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11. 发明专利

AU2018283331A1 Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders 未知
公开(公告)号：AU2018283331A1
公开(公告)日：2019-12-19
申请号：AU2018283331
申请日：2018-06-07
申请人： BAYER AG , BAYER PHARMA AG
发明人： DELBECK MARTINA , HAHN MICHAEL , MÜLLER THOMAS , LUSTIG KLEMENS , COLLINS KARL , LINDNER NIELS , NICOLAI JANINE , BECK-BROICHSITTER MORITZ , ALBUS UDO , GEHRING DORIS , ROSENSTEIN BJÖRN
IPC分类号： C07D471/08 , A61K31/4995 , A61K31/5386 , A61P11/00 , A61P25/00 , C07D498/08
摘要： The present invention relates to novel diazabicyclic substituted imidazo[l,2-a]pyrimidine- derivatives, to methods for producing the same, to the use thereof either alone or in combination for the treatment and/or prevention of diseases, as well as to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.

12. 发明专利

AU2017298421A1 Substituted diazahetero-bicyclic compounds and their use 未知
公开(公告)号：AU2017298421A1
公开(公告)日：2019-01-31
申请号：AU2017298421
申请日：2017-07-10
申请人： BAYER AG , BAYER PHARMA AG
发明人： DELBECK MARTINA , HAHN MICHAEL , MÜLLER THOMAS , LUSTIG KLEMENS , MOSIG JOHANNA , ALBUS UDO , GEHRING DORIS , ROSENSTEIN BJÖRN , COLLINS KARL , LINDNER NIELS , SEELIGER JANINE , BECK-BROICHSITTER MORITZ
IPC分类号： C07D471/08 , A61K31/439 , A61K31/5386 , A61P25/00 , C07D498/08
摘要： The present invention relates to novel (imidazo[1,2-a]pyridine-3-yl)methyl-substituted diazahetero-bicyclic compounds, to methods for preparing same, to their use alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for producing drugs for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring. The present invention further relates to a method for detecting a compound having TASK-1 and/or TASK-3 blocking properties.

13. 发明专利

CA3040166A1 SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF 未知
公开(公告)号：CA3040166A1
公开(公告)日：2018-04-19
申请号：CA3040166
申请日：2017-10-09
申请人： BAYER AG , BAYER PHARMA AG
发明人： GIESE ANJA , KLAR JURGEN , EHRMANN ALEXANDER , WILLWACHER JENS , ENGEL DAVID , DIESKAU ANDRE PHILIPPE , KAHNERT ANTJE , GROMOV ALEXEY , SCHMECK CARSTEN , LINDNER NIELS , MULLER THOMAS , ANDREEVSKI ANNA LENA , DREHER JAN , COLLINS KARL
IPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61P13/12 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

14. 发明专利

AU2018283331B2 Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders 未知
公开(公告)号：AU2018283331B2
公开(公告)日：2022-08-04
申请号：AU2018283331
申请日：2018-06-07
申请人： BAYER AG , BAYER PHARMA AG
发明人： DELBECK MARTINA , HAHN MICHAEL , MÜLLER THOMAS , LUSTIG KLEMENS , COLLINS KARL , LINDNER NIELS , NICOLAI JANINE , BECK-BROICHSITTER MORITZ , ALBUS UDO , GEHRING DORIS , ROSENSTEIN BJÖRN
IPC分类号： C07D471/08 , A61K31/4995 , A61K31/5386 , A61P11/00 , A61P25/00 , C07D498/08
摘要： The present invention relates to novel diazabicyclic substituted imidazo[l,2-a]pyrimidine- derivatives, to methods for producing the same, to the use thereof either alone or in combination for the treatment and/or prevention of diseases, as well as to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.

15. 发明专利

CL2019003650A1 Imidazopirimidinas diazabicíclicas sustituidas y su uso para el tratamiento de trastornos respiratorios. 未知
公开(公告)号：CL2019003650A1
公开(公告)日：2020-07-10
申请号：CL2019003650
申请日：2019-12-12
申请人： BAYER PHARMA AG , BAYER AG
发明人： DELBECK MARTINA , LUSTIG KLEMENS , LINDNER NIELS , HAHN MICHAEL , MÜLLER THOMAS , ALBUS UDO , GEHRING DORIS , ROSENSTEIN BJÖRN , COLLINS KARL , NICOLAI JANINE , BECK-BROICHSITTER MORITZ
IPC分类号： A61K31/4995 , A61K31/5386 , A61P11/00 , A61P25/00 , C07D471/08 , C07D498/08
摘要： LA PRESENTE SOLICITUD SE REFIERE A NUEVOS DERIVADOS DE IMIDAZO[1,2-A] PIRIMIDINA DIAZABICÍCLICOS SUSTITUIDOS, PROCEDIMIENTOS PARA SU PREPARACIÓN, A SU USO SOLOS O EN COMBINACIONES PARA EL TRATAMIENTO Y / O PREVENCIÓN DE ENFERMEDADES Y SU USO PARA LA PREPARACIÓN DE MEDICAMENTOS PARA EL TRATAMIENTO Y / O PREVENCIÓN DE ENFERMEDADES, EN PARTICULAR PARA EL TRATAMIENTO Y / O PREVENCIÓN DE TRASTORNOS RESPIRATORIOS, INCLUYENDO TRASTORNOS RESPIRATORIOS RELACIONADOS CON EL SUEÑO, TALES COMO LA APNEA OBSTRUCTIVA Y LA APNEA CENTRAL DEL SUEÑO Y EL RONQUIDO.

16. 发明专利

CR20200173A AMIDAS DE IMIDAZOPIRIDINA SUSTITUIDAS Y SU USO 未知
公开(公告)号：CR20200173A
公开(公告)日：2020-06-26
申请号：CR20200173
申请日：2018-10-18
申请人： BAYER PHARMA AG , BAYER AG
发明人： ORTEGA HERNANDEZ NURIA , SCHEERER NINA ALEXANDRA , SCHAMBERGER JENS , STRAUB ALEXANDER , WUNDER FRANK , KROH WALTER , MEIBOM DANIEL , MEYER JUTTA , MÜNTER KLAUS , MONDRITZKI THOMAS , GERICKE KERSTEN MATTHIAS , COLLINS KARL , STAMPFUSS JAN , LOBELL MARIO , FREUDENBERGER TILL , LEINEWEBER KIRSTEN
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , C07D519/00
摘要： La presente solicitud se refiere a nuevas amidas de imidazopiridinas sustituidas de 5 la fórmula (I), a procedimientos para su preparación, al uso de los mismos por sí solos o en combinación para el tratamiento y / o la profilaxis de enfermedades y al uso para la preparación de medicamentos para el tratamiento y / o la profilaxis de enfermedades, en particular para el tratamiento y / o la profilaxis de enfermedades cardiovasculares, neurológicas y del sistema nervioso central, así como enfermedades metabólicas.

17. 发明专利

CO2020004968A2 Amidas de imidazopiridina sustituidas y su uso 未知
公开(公告)号：CO2020004968A2
公开(公告)日：2020-05-05
申请号：CO2020004968
申请日：2020-04-22
申请人： BAYER PHARMA AG , BAYER AG
发明人： WUNDER FRANK , MEIBOM DANIEL , MÜNTER KLAUS , STAMPFUSS JAN , STRAUB ALEXANDER , FREUDENBERGER TILL , COLLINS KARL , MONDRITZKI THOMAS , MEYER JUTTA , ORTEGA HERNANDEZ NURIA , SCHEERER NINA ALEXANDRA , LEINEWEBER KIRSTEN , SCHAMBERGER JENS , GERICKE KERSTEN MATTHIAS , KROH WALTER , LOBELL MARIO
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , C07D519/00
摘要： La presente solicitud se refiere a nuevas amidas de imidazopiridinas sustituidas de la fórmula (I), a procedimientos para su preparación, al uso de los mismos por sí solos o en combinación para el tratamiento y / o la profilaxis de enfermedades y al uso para la preparación de medicamentos para el tratamiento y / o la profilaxis de enfermedades, en particular para el tratamiento y / o la profilaxis de enfermedades cardiovasculares, neurológicas y del sistema nervioso central, así como enfermedades metabólicas.

18. 发明专利

CL2019001004A1 Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina y usos de los mismos. 未知
公开(公告)号：CL2019001004A1
公开(公告)日：2019-08-30
申请号：CL2019001004
申请日：2019-04-12
申请人： BAYER PHARMA AG , BAYER AG
发明人： GIESE ANJA , MÜLLER THOMAS , LINDNER NIELS , KLAR JÜRGEN , EHRMANN ALEXANDER , WILLWACHER JENS , ENGEL DAVID , DIESKAU ANDRE PHILIPPE , KAHNERT ANTJE , GROMOV ALEXEY , SCHMECK CARSTEN , ANDREEVSKI ANNA LENA , DREHER JAN , COLLINS KARL
IPC分类号： A61K31/506 , A61K31/5377 , A61P13/12 , C07D403/14 , C07D413/14 , C07D471/04
摘要： LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS SUSTITUIDOS DE 6-(1H-PIRAZOL-1-IL)PIRIMIDIN4-AMINA DE LA FÓRMULA GENERAL (I) TAL COMO SE DESCRIBEN Y DEFINEN EN EL PRESENTE, PROCEDIMIENTOS PARA PREPARAR DICHOS COMPUESTOS, COMPUESTOS DE PRODUCTOS INTERMEDIOS ÚTILES PARA PREPARAR DICHOS COMPUESTOS, COMPOSICIONES FARMACÉUTICAS Y COMBINACIONES QUE COMPRENDEN DICHOS COMPUESTOS, Y EL USO DE DICHOS COMPUESTOS PARA LA FABRICACIÓN DE COMPOSICIONES FARMACÉUTICAS PARA EL TRATAMIENTO O PROFILAXIS DE ENFERMEDADES, EN PARTICULAR PARA EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES CARDIOVASCULARES Y RENALES ,COMO AGENTE ÚNICO O EN COMBINACIÓN CON OTROS COMPUESTOS ACTIVOS.

19. 发明专利

SG11201903305XA SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF 未知
公开(公告)号：SG11201903305XA
公开(公告)日：2019-05-30
申请号：SG11201903305X
申请日：2017-10-09
申请人： BAYER AG , BAYER PHARMA AG
发明人： GIESE ANJA , KLAR JÜRGEN , EHRMANN ALEXANDER , WILLWACHER JENS , ENGEL DAVID , DIESKAU ANDRE PHILIPPE , KAHNERT ANTJE , GROMOV ALEXEY , SCHMECK CARSTEN , LINDNER NIELS , MÜLLER THOMAS , ANDREEVSKI ANNA LENA , DREHER JAN , COLLINS KARL
IPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61P13/12 , C07D413/14 , C07D471/04 , C07D487/04
摘要： Oco O O () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 April 2018 (19.04.2018) WIPO I PCT (51) International Patent Classification: CO7D 403/14 (2006.01) A61K 31/506 (2006.01) CO7D 471/04 (2006.01) A61K 31/5377 (2006.01) C07D 487/04 (2006.01) A61P 13/12 (2006.01) CO7D 413/14 (2006.01) (21) International Application Number: PCT/EP2017/075630 (22) International Filing Date: 09 October 2017 (09.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16193953.3 14 October 2016 (14.10.2016) EP (71) Applicants: BAYER AKTIENGESELLSCHAFT [DE/DE]; Kaiser-Wilhelm-Allee 1, 51373 Leverkusen (DE). BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Miillerstr. 178, 13353 Berlin (DE). (72) Inventors: GIESE, Anja; Horst-Kohl StraBe 15a, 12157 Berlin (DE). KLAR, Jurgen; Leipziger StraBe 6, 42109 Wuppertal (DE). EHRMANN, Alexander; Am Hausberg 2, 45219 Essen (DE). WILLWACHER, Jens; In den Birken 32, 42113 Wuppertal (DE). ENGEL, David; Schone Aussicht 15, 42369 Wuppertal (DE). DIESKAU, An- dre Philippe; Dr.-Tigges-Weg 19, 42115 Wuppertal (DE). KAHNERT, Antje; Paul-Ehrlich-Str. 10, 42113 Wup- pertal (DE). GROMOV, Alexey; Fuhlrottstr. 9, 40699 Erkrath (DE). SCHMECK, Carsten; Carl-Friedrich-Go- erdeler-StraBe 24, 45472 Millheim (DE). LINDNER, Niels; Bodelschwinghweg 4, 42115 Wuppertal (DE). MULLER, Thomas; Parkstr. 24, 40764 Langenfeld (DE). AN- DREEVSKI, Anna Lena; Altenhofer StraBe 123, 42719 Solingen (DE). DREHER, Jan; Ottenbrucher Str. 24, 42105 Wuppertal (DE). COLLINS, Karl; Fiirstenwall 135, 40215 Diisseldorf (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: — with international search report (Art. 21(3)) (54) Title: SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF (57) : The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing phar- maceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients. olimion °nolo omoionolomommio oimIE (10) International Publication Number WO 2018/069222 Al

20. 发明专利

MA45709A COMPOSÉS DIAZAHÉTÉROBICYCLIQUES SUBSTITUÉS ET LEUR UTILISATION 未知
公开(公告)号：MA45709A
公开(公告)日：2019-05-29
申请号：MA45709
申请日：2017-07-10
申请人： BAYER AG , BAYER PHARMA AG
发明人： ALBUS UDO , ANLAHR JOHANNA , BECK-BROICHSITTER MORITZ , COLLINS KARL , DELBECK MARTINA , GEHRING DORIS , HAHN MICHAEL , LINDNER NIELS , LUSTIG KLEMENS , MÜLLER THOMAS , NICOLAI JANINE , ROSENSTEIN BJÖRN
IPC分类号： A61K31/439 , A61K31/5386 , A61P25/00 , C07D471/08 , C07D498/08

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