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11. 发明申请

WO2012140433A4 SYSTEM FOR PURIFYING, PRODUCING AND STORING BIOMELECULES 审中-公开
公开(公告)号：WO2012140433A4
公开(公告)日：2012-10-18
申请号：PCT/GB2012/050812
申请日：2012-04-12
申请人： ADC BIOTECHNOLOGY LTD , EVANS, David
发明人： EVANS, David
IPC分类号： A61K47/48
摘要： The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1) : R 1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is -O, -NR 2 or -S, wherein the free valence of -O, -NR 2 or -S is bonded to the support optionally via a linker; and R 2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.

12. 发明申请

WO2012140433A1 SYSTEM FOR PURIFYING, PRODUCING AND STORING BIOMELECULES 审中-公开
标题翻译：用于纯化，生产和储存生物胶的系统
公开(公告)号：WO2012140433A1
公开(公告)日：2012-10-18
申请号：PCT/GB2012/050812
申请日：2012-04-12
申请人： ADC BIOTECHNOLOGY LTD , EVANS, David
发明人： EVANS, David
IPC分类号： A61K47/48
CPC分类号： C07C319/28 , A61K47/6817 , A61K47/6855 , B01J20/287 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3274 , C07C59/347 , C07C323/58 , C07K1/22 , C07K17/02 , Y10T428/2982
摘要： The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1) : R 1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is -O, -NR 2 or -S, wherein the free valence of -O, -NR 2 or -S is bonded to the support optionally via a linker; and R 2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.
摘要翻译：本发明涉及一种应用于生物分子如抗体的锁定释放方法，以改善生物分子的纯化，生产，稳定性和储存。生物分子与包含二酮基团的聚合物载体共价结合，使得生物分子可以在从载体释放之前被纯化，生产和/或储存。聚合物载体的二酮基团为1,3-酮酯，1,3-酮硫酯或1,3-酮酰胺为式（1）的基团：R 1为任选取代的烃基，全卤代烃基或杂环基; Y是氢，任选取代的烃基或杂环基; X是-O，-NR 2或-S，其中-O，-NR 2或-S的自由价可选地经由连接基与所述载体结合; 并且R 2是氢，任选取代的烃基或杂环基。本发明还涉及包含二酮基团的聚合物载体。

13. 发明申请

WO2011000059A1 METHOD OF OBTAINING A USER SELECTION 审中-公开
标题翻译：获取用户选择的方法
公开(公告)号：WO2011000059A1
公开(公告)日：2011-01-06
申请号：PCT/AU2010/000857
申请日：2010-07-05
申请人： STARPLAYIT PTY LTD , EVANS, David , HARDY, Doug
发明人： EVANS, David , HARDY, Doug
IPC分类号： G06F3/16 , G06F3/048
CPC分类号： A63F13/424 , A63F13/215 , A63F13/814 , A63F2300/6072 , G06F3/0482 , G10H1/0016 , G10H1/18 , G10H3/188 , G10H2220/135
摘要： The present invention provides a method of obtaining a user selection in a software system, from a user with a musical instrument. One or more musical sounds are associated with each of a plurality of selectable objects (e.g. icons, menu items), which are provided to a user on a display. Musical audio is then received from the user, by playing on the musical instrument (e.g. guitar). The audio input may be received via a microphone or other audio input device. Then, the audio signal is analysed to determine whether the user played the one or more musical sounds associated with a selectable object. If so, that object is selected.
摘要翻译：本发明提供一种从具有乐器的用户获得软件系统中的用户选择的方法。一个或多个音乐声音与提供给显示器上的用户的多个可选择对象（例如图标，菜单项）中的每一个相关联。然后通过在乐器（例如吉他）上播放从用户接收音乐。可以经由麦克风或其他音频输入设备接收音频输入。然后，分析音频信号以确定用户是否播放与可选对象相关联的一个或多个音乐声音。如果是，则选择该对象。

14. 发明申请

WO2010121028A2 ARCUATE FIXATION MEMBER 审中-公开
标题翻译： ARCUATE固定会员
公开(公告)号：WO2010121028A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031244
申请日：2010-04-15
申请人： SYNTHES USA, LLC , SYNTHES GMBH , DONNER, Thomas , LAURENCE, Lawton , SINGHATAT, Wamis , SCHOENLY, Jared , EVANS, David , MILLER, William , SCHMURA, Kurt
发明人： DONNER, Thomas , LAURENCE, Lawton , SINGHATAT, Wamis , SCHOENLY, Jared , EVANS, David , MILLER, William , SCHMURA, Kurt
IPC分类号： A61B17/70 , A61F2/44
CPC分类号： A61B17/70 , A61B17/7032 , A61B17/7037 , A61B17/7044 , A61B17/7055 , A61B17/7056 , A61B17/7076 , A61B17/8042 , A61B17/8052 , A61B17/92 , A61B2017/8655 , A61F2/28 , A61F2/30744 , A61F2/30749 , A61F2/30965 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/4611 , A61F2002/2835 , A61F2002/30387 , A61F2002/30509 , A61F2002/30514 , A61F2002/30517 , A61F2002/30578 , A61F2002/30604 , A61F2002/30616 , A61F2002/30777 , A61F2002/30784 , A61F2002/30787 , A61F2002/30841 , A61F2002/30843 , A61F2002/30845 , A61F2002/4475 , A61F2002/4627 , A61F2002/4628 , A61F2220/0008 , A61F2220/0025 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00359
摘要： Arcuate fixation members with varying configurations and/or features are provided, along with additional components for use therewith in provided fixation systems and intervertebral implant systems. The arcuate fixation members may be of varying lengths, cross sectional geometries, and/or cross sectoinal areas, and may be configured with various features such as heads configured to accept other fixation system components, tabs to allow arcuate fixation member-in-arcuate fixation member or fixation anchor-in-arcuate fixation member configurations. Applications of fixation systems and intervertebral implants systems utilizing arcuate fixation members are particularly suitable when a linear line-of-approach for delivering fixation members is undesirable.
摘要翻译：提供具有不同构造和/或特征的弓形固定构件以及用于所提供的固定系统和椎间植入系统中的附加部件。弧形固定构件可以具有不同的长度，横截面几何形状和/或交叉部分区域，并且可以被配置为具有各种特征，例如被配置为接受其他固定系统部件的头部，突片以允许弧形固定构件在弓形固定构件或固定锚固在弓形固定构件构造。当用于输送固定构件的线性线路不期望时，使用弓形固定构件的固定系统和椎间植入物系统的应用是特别合适的。

15. 发明申请

WO2009104051A3 COMBINATIONAL THERAPEUTICS FOR TREATMENT OF PROSTATE CANCER USING EPOXY ENCAPSULATED MAGNETIC PARTICLES AND RNAI MEDICINE 审中-公开
公开(公告)号：WO2009104051A3
公开(公告)日：2009-08-27
申请号：PCT/IB2008/003661
申请日：2008-12-31
申请人： LU, Patrick Y. , GHIAS, Ashgar , EVANS, David
发明人： LU, Patrick Y. , GHIAS, Ashgar , EVANS, David
IPC分类号： A61K31/7105 , C07H21/02 , A61K9/14 , A61P27/02
摘要： The present invention provides compositions and methods for treatment of prostate cancer using siRNA cocktail sequences targeting multiple disease causing genes, and a combined regimen with both RNAi therapeutics and EEMP encapsulated magnetic nanoparticle therapeutics. The invention includes: 1) The algorithm for designing siRNA drug API (active pharmaceutical ingredient); 2)The compositions of multiple siRNA inhibiting expression of the multiple cancer causing genes; 3) The methods of designing siRNA duplexes with different lengths, different ends and to target the same genes from both human and mouse cells; 4) The methods of formulating various siRNA cocktail which are able to inhibit tumorigenic and angiogenesis; 5) The methods of using histidine-lysine copolymer (HKP), PAMAM dendrimer and Liposomal (DOTAP) carrier to enhance siRNA delivery into the cutaneous tissue; and 6) The methods of using two disease relevant mouse xenograft models to validate the siRNA cocktail for its efficacy on controlling tumor growth.

16. 发明申请

WO2008109703A1 TRAVEL SERVICE AGGREGATOR 审中-公开
标题翻译：旅游服务集团
公开(公告)号：WO2008109703A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/055959
申请日：2008-03-05
申请人： ACCENTURE GLOBAL SERVICES GMBH , CABALLERO, Geradino , EVANS, David , HORNBAKER, Terry , DREFS, Martin, J. , WALSH, Jefferson
发明人： CABALLERO, Geradino , EVANS, David , HORNBAKER, Terry , DREFS, Martin, J. , WALSH, Jefferson
IPC分类号： G06Q50/00
CPC分类号： G06Q10/02 , G06Q10/025 , G06Q50/14
摘要： The subject matter of this specification can be embodied in, among other things, a system that includes a user interface to receive an electronic status change for an airline flight and an airline reservation system to determine whether at least one ancillary travel service associated with the airline flight should be modified based on the received electronic status change. The system includes a messaging interface to electronically transmit a request to modify the at least one ancillary travel service based on the electronic status change if the determination is made to modify the at least one ancillary travel service. The messaging interface further electronically transmits payment information to the travel service provider for use in crediting or debiting a payment associated with the at least one modified ancillary travel service. The payment information is associated with a customer that reserved the at least one ancillary travel service.
摘要翻译：本说明书的主题可以包括包括用于接收航空公司航班的电子状态变化的用户界面和航空公司预订系统的系统，以确定与该航空公司相关联的至少一个辅助旅行服务应根据收到的电子状态变更修改航班。该系统包括消息接口，用于如果确定进行修改至少一个辅助旅行服务，则基于电子状态改变来电子地发送修改所述至少一个辅助旅行服务的请求。消息传递界面还将支付信息电子地传送到旅行服务提供商以用于记入或借记与至少一个修改的辅助旅行服务相关联的支付。支付信息与保留至少一个辅助旅行服务的客户相关联。

17. 发明申请

WO2007008919A2 METHOD AND SYSTEM FOR SOFTWARE PROTECTION USING BINARY ENCODING 审中-公开
标题翻译：使用二进制编码进行软件保护的方法和系统
公开(公告)号：WO2007008919A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/026932
申请日：2006-07-11
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , DAVIDSON, Jack , NGUYEN-TUONG, Anh , ROWANHILL, Jonathan , EVANS, David , KNIGHT, John , FILIPI, Adrian , HISER, Jason , HU, Wei
发明人： DAVIDSON, Jack , NGUYEN-TUONG, Anh , ROWANHILL, Jonathan , EVANS, David , KNIGHT, John , FILIPI, Adrian , HISER, Jason , HU, Wei
IPC分类号： G06F21/24
CPC分类号： G06F21/50
摘要： Software is protected by encoding the target software instructions and decoding the target instructions.
摘要翻译：通过对目标软件指令进行编码并解码目标指令来保护软件。

18. 发明申请

WO2004005882A2 MULTI-PARAMETER HIGH THROUGHPUT SCREENING ASSAYS (MPHTS) 审中-公开
标题翻译：多参数高通量筛选测定（MPHTS）
公开(公告)号：WO2004005882A2
公开(公告)日：2004-01-15
申请号：PCT/US2002/019457
申请日：2002-06-18
申请人： PSYCHIATRIC GENOMICS, INC. , ALTAR, C., Anthony , BROCKMAN, Jeffrey, A. , EVANS, David , HOOK, Derek , KLIMCZAK, Leszek , LAENG, Pascal , PALFREYMAN, Michael , RAJAN, Prithi
发明人： ALTAR, C., Anthony , BROCKMAN, Jeffrey, A. , EVANS, David , HOOK, Derek , KLIMCZAK, Leszek , LAENG, Pascal , PALFREYMAN, Michael , RAJAN, Prithi
IPC分类号： G01N
CPC分类号： G01N33/5058 , G01N33/5008 , G01N33/5023 , G01N33/5091 , G01N33/6896 , G01N2500/00
摘要： The present invention relates to screening methods and assays that are referred to herein as multi-parameter hight throughput screening (MPHTS) assays. These MPHTS assays are useful for identifying candidate pharmaceutical compounds. In particular, the screening methods of this invention may be used to identify compounds that have potential therapeutic benefits for the treatment of neuropsychiatric and neurodegenerative disorders, including schizophrenia, bipolar affective disorder (BAD), autism and Alzheimer's disease to name a few.
摘要翻译：本发明涉及在本文中被称为多参数高通量筛选（MPHTS）测定的筛选方法和测定。这些MPHTS分析可用于鉴定候选药物化合物。具体而言，本发明的筛选方法可用于鉴定对治疗神经精神病和神经退行性病症（包括精神分裂症，双相情感性障碍（BAD），自闭症和阿尔茨海默氏病）具有潜在治疗益处的化合物，仅举几例。 p>

19. 发明申请

WO2018064052A2 METHOD AND APPARATUS FOR VISION ACUITY TESTING 审中-公开
标题翻译：用于视觉活性测试的方法和设备
公开(公告)号：WO2018064052A2
公开(公告)日：2018-04-05
申请号：PCT/US2017/053473
申请日：2017-09-26
申请人： EVANS, David
发明人： EVANS, David
IPC分类号： A61B3/032
摘要： A vision testing system and a method of operating a data processing system for displaying an eye test pattern on a computer display to a patient during an eye examination are disclosed. The method includes causing the data processing system to display the eye test pattern in a chart region of a computer display controlled by the data processing system and characterized by a luminance in regions not displaying the eye test pattern. An intensity of light leaving the computer display is measured in a sensor region outside the chart region using a display luminance sensor. The luminance of the computer display is adjusted to provide a light level within a predetermined range of light levels based on the measured intensity of light. The data processing system can receive the measured intensity and adjust the display luminescence.
摘要翻译：公开了一种视力测试系统和操作数据处理系统的方法，用于在眼睛检查期间在计算机显示器上向患者显示眼睛测试图案。该方法包括使数据处理系统在由数据处理系统控制的计算机显示器的图表区域中显示眼睛测试图案，并且以不显示眼睛测试图案的区域中的亮度为特征。使用显示器亮度传感器在图表区域之外的传感器区域中测量离开计算机显示器的光的强度。计算机显示器的亮度被调节以基于测量的光强度提供在预定范围的光水平内的光水平。数据处理系统可以接收测量的强度并调整显示发光。

20. 发明申请

WO2018049354A1 VARIABLE TRAVEL VALVE APPARATUS FOR AN INTERNAL COMBUSTION ENGINE 审中-公开
标题翻译：用于内燃机的变量行程阀装置
公开(公告)号：WO2018049354A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/051016
申请日：2017-09-11
申请人： PRICE, Charles , MCFARLANE, Jay , CHARLTON, Stephen John , ANDERSON, William , EVANS, David , BABBITT, Guy Robert , TURNER, Christopher Wayne , PEDERSEN, Daniel S. , JACOBS, Clayton , COHEN, Drew , ECHTER, Nicholas Paul , WEYER-GEIGEL, Kristina , ALVARADO, Caleb
发明人： PRICE, Charles , MCFARLANE, Jay , CHARLTON, Stephen John , ANDERSON, William , EVANS, David , BABBITT, Guy Robert , TURNER, Christopher Wayne , PEDERSEN, Daniel S. , JACOBS, Clayton , COHEN, Drew , ECHTER, Nicholas Paul , WEYER-GEIGEL, Kristina , ALVARADO, Caleb
IPC分类号： F01L1/12 , F01L5/02 , F01L5/04 , F02D9/12 , F02D9/14
摘要： An apparatus includes a valve and an actuator. The valve has a portion movably disposed within a valve pocket defined by a cylinder head of an engine. The valve is configured to move relative to the cylinder head a distance between a closed position and an opened position. The portion of the valve defines a flow opening that is in fluid communication with a cylinder of an engine when the valve is in the opened position. The actuator is configured to selectively vary the distance between the closed position and the opened position.
摘要翻译：一种装置包括阀门和致动器。该阀具有可移动地设置在由发动机的气缸盖限定的阀腔内的部分。该阀构造成相对于气缸盖在关闭位置和打开位置之间移动一段距离。当阀处于打开位置时，阀的该部分限定流动开口，该流动开口与发动机的气缸流体连通。致动器配置为选择性地改变关闭位置和打开位置之间的距离。

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