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11. 发明申请

US20090191627A1 SYNTHETIC SURFACES FOR CULTURING CELLS IN CHEMICALLY DEFINED MEDIA 有权
标题翻译：用于培养细胞的合成表面在化学定义的介质中
公开(公告)号：US20090191627A1
公开(公告)日：2009-07-30
申请号：US12362924
申请日：2009-01-30
申请人： Andrei Gennadyevich Fadeev , Jennifer Gehman , Zara Melkoumian , David Michael Weber , Yue Zhou
发明人： Andrei Gennadyevich Fadeev , Jennifer Gehman , Zara Melkoumian , David Michael Weber , Yue Zhou
IPC分类号： C12N5/08 , C12N5/06
CPC分类号： C12N5/0068 , C12N5/0606 , C12N2533/30 , C12N2533/50 , C12N2537/10
摘要： Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.
摘要翻译：能够支持培养真核细胞（包括干细胞和未分化的人类胚胎干细胞）的合成表面包括可溶胀的（甲基）丙烯酸酯层和与可溶胀的（甲基）丙烯酸酯层共轭的多肽。可溶胀的（甲基）丙烯酸酯层可以通过将包含含羧基的（甲基）丙烯酸酯单体，交联（二官能或更高官能）（甲基）丙烯酸酯单体和亲水性（甲基）丙烯酸酯单体）的组合物中的单体聚合而形成能够与含羧基（甲基）丙烯酸酯单体和交联（甲基）丙烯酸酯单体聚合的单体。可溶胀的（甲基）丙烯酸酯层在水中的平衡水含量为约5％至约70％。缀合的肽可以包括RGD氨基酸序列。

12. 发明申请

US20140134725A1 SYNTHETIC SURFACES FOR CULTURING STEM CELL DERIVED CARDIOMYOCYTES 有权
标题翻译：用于培养干细胞衍生的心脏细胞的合成表面
公开(公告)号：US20140134725A1
公开(公告)日：2014-05-15
申请号：US14028808
申请日：2013-09-17
申请人： Christopher Bankole Shogbon , Yue Zhou , Ralph Brandenberger
发明人： Christopher Bankole Shogbon , Yue Zhou , Ralph Brandenberger
IPC分类号： C12N5/077
CPC分类号： C12N5/0657 , C12N5/0068 , C12N2500/90 , C12N2506/02 , C12N2533/30
摘要： Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.
摘要翻译：适合于培养干细胞衍生的心肌细胞的合成表面含有由一种或多种丙烯酸酯单体形成的丙烯酸酯聚合物。在许多情况下，丙烯酸酯表面适合于在化学上限定的培养基中培养干细胞来源的心肌细胞。

13. 发明授权

US08666914B1 Ranking non-product documents 有权
标题翻译：排列非产品文件
公开(公告)号：US08666914B1
公开(公告)日：2014-03-04
申请号：US13113979
申请日：2011-05-23
申请人： Benoit J. Dupin , Dimitris Margaritis , Steve L. Martin , Diane Hernek , Nicholas E. Matsakis , Yue Zhou
发明人： Benoit J. Dupin , Dimitris Margaritis , Steve L. Martin , Diane Hernek , Nicholas E. Matsakis , Yue Zhou
IPC分类号： G06F15/18
CPC分类号： G06F17/30687
摘要： Systems, methods, and apparatus are provided for determining relevance of documents to queries. An optimized relevance function is configured to determine a relevance value of documents of a first type that are linked to documents of a second type. The relevance function is optimized to satisfy certain criteria. According to one criterion, a relevance value produced by the optimized relevance function, when invoked for documents of the first type, should have a locally maximal degree of fit to the results of the existing relevance function for the sample training documents of the second type. An assessed degree of fit of a document can be increased or decreased to arrive at an optimized relevance function that ranks the documents of the first type in a desired position relative to documents of the second type in search results. The degree of fit can be assessed by a user-provided objective function.
摘要翻译：提供了系统，方法和装置，用于确定文档与查询的相关性。优化的相关性功能被配置为确定链接到第二类型的文档的第一类型的文档的相关性值。相关性功能被优化以满足某些标准。根据一个标准，当针对第一类型的文档调用时，由优化的相关性函数产生的相关性值应当具有对于第二类型的样本训练文档的现有相关性函数的结果的局部最大拟合度。可以增加或减少文档的评估的适合度以获得优化的相关性功能，其将相对于搜索结果中的第二类型的文档排列在期望位置的第一类型的文档。可以通过用户提供的目标函数来评估拟合度。

14. 发明授权

US08281334B2 Facilitating advertisement placement over video content 有权
标题翻译：促进视频内容的广告放置
公开(公告)号：US08281334B2
公开(公告)日：2012-10-02
申请号：US12059255
申请日：2008-03-31
申请人： Ying Shan , Yue Zhou , Xu Liu , Ying Li , Zhengyou Zhang
发明人： Ying Shan , Yue Zhou , Xu Liu , Ying Li , Zhengyou Zhang
IPC分类号： H04N7/10 , G06F3/048
CPC分类号： G06Q30/02 , G06T7/97 , G06T2207/10016 , G06T2207/20021
摘要： Systems, methods, computer-readable media, and graphical user interfaces for facilitating advertisement placement over video content are provided. Images within a video are partitioned into image regions. Upon partitioning images into image regions, an intrusiveness score is determined for each image region. Based on the intrusiveness scores, optimal placement of an advertisement within the video is determined.
摘要翻译：提供了系统，方法，计算机可读介质和图形用户界面，以便于通过视频内容进行广告放置。视频内的图像被分割成图像区域。在将图像分割成图像区域时，针对每个图像区域确定侵入性分数。基于侵入性分数，确定视频内的广告的最佳放置。

15. 发明授权

US08241907B2 Synthetic surfaces for culturing stem cell derived cardiomyocytes 有权
标题翻译：用于培养干细胞衍生的心肌细胞的合成表面
公开(公告)号：US08241907B2
公开(公告)日：2012-08-14
申请号：US12362190
申请日：2009-01-29
申请人： Christopher Bankole Shogbon , Yue Zhou , Ralph Brandenberger
发明人： Christopher Bankole Shogbon , Yue Zhou , Ralph Brandenberger
IPC分类号： C12N5/00 , C12N5/02 , C12N5/07 , C12N5/10
CPC分类号： C12N5/0657 , C12N5/0068 , C12N2500/90 , C12N2506/02 , C12N2533/30
摘要： Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.
摘要翻译：适合于培养干细胞衍生的心肌细胞的合成表面含有由一种或多种丙烯酸酯单体形成的丙烯酸酯聚合物。在许多情况下，丙烯酸酯表面适合于在化学上限定的培养基中培养干细胞来源的心肌细胞。

16. 发明申请

US20090149873A1 USE OF COUPLING AGENTS TO IMPROVE THE INTERFACE IN ABSORBABLE POLYMER COMPOSITES 有权
标题翻译：使用耦合剂改善可吸收的聚合物复合材料的界面
公开(公告)号：US20090149873A1
公开(公告)日：2009-06-11
申请号：US11952218
申请日：2007-12-07
申请人： Yue Zhou , Kevin Cooper , Yufu Li , Zhigang Li
发明人： Yue Zhou , Kevin Cooper , Yufu Li , Zhigang Li
IPC分类号： A61B17/08 , A61L27/44
CPC分类号： C08K9/08 , C08L23/08 , C08L67/02 , C08L67/04 , C08L69/00 , C08L2666/04
摘要： A composite having a poly(ethylene-co-acrylic acid) coupling agent, a filler, and a biocompatible, biodegradable polymer matrix is disclosed. The composites described herein are useful for biomedical applications such as, tissue engineering, drug delivery, and implantable medical devices.
摘要翻译：公开了具有聚（乙烯 - 共 - 丙烯酸）偶联剂，填料和生物相容的可生物降解的聚合物基质的复合材料。本文所述的复合材料可用于生物医学应用，例如组织工程，药物递送和可植入医疗装置。

17. 发明授权

US08820016B2 External insulation wall having grid-reinforced insulation board mechanically anchored 有权
标题翻译：外墙保温墙机械锚定有网格加强保温板
公开(公告)号：US08820016B2
公开(公告)日：2014-09-02
申请号：US13814498
申请日：2011-07-29
申请人： Jinlie Zhou , Yue Zhou
发明人： Jinlie Zhou , Yue Zhou
IPC分类号： E04B1/74 , E04B2/02 , E04B1/76
CPC分类号： E04B2/02 , E04B1/762 , E04B1/7633
摘要： An external insulation wall having grid-reinforced insulation board anchored with mechanical devices includes: a base course wall (1), wherein a leveling and bonding layer (2), grid-reinforced insulation boards (3), plastic expansion anchor bolts (4), a thin plaster protecting layer (5), and a finishing layer (6) are provided on the base course wall (1) from inside to outside in turn. Holes are dilled on the grid-reinforced insulation boards (3), and the grid-reinforced insulation boards (3) are directly fixed on the base course wall with the plastic expansion anchor bolts (4), in such a manner that all load of an external insulation system is born by the plastic expansion anchor bolts (4), and the plastic expansion anchor bolts (4) transmits the load to the base course wall (1). The external insulation wall can solve technical problems of low bearing capacity and difficult surface treatment caused by an old base course wall.
摘要翻译：具有锚定机械装置的格栅加强绝缘板的外部绝缘壁包括：基底层壁（1），其中平整和粘结层（2），网格加强绝缘板（3），塑料膨胀锚固螺栓（4），依次从内向外设置在基层（1）上的薄石膏保护层（5）和精加工层（6）。在格栅加强绝缘板（3）上填充孔，并且使用塑料膨胀锚栓（4）将格栅加强绝缘板（3）直接固定在基础坡道壁上，使得所有载荷外部绝缘系统由塑料膨胀锚固螺栓（4）承载，塑料膨胀锚栓（4）将载荷传递到基础挡土墙（1）。外部隔热墙可以解决低基座墙壁承受能力低，表面处理困难的技术问题。

18. 发明申请

US20130143061A1 Grid-Reinforced Insulation Board 审中-公开
标题翻译：电网加固绝缘板
公开(公告)号：US20130143061A1
公开(公告)日：2013-06-06
申请号：US13814444
申请日：2011-07-29
申请人： Jinlie Zhou , Yue Zhou
发明人： Jinlie Zhou , Yue Zhou
IPC分类号： B32B5/26 , B32B3/26 , B32B19/06 , B32B5/02
CPC分类号： B32B5/26 , B32B3/266 , B32B5/026 , B32B19/06 , E04B1/80 , E04C2/22 , Y10T428/12444 , Y10T442/10
摘要： A grid-reinforced insulation board includes an insulation core board (1), a bidirectional grid reinforcer (2) provided underneath a surface layer thereof and an insulation board protective layer (3) of the bidirectional grid reinforcer (2) provided on an outer surface thereof. The bidirectional grid reinforcer (2) is formed by glass fibers, metal fibers and man-made fiber to improve a tensile strength and a folding strength thereof. The insulation board protective layer (3) is able to improve the corrosion resistance of the bidirectional grid reinforcer (2).
摘要翻译：格栅加强绝缘板包括绝缘芯板（1），设置在其表面层下方的双向格栅加强件（2）和设置在外表面上的双向格栅加强件（2）的绝缘板保护层（3）其中。双向格栅加强件（2）由玻璃纤维，金属纤维和人造纤维形成，以提高拉伸强度和抗折强度。绝缘板保护层（3）能够提高双向栅格加强件（2）的耐腐蚀性。

19. 发明申请

US20120276626A1 SYNTHETIC SURFACES FOR CULTURING STEM CELL DERIVED CARDIOMYOCYTES 有权
标题翻译：用于培养干细胞衍生的心脏细胞的合成表面
公开(公告)号：US20120276626A1
公开(公告)日：2012-11-01
申请号：US13546381
申请日：2012-07-11
申请人： Christopher Bankole Shogbon , Yue Zhou , Ralph Brandenberger
发明人： Christopher Bankole Shogbon , Yue Zhou , Ralph Brandenberger
IPC分类号： C12N5/02 , C12N5/073 , B05D3/10 , C12M3/00
CPC分类号： C12N5/0657 , C12N5/0068 , C12N2500/90 , C12N2506/02 , C12N2533/30
摘要： Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.
摘要翻译：适合于培养干细胞衍生的心肌细胞的合成表面含有由一种或多种丙烯酸酯单体形成的丙烯酸酯聚合物。在许多情况下，丙烯酸酯表面适合于在化学上限定的培养基中培养干细胞来源的心肌细胞。

20. 发明申请

US20120220720A1 FUNCTIONALIZED CELL BINDING PEPTIDES AND CELL CULTURE ARTICLES 审中-公开
标题翻译：功能性细胞结合蛋白和细胞培养物品
公开(公告)号：US20120220720A1
公开(公告)日：2012-08-30
申请号：US13121825
申请日：2010-07-29
申请人： Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Yue Zhou
发明人： Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Yue Zhou
IPC分类号： C08F8/00 , C08G65/48 , C07K14/00 , C08G59/14 , C07K7/08 , C07K7/06
CPC分类号： C07K14/70503 , C12N5/0068 , C12N5/0606 , C12N2533/30 , C12N2533/50
摘要： Synthetic surfaces capable of supporting culture of cells in culture, particularly cells that will be used therapeutically, are disclosed. The synthetic cell culture surfaces have a functionalized peptide, a peptide that has been functionalized to contain a polymerization moiety, and optionally a spacer, grafted to a hydrophilic polymeric base material. Methods of making the surfaces and methods of using the surfaces are also disclosed.
摘要翻译：公开了能够支持培养细胞培养的合成表面，特别是治疗性细胞的细胞。合成细胞培养物表面具有官能化肽，已被官能化以含有聚合部分的肽，以及任选的间接物，接枝到亲水性聚合物基材上。还公开了制造表面的方法和使用表面的方法。

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