
申请号：US12990364
申请日：2009-04-30
申请人： Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
发明人： Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
IPC分类号： C07D295/145 , C07D211/34 , C07D265/30
CPC分类号： C07D295/145 , C07D231/14
摘要： The present invention relates to a process for preparing 2-(aminomethylidene)-4,4-dihalo-3-oxobutyric esters of the formula (I), wherein R1, R2, R3 are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl, and/or R2 together with R3 and the nitrogen atom to which the two radicals are attached are a heterocyclic radical, in which a corresponding 3-aminoacrylic ester is reacted with a halogen-substituted acetyl fluoride in the presence of at least one alkali or alkaline earth metal fluoride; and the further conversion of halogen-substituted 2-(aminomethylidene)-3-oxobutyric esters of the formula (I) to halomethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.
摘要翻译：本发明涉及制备式（I）的2-（氨基亚甲基）-4,4-二卤代-3-氧代丁酸酯的方法，其中R1，R2，R3是C1-C6-烷基，C1-C6-卤代烷基，C 2 -C 6 - 烯基，C 3 -C 10 - 环烷基或苄基，和/或R 2与R 3和两个基团所连接的氮原子是杂环基团，其中相应的3-氨基丙烯酸酯与卤素取代的乙酰氟在至少一种碱金属或碱土金属氟化物的存在下; 以及将式（I）的卤素取代的2-（氨基亚甲基）-3-氧代丁酸酯进一步转化为卤代甲基取代的吡唑-4-基羧酸及其酯。

16. 发明授权

US08344157B2 Process for preparing 1,3-disubstituted pyrazolecarboxylic esters 失效
标题翻译： 1,3-二取代吡唑羧酸酯的制备方法
公开(公告)号：US08344157B2
公开(公告)日：2013-01-01
申请号：US13054642
申请日：2009-07-10
申请人： Bernd Wolf , Sebastian Peer Smidt , Volker Maywald , Christopher Koradin , Michael Keil , Thomas Zierke , Michael Rack
发明人： Bernd Wolf , Sebastian Peer Smidt , Volker Maywald , Christopher Koradin , Michael Keil , Thomas Zierke , Michael Rack
IPC分类号： C07D231/10
CPC分类号： C07D233/90
摘要： A process for preparing 1,3-disubstituted pyrazolecarboxylic esters of the formula (I) where X, Y, Z=hydrogen or halogen and R1=C1-C6-alkyl, by metering an enol ether of the formula III where R2 is C1-C6-alkyl at from (−41) to (−80)° C. into an alkyl hydrazine of the formula II H2N—NH-lower alkyl (II).
摘要翻译：通过计量式III的烯醇醚制备其中X，Y，Z =氢或R 1 = C 1 -C 6烷基的式（I）的1,3-二取代吡唑羧酸酯的方法，其中R2是C1- （-41）至（-80）℃的C 6 - 烷基转化为式II的烷基肼H 2 NH-NH-低级烷基（II）。

17. 发明申请

US20110172436A1 Method for preparing 1,3,4-substituted pyrazol compounds 有权
标题翻译：制备1,3,4-取代吡唑化合物的方法
公开(公告)号：US20110172436A1
公开(公告)日：2011-07-14
申请号：US12990340
申请日：2009-05-04
申请人： Bernd Wolf , Volker Maywald , Michael Keil , Christopher Koradin , Michael Rack , Thomas Zierke , Martin Sukopp
发明人： Bernd Wolf , Volker Maywald , Michael Keil , Christopher Koradin , Michael Rack , Thomas Zierke , Martin Sukopp
IPC分类号： C07D231/14 , C07C243/10
CPC分类号： C07D409/12 , C07C251/76 , C07C251/84 , C07C251/86 , C07D231/14
摘要： The invention provides an Ethernet bridge or router comprising a network fabric adapted to provide interconnectivity to a plurality of Ethernet ports, each of the Ethernet ports being adapted to receive and/or transmit Ethernet frames, and wherein the Ethernet bridge or router further comprises an encapsulator connected to receive Ethernet Protocol Data Units from the Ethernet ports, wherein the encapsulator is operable to generate a Fabric Protocol Data Unit from a received Ethernet Protocol Data Unit, the Fabric Protocol Data Unit comprising a header portion, and a payload portion which comprises the Ethernet Protocol Data Unit concerned, and wherein the encapsulator is operable to transform Ethernet destination address information from the Ethernet Protocol Data Unit into a routing definition for the network fabric, and to include this routing definition in the header portion of the Fabric Protocol Data Unit. Also provided is a method of data delivery across a network.
摘要翻译：本发明提供了一种以太网桥或路由器，其包括适于提供与多个以太网端口的互连性的网络结构，每个以太网端口适于接收和/或发送以太网帧，并且其中所述以太网桥或路由器还包括封装器连接以从以太网端口接收以太网协议数据单元，其中所述封装器可操作以从接收到的以太网协议数据单元生成结构协议数据单元，所述结构协议数据单元包括报头部分和包括以太网的有效载荷部分协议数据单元，并且其中所述封装器可操作以将以太网目的地地址信息从以太网协议数据单元转换为所述网络结构的路由定义，并将所述路由定义包括在所述结构协议数据单元的报头部分中。还提供了一种通过网络进行数据传送的方法。

18. 发明授权

US09359312B2 Process for manufacturing benzoxazinones 有权
标题翻译：制备苯并恶嗪酮的方法
公开(公告)号：US09359312B2
公开(公告)日：2016-06-07
申请号：US14365829
申请日：2012-12-20
申请人： Maximilian Dochnahl , Michael Rack , Michael Keil , Bernd Wolf , Uwe Josef Vogelbacher , Joachim Gebhardt , Timo Frassetto , Volker Maywald
发明人： Maximilian Dochnahl , Michael Rack , Michael Keil , Bernd Wolf , Uwe Josef Vogelbacher , Joachim Gebhardt , Timo Frassetto , Volker Maywald
IPC分类号： C07D265/36 , C07D413/04 , C07C231/12
CPC分类号： C07D265/36 , C07C231/12 , C07D413/04
摘要： The present invention relates to a process for manufacturing a benzoxazinone of formula (I), by reacting a nitro compound of formula (II) with a reducing agent to obtain an amino compound of formula (III), and then reacting the amino compound of formula (III) with an acid; wherein the variables are defined according to the description, and benzoxazinone of formula (I).
摘要翻译：本发明涉及式（I）的苯并恶嗪酮的制备方法，通式（II）的硝基化合物与还原剂反应得到式（III）的氨基化合物，然后使式（III）与酸反应; 其中根据描述定义变量，和式（I）的苯并嗪酮。

19. 发明授权

US09000152B2 Process for manufacturing triazinon-benzoxazinones 有权
标题翻译：制备三嗪酮 - 苯并恶嗪酮的方法
公开(公告)号：US09000152B2
公开(公告)日：2015-04-07
申请号：US14364160
申请日：2012-12-20
申请人： Bernd Wolf , Volker Maywald , Uwe Josef Vogelbacher , Michael Rack , Maximilian Dochnahl , Michael Keil , Timo Frassetto , Joachim Gebhardt
发明人： Bernd Wolf , Volker Maywald , Uwe Josef Vogelbacher , Michael Rack , Maximilian Dochnahl , Michael Keil , Timo Frassetto , Joachim Gebhardt
IPC分类号： C07D413/14 , A01N43/84 , C07D413/04
CPC分类号： C07D413/04 , A01N43/84
摘要： The present invention relates to a process for manufacturing triazinon-benzoxazinones of formula (I), by reacting amino-benzoxazinones of formula (II) with 1,1′-carbonyldiimidazole (CDI) and a (thio)urea compound of formula (III); wherein the variables are defined according to the description.
摘要翻译：本发明涉及通过使式（II）的氨基 - 苯并嗪酮与1,1'-羰基二咪唑（CDI）和式（III）的（硫代）脲化合物反应制备式（I）的三嗪酮 - 苯并恶嗪酮的方法， ; 其中根据描述定义变量。

20. 发明授权

US08207354B2 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates 有权
标题翻译：制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法
公开(公告)号：US08207354B2
公开(公告)日：2012-06-26
申请号：US12919842
申请日：2009-02-27
申请人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
发明人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
IPC分类号： C07D231/10 , C07C69/00
CPC分类号： C07D231/14 , C07C67/343 , C07C69/72
摘要： A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting where M is a sodium or potassium ion, and without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
摘要翻译：由烷基4,4-二氟乙酰乙酸酯（I）的粗反应混合物制备R为甲基或乙基的2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI）的方法，通过a）使M 钠离子或钾离子，无另外的溶剂以形成烯醇化物（Ⅴ）b）通过酸从烯醇化物（Ⅴ）中释出相应的4,4-二氟乙酰乙酸烷基酯（Ⅰ），c）除去由阳离子M形成的盐和酸阴离子作为固体，以及d）将（I）从粗反应混合物中分离出来，转化为2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI），以及（VI）用于制备1-甲基-3-二氟甲基 - 吡唑-3-基羧酸酯VII

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