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11. 发明专利

AT289988T 未知
公开(公告)号：AT289988T
公开(公告)日：2005-03-15
申请号：AT01122344
申请日：2001-09-19
申请人： BASF AG
发明人： GRIMMER JOHANNES , MUELLER THOMAS DR , ERNST HANSGEORG DR
IPC分类号： C07D317/46 , A61K31/045 , A61K31/12 , C07C45/00 , C07C45/62 , C07C49/743 , C07C49/753 , C07C403/08 , C07D317/00 , C07D317/12 , C07D317/48 , C07F7/18
摘要： A process is provided for the preparation of cyclohexene derivatives of general formula I or II:in which the substituents R and R independently of one another are defined as follows:R isR is OH or a protective group convertible to a hydroxyl group by hydrolysis;R and R are hydrogen or C1-C4-alkyl; andR is hydrogen or C1-C4-acyl,by the reduction of alkyne compounds of general formula III or IV:in which the substituents R and X are as defined above, wherein the reducing agent used is a mixture of zinc and at least one compound B selected from the group consisting of ammonium salts, copper salts and alkali metal and alkaline earth metal salts.

12. 发明专利

DE3564576D1 PROCESS FOR THE PREPARATION OF RIBOFLAVIN 未知
公开(公告)号：DE3564576D1
公开(公告)日：1988-09-29
申请号：DE3564576
申请日：1985-02-15
申请人： BASF AG
发明人： GRIMMER JOHANNES , HORN HANS CHRISTOPH DR
IPC分类号： C07D475/14
摘要： Riboflavin of the formula I I is prepared by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline of the formula II II where X is H, -Cl, -NO2 or -CH3 in the o- or p-position, with barbituric acid of the formula III III in the presence of an acidic condensing agent in an inert organic solvent by an improved process in which the reaction is carried out in an aliphatic diol or triol derivative of the general formula IV (IV) where R1 is H or CH3, R2 is H or CH3- or, when n is 0, is CH3-CO-O-CH2-, R3 is CH3-, C2H5- or CH3-, R4 is CH3-CO-, or is H when R3 is CH3- or C2H5-, and n is 0 or 2, preferably 0, having a boiling point of 80 DEG -180 DEG C., or in a mixture of these as a solvent. In this process, the riboflavin is obtained in particularly pure form and in very good yields.

13. 发明专利

DE3421714A1 未知
公开(公告)号：DE3421714A1
公开(公告)日：1985-12-12
申请号：DE3421714
申请日：1984-06-12
申请人： BASF AG
发明人： GRIMMER JOHANNES , HORN HANS CHRISTOPH DR
IPC分类号： C07D475/14
摘要： Very pure riboflavin (I) is obtained by a process in which the riboflavin is dissolved in dilute aqueous alkali metal hydroxide solution, if necessary the alkaline solution is purified by treatment with active carbon or with a solvent which is insoluble or only slightly soluble in water, the resulting alkaline solution of I is introduced into water which is at 90 DEG -100 DEG C. and to which an acid has been added in an amount such that the reaction mixture is brought to a pH of from 6.5 to 0.8, the temperature being maintained at from 40 DEG to 100 DEG C., the reaction mixture is kept at from 90 DEG to 100 DEG C. for from 10 to 80 minutes and cooled, and I is then isolated.

14. 发明专利

DK79685A 未知
公开(公告)号：DK79685A
公开(公告)日：1985-08-23
申请号：DK79685
申请日：1985-02-21
申请人： BASF AG
发明人： GRIMMER JOHANNES , HORN HANS CHRISTOPH
IPC分类号： C07D475/14 , C07D
摘要： Riboflavin of the formula I I is prepared by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline of the formula II II where X is H, -Cl, -NO2 or -CH3 in the o- or p-position, with barbituric acid of the formula III III in the presence of an acidic condensing agent in an inert organic solvent by an improved process in which the reaction is carried out in an aliphatic diol or triol derivative of the general formula IV (IV) where R1 is H or CH3, R2 is H or CH3- or, when n is 0, is CH3-CO-O-CH2-, R3 is CH3-, C2H5- or CH3-, R4 is CH3-CO-, or is H when R3 is CH3- or C2H5-, and n is 0 or 2, preferably 0, having a boiling point of 80 DEG -180 DEG C., or in a mixture of these as a solvent. In this process, the riboflavin is obtained in particularly pure form and in very good yields.

15. 发明专利

DE3247381A1 未知
公开(公告)号：DE3247381A1
公开(公告)日：1984-06-28
申请号：DE3247381
申请日：1982-12-22
申请人： BASF AG
发明人： GRIMMER JOHANNES , HORN HANS CHRISTOPH DR
IPC分类号： C07D475/02 , C07D475/14
摘要： An improved process for the purification of crude riboflavin which has been prepared by condensation of an N-(D)-ribityl-2-arylazo-4,5-dimethylaniline and barbituric acid or another N-(D)-ribityl-4,5-dimethyl-aniline derivative with a barbituric acid derivative, by dissolving the crude riboflavin in sulfuric acid or phosphoric acid which has been diluted with water and oxidizing the impurities by treating the solution with hydrogen peroxide, or by dissolving the riboflavin in dilute nitric acid at elevated temperature and then isolating the pure riboflavin by precipitation with water, wherein the mineral acid solution of the riboflavin and the oxidizing agent or the solution of the riboflavin in 20 to 70% strength by weight nitric acid is heated extremely rapidly to a temperature at which the solution clearly changes color from greenish to yellow-orange, the solution is kept at this temperature for from 1 to 50, seconds and the oxidation reaction is then interrupted by addition of water. The best results are achieved in this process if from 20 to 65% strength by weight nitric acid is used simultaneously as the acid and oxidative agent and if, after the change in color, the mineral acid solution, in particular the nitric acid solution, is passed, immediately or after prior interruption of the oxidation reaction by addition of cold water, into hot water at from 90 DEG to 100 DEG C. and the suspension thereby formed is kept at this temperature for about a further 10-30 minutes.

16. 发明专利

DK589383A 未知
公开(公告)号：DK589383A
公开(公告)日：1984-06-23
申请号：DK589383
申请日：1983-12-21
申请人： BASF AG
发明人： GRIMMER JOHANNES , HORN HANS CHRISTOPH
IPC分类号： C07D475/02 , C07D475/14 , C07D
摘要： An improved process for the purification of crude riboflavin which has been prepared by condensation of an N-(D)-ribityl-2-arylazo-4,5-dimethylaniline and barbituric acid or another N-(D)-ribityl-4,5-dimethyl-aniline derivative with a barbituric acid derivative, by dissolving the crude riboflavin in sulfuric acid or phosphoric acid which has been diluted with water and oxidizing the impurities by treating the solution with hydrogen peroxide, or by dissolving the riboflavin in dilute nitric acid at elevated temperature and then isolating the pure riboflavin by precipitation with water, wherein the mineral acid solution of the riboflavin and the oxidizing agent or the solution of the riboflavin in 20 to 70% strength by weight nitric acid is heated extremely rapidly to a temperature at which the solution clearly changes color from greenish to yellow-orange, the solution is kept at this temperature for from 1 to 50, seconds and the oxidation reaction is then interrupted by addition of water. The best results are achieved in this process if from 20 to 65% strength by weight nitric acid is used simultaneously as the acid and oxidative agent and if, after the change in color, the mineral acid solution, in particular the nitric acid solution, is passed, immediately or after prior interruption of the oxidation reaction by addition of cold water, into hot water at from 90 DEG to 100 DEG C. and the suspension thereby formed is kept at this temperature for about a further 10-30 minutes.

17. 发明专利

DE3061167D1 PROCESS FOR THE CONTINUOUS PRODUCTION OF ISATOIC ANHYDRIDE 未知
公开(公告)号：DE3061167D1
公开(公告)日：1983-01-05
申请号：DE3061167
申请日：1980-01-09
申请人： BASF AG
发明人： KILPPER GERHARD DR , GRIMMER JOHANNES , TONNE PETER DR , HORN HANS , HETZEL ECKHARD
IPC分类号： C07D265/26

18. 发明专利

BR8200418A 未知
公开(公告)号：BR8200418A
公开(公告)日：1982-11-30
申请号：BR8200418
申请日：1982-01-26
申请人： BASF AG
发明人： TONNE PETER , LUDWIG WINFRIED , KILPPER GERHARD , GRIMMER JOHANNES
IPC分类号： C07C231/00 , C07C233/00 , C07C103/76
摘要： Anthranilic acid amides are prepared by mixing phthalamic acid with a caustic alkali solution, a catalyst and a hypohalite, allowing the mixture to stand for from 1 to 1,000 seconds, then introducing the amine and thereafter addig acid until the pH of the mixture is from 6 to 8. The anthranilic acid amides obtainable by the process of the invention are valuable starting materials for the preparation of dyes, scents and pesticides.

19. 发明专利

DE2911245A1 未知
公开(公告)号：DE2911245A1
公开(公告)日：1980-10-02
申请号：DE2911245
申请日：1979-03-22
申请人： BASF AG
发明人： KILPPER GERHARD DIPL CHEM DR , GRIMMER JOHANNES
IPC分类号： C07D209/48
摘要： A process for the continuous preparation of phthalimide by reacting phthalic anhydride with ammonia in about the stoichiometric ratio, in a mixing apparatus and subsequently in a reaction tube at a particular flow velocity and a particular temperature. The phthalimide obtainable by the process of the invention is a valuable starting material for the preparation of dyes, pesticides and pigments, especially copper phthalocyanines.

20. 发明专利

DE59209522D1 未知
公开(公告)号：DE59209522D1
公开(公告)日：1998-11-19
申请号：DE59209522
申请日：1992-07-11
申请人： BASF AG
发明人： BORCH CHRISTENSEN KURT , JENSEN-DAHM LARS , CHRISTENSEN SVEND E , GRIMMER JOHANNES , KIEFER HANS DR
IPC分类号： C07F9/6561
摘要： An improved process for preparing riboflavin 5'-phosphate monosodium salt by reacting riboflavin or its sodium salt with excess phosphorus oxychloride in a suitable organic solvent, hydrolysing the resulting reaction mixture by treating with water at elevated temperature, reacting the reaction mixture obtained in the hydrolysis with a sodium-containing base to a pH of 4.0 to 6.0, and isolating the riboflavin 5'-phosphate sodium salt crystallising out which is characterised in that the reaction mixture obtained in the hydrolysis is reacted with sodium-containing base at such high temperatures that the riboflavin 5'-phosphate to be reacted is completely dissolved in the reaction mixture. Suitable temperatures are 50 to 100 DEG C.

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