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11. 发明申请

US20100087886A1 METHOD AND DEVICE FOR PROCESSING CARDIAC SIGNALS 有权
标题翻译：用于处理心脏信号的方法和装置
公开(公告)号：US20100087886A1
公开(公告)日：2010-04-08
申请号：US12557770
申请日：2009-09-11
申请人： Ulrich Busch , Andreas Neumann , Ulrich Tietze
发明人： Ulrich Busch , Andreas Neumann , Ulrich Tietze
IPC分类号： A61N1/368 , A61N1/08
CPC分类号： A61N1/368 , A61B5/04011 , A61B5/0422 , A61B5/726 , A61N1/3682 , A61N1/37217
摘要： An electromedical implant having a far-field electrocardiogram detection unit connected or connectable to at least two implantable electrodes, at least one electrode of which is to be placed in the right atrium or right ventricle and is designed to record a far-field electrocardiogram via the terminal for the electrode to be placed in the right atrium or the right ventricle and one other electrode. The far-field electrocardiogram detection unit is connected to a far-field electrocardiogram evaluation unit, which is configured to detect signal features of the far-field electrocardiogram associated with an excitation or contraction of the left atrium and/or the left ventricle of the heart in a far-field electrocardiogram recorded by the far-field electrocardiogram detection unit.
摘要翻译：一种具有远场心电图检测单元的电离植入物，所述远场心电图检测单元连接或连接至至少两个可植入电极，其至少一个电极将被放置在右心房或右心室中，并被设计成通过该心电图记录远场心电图电极的末端放置在右心房或右心室和另一个电极中。远场心电图检测单元连接到远场心电图评估单元，其被配置为检测与心脏的左心房和/或左心室的激发或收缩相关联的远场心电图的信号特征在由远场心电图检测单元记录的远场心电图中。

12. 发明申请

US20090163967A1 BIVENTRICULAR HEART STIMULATOR 有权
标题翻译：双向心脏刺激器
公开(公告)号：US20090163967A1
公开(公告)日：2009-06-25
申请号：US12271908
申请日：2008-11-16
申请人： Bruno ISMER , Thomas Koerber , Wolfgang Voss , Georg Heinrich von Knorre , Bjoern Riedel , Andreas Neumann , Ulrich Busch , Juergen Pilz , Thomas Brueggemann , Ralf Peters
发明人： Bruno ISMER , Thomas Koerber , Wolfgang Voss , Georg Heinrich von Knorre , Bjoern Riedel , Andreas Neumann , Ulrich Busch , Juergen Pilz , Thomas Brueggemann , Ralf Peters
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/368 , A61B5/0452 , A61B5/726 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702
摘要： An implantable heart stimulator (10), which has a right-atrial sensing unit (62), which is connected or is to be connected to a right-atrial electrode for recording electrical potentials of the myocardium of a right atrium, and is implemented to process electrical signals recorded via the right-atrial electrode, and to detect signal features characterizing a right-atrial stimulation and contraction in the electrical signal recorded via the right-atrial electrode. The heart stimulator (10) additionally has a left-ventricular sensing unit (66), which is connected or is to be connected to a left-ventricular electrode for recording electrical potentials of the myocardium of a left ventricle of a heart and is implemented to process electrical signals recorded via the left-ventricular electrode. The left-ventricular sensing unit (66) is implemented to detect signal features in the electrical signal recorded via the left-ventricular electrode which characterize a left-atrial contraction.
摘要翻译：具有右心房感测单元（62）的可植入心脏刺激器（10），其连接或连接到右心房电极，用于记录右心房心肌的电位，并被实施为处理通过右心房电极记录的电信号，并且检测表征通过右心房电极记录的电信号中的右心房刺激和收缩的信号特征。心脏刺激器（10）还具有左心室感测单元（66），其连接或连接到左心室电极，用于记录心脏左心室的心肌的电位，并被实施为处理通过左心室电极记录的电信号。实施左心室感测单元（66）以检测表征左心房收缩的经左心室电极记录的电信号中的信号特征。

13. 发明授权

US06900229B2 Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide 有权
标题翻译： 1-甲基-2-（4-脒基苯基氨基甲基） - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-羟基羰基乙基） - 酰胺的前药
公开(公告)号：US06900229B2
公开(公告)日：2005-05-31
申请号：US10631645
申请日：2003-07-31
申请人： Norbert Hauel , Florian Colbatzky , Ulrich Busch
发明人： Norbert Hauel , Florian Colbatzky , Ulrich Busch
IPC分类号： A61K31/4439 , A61P7/02 , A61P43/00 , C07D401/12 , A61K31/44
CPC分类号： C07D401/12
摘要： The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and 1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.
摘要翻译：本发明涉及具有凝血酶抑制活性的新型通式化合物。示例性的是：1-甲基-2- [4-（N-羟基脒基） - 苯基氨基甲基] - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-乙氧基羰基乙基） - 酰胺和1-甲基 -2- [4-（N-甲氧基羰基脒基） - 苯基氨基甲基] - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-羟基羰基乙基） - 酰胺。

14. 发明申请

US20050107438A1 Pharmaceutical composition comprising 3-[(2-{[4-(Hexyloxycarbonylaminoiminomethyl) phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester or a salt therefore 审中-公开
标题翻译：包含3 - [（2 - {[4-（己氧基羰基氨基亚氨基甲基）苯基氨基] - 甲基} -1-甲基-1H-苯并咪唑-5-羰基） - 吡啶-2-基 - 氨基] - 丙酸乙酯或因此盐
公开(公告)号：US20050107438A1
公开(公告)日：2005-05-19
申请号：US10925598
申请日：2004-08-25
申请人： Guido Radtke , Ulrich Busch , Achim Sauer
发明人： Guido Radtke , Ulrich Busch , Achim Sauer
IPC分类号： A61K9/107 , A61K9/48 , A61K31/4439
CPC分类号： A61K9/4858 , A61K9/1075 , A61K9/4866 , A61K31/4439
摘要： A pharmaceutical composition comprising: ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable lipophilic liquid, solid, or semi-solid carrier system.
摘要翻译：一种药物组合物，其包含：3 - [（2 - {[4-（己氧基羰基氨基亚氨基甲基）苯基氨基]甲基} -1-甲基-1H-苯并咪唑-5-羰基）吡啶-2-基氨基]丙酸乙酯或其药学上可接受的盐; 和药学上可接受的亲脂性液体，固体或半固体载体体系。

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