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11. 发明授权

US5211950A Stabilized calcitonin pharmaceutical composition 失效
标题翻译：稳定的CALCITONIN药物组合物
公开(公告)号：US5211950A
公开(公告)日：1993-05-18
申请号：US527461
申请日：1990-05-23
申请人： Hideki Kobayashi , Seiji Mochizuki , Yuji Makino , Yoshiki Suzuki
发明人： Hideki Kobayashi , Seiji Mochizuki , Yuji Makino , Yoshiki Suzuki
IPC分类号： A61K9/00 , A61K9/14 , A61K9/48 , A61K38/23 , A61K47/18 , A61P3/00 , A61P43/00
CPC分类号： A61K38/23 , A61K47/183 , A61K9/0043
摘要： A solid calcitonin pharmaceutical composition comprised of a therapeutically effective amount of calcitonins and ethylene diamine tetraacetates.

12. 发明授权

US4597915A Carburetor percolation prevention system 失效
标题翻译：化油器渗滤预防系统
公开(公告)号：US4597915A
公开(公告)日：1986-07-01
申请号：US573488
申请日：1984-01-24
申请人： Hidenobu Nagase , Yuji Makino
发明人： Hidenobu Nagase , Yuji Makino
IPC分类号： F02M5/10 , F02M37/00
CPC分类号： F02M5/10 , Y10S261/51 , Y10S261/81
摘要： The invention discloses a carburetor percolation prevention system which utilizes an electrically controlled fuel drain valve disposed in a fuel drain passage between the carburetor float chamber and the fuel tank. The electrical fuel drain valve is opened only when the engine condition sensor and the temperature sensor indicate that both the ignition switch is de-energized and the temperature near the float chamber exceeds a predetermined level.
摘要翻译：本发明公开了一种化油器渗滤防止系统，其利用设置在化油器浮子室和燃料箱之间的燃料排放通道中的电控燃油排放阀。只有当发动机状态传感器和温度传感器指示点火开关断电并且浮子室附近的温度超过预定水平时，电气排放阀才打开。

13. 发明授权

US08206748B2 Powdery composition for nasal administration 失效
标题翻译：用于鼻腔给药的粉状组合物
公开(公告)号：US08206748B2
公开(公告)日：2012-06-26
申请号：US12610901
申请日：2009-11-02
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Takao Fujii
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Takao Fujii
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水 - 不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量相对于吸水和凝胶形成的总量为约5-40重量％基材和吸水性和水不溶性基材，和（3）其中药物在吸水性和水不溶性基材中/吸水凝胶形成中的/不均匀分散基材。

14. 发明申请

US20100047206A1 POWDERY COMPOSITION FOR NASAL ADMINISTRATION 失效
标题翻译：粉末成分为NASAL管理
公开(公告)号：US20100047206A1
公开(公告)日：2010-02-25
申请号：US12610901
申请日：2009-11-02
申请人： Masahiko DOHI , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
发明人： Masahiko DOHI , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
IPC分类号： A61P9/14 , A61K47/38 , A61K38/00 , A61K45/00 , A61K38/22 , A61K38/28 , A61K38/21
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水 - 不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量相对于吸水和凝胶形成的总量为约5-40重量％基材和吸水性和水不溶性基材，和（3）其中药物在吸水性和水不溶性基材中/吸水凝胶形成中的/不均匀分散基材。

15. 发明授权

US5987878A Fuel reforming apparatus and electric power generating system having the same 失效
标题翻译：燃料重整装置及其发电系统
公开(公告)号：US5987878A
公开(公告)日：1999-11-23
申请号：US115521
申请日：1998-07-15
申请人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
发明人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
IPC分类号： F02M27/02 , B01B1/00 , B01J8/02 , C01B3/38 , F01K21/04 , F01K23/10 , F02C3/22 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , F02C6/18 , F02C7/22 , F02B43/00
CPC分类号： B01B1/005 , B01J8/0285 , C01B3/38 , C01B3/382 , F01K21/047 , F01K23/10 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , B01J2208/00504 , Y02E20/14 , Y02P20/129
摘要： A cylindrical fuel reforming apparatus covered with a thermal insulating layer 16 comprises a fuel flow passage 1 contoured by a cylindrical contour wall 2 in its central axial direction and a reforming catalyst bed 3 in the middle of the flow passage for reforming gas to be reformed flowing from the upstream of the fuel flow passage 1 into a proper reformed gas. A cooling jacket 10 is arranged in the upstream of the reforming catalyst bed 3 so as to surround the fuel flow passage 1 and to be supplied with steam 11 for cooling the cylindrical contour wall 2. There are provided in the cylindrical contour wall 2 in the upstream of the reforming catalyst bed 3 a plurality of injection nozzles 15 communicating the cooling jacket 10 with the fuel flow passage 1 so that the steam 11 introduced into the cooling jacket 10 is allowed to flow into the fuel flow passage 1.
摘要翻译：被绝热层16覆盖的圆柱形燃料重整装置包括由中心轴线的圆柱形轮廓壁2构成的燃料流路1和流路中间的重整催化剂床3，用于使重整气流重整从燃料流路1的上游到适当的重整气体。在重整催化剂床3的上游设置有冷却套10，以围绕燃料流路1并供给蒸汽11，以冷却圆筒形轮廓壁2.在圆筒形轮廓壁2中设置有冷却套在重整催化剂床3的上游设置有使冷却套10与燃料流路1连通的多个喷嘴15，使得导入冷却套管10的蒸汽11能够流入燃料流路1。

16. 发明授权

US5958908A Sodium alendronate preparation for local administration 失效
标题翻译：阿仑膦酸钠用于局部给药
公开(公告)号：US5958908A
公开(公告)日：1999-09-28
申请号：US59555
申请日：1998-04-13
申请人： Masahiko Dohi , Yuji Makino , Takao Hujii
发明人： Masahiko Dohi , Yuji Makino , Takao Hujii
IPC分类号： A61K31/66 , A61K9/00 , A61K31/663 , A61P3/00 , A61P19/08 , A61P43/00
CPC分类号： A61K31/663
摘要： The present invention provides a method local administration of an effective amount of sodium alendronate to permit selective delivery to the bone site where bone resorption is accentuated.
摘要翻译：本发明提供了局部施用有效量的阿仑膦酸钠的方法，以允许选择性递送到骨吸收增强的骨部位。

17. 发明授权

US5873236A Fuel reforming apparatus and electric power generating system having the same 失效
公开(公告)号：US5873236A
公开(公告)日：1999-02-23
申请号：US822934
申请日：1997-03-21
申请人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
发明人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
IPC分类号： F02M27/02 , B01B1/00 , B01J8/02 , C01B3/38 , F01K21/04 , F01K23/10 , F02C3/22 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , F02C6/18 , F02C7/22 , F02C7/12 , F02B43/00
CPC分类号： B01B1/005 , B01J8/0285 , C01B3/38 , C01B3/382 , F01K21/047 , F01K23/10 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , B01J2208/00504 , Y02E20/14 , Y02P20/129
摘要： A cylindrical fuel reforming apparatus covered with a thermal insulating layer 16 comprises a fuel flow passage 1 contoured by a cylindrical contour wall 2 in its central axial direction and a reforming catalyst bed 3 in the middle of the flow passage for reforming gas to be reformed flowing from the upstream of the fuel flow passage 1 into a proper reformed gas. A cooling jacket 10 is arranged in the upstream of the reforming catalyst bed 3 so as to surround the fuel flow passage 1 and to be supplied with steam 11 for cooling the cylindrical contour wall 2. There are provided in the cylindrical contour wall 2 in the upstream of the reforming catalyst bed 3 a plurality of injection nozzles 15 communicating the cooling jacket 10 with the fuel flow passage 1 so that the steam 11 introduced into the cooling jacket 10 is allowed to flow into the fuel flow passage 1.

18. 发明授权

US5826422A Fuel reforming apparatus and electric power generating system having the same 失效
标题翻译：燃料重整装置及其发电系统
公开(公告)号：US5826422A
公开(公告)日：1998-10-27
申请号：US901266
申请日：1997-07-28
申请人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
发明人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
IPC分类号： F02M27/02 , B01B1/00 , B01J8/02 , C01B3/38 , F01K21/04 , F01K23/10 , F02C3/22 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , F02C6/18 , F02C7/22 , F02B43/00
CPC分类号： B01B1/005 , B01J8/0285 , C01B3/38 , C01B3/382 , F01K21/047 , F01K23/10 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , B01J2208/00504 , Y02E20/14 , Y02P20/129
摘要： A cylindrical fuel reforming apparatus covered with a thermal insulating layer 16 has a fuel flow passage 1 contoured by a cylindrical contour wall 2 in its central axial direction, and a reforming catalyst bed 3 is disposed in the middle of the flow passage for reforming gas, flowing from the upstream end of the fuel flow passage 1, into a proper reformed gas. A cooling jacket 10 is arranged upstream of the reforming catalyst bed 3 so as to surround the fuel flow passage 1 and the cooling jacket is supplied with steam 11 for cooling the cylindrical contour wall 2. There are provided in the cylindrical contour wall 2 upstream of the reforming catalyst bed 3 a plurality of injection nozzles 15 for effecting communication between the cooling jacket 10 and the fuel flow passage 1 so that the steam 11 introduced into the cooling jacket 10 is allowed to flow into the fuel flow passage 1.
摘要翻译：被绝热层16覆盖的圆柱形燃料重整装置具有由圆筒形轮廓壁2在其中心轴线方向上成型的燃料流路1，并且重整催化剂床3设置在用于重整气体的流路的中间，从燃料流路1的上游端流入适当的重整气体。冷却套10设置在重整催化剂床3的上游，以围绕燃料流动通道1，并且冷却套被供应有用于冷却圆柱形轮廓壁2的蒸汽11.在圆柱形轮廓壁2中设置有圆柱形轮廓壁2 重整催化剂床3具有用于实现冷却套10和燃料流动通道1之间的连通的多个喷嘴15，从而允许引入冷却套10的蒸汽11流入燃料流动通道1。

19. 发明授权

US5612327A 1.alpha.,24-(OH).sub.2 -cholecalciferol emulsion composition and method for treating psoriasis 失效
标题翻译： 1α，24-（OH）2 - 胆钙化醇乳剂组合物和治疗牛皮癣的方法
公开(公告)号：US5612327A
公开(公告)日：1997-03-18
申请号：US428106
申请日：1995-04-28
申请人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
发明人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
IPC分类号： A61K9/00 , A61K31/59 , A61K47/00 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/44
CPC分类号： A61K9/0014 , A61K31/59 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/44
摘要： A 1.alpha.,24-(OH).sub.2 --V.D.sub.3 cream composition comprising(a) a therapeutically effective amount of 1.alpha.,24-(OH).sub.2 --V.D.sub.3,(b) an oil phase component including(i) a solid oil component composed of 5 to 20 parts by weight of white petrolatum and 5 to 15 parts by weight of higher alcohols and(ii) a liquid oil component comprising of 3 to 10 parts by weight of squalane,(c) an aqueous phase component, and(d) 2.5 to 7.5 parts by weight at least two surfactants, wherein the 1.alpha.,24-(OH).sub.2 --V.D.sub.3 cream composition has a weight ratio of the solid oil component to the liquid oil component (i.e., solid oil component/liquid oil component) of at least approximately 2, the higher alcohols are composed of stearyl alcohol and cetyl alcohol, the weight ratio of the stearyl alcohol to the higher alcohols (i.e., stearyl alcohol/higher alcohols) is approximately 0.65 to approximately 0.9, at least 50% by weight of the surfactants is at least one surfactant having an HLB value of approximately 5 or less, and the HLB value of the surfactants as a whole is approximately 8 to approximately 18.
摘要翻译： PCT No.PCT / JP94 / 01443 Sec。 371日期：1995年4月28日 102（e）日期1995年4月28日PCT 1994年9月1日PCT公布。公开号WO95 / 06482 日期：1995年3月9日A 1α，24-（OH）2-V.D3乳膏组合物，其包含（a）治疗有效量的1α，24-（OH）2-V.D3，（b）油相组分包括（i）由5至20重量份的白凡士林和5至15重量份的高级醇组成的固体油组分和（ii）包含3至10重量份的角鲨烷的液体油组分（ c）水相组分，和（d）2.5至7.5重量份的至少两种表面活性剂，其中所述1α，24-（OH）2-V.D3乳膏组合物具有固体油组分与液体油组分（即固体油组分/液体油组分）至少约为2，高级醇由硬脂醇和鲸蜡醇组成，硬脂醇与高级醇的重量比（即硬脂醇/更高醇）为约0.65至约0.9，至少50重量％的表面活性剂是至少一种HLB值为约实际为5以下，表面活性剂整体的HLB值约为8〜18。

20. 发明授权

US5578324A Peptide proteinaceous drug nasal powder composition 失效
标题翻译：肽蛋白质药物鼻粉组合物
公开(公告)号：US5578324A
公开(公告)日：1996-11-26
申请号：US407000
申请日：1995-03-29
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Yoshiki Suzuki
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Yoshiki Suzuki
IPC分类号： A61K9/00 , A61K9/14 , A61K38/00 , A61K38/04 , A61K38/09 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/25 , A61K38/26 , A61K38/27 , A61K38/28 , A61K47/18 , A61K47/20 , A61K47/24 , B60H1/00 , B60H1/08 , F01P7/14 , G05D23/13 , A61K9/50
CPC分类号： B60H1/00485 , A61K38/09 , A61K38/23 , A61K38/25 , A61K47/183 , A61K9/0043
摘要： A peptide proteinaceous drug nasal powder composition containing (i) an absorption accelerant comprised of a compound, or its salt, having in its molecule a group expressed by the formula (I): ##STR1## wherein, ##STR2## indicates a cyclohexane ring or a benzene ring which may be substituted at least one of its 3-position, 4-position, and 5-position and n is an integer of 1 to 3 and (ii) a therapeutically effective amount of a peptide proteinaceous drug.
摘要翻译： PCT No.PCT / JP94 / 01257 Sec。 371日期1995年3月29日 102（e）1995年3月29日PCT PCT 1994年7月29日PCT公布。第WO95 / 03818号公报日期1995年2月9日一种肽蛋白质药物鼻粉组合物，其含有（i）由分子中具有式（I）表示的基团的化合物或其盐组成的吸收促进剂：环己烷环或苯环，取代其3-位，4-位和5-位中的至少一个，n为1〜3的整数，和（ii）治疗有效量的肽蛋白质药物。

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